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Conserved domains on  [gi|1421325|pdb|1XXC|E]
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Chain E, ARGININE REPRESSOR

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05066 super family cl29389
transcriptional regulator ArgR;
2-78 4.02e-49

transcriptional regulator ArgR;


The actual alignment was detected with superfamily member PRK05066:

Pssm-ID: 179922 [Multi-domain]  Cd Length: 156  Bit Score: 151.69  E-value: 4.02e-49
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1XXC_E         2 SPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL 78
Cdd:PRK05066  80 SPLKNLVLDIDHNDALIVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFITPASGFTIKELLEAILELFEQEL 156
 
Name Accession Description Interval E-value
PRK05066 PRK05066
transcriptional regulator ArgR;
2-78 4.02e-49

transcriptional regulator ArgR;


Pssm-ID: 179922 [Multi-domain]  Cd Length: 156  Bit Score: 151.69  E-value: 4.02e-49
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1XXC_E         2 SPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL 78
Cdd:PRK05066  80 SPLKNLVLDIDHNDALIVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFITPASGFTIKELLEAILELFEQEL 156
argR_whole TIGR01529
arginine repressor; This model includes most members of the arginine-responsive ...
 3-74 4.27e-28

arginine repressor; This model includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family, Regulatory functions, DNA interactions]


Pssm-ID: 130592  Cd Length: 146  Bit Score: 98.17  E-value: 4.27e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1XXC_E          3 PLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKaEGILGTIAGDDTIFTTPANGFTVKDLYEAILELF 74
Cdd:TIGR01529  76 LLKNLVLSIDRAGNLIVIRTKPGEASVIANLLDRLDK-DEILGTIAGDDTILVICRDPETAELLMERLLELL 146
ArgR COG1438
Arginine repressor [Transcription];
2-76 2.53e-27

Arginine repressor [Transcription];


Pssm-ID: 441047  Cd Length: 152  Bit Score: 96.35  E-value: 2.53e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXC_E        2 SPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKaEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQ 76
Cdd:COG1438  78 RLLRELVVSIDHSGNLVVIKTLPGAAQAVASAIDSLGL-PEILGTIAGDDTILVIPRSEEDAEELAERLLKLLEG 151
Arg_repressor_C pfam02863
Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, ...
 4-72 6.44e-23

Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 460726  Cd Length: 68  Bit Score: 82.43  E-value: 6.44e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1XXC_E         4 LKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGkAEGILGTIAGDDTIFTTPANGFTVKDLYEAILE 72
Cdd:pfam02863  1 LREAVVSIDHAGNLVVIKTLPGNAQAVAAAIDSLN-WPEILGTIAGDDTILVICRSEEDAEELAERLKK 68
 
Name Accession Description Interval E-value
PRK05066 PRK05066
transcriptional regulator ArgR;
2-78 4.02e-49

transcriptional regulator ArgR;


Pssm-ID: 179922 [Multi-domain]  Cd Length: 156  Bit Score: 151.69  E-value: 4.02e-49
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1XXC_E         2 SPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL 78
Cdd:PRK05066  80 SPLKNLVLDIDHNDALIVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFITPASGFTIKELLEAILELFEQEL 156
argR_whole TIGR01529
arginine repressor; This model includes most members of the arginine-responsive ...
 3-74 4.27e-28

arginine repressor; This model includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family, Regulatory functions, DNA interactions]


Pssm-ID: 130592  Cd Length: 146  Bit Score: 98.17  E-value: 4.27e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1XXC_E          3 PLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKaEGILGTIAGDDTIFTTPANGFTVKDLYEAILELF 74
Cdd:TIGR01529  76 LLKNLVLSIDRAGNLIVIRTKPGEASVIANLLDRLDK-DEILGTIAGDDTILVICRDPETAELLMERLLELL 146
ArgR COG1438
Arginine repressor [Transcription];
2-76 2.53e-27

Arginine repressor [Transcription];


Pssm-ID: 441047  Cd Length: 152  Bit Score: 96.35  E-value: 2.53e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXC_E        2 SPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKaEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQ 76
Cdd:COG1438  78 RLLRELVVSIDHSGNLVVIKTLPGAAQAVASAIDSLGL-PEILGTIAGDDTILVIPRSEEDAEELAERLLKLLEG 151
Arg_repressor_C pfam02863
Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, ...
 4-72 6.44e-23

Arginine repressor, C-terminal domain; This is the C-terminal domain of the arginine repressor, responsible for arginine binding and multimerization. It binds mainly Arg, but also ornithine, Pro and Tyr (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 460726  Cd Length: 68  Bit Score: 82.43  E-value: 6.44e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1XXC_E         4 LKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGkAEGILGTIAGDDTIFTTPANGFTVKDLYEAILE 72
Cdd:pfam02863  1 LREAVVSIDHAGNLVVIKTLPGNAQAVAAAIDSLN-WPEILGTIAGDDTILVICRSEEDAEELAERLKK 68
argR PRK00441
arginine repressor; Provisional
 4-73 1.06e-10

arginine repressor; Provisional


Pssm-ID: 179027 [Multi-domain]  Cd Length: 149  Bit Score: 53.52  E-value: 1.06e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXC_E         4 LKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGkAEGILGTIAGDDTIFTTPANGFTVKDLYEAILEL 73
Cdd:PRK00441  79 FSNTVISVENVDNMIVIKTISGSASAAAEAIDTLN-FDGIAGTIAGDNTIFVLVRSEEKAQEIVEKIKKL 147
PRK03341 PRK03341
arginine repressor; Provisional
 4-73 7.16e-09

arginine repressor; Provisional


Pssm-ID: 235116  Cd Length: 168  Bit Score: 49.25  E-value: 7.16e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXC_E         4 LKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEgILGTIAGDDTIFTTPANGFTVKDLYEAILEL 73
Cdd:PRK03341  96 LGELLVSADASANLAVLRTPPGAAQYLASAIDRAALPE-VVGTIAGDDTVLVIARDPMTGAELAARLLRL 164
PRK04280 PRK04280
transcriptional regulator ArgR;
4-65 2.77e-08

transcriptional regulator ArgR;


Pssm-ID: 179807  Cd Length: 148  Bit Score: 47.31  E-value: 2.77e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1XXC_E         4 LKNLVLD----IDYNDAVVVIHTSPGAAQLIARLLDSLGKAEgILGTIAGDDTIFT---TPANGFTVKD 65
Cdd:PRK04280  75 LKRALMDsfvkIDGAGNLLVLKTLPGNANSIGALIDNLDWDE-ILGTICGDDTCLIicrTEEDAEEVKD 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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