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Conserved domains on  [gi|6137606|pdb|1QSN|A]
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Chain A, TGCN5 HISTONE ACETYL TRANSFERASE

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5076 super family cl34891
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 14-152 6.55e-26

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


The actual alignment was detected with superfamily member COG5076:

Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 101.04  E-value: 6.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A       14 NMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHHESMVILKNKQKVIGGICFR-----QYKPQRFAEVAFLAVTANEQVRG 88
Cdd:COG5076  38 NAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSpfeknRPESLRFDEIVFLAIESVTPESG 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1QSN_A       89 YGTRLMNKFKDHMQKQN---IEYLLTYADNFAIGYFKKQGFTKEHRMPQEKWKGYIKDYDGGTLMEC 152
Cdd:COG5076 118 LGSLLMAHLKTSVKKRKtpkIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEI 184
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 14-152 6.55e-26

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 101.04  E-value: 6.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A       14 NMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHHESMVILKNKQKVIGGICFR-----QYKPQRFAEVAFLAVTANEQVRG 88
Cdd:COG5076  38 NAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSpfeknRPESLRFDEIVFLAIESVTPESG 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1QSN_A       89 YGTRLMNKFKDHMQKQN---IEYLLTYADNFAIGYFKKQGFTKEHRMPQEKWKGYIKDYDGGTLMEC 152
Cdd:COG5076 118 LGSLLMAHLKTSVKKRKtpkIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEI 184
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 18-126 2.54e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 2.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A         18 LIDLKNIFSRQLPKMPKEYIVKLVFDRHH---ESMVILKNKQKVIGGICFRQ-YKPQRFAEVAFLAVTANEQVRGYGTRL 93
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEdasEGFFVAEEDGELVGFASLSIiDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
1QSN_A         94 MNKFKDHMQKQNIE--YLLTYADNF-AIGYFKKQGF 126
Cdd:pfam00583  81 LQALLEWARERGCEriFLEVAADNLaAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 49-109 2.25e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.03  E-value: 2.25e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
1QSN_A       49 MVILKNKQKVIGGICFRQYKP-QRFAEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYL 109
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGSgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 14-152 6.55e-26

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 101.04  E-value: 6.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A       14 NMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHHESMVILKNKQKVIGGICFR-----QYKPQRFAEVAFLAVTANEQVRG 88
Cdd:COG5076  38 NAPEEEGSKNLFQKQLKRMPKEYITSIVDDREPGSMANVNDDLENVGGITYSpfeknRPESLRFDEIVFLAIESVTPESG 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1QSN_A       89 YGTRLMNKFKDHMQKQN---IEYLLTYADNFAIGYFKKQGFTKEHRMPQEKWKGYIKDYDGGTLMEC 152
Cdd:COG5076 118 LGSLLMAHLKTSVKKRKtpkIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEI 184
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 18-126 2.54e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 2.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A         18 LIDLKNIFSRQLPKMPKEYIVKLVFDRHH---ESMVILKNKQKVIGGICFRQ-YKPQRFAEVAFLAVTANEQVRGYGTRL 93
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEdasEGFFVAEEDGELVGFASLSIiDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
1QSN_A         94 MNKFKDHMQKQNIE--YLLTYADNF-AIGYFKKQGF 126
Cdd:pfam00583  81 LQALLEWARERGCEriFLEVAADNLaAIALYEKLGF 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 57-127 1.34e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 53.07  E-value: 1.34e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1QSN_A       57 KVIGGICFRQYkPQRFAEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYLLTYADNFAIGYFKKQGFT 127
Cdd:COG1246  38 EIVGCAALHPL-DEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFE 107
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 46-128 5.17e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.53  E-value: 5.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A         46 HESMVILKNKQKVIGGICFRQYKPQRFAEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYLLTYADNFAIGYFKKQG 125
Cdd:pfam13508   2 GGRFFVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLG 81


                  ...
1QSN_A        126 FTK 128
Cdd:pfam13508  82 FEE 84
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 60-133 1.68e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 49.27  E-value: 1.68e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1QSN_A       60 GGICFRQYKPQRFAEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIE--YLLTYADNF-AIGYFKKQGFTKEHRMP 133
Cdd:COG0456   1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARrlRLEVREDNEaAIALYEKLGFEEVGERP 77
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
57-132 5.99e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.93  E-value: 5.99e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
1QSN_A       57 KVIGGICF---RQYKPQRFAEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYLLTYADNFAIGYFKKQGFTKEHRM 132
Cdd:COG3153  49 EIVGHVALspvDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFRPAGEL 127
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 49-109 2.25e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.03  E-value: 2.25e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
1QSN_A       49 MVILKNKQKVIGGICFRQYKP-QRFAEVAFLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYL 109
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGSgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
57-139 1.23e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.06  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QSN_A       57 KVIGGICFRQYKP----QRFAEVAfLAVTANEQVRGYGTRLMNKFKDHMQKQNIEYLL--TYADN-FAIGYFKKQGFTKE 129
Cdd:COG1247  62 EVVGFASLGPFRPrpayRGTAEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVavVLADNeASIALYEKLGFEEV 140

                        90
                ....*....|
1QSN_A      130 HRMPQEKWKG 139
Cdd:COG1247 141 GTLPEVGFKF 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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