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Conserved domains on  [gi|58176701|pdb|1S4U|X]
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Chain X, Antiviral protein SKI8

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-346 6.78e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 6.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      200 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQhsminnSNSIRSVKFSPQGSLLAIAHDSNSfgcITLYETEFG 278
Cdd:COG2319 208 RSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGT---VRLWDLATG 278

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1S4U_X      279 ERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319 279 ELLRTLT-------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-361 1.41e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X       23 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDnklLDNENPKDKSYshfVHKSGLHHVDVLQAierdafeLCLVATTSFS 100
Cdd:cd00200   6 KGHTGGVTCVafSPDGKLLATGSGDGTIKVWD---LETGELLRTLK---GHTGPVRDVAASAD-------GTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      101 GDLLFYRItredETKKVIFEkldlldsdMKKHSF--WALKWgaSNDRLLshrLVATDVKGTTYIWKFHPFadesnsltln 178
Cdd:cd00200  73 KTIRLWDL----ETGECVRT--------LTGHTSyvSSVAF--SPDGRI---LSSSSRDKTIKVWDVETG---------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      179 wSPTLELQGtvespmtPSQFATSVDISE-RGLIATGFNNGTVQISELSTLRPLYNFESqHSminnsNSIRSVKFSPQGSL 257
Cdd:cd00200 126 -KCLTTLRG-------HTDWVNSVAFSPdGTFVASSSQDGTIKLWDLRTGKCVATLTG-HT-----GEVNSVAFSPDGEK 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      258 LAIAHDSNSfgcITLYETEFGERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERIT 337
Cdd:cd00200 192 LLSSSSDGT---IKLWDLSTGKCLGTLR-------------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                       330       340
                ....*....|....*....|....
1S4U_X      338 TLNMHcddieiEEDILAVDEHGDS 361
Cdd:cd00200 256 TLSGH------TNSVTSLAWSPDG 273
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-346 6.78e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 6.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      200 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQhsminnSNSIRSVKFSPQGSLLAIAHDSNSfgcITLYETEFG 278
Cdd:COG2319 208 RSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGT---VRLWDLATG 278

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1S4U_X      279 ERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319 279 ELLRTLT-------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-361 1.41e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X       23 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDnklLDNENPKDKSYshfVHKSGLHHVDVLQAierdafeLCLVATTSFS 100
Cdd:cd00200   6 KGHTGGVTCVafSPDGKLLATGSGDGTIKVWD---LETGELLRTLK---GHTGPVRDVAASAD-------GTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      101 GDLLFYRItredETKKVIFEkldlldsdMKKHSF--WALKWgaSNDRLLshrLVATDVKGTTYIWKFHPFadesnsltln 178
Cdd:cd00200  73 KTIRLWDL----ETGECVRT--------LTGHTSyvSSVAF--SPDGRI---LSSSSRDKTIKVWDVETG---------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      179 wSPTLELQGtvespmtPSQFATSVDISE-RGLIATGFNNGTVQISELSTLRPLYNFESqHSminnsNSIRSVKFSPQGSL 257
Cdd:cd00200 126 -KCLTTLRG-------HTDWVNSVAFSPdGTFVASSSQDGTIKLWDLRTGKCVATLTG-HT-----GEVNSVAFSPDGEK 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      258 LAIAHDSNSfgcITLYETEFGERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERIT 337
Cdd:cd00200 192 LLSSSSDGT---IKLWDLSTGKCLGTLR-------------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                       330       340
                ....*....|....*....|....
1S4U_X      338 TLNMHcddieiEEDILAVDEHGDS 361
Cdd:cd00200 256 TLSGH------TNSVTSLAWSPDG 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-329 9.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.56e-06
                           10        20        30
                   ....*....|....*....|....*....|.
1S4U_X         299 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 329
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
299-329 2.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.07e-05
                          10        20        30
                  ....*....|....*....|....*....|.
1S4U_X        299 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 329
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-346 6.78e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 6.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      200 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQhsminnSNSIRSVKFSPQGSLLAIAHDSNSfgcITLYETEFG 278
Cdd:COG2319 208 RSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGT---VRLWDLATG 278

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1S4U_X      279 ERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319 279 ELLRTLT-------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
200-346 1.71e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      200 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQhsminnSNSIRSVKFSPQGSLLAIAHDSNSfgcITLYETEFG 278
Cdd:COG2319 124 RSVAFSPDGkTLASGSADGTVRLWDLATGKLLRTLTGH------SGAVTSVAFSPDGKLLASGSDDGT---VRLWDLATG 194

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1S4U_X      279 ERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319 195 KLLRTLT-------------GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
195-346 2.50e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.50e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      195 PSQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESqHSminnsNSIRSVKFSPQGSLLAIAHDSNSfgcITLY 273
Cdd:COG2319 161 HSGAVTSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTG-HT-----GAVRSVAFSPDGKLLASGSADGT---VRLW 231

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1S4U_X      274 ETEFGERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319 232 DLATGKLLRTLT-------------GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291
WD40 COG2319
WD40 repeat [General function prediction only];
200-346 8.64e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 8.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      200 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQhsminnSNSIRSVKFSPQGSLLAIAHDSNSfgcITLYETEFG 278
Cdd:COG2319 250 RSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGT---VRLWDLATG 320

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1S4U_X      279 ERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319 321 KLLRTLT-------------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-361 1.41e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X       23 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDnklLDNENPKDKSYshfVHKSGLHHVDVLQAierdafeLCLVATTSFS 100
Cdd:cd00200   6 KGHTGGVTCVafSPDGKLLATGSGDGTIKVWD---LETGELLRTLK---GHTGPVRDVAASAD-------GTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      101 GDLLFYRItredETKKVIFEkldlldsdMKKHSF--WALKWgaSNDRLLshrLVATDVKGTTYIWKFHPFadesnsltln 178
Cdd:cd00200  73 KTIRLWDL----ETGECVRT--------LTGHTSyvSSVAF--SPDGRI---LSSSSRDKTIKVWDVETG---------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      179 wSPTLELQGtvespmtPSQFATSVDISE-RGLIATGFNNGTVQISELSTLRPLYNFESqHSminnsNSIRSVKFSPQGSL 257
Cdd:cd00200 126 -KCLTTLRG-------HTDWVNSVAFSPdGTFVASSSQDGTIKLWDLRTGKCVATLTG-HT-----GEVNSVAFSPDGEK 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      258 LAIAHDSNSfgcITLYETEFGERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERIT 337
Cdd:cd00200 192 LLSSSSDGT---IKLWDLSTGKCLGTLR-------------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                       330       340
                ....*....|....*....|....
1S4U_X      338 TLNMHcddieiEEDILAVDEHGDS 361
Cdd:cd00200 256 TLSGH------TNSVTSLAWSPDG 273
WD40 COG2319
WD40 repeat [General function prediction only];
200-332 3.34e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 3.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      200 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFEsqhsmiNNSNSIRSVKFSPQGSLLAIAHDSNSfgcITLYETEFG 278
Cdd:COG2319 292 NSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLT------GHTGAVRSVAFSPDGKTLASGSDDGT---VRLWDLATG 362

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
1S4U_X      279 ERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKT 332
Cdd:COG2319 363 ELLRTLT-------------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-329 2.31e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 2.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X       23 KAHDADIFSVSACNSFT--VSCSGDGYLKVWDnklLDNENpkdKSYSHFVHKSGLHHVDVLQAIErdafelcLVATTSFS 100
Cdd:cd00200  48 KGHTGPVRDVAASADGTylASGSSDKTIRLWD---LETGE---CVRTLTGHTSYVSSVAFSPDGR-------ILSSSSRD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      101 GDLLFYRItredETKKVIFEkldlldsdMKKHSFW--ALKWGASNDRLLShrlVATDvkGTTYIWKFHpfadesnsltlN 178
Cdd:cd00200 115 KTIKVWDV----ETGKCLTT--------LRGHTDWvnSVAFSPDGTFVAS---SSQD--GTIKLWDLR-----------T 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      179 WSPTLELQGtvespmtPSQFATSVDISERG-LIATGFNNGTVQISELSTlrplynFESQHSMINNSNSIRSVKFSPQGSL 257
Cdd:cd00200 167 GKCVATLTG-------HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLST------GKCLGTLRGHENGVNSVAFSPDGYL 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1S4U_X      258 LAIAHDSNSfgcITLYETEFGERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 329
Cdd:cd00200 234 LASGSEDGT---IRVWDLRTGECVQTLS-------------GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
169-342 1.26e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      169 ADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRS 248
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S4U_X      249 VKFSPQGSLLAIAHDSNSfgcITLYETEFGERIGSLSvpthssqaslgefAHSSWVMSLSFNDSGETLCSAGWDGKLRFW 328
Cdd:COG2319  84 VAFSPDGRLLASASADGT---VRLWDLATGLLLRTLT-------------GHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                       170
                ....*....|....
1S4U_X      329 DVKTKERITTLNMH 342
Cdd:COG2319 148 DLATGKLLRTLTGH 161
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-329 9.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.56e-06
                           10        20        30
                   ....*....|....*....|....*....|.
1S4U_X         299 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 329
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
299-329 2.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.07e-05
                          10        20        30
                  ....*....|....*....|....*....|.
1S4U_X        299 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 329
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
300-346 1.50e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.50e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
1S4U_X      300 HSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 346
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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