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Conserved domains on  [gi|442906|pdb|1FIA|A]
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Chain A, FACTOR FOR INVERSION STIMULATION (FIS)

Protein Classification

DNA-binding transcriptional regulator Fis( domain architecture ID 10011435)

DNA-binding transcriptional regulator Fis is a versatile global regulator that controls basic cellular processes and specific genetic programs such as virulence programs

Gene Symbol:  fis
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  1946369|15808743|27327277
SCOP:  4000189

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fis PRK00430
DNA-binding transcriptional regulator Fis;
4-98 1.49e-58

DNA-binding transcriptional regulator Fis;


:

Pssm-ID: 179020 [Multi-domain]  Cd Length: 95  Bit Score: 174.48  E-value: 1.49e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIA_A        4 QRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGI 83
Cdd:PRK00430  1 QRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEAPLLDMVMQYTRGNQTRAALMLGI 80

                        90
                ....*....|....*
1FIA_A       84 NRGTLRKKLKKYGMN 98
Cdd:PRK00430 81 NRGTLRKKLKKYGMN 95
 
Name Accession Description Interval E-value
fis PRK00430
DNA-binding transcriptional regulator Fis;
4-98 1.49e-58

DNA-binding transcriptional regulator Fis;


Pssm-ID: 179020 [Multi-domain]  Cd Length: 95  Bit Score: 174.48  E-value: 1.49e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIA_A        4 QRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGI 83
Cdd:PRK00430  1 QRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEAPLLDMVMQYTRGNQTRAALMLGI 80

                        90
                ....*....|....*
1FIA_A       84 NRGTLRKKLKKYGMN 98
Cdd:PRK00430 81 NRGTLRKKLKKYGMN 95
Fis COG2901
DNA-binding protein Fis (factor for inversion stimulation) [Transcription];
17-98 3.83e-44

DNA-binding protein Fis (factor for inversion stimulation) [Transcription];


Pssm-ID: 442146 [Multi-domain]  Cd Length: 83  Bit Score: 137.64  E-value: 3.83e-44
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIA_A      17 NSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYG 96
Cdd:COG2901  2 NASDTASSPPLRDCVRQALENYFADLDGEPPSDLYDMVLAEVEKPLLETVLEHTRGNQSRAAEMLGINRNTLRKKLKQYG 81


               ..
1FIA_A      97 MN 98
Cdd:COG2901 82 LL 83
HTH_8 pfam02954
Bacterial regulatory protein, Fis family;
55-94 2.80e-11

Bacterial regulatory protein, Fis family;


Pssm-ID: 427077 [Multi-domain]  Cd Length: 40  Bit Score: 53.17  E-value: 2.80e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
1FIA_A        55 LAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKK 94
Cdd:pfam02954  1 LEEVEKELIEAALERTGGNKSKAARLLGISRRTLYRKLKK 40
 
Name Accession Description Interval E-value
fis PRK00430
DNA-binding transcriptional regulator Fis;
4-98 1.49e-58

DNA-binding transcriptional regulator Fis;


Pssm-ID: 179020 [Multi-domain]  Cd Length: 95  Bit Score: 174.48  E-value: 1.49e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIA_A        4 QRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGI 83
Cdd:PRK00430  1 QRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEAPLLDMVMQYTRGNQTRAALMLGI 80

                        90
                ....*....|....*
1FIA_A       84 NRGTLRKKLKKYGMN 98
Cdd:PRK00430 81 NRGTLRKKLKKYGMN 95
Fis COG2901
DNA-binding protein Fis (factor for inversion stimulation) [Transcription];
17-98 3.83e-44

DNA-binding protein Fis (factor for inversion stimulation) [Transcription];


Pssm-ID: 442146 [Multi-domain]  Cd Length: 83  Bit Score: 137.64  E-value: 3.83e-44
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIA_A      17 NSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYG 96
Cdd:COG2901  2 NASDTASSPPLRDCVRQALENYFADLDGEPPSDLYDMVLAEVEKPLLETVLEHTRGNQSRAAEMLGINRNTLRKKLKQYG 81


               ..
1FIA_A      97 MN 98
Cdd:COG2901 82 LL 83
PRK01905 PRK01905
Fis family transcriptional regulator;
23-97 4.64e-19

Fis family transcriptional regulator;


Pssm-ID: 179348 [Multi-domain]  Cd Length: 77  Bit Score: 74.07  E-value: 4.64e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1FIA_A       23 TQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGM 97
Cdd:PRK01905  2 SKHNIEQCIRDSLDQYFRDLDGSNPHDVYDMVLSCVEKPLLEVVMEQAGGNQSLAAEYLGINRNTLRKKLQQHGL 76
HTH_8 pfam02954
Bacterial regulatory protein, Fis family;
55-94 2.80e-11

Bacterial regulatory protein, Fis family;


Pssm-ID: 427077 [Multi-domain]  Cd Length: 40  Bit Score: 53.17  E-value: 2.80e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
1FIA_A        55 LAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKK 94
Cdd:pfam02954  1 LEEVEKELIEAALERTGGNKSKAARLLGISRRTLYRKLKK 40
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 46-96 1.61e-10

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 55.74  E-value: 1.61e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
1FIA_A       46 DVNDLYElVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYG 96
Cdd:COG2204 369 TAEDLPE-ALEEVERELIERALEETGGNVSRAAELLGISRRTLYRKLKKYG 418
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 55-98 1.44e-09

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 52.85  E-value: 1.44e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
1FIA_A       55 LAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN 98
Cdd:COG3829 405 LEEVEKELIEEALEKTGGNKSKAAKALGISRSTLYRKLKKYGIK 448
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 41-98 3.04e-08

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 49.46  E-value: 3.04e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
1FIA_A       41 QLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN 98
Cdd:COG3604 281 VLDADDLAPGSREALEEVEREHILEALERTGGNIAGAARLLGLTPSTLRSRMKKLGIK 338
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
55-98 9.24e-06

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 42.14  E-value: 9.24e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
1FIA_A        55 LAEVEQPLLDMVMQYTR-----------GNQTRAALMMGINRGTLRKKLKKYGMN 98
Cdd:PRK11361 403 APVGERNLKEEIKRVEKriimevleqqeGNRTRTALMLGISRRALMYKLQEYGID 457
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 49-97 1.47e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 41.78  E-value: 1.47e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
1FIA_A        49 DLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGM 97
Cdd:PRK10923 420 NLLSEAQPELERTLLTTALRHTQGHKQEAARLLGWGRNTLTRKLKELGM 468
AcoR COG3284
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];
55-96 1.04e-04

Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];


Pssm-ID: 442514 [Multi-domain]  Cd Length: 625  Bit Score: 39.11  E-value: 1.04e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
1FIA_A       55 LAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYG 96
Cdd:COG3284 584 LEEAERDAILRALRACGGNVSAAARALGISRSTLYRKLKRYG 625
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
55-94 1.25e-03

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 36.16  E-value: 1.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
1FIA_A        55 LAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKK 94
Cdd:PRK10365 402 LVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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