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Conserved domains on  [gi|85544485|pdb|2CXF|A]
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Chain A, rap2 interacting protein x

Protein Classification

RUN domain-containing protein (domain architecture ID 10651938)

RUN domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RUN pfam02759
RUN domain. This domain is present in several proteins that are linked to the functions of ...
46-166 2.85e-40

RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


:

Pssm-ID: 367169  Cd Length: 129  Bit Score: 133.16  E-value: 2.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CXF_A         46 QFFVV*EHCLKHGLKAKKT------FLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLAL*QKKL 119
Cdd:pfam02759   1 SLCAALEALLSHGLKRSSLsaeraaGLLRERSFWALLERVGKLVPPAESLLSSVQELEQIHTSDGRGRAWIRLALNEKLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
2CXF_A        120 SEY*KALINKKELLSEFYEVNAL**EEEGA-IIAGLLVGLNVIDANFC 166
Cdd:pfam02759  81 ERWLSLLLSDKELLSRYYEPWALLRDPEFGsILLGLLVGLSALDFNLC 128
 
Name Accession Description Interval E-value
RUN pfam02759
RUN domain. This domain is present in several proteins that are linked to the functions of ...
46-166 2.85e-40

RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 367169  Cd Length: 129  Bit Score: 133.16  E-value: 2.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CXF_A         46 QFFVV*EHCLKHGLKAKKT------FLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLAL*QKKL 119
Cdd:pfam02759   1 SLCAALEALLSHGLKRSSLsaeraaGLLRERSFWALLERVGKLVPPAESLLSSVQELEQIHTSDGRGRAWIRLALNEKLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
2CXF_A        120 SEY*KALINKKELLSEFYEVNAL**EEEGA-IIAGLLVGLNVIDANFC 166
Cdd:pfam02759  81 ERWLSLLLSDKELLSRYYEPWALLRDPEFGsILLGLLVGLSALDFNLC 128
RUN smart00593
domain involved in Ras-like GTPase signaling;
106-168 5.43e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736  Cd Length: 64  Bit Score: 66.10  E-value: 5.43e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
2CXF_A         106 GRAWLRLAL*QKKLSEY*KALINKKELLSEFYEVNA-L**EEEGAIIAGLLVGLNVIDANFC*K 168
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAfLRDPEEGEQLLGLLVGLSALDFNLPVD 64
 
Name Accession Description Interval E-value
RUN pfam02759
RUN domain. This domain is present in several proteins that are linked to the functions of ...
46-166 2.85e-40

RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 367169  Cd Length: 129  Bit Score: 133.16  E-value: 2.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CXF_A         46 QFFVV*EHCLKHGLKAKKT------FLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLAL*QKKL 119
Cdd:pfam02759   1 SLCAALEALLSHGLKRSSLsaeraaGLLRERSFWALLERVGKLVPPAESLLSSVQELEQIHTSDGRGRAWIRLALNEKLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
2CXF_A        120 SEY*KALINKKELLSEFYEVNAL**EEEGA-IIAGLLVGLNVIDANFC 166
Cdd:pfam02759  81 ERWLSLLLSDKELLSRYYEPWALLRDPEFGsILLGLLVGLSALDFNLC 128
RUN smart00593
domain involved in Ras-like GTPase signaling;
106-168 5.43e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736  Cd Length: 64  Bit Score: 66.10  E-value: 5.43e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
2CXF_A         106 GRAWLRLAL*QKKLSEY*KALINKKELLSEFYEVNA-L**EEEGAIIAGLLVGLNVIDANFC*K 168
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAfLRDPEEGEQLLGLLVGLSALDFNLPVD 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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