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Conserved domains on  [gi|2392456|pdb|1MKX|L]
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Chain L, ALPHA-THROMBIN

Protein Classification

Thrombin_light domain-containing protein( domain architecture ID 10559391)

Thrombin_light domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Thrombin_light pfam09396
Thrombin light chain; Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts ...
2-49 4.08e-25

Thrombin light chain; Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.


:

Pssm-ID: 430582  Cd Length: 48  Bit Score: 86.19  E-value: 4.08e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
1MKX_L         2 SEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGR 49
Cdd:pfam09396  1 TTEEFKTFFNPRTFGAGEADCGLRPLFEKKSKKDKTEKELLESYIGGR 48
 
Name Accession Description Interval E-value
Thrombin_light pfam09396
Thrombin light chain; Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts ...
2-49 4.08e-25

Thrombin light chain; Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.


Pssm-ID: 430582  Cd Length: 48  Bit Score: 86.19  E-value: 4.08e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
1MKX_L         2 SEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGR 49
Cdd:pfam09396  1 TTEEFKTFFNPRTFGAGEADCGLRPLFEKKSKKDKTEKELLESYIGGR 48
 
Name Accession Description Interval E-value
Thrombin_light pfam09396
Thrombin light chain; Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts ...
2-49 4.08e-25

Thrombin light chain; Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.


Pssm-ID: 430582  Cd Length: 48  Bit Score: 86.19  E-value: 4.08e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
1MKX_L         2 SEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGR 49
Cdd:pfam09396  1 TTEEFKTFFNPRTFGAGEADCGLRPLFEKKSKKDKTEKELLESYIGGR 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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