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Conserved domains on  [gi|408489450|pdb|1HGJ|B]
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Chain B, HEMAGGLUTININ, CHAIN HA1

Protein Classification

hemagglutinin( domain architecture ID 164)

hemagglutinin is a class I fusion protein, having multifunctional activity as both an attachment factor and membrane fusion protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Hemagglutinin super family cl10565
Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral ...
1-175 2.84e-76

Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalizes the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.


The actual alignment was detected with superfamily member pfam00509:

Pssm-ID: 395409  Cd Length: 504  Bit Score: 236.01  E-value: 2.84e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HGJ_B          1 GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDL 80
Cdd:pfam00509 329 GLFGAIAGFIEGGWQGMIDGWYGYHHSNEQGSGYAADKKSTQKAINGITNKVNSIIEKMNTQFEAVGREFNNLERRIENL 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HGJ_B         81 EKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHD 160
Cdd:pfam00509 409 NKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVKNLYDKVKLQLRDNAKEIGNGCFEFYHKCDNECMESVRNGTYDYP 488
                         170
                  ....*....|....*
1HGJ_B        161 VYRDEALNNRFQIKG 175
Cdd:pfam00509 489 QYSEEARLNREEIDG 503
 
Name Accession Description Interval E-value
Hemagglutinin pfam00509
Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral ...
1-175 2.84e-76

Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalizes the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.


Pssm-ID: 395409  Cd Length: 504  Bit Score: 236.01  E-value: 2.84e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HGJ_B          1 GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDL 80
Cdd:pfam00509 329 GLFGAIAGFIEGGWQGMIDGWYGYHHSNEQGSGYAADKKSTQKAINGITNKVNSIIEKMNTQFEAVGREFNNLERRIENL 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HGJ_B         81 EKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHD 160
Cdd:pfam00509 409 NKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVKNLYDKVKLQLRDNAKEIGNGCFEFYHKCDNECMESVRNGTYDYP 488
                         170
                  ....*....|....*
1HGJ_B        161 VYRDEALNNRFQIKG 175
Cdd:pfam00509 489 QYSEEARLNREEIDG 503
 
Name Accession Description Interval E-value
Hemagglutinin pfam00509
Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral ...
1-175 2.84e-76

Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalizes the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.


Pssm-ID: 395409  Cd Length: 504  Bit Score: 236.01  E-value: 2.84e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HGJ_B          1 GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDL 80
Cdd:pfam00509 329 GLFGAIAGFIEGGWQGMIDGWYGYHHSNEQGSGYAADKKSTQKAINGITNKVNSIIEKMNTQFEAVGREFNNLERRIENL 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HGJ_B         81 EKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHD 160
Cdd:pfam00509 409 NKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVKNLYDKVKLQLRDNAKEIGNGCFEFYHKCDNECMESVRNGTYDYP 488
                         170
                  ....*....|....*
1HGJ_B        161 VYRDEALNNRFQIKG 175
Cdd:pfam00509 489 QYSEEARLNREEIDG 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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