Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A        8 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISS*DQLVEGESYVCGSI 87
Cdd:cd17140   1 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 80

                ....*....
1MFW_A       88 EPFKKLEYT 96
Cdd:cd17140  81 EPFKKLEYT 89

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A        8 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISS*DQLVEGESYVCGSI 87
Cdd:cd17140   1 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 80

                ....*....
1MFW_A       88 EPFKKLEYT 96
Cdd:cd17140  81 EPFKKLEYT 89

Doublecortin;

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1MFW_A         28 AISPDRFRSFEALLADLTRTLsdnVNLPQG-VRTIYTIDGlKKISS*DQLVEGESYVCGSIEPF 90
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKV---VKLPFGaVRKLYTLDG-KRVTSLDELEDGGVYVAAGREKF 60

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A        8 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISS*DQLVEGESYVCGSI 87
Cdd:cd17140   1 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 80

                ....*....
1MFW_A       88 EPFKKLEYT 96
Cdd:cd17140  81 EPFKKLEYT 89

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A        8 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISS*DQLVEGESYVCGSI 87
Cdd:cd17141   1 KAKKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTRSLSDNVNLPQGVRTIYTIDGSKKITSLDELLEGESYVCASN 80

                ....*
1MFW_A       88 EPFKK 92
Cdd:cd17141  81 EPFRK 85

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A           5 SEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRtlSDNVNLPQGVRTIYTIDGlKKISS*DQLVEGESYVC 84
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTE--VVKLDLPHGVRKLYTLDG-KKVTSLDELEDGGSYVA 77

                           90
                   ....*....|.
1MFW_A          85 GSIEPFKKLEY 95
Cdd:smart00537  78 SGTEAFKKVDY 88

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1MFW_A       10 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNvnlPQGVRTIYTIDGlKKISS*DQLVEGESYVCGS 86
Cdd:cd01617   1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLP---TGGVRKLYTPSG-KLVKSLSDLEDGESYVVCG 73

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A       10 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLtrtlSDNVNLPQGVRTIYTIDGLKKISS*DQLVEGESYVCGSIEP 89
Cdd:cd17146   1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDL----SQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYLCSDKKY 76

                ..
1MFW_A       90 FK 91
Cdd:cd17146  77 VK 78

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A       10 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGLKKISS*DQLVEGESYVCGSIE 88
Cdd:cd17149   1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVT----GGVQAPFGaVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRE 76

                ....
1MFW_A       89 PFKK 92
Cdd:cd17149  77 RFKK 80

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A       10 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTlsdnVNLPQGVRTIYTIDGLKKISS*DQLVEGESYVCGSIEP 89
Cdd:cd17151   1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTET----VKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRER 76

                ...
1MFW_A       90 FKK 92
Cdd:cd17151  77 FKK 79

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1MFW_A        9 AKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGlKKISS*DQLVEGESYV 83
Cdd:cd16113   1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVT----EKVKLQTGaVRKLYTLDG-KRISDPDELVNGGQYV 71

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
1MFW_A       15 YRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGLKkISS*DQLVEGESYVCGSIEPFKK 92
Cdd:cd17153   7 FRNGDLLSPPFRLLIPKHMLQDWETILSLLT----EKANLRTGaVRKLCTLDGVP-LSSGKELVSGQYYVAVGSEKFKD 80

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MFW_A       10 KKVRFYRNGDRYFKGIVYAISPDrfRSFEALLADLTRTLsdnvNLPQGVRTIYTIDGlKKISS-----*DQLVegesYV- 83
Cdd:cd17072   1 VRLRVLKNGERDLERAVYVVGPD--LELQLFLDRCTERL----NLPFAARRLFDENG-KEIFTlrdleRDQLV----YVs 69

                ..
1MFW_A       84 CG 85
Cdd:cd17072  70 CG 71