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Conserved domains on  [gi|217035450|pdb|3EX7|D]
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Chain D, Protein CASC3

Protein Classification

Btz domain-containing protein( domain architecture ID 10660175)

Btz domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 9-111 1.95e-38

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


:

Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 126.02  E-value: 1.95e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EX7_D           9 RQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEV-RPKGRQ-RKLW-KDEGRWEHDK 85
Cdd:smart01044   1 RGSGDGDEKSAPVANKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGnRPKGRGrRRLWqTDEGRWTHDR 80

                           90       100
                   ....*....|....*....|....*.
3EX7_D          86 FREDEQAPKSRQELIALYGYDIRSAH 111
Cdd:smart01044  81 FEEDEQAPKSRPELVSTYGYDIRSKD 106
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 9-111 1.95e-38

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 126.02  E-value: 1.95e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EX7_D           9 RQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEV-RPKGRQ-RKLW-KDEGRWEHDK 85
Cdd:smart01044   1 RGSGDGDEKSAPVANKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGnRPKGRGrRRLWqTDEGRWTHDR 80

                           90       100
                   ....*....|....*....|....*.
3EX7_D          86 FREDEQAPKSRQELIALYGYDIRSAH 111
Cdd:smart01044  81 FEEDEQAPKSRPELVSTYGYDIRSKD 106
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 4-112 1.23e-28

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 101.44  E-value: 1.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EX7_D          4 TVTGERQSG--DGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQ------EEEVRPKGRQRKLW 75
Cdd:pfam09405   1 KGESESQSGrtPSAPPTEPKEDAERKRREHEKYEKERDENPAFVPTRGAFFLHDDRFAEPaangfgKSKGRPYGRRRRLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
3EX7_D         76 KD--EGRWEHDKFRE--DEQAPKSRQELIALYGYDIRSAHN 112
Cdd:pfam09405  81 DDasEGKWTHDLFEEvaGEQAPKSKPERVPRSGYDIRNGPG 121
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 9-111 1.95e-38

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 126.02  E-value: 1.95e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EX7_D           9 RQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEV-RPKGRQ-RKLW-KDEGRWEHDK 85
Cdd:smart01044   1 RGSGDGDEKSAPVANKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGnRPKGRGrRRLWqTDEGRWTHDR 80

                           90       100
                   ....*....|....*....|....*.
3EX7_D          86 FREDEQAPKSRQELIALYGYDIRSAH 111
Cdd:smart01044  81 FEEDEQAPKSRPELVSTYGYDIRSKD 106
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 4-112 1.23e-28

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 101.44  E-value: 1.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EX7_D          4 TVTGERQSG--DGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQ------EEEVRPKGRQRKLW 75
Cdd:pfam09405   1 KGESESQSGrtPSAPPTEPKEDAERKRREHEKYEKERDENPAFVPTRGAFFLHDDRFAEPaangfgKSKGRPYGRRRRLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
3EX7_D         76 KD--EGRWEHDKFRE--DEQAPKSRQELIALYGYDIRSAHN 112
Cdd:pfam09405  81 DDasEGKWTHDLFEEvaGEQAPKSKPERVPRSGYDIRNGPG 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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