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Conserved domains on  [gi|809371|pdb|1RHP|C]
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Chain C, PLATELET FACTOR 4

Protein Classification

CXC family chemokine( domain architecture ID 10084510)

CXC family chemokine such as interleukin-8, also called C-X-C motif chemokine 8, that is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes, and is involved in neutrophil activation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 7-69 3.37e-22

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


:

Pssm-ID: 238171  Cd Length: 64  Bit Score: 80.38  E-value: 3.37e-22
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....
1RHP_C       7 DLQCLCVKTTSQ-VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLE 69
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKNGRKVCLNPEAPWVQKIIKKLLK 64
 
Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 7-69 3.37e-22

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 80.38  E-value: 3.37e-22
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....
1RHP_C       7 DLQCLCVKTTSQ-VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLE 69
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKNGRKVCLNPEAPWVQKIIKKLLK 64
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 7-67 1.57e-12

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 55.71  E-value: 1.57e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
1RHP_C          7 DLQClCVKTTSQ-VRPRHITSLEVikAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKL 67
Cdd:smart00199  1 PLRC-CLSYTSKkIPLKRIKSYYP--TSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 12-67 2.03e-11

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 53.04  E-value: 2.03e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
1RHP_C        12 CVKTTSQ-VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKL 67
Cdd:pfam00048  4 CLRYSSKpIPLKRVKSYEIQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
 
Name Accession Description Interval E-value
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 7-69 3.37e-22

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 80.38  E-value: 3.37e-22
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....
1RHP_C       7 DLQCLCVKTTSQ-VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLE 69
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKNGRKVCLNPEAPWVQKIIKKLLK 64
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 12-68 1.52e-14

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 60.81  E-value: 1.52e-14
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*...
1RHP_C      12 CVKTTSQ-VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLL 68
Cdd:cd00169  2 CLKYTSKpIPPKNIKSYRVQEAGGHCSIPAVIFTTKKGRKVCADPKEPWVKDLIQKLD 59
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 7-67 1.57e-12

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 55.71  E-value: 1.57e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
1RHP_C          7 DLQClCVKTTSQ-VRPRHITSLEVikAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKL 67
Cdd:smart00199  1 PLRC-CLSYTSKkIPLKRIKSYYP--TSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 12-67 2.03e-11

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 53.04  E-value: 2.03e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
1RHP_C        12 CVKTTSQ-VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKL 67
Cdd:pfam00048  4 CLRYSSKpIPLKRVKSYEIQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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