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Conserved domains on  [gi|6980476|pdb|2LIS|A]
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Chain A, Sperm Lysin

Protein Classification

Lysin-Sp18 domain-containing protein( domain architecture ID 10473618)

Lysin-Sp18 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Egg_lysin pfam01303
Egg lysin (Sperm-lysin); Egg lysin creates a hole in the envelope of the egg thereby allowing ...
 11-131 2.53e-61

Egg lysin (Sperm-lysin); Egg lysin creates a hole in the envelope of the egg thereby allowing the sperm to pass through the envelope and fuse with the egg.


:

Pssm-ID: 460155  Cd Length: 121  Bit Score: 184.02  E-value: 2.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2LIS_A         11 LNKAFEVALKVQIIAGFDRGLVKWLRVHGRTLSTVQKKALYFVNRRYMQTHWANYMLWINKKIDALGRTPVVGDYTRLGA 90
Cdd:pfam01303   1 VSRANEVALKVQIIAGLDRKLTKWLRRHGSRLSPPQKKTLYFVNRRRMQTHWQNYMLWVSKKIRKLGRPPNVKDYTRLGR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
2LIS_A         91 EIGRRIDMAYFYDFLKDKNMIPKYLPYMEEINRMRPADVPV 131
Cdd:pfam01303  81 EIGRRIPMERMYSFLVRRNMRPKWTPYMRKLLAKRPADLPV 121
 
Name Accession Description Interval E-value
Egg_lysin pfam01303
Egg lysin (Sperm-lysin); Egg lysin creates a hole in the envelope of the egg thereby allowing ...
 11-131 2.53e-61

Egg lysin (Sperm-lysin); Egg lysin creates a hole in the envelope of the egg thereby allowing the sperm to pass through the envelope and fuse with the egg.


Pssm-ID: 460155  Cd Length: 121  Bit Score: 184.02  E-value: 2.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2LIS_A         11 LNKAFEVALKVQIIAGFDRGLVKWLRVHGRTLSTVQKKALYFVNRRYMQTHWANYMLWINKKIDALGRTPVVGDYTRLGA 90
Cdd:pfam01303   1 VSRANEVALKVQIIAGLDRKLTKWLRRHGSRLSPPQKKTLYFVNRRRMQTHWQNYMLWVSKKIRKLGRPPNVKDYTRLGR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
2LIS_A         91 EIGRRIDMAYFYDFLKDKNMIPKYLPYMEEINRMRPADVPV 131
Cdd:pfam01303  81 EIGRRIPMERMYSFLVRRNMRPKWTPYMRKLLAKRPADLPV 121
Lysin-Sp18 cd00243
Sp18 and Lysin from Archaegastropoda (marine mollusks of the families Halotidae and Trochidae) ...
 11-132 1.70e-58

Sp18 and Lysin from Archaegastropoda (marine mollusks of the families Halotidae and Trochidae) sperm. Both proteins play an important role in fertilization: sp18 mediates fusion between sperm and egg cell membrane, lysin dissolves the vitelline envelope surrounding the egg; they are believed to be a product of gene duplication and subsequent divergence.


Pssm-ID: 119415  Cd Length: 122  Bit Score: 177.07  E-value: 1.70e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2LIS_A       11 LNKAFEVALKVQIIAGFDRGLVKWLRVHGRTLSTVQKKALYFVNRRYMQTHWANYMLWINKKIDALGRTPVVGDYTRLGA 90
Cdd:cd00243   1 VGRENEVALKVGIIAGLDRKLDKWLRRHGDRLSPPQKKTLYFVNRRRMQTHWQNYMLWSKKIIRKLGRPPNVKDYTRLGR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
2LIS_A       91 EIGRRIDMAYFYDFLKDKNMIPKYLPYMEEINRMRPADVPVK 132
Cdd:cd00243  81 EIGRRIYMEHLYSFLVRRNRRPKLTPYMRKLLATRPADLPVR 122
 
Name Accession Description Interval E-value
Egg_lysin pfam01303
Egg lysin (Sperm-lysin); Egg lysin creates a hole in the envelope of the egg thereby allowing ...
 11-131 2.53e-61

Egg lysin (Sperm-lysin); Egg lysin creates a hole in the envelope of the egg thereby allowing the sperm to pass through the envelope and fuse with the egg.


Pssm-ID: 460155  Cd Length: 121  Bit Score: 184.02  E-value: 2.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2LIS_A         11 LNKAFEVALKVQIIAGFDRGLVKWLRVHGRTLSTVQKKALYFVNRRYMQTHWANYMLWINKKIDALGRTPVVGDYTRLGA 90
Cdd:pfam01303   1 VSRANEVALKVQIIAGLDRKLTKWLRRHGSRLSPPQKKTLYFVNRRRMQTHWQNYMLWVSKKIRKLGRPPNVKDYTRLGR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
2LIS_A         91 EIGRRIDMAYFYDFLKDKNMIPKYLPYMEEINRMRPADVPV 131
Cdd:pfam01303  81 EIGRRIPMERMYSFLVRRNMRPKWTPYMRKLLAKRPADLPV 121
Lysin-Sp18 cd00243
Sp18 and Lysin from Archaegastropoda (marine mollusks of the families Halotidae and Trochidae) ...
 11-132 1.70e-58

Sp18 and Lysin from Archaegastropoda (marine mollusks of the families Halotidae and Trochidae) sperm. Both proteins play an important role in fertilization: sp18 mediates fusion between sperm and egg cell membrane, lysin dissolves the vitelline envelope surrounding the egg; they are believed to be a product of gene duplication and subsequent divergence.


Pssm-ID: 119415  Cd Length: 122  Bit Score: 177.07  E-value: 1.70e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2LIS_A       11 LNKAFEVALKVQIIAGFDRGLVKWLRVHGRTLSTVQKKALYFVNRRYMQTHWANYMLWINKKIDALGRTPVVGDYTRLGA 90
Cdd:cd00243   1 VGRENEVALKVGIIAGLDRKLDKWLRRHGDRLSPPQKKTLYFVNRRRMQTHWQNYMLWSKKIIRKLGRPPNVKDYTRLGR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
2LIS_A       91 EIGRRIDMAYFYDFLKDKNMIPKYLPYMEEINRMRPADVPVK 132
Cdd:cd00243  81 EIGRRIYMEHLYSFLVRRNRRPKLTPYMRKLLATRPADLPVR 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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