Chain A, Ganglioside M2 Activator Protein
GM2-AP domain-containing protein( domain architecture ID 10083577)
GM2-AP domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
GM2-AP | cd00258 | GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in ... |
1-162 | 1.27e-100 | ||||
GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3. Mutation of the gene results in the AB variant of Tay-Sachs disease. GM2-AP and similar proteins belong to the ML domain family. : Pssm-ID: 238161 Cd Length: 162 Bit Score: 286.01 E-value: 1.27e-100
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Name | Accession | Description | Interval | E-value | ||||
GM2-AP | cd00258 | GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in ... |
1-162 | 1.27e-100 | ||||
GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3. Mutation of the gene results in the AB variant of Tay-Sachs disease. GM2-AP and similar proteins belong to the ML domain family. Pssm-ID: 238161 Cd Length: 162 Bit Score: 286.01 E-value: 1.27e-100
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E1_DerP2_DerF2 | pfam02221 | ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins ... |
2-159 | 2.60e-26 | ||||
ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains. Pssm-ID: 426667 Cd Length: 133 Bit Score: 96.67 E-value: 2.60e-26
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ML | smart00737 | Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) ... |
5-157 | 9.60e-14 | ||||
Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids. Pssm-ID: 214796 Cd Length: 119 Bit Score: 63.54 E-value: 9.60e-14
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Name | Accession | Description | Interval | E-value | ||||
GM2-AP | cd00258 | GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in ... |
1-162 | 1.27e-100 | ||||
GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3. Mutation of the gene results in the AB variant of Tay-Sachs disease. GM2-AP and similar proteins belong to the ML domain family. Pssm-ID: 238161 Cd Length: 162 Bit Score: 286.01 E-value: 1.27e-100
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ML | cd00912 | The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, ... |
5-157 | 1.71e-26 | ||||
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of unknown function in plants, animals and fungi. These single-domain proteins form two anti-parallel beta-pleated sheets stabilized by three disulfide bonds and with an accessible central hydrophobic cavity, and are predicted to mediate diverse biological functions through interaction with specific lipids. Pssm-ID: 238454 Cd Length: 127 Bit Score: 96.82 E-value: 1.71e-26
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E1_DerP2_DerF2 | pfam02221 | ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins ... |
2-159 | 2.60e-26 | ||||
ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains. Pssm-ID: 426667 Cd Length: 133 Bit Score: 96.67 E-value: 2.60e-26
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ML | smart00737 | Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) ... |
5-157 | 9.60e-14 | ||||
Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids. Pssm-ID: 214796 Cd Length: 119 Bit Score: 63.54 E-value: 9.60e-14
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DUF1091 | pfam06477 | Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on ... |
98-139 | 8.89e-04 | ||||
Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on its distant similarity to pfam02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding. Pssm-ID: 428966 Cd Length: 83 Bit Score: 36.52 E-value: 8.89e-04
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Blast search parameters | ||||
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