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Conserved domains on  [gi|261278557|pdb|2WML|A]
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Chain A, Cmp-n-acetylneuraminate-beta-galactosamide -alpha-2,3-sialyltransferase

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 17-296 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


:

Pssm-ID: 467708  Cd Length: 280  Bit Score: 579.14  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       17 CTCTRCIEEQRVSAWFDERFNRS*QPLLTAKNAHLEEDTYKWWLRLQREKKPNNLNDTIRELFQVVPGNVDPLLEKRLVS 96
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTTDLEWVI 176
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      177 SATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWH 256
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
2WML_A      257 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 296
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 17-296 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 579.14  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       17 CTCTRCIEEQRVSAWFDERFNRS*QPLLTAKNAHLEEDTYKWWLRLQREKKPNNLNDTIRELFQVVPGNVDPLLEKRLVS 96
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTTDLEWVI 176
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      177 SATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWH 256
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
2WML_A      257 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 296
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 43-282 2.07e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 271.79  E-value: 2.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A         43 LLTAKNAHLEEDTY--KWWLRLqrekkpNNLNDTIRELFQVVPGNVDPllekrlvsCRRCAVVGNSGNLKESYYGPQIDS 120
Cdd:pfam00777   1 FLTKENFPLGEWIRysEWWLPF------TVTEELLELLPKVSPFDNKR--------CRRCAVVGNGGILRGSGCGKEIDS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A        121 HDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFR-----------ELAQEVS*ILVPFKTTDLEWVISATTTGRISH--- 186
Cdd:pfam00777  67 HDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslr 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A        187 -TYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHG---RYPSTGILSVIFSLHICDEVDLYGFGA--DSKGNWHHYWE 260
Cdd:pfam00777 147 vLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYD 226

                         250       260
                  ....*....|....*....|..
2WML_A        261 NNPSAgAFRKTGVHDGDFESNV 282
Cdd:pfam00777 227 NVLMK-KGGFYGVHDMPFEFKL 247
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 17-296 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 579.14  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       17 CTCTRCIEEQRVSAWFDERFNRS*QPLLTAKNAHLEEDTYKWWLRLQREKKPNNLNDTIRELFQVVPGNVDPLLEKRLVS 96
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTTDLEWVI 176
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      177 SATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWH 256
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
2WML_A      257 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 296
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 19-296 2.79e-179

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 495.26  E-value: 2.79e-179
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       19 CTRCIEEQRVSAWFDERFNRS*QPLLTAKNAHLEEDTYKWWLRLQREKKpNNLNDTIRELFQVVPGNvDPLLEKRLVSCR 98
Cdd:cd23966   1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKN-SDLREVLEKLFQVVPGE-NPYRTRDPNRCR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       99 RCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTTDLEWVISA 178
Cdd:cd23966  79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      179 TTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWHHY 258
Cdd:cd23966 159 LTTGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHY 238

                       250       260       270
                ....*....|....*....|....*....|....*...
2WML_A      259 WENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 296
Cdd:cd23966 239 WEKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 17-296 5.10e-135

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 383.45  E-value: 5.10e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       17 CTCTRCIEEQRVSAWFDERFNRS*QPLLTAKNAHLEEDTYKWWLRLQREKKPNNLNDTIRELFQVVPGNvDPLLEKRLVS 96
Cdd:cd23979   1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGE-NPYRSWDPSR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTTDLEWVI 176
Cdd:cd23979  80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWIT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      177 SATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWH 256
Cdd:cd23979 160 SALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
2WML_A      257 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 296
Cdd:cd23979 240 HYWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 43-282 2.07e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 271.79  E-value: 2.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A         43 LLTAKNAHLEEDTY--KWWLRLqrekkpNNLNDTIRELFQVVPGNVDPllekrlvsCRRCAVVGNSGNLKESYYGPQIDS 120
Cdd:pfam00777   1 FLTKENFPLGEWIRysEWWLPF------TVTEELLELLPKVSPFDNKR--------CRRCAVVGNGGILRGSGCGKEIDS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A        121 HDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFR-----------ELAQEVS*ILVPFKTTDLEWVISATTTGRISH--- 186
Cdd:pfam00777  67 HDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslr 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A        187 -TYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHG---RYPSTGILSVIFSLHICDEVDLYGFGA--DSKGNWHHYWE 260
Cdd:pfam00777 147 vLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYD 226

                         250       260
                  ....*....|....*....|..
2WML_A        261 NNPSAgAFRKTGVHDGDFESNV 282
Cdd:pfam00777 227 NVLMK-KGGFYGVHDMPFEFKL 247
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 100-282 1.06e-56

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 181.02  E-value: 1.06e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      100 CAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKttDLEWVISAT 179
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLP--LEEEVVLIL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      180 TTGRISHTYVPVPAKIKVKKEKILIYHPA--FIKYVFDRWLQGH------GRYPSTGILSVIFSLHICDEVDLYGFGADS 251
Cdd:cd19952  79 SRAAAADFKRLKRRKKRHDNAVLLLTDPApdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGVDS 158

                       170       180       190
                ....*....|....*....|....*....|....
2WML_A      252 ---KGNWHHYWENnpsAGAFRKTGVHDGDFESNV 282
Cdd:cd19952 159 ghaPKVPYHYYDL---VEAEEGTAVHSFDLEAEL 189
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 29-279 5.57e-54

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 177.45  E-value: 5.57e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       29 SAWFDERFNRS*QPLLTAknahlEEDTYKWWLRLQREKKPNNLNDTIRELFQVVPGNvDPLLEKRLVS--------CRRC 100
Cdd:cd23964  12 SPWFRERFIPDIKVLLDS-----EDFNPEEYNRLSHYKLPFGWGGLNREVVERLLRN-LNLTSSRYMFvlrggrprCIRC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      101 AVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRE-------LAQEVS*ILVPFKTTDLE 173
Cdd:cd23964  86 AVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNsllkhvpQDKDTKYLFIPFKIRDYD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      174 WVISATTTGRI------SHTYVPVPAKiKVKKEKILIYHPAFIKYVFDRWLQGH-GRYPSTGILSVIFSLHICDEVDLYG 246
Cdd:cd23964 166 YLDAVLSGKPVpdgcdkGKRPPPLFGP-KLNATNVRLLHPDFIRYLFNRWLNSStSYRPTTGALMLLTALHTCDQVSVYG 244

                       250       260       270
                ....*....|....*....|....*....|...
2WML_A      247 FGADSKGNWHHYweNNPSAGAFRKTGVHDGDFE 279
Cdd:cd23964 245 FGYDPRFSLHYY--DKTFVKFTVFYANHDFTNE 275
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 96-280 3.62e-45

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 152.06  E-value: 3.62e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       96 SCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPES-FR---ELAQEVS*ILVPFKTTD 171
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESaFRdpeEYDSDWLLVLVPFKSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      172 LEW---VISATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQ------GHGRYPSTGILSVIFSLHICDEV 242
Cdd:cd23967  81 LLWlqaVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGlpmngkQGKNVPTTGIIAIVMALHYCDEV 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
2WML_A      243 DLYGFGADSK--GNWHHYWENNPSAGAFRKTGvHDGDFES 280
Cdd:cd23967 161 DIAGFGYDPSdpNAPLHYYDSLTMKAIKRSWT-HNVTKEK 199
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 97-261 1.21e-37

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 132.48  E-value: 1.21e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*-----ILVPFKTTD 171
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDpdtllVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      172 LEWVISATTTGRISHT--YVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQ-----GHGRYPSTGILSVIFSLHICDEVDL 244
Cdd:cd23982  82 FYWLYEILSNEKRVRKgfWKQPPRIWDANPKQIRILNPYYTYVAATKLLQvpgqrKKKQKPTTGLLAITLALHLCDEVHI 161

                       170       180
                ....*....|....*....|
2WML_A      245 YGFGADSKGN---WHHYWEN 261
Cdd:cd23982 162 AGFGYPDNGNsnqPIHYYNQ 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 96-261 3.31e-32

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 118.31  E-value: 3.31e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       96 SCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESF----RELAQEVS*ILVPFKTTD 171
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpSHYDPNTTVVLIPFKPHD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      172 LEWVISATTTGRISHT--YVPVPAKIKVKKEKILIYHPAFIKYVFDRWL--------QGHGRYPSTGILSVIFSLHICDE 241
Cdd:cd23984  81 LRWLLDLLMGKKVSAKgfWKKPALNLIYKPNQIRILNPFILRIAAYELLhfpkrfpkEKKPKHPTTGIIAITLALHICNE 160

                       170       180
                ....*....|....*....|..
2WML_A      242 VDLYGFGAD--SKGNWHHYWEN 261
Cdd:cd23984 161 VHIAGFKYDfsNLNSTLHYYGN 182
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 34-263 3.47e-32

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 120.06  E-value: 3.47e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       34 ERFNRS*QPLLTAKNAHLEEDTYKwwlrLQREKKPNNLNDTIRELFQvvpgNVDPLLEKRLvscRRCAVVGNSGNLKESY 113
Cdd:cd23963  11 ERLLNTRKLFLTQKNTPLGDVLYY----SYFKKKTFKITKSLYELLP----KTSPFSHKRY---KTCAVVGNSGILLGSG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      114 YGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEvs*ilvPFKTTDLEW-----------VISATTTG 182
Cdd:cd23963  80 CGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNS------LKKNRDRDKflnrlkeyngsILWYPKFS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      183 RISHTYVPVPAKIKVKKE----KILIYHPAFIKYVFDRW-LQGHGRYPSTGILSVIFSLHICDEVDLYGF---GADSKGN 254
Cdd:cd23963 154 FKSSTNLLLKAARALKKNglnlTVVYSNPEHFLAVQKFWkRRGLEKRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGR 233

                       250
                ....*....|.
2WML_A      255 W--HHYWENNP 263
Cdd:cd23963 234 PvpYHYYDDLS 244
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 97-275 6.42e-32

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 117.53  E-value: 6.42e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*----ILVPFKTTDL 172
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPtslfVAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      173 EW---VISATTTGRISHTYV--PVPAKIKVKKEKILIYHPAFIKYV-FD---------RWLQGHGRYPSTGILSVIFSLH 237
Cdd:cd23983  82 AWlkaMVKKEPLSFWSRLFFwkEVADSIPLKPSQFRILNPLIIKETaLDilqypepqsRLWGWDKNVPTLGVTAVVLATH 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
2WML_A      238 ICDEVDLYGFGAD--SKGNWHHYWENNPSAgAFRKTGVHD 275
Cdd:cd23983 162 LCDEVSLAGFGYDlsQPHAPLHYYDSVCMA-AMNTQTMHN 200
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 96-261 5.09e-28

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 107.32  E-value: 5.09e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       96 SCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*----ILVPFKTTD 171
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKdslfVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      172 LEWVISATTTGRISHT---YVPVPAKIKVKKEKILIYHPAFIKYV--------FDRWLQGHGRYPSTGILSVIFSLHICD 240
Cdd:cd23981  81 FKWLKYIVYKEKVSASdgfWKSVATRVPREPHEIRILNPYFIQEAafsfiglpFNNGLMGRGNIPTLGSVAITMALHNCD 160

                       170       180
                ....*....|....*....|...
2WML_A      241 EVDLYGFGAD--SKGNWHHYWEN 261
Cdd:cd23981 161 EVAVAGFGYDmnTPNAPLHYYET 183
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 88-247 1.84e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 104.66  E-value: 1.84e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       88 PLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTT-----HHFVYPESFRELAQEV-- 160
Cdd:cd23968  36 ESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrlinSQILSKPEFNFLTDPLyr 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      161 -S*ILV----PFKTTDLEW-------VISATTTGRISHtyvpvpakikvKKEKILIYHPAFIKYVFDrWLQ------GHG 222
Cdd:cd23968 116 nVTLLVwdpsSYNVNLEKWykkpdfdFFPNYIKYRRRH-----------PEEPFYLIDPRFLWRLWD-ILQeytpekIKP 183

                       170       180
                ....*....|....*....|....*
2WML_A      223 RYPSTGILSVIFSLHICDEVDLYGF 247
Cdd:cd23968 184 NPPSSGFIGIVLMLHLCDWVDVYEY 208
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 96-262 5.68e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 104.45  E-value: 5.68e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       96 SCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRE--------------LAQEVS 161
Cdd:cd23974  83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNslrayagvgfngppQSKETR 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      162 *ILVPFKTTDLEWVISATT-----TGRISHTYVPVPAKIKVKKEKILIYHPAFIKYVFDRWLQ------GHGRY--PSTG 228
Cdd:cd23974 163 YIFLPDHDRDYLLVKAALThtpidRGRDKSKRPSKYFGKDVTAEKFKIYHPDFIRYLRNRFLWspilntKQRDIyrPSTG 242

                       170       180       190
                ....*....|....*....|....*....|....*
2WML_A      229 ILSVIFSLHICDEVDLYGFGADSKGNWH-HYWENN 262
Cdd:cd23974 243 AVMLLAALHTCDQVSAYGFMTPDYGKYSdHYYDKT 277
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 19-296 8.60e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 103.75  E-value: 8.60e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       19 CTRCIEEQ-RVSAWFDERFNRS*QPLLtaKNAHLEEDTykwWLRLQREKKPNNLndtiRELFQVVPGNVDPLL----EKR 93
Cdd:cd23972   1 CPHSLHLRiQRDPHFRGLFNFDIPVLL--WGQHFTPAL---WDRLSQRKVPYGW----KGLSHQVVASTLSLLndsaNAK 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       94 LV-------SCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHH-----------FVYPE-SFR 154
Cdd:cd23972  72 LFfprdtpgKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvntmknslISYWNlGFT 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      155 ELAQE--VS*ILVPFKTTDLEWVISATTTgrishtyVPVPA--------------KIKVKKEKILiyHPAFIKYVFDRWL 218
Cdd:cd23972 152 RTPQGqdLQYIFIPSDIRDYVMLRSAILG-------VPVPEgldkgdrphkyfgpEASAKKFKLL--HPDFISYLTDRFL 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      219 Q--------GHGRYPSTGILSVIFSLHICDEVDLYGFGADSKGNWH-HYWENNPSAGAFRKTgvHDGDFESNVTTILASI 289
Cdd:cd23972 223 KskllnthyGHLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSdHYYERKKKPLVFYAN--HDMLLEAALWRRLHKA 300


                ....*..
2WML_A      290 NKIRIFK 296
Cdd:cd23972 301 GILQLYQ 307
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 22-247 3.20e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 99.44  E-value: 3.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       22 CIEEQRVSA----WFDERFNRS*QPLLTAKNAHLEEdtykwWLRLQREKKP---NNLNDT-IRELFQVVPGNVDPLL--- 90
Cdd:cd23973   1 CPTSVRSKAaksdWFKKLFLPNITLFLDKDHFNMSE-----WDRLEHFNPPfgfMGLNYTlVKEVVELIPKPKEQQLlal 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       91 -EKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPES------------FRELA 157
Cdd:cd23973  76 sPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSitsslmilqkrgFKNIP 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      158 Q--EVS*ILVPFKTTDLEW---------VISATTTGRISHTYVpvpaKIKVKKEKILIYHPAFIKYVFDRWLQGH---GR 223
Cdd:cd23973 156 QdkDIKYILFPEGPRDYQWleallknktIPSGAYYGRRPRSYF----SGDFTEDKYLVLHPDFLRYVKNRFLRSKtlkGK 231

                       250       260
                ....*....|....*....|....*....
2WML_A      224 Y-----PSTGILSVIFSLHICDEVDLYGF 247
Cdd:cd23973 232 YwaiyrPTTGAFLLLTALHLCDTVSAYGF 260
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 45-265 8.37e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 95.17  E-value: 8.37e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       45 TAKNAHLEEDTYKWWLRLQREKKPNNLNDTIRELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFV 124
Cdd:cd23969  16 PEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLP-EVSPLKGKHF---RTCAVVGNSGILLNSGCGQEIDSHDFV 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      125 LR*NKAPTEGFEADVGSK----TTHHFVYPESF-------------RELAQEVS*ILvpfkttdleWVISATTTGRISH- 186
Cdd:cd23969  92 IRCNLAPVEGYEKDVGTKsnltTMNPSVIPHAYgdlvnatdkekfvERLRQLGDSIL---------WIPAFVSKGGEEHv 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      187 ---TYVPVPAKIKVKkekiLIYHPA-FIKYVFDRWLQG--HGRYPSTGILSVIFSLHICDEVDLYG---FGADSKGN--W 255
Cdd:cd23969 163 qwtNEIILKHKLNVK----TAYPPLrLNHAIRGYWLTTkfRIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRavK 238

                       250
                ....*....|
2WML_A      256 HHYWENNPSA 265
Cdd:cd23969 239 YHYYDNRKYL 248
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-275 3.39e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 90.39  E-value: 3.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       77 ELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEgFEADVGSKTthHFV-------- 148
Cdd:cd23971  48 KLFSMLP-KESPFSNKPL---KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT--NLVtanpsilr 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      149 --------YPESFRELAQEV--S*ILVP-FKTTdlewviSATTTG-RISHTYVPVPAKIKVkkekiLIYHPAFIKYVFDR 216
Cdd:cd23971 121 ekfhnlkkRRRPFVERMKVYgnALLLLPaFSYT------SNTEPSlRALYTLEDFGSPQKV-----LFFNPEYLRNLSRY 189

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2WML_A      217 WL-QG-HGRYPSTGILSVIFSLHICDEVDLYGF---GADSKGNW--HHYWENNPSagafrKTGVHD 275
Cdd:cd23971 190 WKsKGlKARRLSTGLMLVSAALELCENVHLYGFwpfSTDLDGNPisHHYYDNVLP-----KKGVHA 250
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 76-261 1.26e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 89.24  E-value: 1.26e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       76 RELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPE---- 151
Cdd:cd23988  47 QNLHSLLP-EVSPMKNRRF---KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqr 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      152 ---SFRELAQEVS*ILVPFKTTD-LEWVISATTTGRISHTYVpVPAKIKVKKEKILIYHPA--FIKYVFDRWLQG--HGR 223
Cdd:cd23988 123 afgGFRNESDREKFVHRLSMLNDsVLWIPAFMVKGGEKHVEW-VNALILKNKLKVRTAYPSlrLIHAVRGYWLTNkvNIK 201

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
2WML_A      224 YPSTGILSVIFSLHICDEVDLYG---FGADSKGN--WHHYWEN 261
Cdd:cd23988 202 RPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNpvKYHYYDD 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 97-246 9.09e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 85.76  E-value: 9.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQevS*ILVPFKTTDLEWVI 176
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLR--NAILLLAGTRAPTVVV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      177 ---SATTTGRISHTYVPVPAKIKVKKEKILIYHPAFIKY-----VFDR-----------WLqghgrypSTGILSVIFSLH 237
Cdd:cd23965  79 fwgPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMdyadeLFEKetgksriksgtWL-------STGWFTMLLALD 151


                ....*....
2WML_A      238 ICDEVDLYG 246
Cdd:cd23965 152 VCDEIKVYG 160
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 86-261 1.67e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 86.29  E-value: 1.67e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       86 VDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYP----ESFRELA--QE 159
Cdd:cd23970  60 VSPFQNKHY---NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPsileKYYNNLLtiQD 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      160 VS*ILVPFKTTD--LEWV------ISATTTGRISHTYVPVPAKIKVKkekiLIYHPAFIKYVFDRWLQGHG--RYPSTGI 229
Cdd:cd23970 137 RNNFFLSLKKLDgaILWIpafffhTSATVTRTLVDFFVEHRGQLKVQ----LAWPGNIMQHVNRYWKTKHLspKRLSTGI 212

                       170       180       190
                ....*....|....*....|....*....|....*..
2WML_A      230 LSVIFSLHICDEVDLYGF---GADSKGNW--HHYWEN 261
Cdd:cd23970 213 LMYTLASAICEEIHLYGFwpfGFDPTGTPlpYHYYDK 249
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 98-274 2.54e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 85.58  E-value: 2.54e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       98 RRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEG-FEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTT-----D 171
Cdd:cd23991  65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETvsvygD 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      172 LEWVISA-------TTTGRISHTYVPVPAKIKVkkekiLIYHPAFIKYVFDRWL-QGHGRYP-STGILSVIFSLHICDEV 242
Cdd:cd23991 145 AFLLLPAfsyrsntALSFKVYYTLEDFKAKQKV-----IFFHPIYLKHLAQFWRsKGVQVYRlSTGLMITSAALELCEEV 219

                       170       180       190
                ....*....|....*....|....*....|....*..
2WML_A      243 DLYGFGADSKGN-----WHHYWENNPSagafrKTGVH 274
Cdd:cd23991 220 KLYGFWPFSKNTegkpiSHHYYDNQLP-----KPGFH 251
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 98-247 6.24e-19

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 84.37  E-value: 6.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       98 RRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTT-------------HHFVYPESFRElaqevs*IL 164
Cdd:cd23985  46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTirlinsqlvttekHKFLKDSLYNE------GIL 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      165 V-----PFKTTDLEW-------VISATTTGRISHTYVPvpakikvkkekILIYHPAFIKYVFDRWLQGHGRY-----PST 227
Cdd:cd23985 120 IvwdpaPYHSDIPEWyknpdynFFENYKTYRRLNPNQP-----------FYILHPQMQWELWDIIQENSPEEiqpnpPSS 188

                       170       180
                ....*....|....*....|
2WML_A      228 GILSVIFSLHICDEVDLYGF 247
Cdd:cd23985 189 GMLGIILMMTLCDQVDVYEF 208
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 87-268 1.62e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 83.34  E-value: 1.62e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       87 DPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAP-TEGFEADVGSKTTHHFVYP----ESFRELAQEVS 161
Cdd:cd23989  56 DTPLQLPL---KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPsiidKRFQNLLWSRK 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      162 *ILVPFKTTDLEWVIS---ATTTG-----RISHTYVPVPAkikvkKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILS 231
Cdd:cd23989 133 SFVESMKVYGRSYIYMpafSMKTGtdpslRVYYTLADVGA-----NQTVLFANPNFLRNVGKFWKSKgvHAKRLSTGLFL 207

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2WML_A      232 VIFSLHICDEVDLYGF-----GADSKGNWHHYWENNPSAGAF 268
Cdd:cd23989 208 VSAALGLCEEVTIYGFwpfsvDLDERTISHHYYDNVLPDSGF 249
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 97-260 1.44e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 79.91  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFV-----------YPESFRELAQEVS*ILV 165
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVshtsvplllrnQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      166 PFKTTDLEwvISATTTGRISHTYVPVP-AKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDL 244
Cdd:cd23977  81 PERNMDRD--GGGKTYRALLTLAKMYPhLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILV 158

                       170       180
                ....*....|....*....|...
2WML_A      245 YGFGADS--KGNWH-----HYWE 260
Cdd:cd23977 159 YGMVSDSycRNKNHssvpyHYYE 181
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 98-261 2.48e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 77.18  E-value: 2.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       98 RRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAP-TEGFEADVGSKTTHHFVYPESFRELAQEVS*ILVPFKTtdlewVI 176
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYE-----VL 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      177 SAtttgrISHTYVPVPA---------KIKVK--------KEKILIYHPAFIKYVFDRWL-QG-HGRYPSTGILSVIFSLH 237
Cdd:cd23990 140 QV-----YENASVVLPAfyntrntdvSIRVKyvlddfesQQAVYYFHPQYLLNVSRFWLrQGvRAKRISSGLMLVTAALE 214

                       170       180
                ....*....|....*....|....*....
2WML_A      238 ICDEVDLYGFGA---DSKGNW--HHYWEN 261
Cdd:cd23990 215 LCEEVHLYGFWAfpmNPSGIFitHHYYDN 243
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 76-247 2.01e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 74.59  E-value: 2.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       76 RELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYP----E 151
Cdd:cd23987  47 QNLYELLP-RTSPLKNKHF---KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPsvvqR 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      152 SFRELAQEV--------------S*ILVP-FKTTD----LEWVISATTTGRIS-HTYVPvpakikvkkeKILIYHPafik 211
Cdd:cd23987 123 AFEDLVNETwkekflqrlqslngSILWIPaFMAKGgeerVEWVNDLILKHHINvRTAYP----------SLRLLHA---- 188

                       170       180       190
                ....*....|....*....|....*....|....*...
2WML_A      212 yVFDRWLQG--HGRYPSTGILSVIFSLHICDEVDLYGF 247
Cdd:cd23987 189 -VRGYWLTNkvHIKRPTTGLLMYTLATRFCNRIHLYGF 225
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 88-247 4.00e-15

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 73.72  E-value: 4.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       88 PLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTT-------------HHFVYPESFR 154
Cdd:cd23986  40 PLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpnHHFIDSSLYK 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      155 ELaqevs*ILV-----PFKTTDLEWVISATTtgrisHTYVP-VPAKIKVKKEKILIYHPAFIKYVFDrWLQGHGRY---- 224
Cdd:cd23986 120 DV------ILVawdpaPYSANLHKWYKKPDY-----NLFTPyVQYRKRNPNQPFYILHPKFIWQLWD-IIQENTQEkiqp 187

                       170       180
                ....*....|....*....|....*
2WML_A      225 --PSTGILSVIFSLHICDEVDLYGF 247
Cdd:cd23986 188 npPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 97-246 5.24e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 64.11  E-value: 5.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTT-----HHFVY-----PESFRELAQEVS*IL-- 164
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTlrvvaHSSVYrvlrrPQEFLNRTPETTLIFwg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      165 ------VPFKTTDLEWVISATTTGRISHTYVPVPAKIKvkkekiliyhpafikyVFDRWLQGH-GR-------YPSTGIL 230
Cdd:cd23978  81 ppnkmqKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMR----------------QFDDLFRGEtGRdrkkshsWLSTGWF 144

                       170
                ....*....|....*.
2WML_A      231 SVIFSLHICDEVDLYG 246
Cdd:cd23978 145 TMVIAVELCDNVHVYG 160
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 97-260 6.93e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.10  E-value: 6.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPES-----------FRELAQEVS*ILV 165
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSvplllknpdyfFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      166 PFKTTDLEWV-ISATTTGRISHTYvpVPAKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHICDEVDL 244
Cdd:cd23975  81 PFRNMRKDGKgIVYNMLKKAVESY--PQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHV 158

                       170       180
                ....*....|....*....|...
2WML_A      245 YGFGADS-------KGNWHHYWE 260
Cdd:cd23975 159 YGMINDTycktegyRKVPYHYYE 181
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 97-246 3.84e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 56.03  E-value: 3.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A       97 CRRCAVVGNSGNLKESYYGPQIDSHDFVLR*NKAPTEGFEADVGSKTTHHFVYPESFRELAQEVS*IL-VPFKTTDLEWV 175
Cdd:cd23976  15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLnVSQGTVFIFWG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WML_A      176 ISATTTG----------RISHTYVPVPAKIKVKKEKILIYHPAFIK------YVFDRWLqghgrypSTGILSVIFSLHIC 239
Cdd:cd23976  95 PSNYMRRdgkglvynnlQLMNQILPKLKVYTITRHKMLQFDELFKRetgkdrKISNTWL-------STGWFTMIIALELC 167


                ....*..
2WML_A      240 DEVDLYG 246
Cdd:cd23976 168 DRINVYG 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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