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Conserved domains on  [gi|253722847|pdb|1FNF|A]
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Chain A, FIBRONECTIN

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10440908)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
277-358 7.57e-20

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 82.85  E-value: 7.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        277 DVPRDLEVVAATPTSLLISWDAPAV---TVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
1FNF_A        354 DSPAS 358
Cdd:pfam00041  81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
96-177 3.89e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 3.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         96 PPPTDLRFTNIGPDTMRVTWAPPP--SIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....
1FNF_A        174 ESTP 177
Cdd:pfam00041  81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
187-266 4.56e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 4.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        187 DSPTGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGRE 263
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ...
1FNF_A        264 ESP 266
Cdd:pfam00041  81 EGP 83
fn3 pfam00041
Fibronectin type III domain;
3-86 5.08e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A          3 SPPTNLHLEANPDTGvLTVSWERSTTP--DITGYRITTTPTNGQQGnSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKD 80
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPDGngPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*.
1FNF_A         81 DKESVP 86
Cdd:pfam00041  79 GGEGPP 84
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
277-358 7.57e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 82.85  E-value: 7.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        277 DVPRDLEVVAATPTSLLISWDAPAV---TVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
1FNF_A        354 DSPAS 358
Cdd:pfam00041  81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
96-177 3.89e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 3.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         96 PPPTDLRFTNIGPDTMRVTWAPPP--SIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....
1FNF_A        174 ESTP 177
Cdd:pfam00041  81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
187-266 4.56e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 4.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        187 DSPTGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGRE 263
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ...
1FNF_A        264 ESP 266
Cdd:pfam00041  81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 277-359 2.03e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 2.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      277 DVPRDLEVVAATPTSLLISWDAPAVT---VRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                ....*.
1FNF_A      354 DSPASS 359
Cdd:cd00063  82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 96-175 9.26e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.40  E-value: 9.26e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A          96 PPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   ..
1FNF_A         174 ES 175
Cdd:smart00060  82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 96-177 1.57e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A       96 PPPTDLRFTNIGPDTMRVTWAPPPSI--DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                ....
1FNF_A      174 ESTP 177
Cdd:cd00063  82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 187-266 3.25e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 3.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      187 DSPTGIDFSDITANSFTVHWIAPRAT---ITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGRE 263
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                ...
1FNF_A      264 ESP 266
Cdd:cd00063  82 ESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 279-355 8.74e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 8.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         279 PRDLEVVAATPTSLLISWDAPAVT-----VRYYRITYGETGGNspVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   ..
1FNF_A         354 DS 355
Cdd:smart00060  82 EG 83
fn3 pfam00041
Fibronectin type III domain;
3-86 5.08e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A          3 SPPTNLHLEANPDTGvLTVSWERSTTP--DITGYRITTTPTNGQQGnSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKD 80
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPDGngPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*.
1FNF_A         81 DKESVP 86
Cdd:pfam00041  79 GGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 187-265 1.26e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         187 DSPTGIDFSDITANSFTVHWIAPRAT-----ITGYRIRHHPEhfSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNG 261
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREE--GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
1FNF_A         262 REES 265
Cdd:smart00060  80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3-92 6.50e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 6.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        3 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGNSLEeVVHADQSSCTFDNLSPGLEYNVSVYTVKD 80
Cdd:cd00063   2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                        90
                ....*....|..
1FNF_A       81 DKESVPISDTII 92
Cdd:cd00063  80 GGESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3-364 8.06e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 8.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        3 SPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDK 82
Cdd:COG3401  51 SPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A       83 ESVPISDTIIPAVPPPTDLRFTNIGPDTMRVTWAPPpsidlTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEY 162
Cdd:COG3401 131 VAGGAATAGTYALGAGLYGVDGANASGTTASSVAGA-----GVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTY 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      163 VVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA-PRATITGYRIRHHPEHFSGRPREDRVphS 237
Cdd:COG3401 206 YYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATV--T 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      238 RNSITLTNLTPGTEYVVSIVALNGREEspllIGQQSTVSDV---------PRDLEVVAATPTSLLISWDAPA-VTVRYYR 307
Cdd:COG3401 284 TTSYTDTGLTNGTTYYYRVTAVDAAGN----ESAPSNVVSVttdltppaaPSGLTATAVGSSSITLSWTASSdADVTGYN 359

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
1FNF_A      308 ItYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISI 364
Cdd:COG3401 360 V-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3-84 1.17e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A           3 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGNSLEEV-VHADQSSCTFDNLSPGLEYNVSVYTVKDD 81
Cdd:smart00060   2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
1FNF_A          82 KES 84
Cdd:smart00060  81 GEG 83
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
277-358 7.57e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 82.85  E-value: 7.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        277 DVPRDLEVVAATPTSLLISWDAPAV---TVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
1FNF_A        354 DSPAS 358
Cdd:pfam00041  81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
96-177 3.89e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 3.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         96 PPPTDLRFTNIGPDTMRVTWAPPP--SIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....
1FNF_A        174 ESTP 177
Cdd:pfam00041  81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
187-266 4.56e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 4.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        187 DSPTGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGRE 263
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ...
1FNF_A        264 ESP 266
Cdd:pfam00041  81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 277-359 2.03e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 2.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      277 DVPRDLEVVAATPTSLLISWDAPAVT---VRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                ....*.
1FNF_A      354 DSPASS 359
Cdd:cd00063  82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 96-175 9.26e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.40  E-value: 9.26e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A          96 PPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   ..
1FNF_A         174 ES 175
Cdd:smart00060  82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 96-177 1.57e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A       96 PPPTDLRFTNIGPDTMRVTWAPPPSI--DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 173
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                ....
1FNF_A      174 ESTP 177
Cdd:cd00063  82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 187-266 3.25e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 3.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      187 DSPTGIDFSDITANSFTVHWIAPRAT---ITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGRE 263
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                ...
1FNF_A      264 ESP 266
Cdd:cd00063  82 ESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 279-355 8.74e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 8.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         279 PRDLEVVAATPTSLLISWDAPAVT-----VRYYRITYGETGGNspVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 353
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                   ..
1FNF_A         354 DS 355
Cdd:smart00060  82 EG 83
fn3 pfam00041
Fibronectin type III domain;
3-86 5.08e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A          3 SPPTNLHLEANPDTGvLTVSWERSTTP--DITGYRITTTPTNGQQGnSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKD 80
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPDGngPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*.
1FNF_A         81 DKESVP 86
Cdd:pfam00041  79 GGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 187-265 1.26e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A         187 DSPTGIDFSDITANSFTVHWIAPRAT-----ITGYRIRHHPEhfSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNG 261
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREE--GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
1FNF_A         262 REES 265
Cdd:smart00060  80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3-92 6.50e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 6.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        3 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGNSLEeVVHADQSSCTFDNLSPGLEYNVSVYTVKD 80
Cdd:cd00063   2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                        90
                ....*....|..
1FNF_A       81 DKESVPISDTII 92
Cdd:cd00063  80 GGESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3-364 8.06e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 8.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        3 SPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDK 82
Cdd:COG3401  51 SPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A       83 ESVPISDTIIPAVPPPTDLRFTNIGPDTMRVTWAPPpsidlTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEY 162
Cdd:COG3401 131 VAGGAATAGTYALGAGLYGVDGANASGTTASSVAGA-----GVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTY 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      163 VVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA-PRATITGYRIRHHPEHFSGRPREDRVphS 237
Cdd:COG3401 206 YYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATV--T 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      238 RNSITLTNLTPGTEYVVSIVALNGREEspllIGQQSTVSDV---------PRDLEVVAATPTSLLISWDAPA-VTVRYYR 307
Cdd:COG3401 284 TTSYTDTGLTNGTTYYYRVTAVDAAGN----ESAPSNVVSVttdltppaaPSGLTATAVGSSSITLSWTASSdADVTGYN 359

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
1FNF_A      308 ItYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISI 364
Cdd:COG3401 360 V-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1-366 1.76e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        1 PLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTngqQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKD 80
Cdd:COG3401 232 PPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNS---GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A       81 DKESVPISDTI-----IPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVrYSPVKNEEDVAELSISPSDNAVVLTN 155
Cdd:COG3401 308 AGNESAPSNVVsvttdLTPPAAPSGLTATAVGSSSITLSWTASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTG 386

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      156 LLPGTEYVVSVSSVY---------EQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHhpeHFS 226
Cdd:COG3401 387 LTPGTTYYYKVTAVDaagnesapsEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLAD---GGD 463

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      227 GRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYY 306
Cdd:COG3401 464 TGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTG 543

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      307 RITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINY 366
Cdd:COG3401 544 DVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGTLLVL 603
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3-84 1.17e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A           3 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGNSLEEV-VHADQSSCTFDNLSPGLEYNVSVYTVKDD 81
Cdd:smart00060   2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
1FNF_A          82 KES 84
Cdd:smart00060  81 GEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1-368 1.32e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 40.70  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A        1 PLSPPTNLHLEANPDTGV---LTVSWErsTTPDITGYRITTTPTNGQQGNSLEEvvhaDQSSCTFDNLSPGlEYNVSVYT 77
Cdd:COG4733 533 PVNVTTSESLSVVAQGTAvttLTVSWD--APAGAVAYEVEWRRDDGNWVSVPRT----SGTSFEVPGIYAG-DYEVRVRA 605

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A       78 V-KDDKESVPISDT------IIPAVPPPTDLRFTNiGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNA 150
Cdd:COG4733 606 InALGVSSAWAASSettvtgKTAPPPAPTGLTATG-GLGGITLSWSFPVDADTLRTEIRYSTTGDWASATVAQALYPGNT 684

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      151 VVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDF--SDITANSFTVH--WIAPRATITGYRIRHHPEHFS 226
Cdd:COG4733 685 YTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGILDAitGQILETELGQEldAIIQNATVAEVVAATVTDVTA 764

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FNF_A      227 GRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREEsplliGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYY 306
Cdd:COG4733 765 QIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATG-----TAADAAGDASGGVTAGTSGTTGAGDTAASTTRVAAAV 839

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
1FNF_A      307 RITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRT 368
Cdd:COG4733 840 VLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADSTAASLTAIV 901
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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