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Conserved domains on  [gi|2098510|pdb|1FIC|A]
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Chain A, GAMMA FIBRINOGEN

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
7-246 2.00e-114

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 327.94  E-value: 2.00e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A          7 TGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPtgtTEFWL 86
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSP---GEFWL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A         87 GNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAgGDAGDAFDGFdfgddpsDKFFTSHN 166
Cdd:pfam00147  78 GNDKIHLLTKQG--PYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYI-GDAGDALDTA-------GRSMTYHN 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A        167 GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKastpngyDNGIIWATWKTRWYSMKKTTMKIIP 246
Cdd:pfam00147 148 GMQFSTWDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKIRP 220
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
7-246 2.00e-114

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 327.94  E-value: 2.00e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A          7 TGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPtgtTEFWL 86
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSP---GEFWL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A         87 GNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAgGDAGDAFDGFdfgddpsDKFFTSHN 166
Cdd:pfam00147  78 GNDKIHLLTKQG--PYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYI-GDAGDALDTA-------GRSMTYHN 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A        167 GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKastpngyDNGIIWATWKTRWYSMKKTTMKIIP 246
Cdd:pfam00147 148 GMQFSTWDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKIRP 220
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
6-247 7.44e-112

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040  Cd Length: 215  Bit Score: 321.11  E-value: 7.44e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A        6 ITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSptgtTEFW 85
Cdd:cd00087   1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD----GEFW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A       86 LGNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFaGGDAGDAfdgfdfgddpsdkfFTSH 165
Cdd:cd00087  77 LGLEKIHLLTSQG--PYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDA--------------LSYH 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A      166 NGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGtyskasTPNGYDNGIIWATWKTRWYSMKKTTMKII 245
Cdd:cd00087 140 NGMKFSTFDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG------HRNEYDNGINWATWKGSTYSLKFTEMKIR 213

                ..
1FIC_A      246 PF 247
Cdd:cd00087 214 PK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
7-247 2.27e-104

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 301.89  E-value: 2.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A           7 TGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSptgtTEFWL 86
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA----GEFWL 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A          87 GNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLtyayFAGGDAGDAFDGfdfgddpsdkFFTSHN 166
Cdd:smart00186  77 GNENIHLLTSQG--KYELRIDLEDWEGNTAYALYDSFKVADEADGYRL----HIGGYSGTAGDA----------SLTYHN 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A         167 GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQggtyskastPNGYDNGIIWATWKTRWYSMKKTTMKIIP 246
Cdd:smart00186 141 GMQFSTYDRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTEMKIRP 211

                   .
1FIC_A         247 F 247
Cdd:smart00186 212 L 212
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
7-246 2.00e-114

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 327.94  E-value: 2.00e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A          7 TGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPtgtTEFWL 86
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSP---GEFWL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A         87 GNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAgGDAGDAFDGFdfgddpsDKFFTSHN 166
Cdd:pfam00147  78 GNDKIHLLTKQG--PYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYI-GDAGDALDTA-------GRSMTYHN 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A        167 GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKastpngyDNGIIWATWKTRWYSMKKTTMKIIP 246
Cdd:pfam00147 148 GMQFSTWDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKIRP 220
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
6-247 7.44e-112

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040  Cd Length: 215  Bit Score: 321.11  E-value: 7.44e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A        6 ITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSptgtTEFW 85
Cdd:cd00087   1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD----GEFW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A       86 LGNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFaGGDAGDAfdgfdfgddpsdkfFTSH 165
Cdd:cd00087  77 LGLEKIHLLTSQG--PYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDA--------------LSYH 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A      166 NGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGtyskasTPNGYDNGIIWATWKTRWYSMKKTTMKII 245
Cdd:cd00087 140 NGMKFSTFDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG------HRNEYDNGINWATWKGSTYSLKFTEMKIR 213

                ..
1FIC_A      246 PF 247
Cdd:cd00087 214 PK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
7-247 2.27e-104

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 301.89  E-value: 2.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A           7 TGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSptgtTEFWL 86
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA----GEFWL 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A          87 GNEKIHLISTQSaiPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLtyayFAGGDAGDAFDGfdfgddpsdkFFTSHN 166
Cdd:smart00186  77 GNENIHLLTSQG--KYELRIDLEDWEGNTAYALYDSFKVADEADGYRL----HIGGYSGTAGDA----------SLTYHN 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FIC_A         167 GMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQggtyskastPNGYDNGIIWATWKTRWYSMKKTTMKIIP 246
Cdd:smart00186 141 GMQFSTYDRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTEMKIRP 211

                   .
1FIC_A         247 F 247
Cdd:smart00186 212 L 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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