|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
70-400 |
2.10e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.84 E-value: 2.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 70 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 148
Cdd:COG2319 89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 149 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 229 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 306
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 307 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 386
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345
|
330
....*....|....
3JPX_A 387 IAVCDDASIWRWDR 400
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
111-399 |
2.96e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 95.48 E-value: 2.96e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 111 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 190
Cdd:cd00200 15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 191 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 259
Cdd:cd00200 90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 260 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 331
Cdd:cd00200 164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
3JPX_A 332 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:cd00200 229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
140-180 |
8.86e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.60 E-value: 8.86e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
3JPX_A 140 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
141-180 |
4.05e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.71 E-value: 4.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|
3JPX_A 141 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
128-230 |
1.09e-03 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 41.09 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 128 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 202
Cdd:PTZ00420 51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130
|
90 100 110
....*....|....*....|....*....|
3JPX_A 203 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 230
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
70-400 |
2.10e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.84 E-value: 2.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 70 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 148
Cdd:COG2319 89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 149 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 229 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 306
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 307 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 386
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345
|
330
....*....|....
3JPX_A 387 IAVCDDASIWRWDR 400
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
123-399 |
1.46e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.14 E-value: 1.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 123 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 202
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLI 280
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELL----------------------------RTLTGHSGGVNSVAFSpdGKLL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 281 LSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVedphKA 360
Cdd:COG2319 304 ASGSDDGTVRLW-------DLATGKL-------LRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLAT----GE 363
|
250 260 270
....*....|....*....|....*....|....*....
3JPX_A 361 KCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:COG2319 364 LLRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
111-399 |
2.96e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 95.48 E-value: 2.96e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 111 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 190
Cdd:cd00200 15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 191 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 259
Cdd:cd00200 90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 260 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 331
Cdd:cd00200 164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
3JPX_A 332 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:cd00200 229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
44-353 |
4.68e-18 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 85.35 E-value: 4.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 44 KCVNSLKEdHNQPLFGVQFnwhSKEGDPLvfATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshp 122
Cdd:COG2319 153 KLLRTLTG-HSGAVTSVAF---SPDGKLL--ASGSDdGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKL--- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 123 lLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFGgveGHRDEVLS 202
Cdd:COG2319 219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNS 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRW--LGDLI 280
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------------------------HTGAVRSVAFspDGKTL 345
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
3JPX_A 281 LSKSCENAIVCWkpgkmedDIDkikpsesNVTILGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLE 353
Cdd:COG2319 346 ASGSDDGTVRLW-------DLA-------TGELLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
44-228 |
1.95e-16 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 80.34 E-value: 1.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 44 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshpl 123
Cdd:COG2319 237 KLLRTLT-GHSGSVRSVAF---SPDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-----VNSVAFSPDGKL---- 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 124 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 203
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSV 378
|
170 180
....*....|....*....|....*
3JPX_A 204 DYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
42-225 |
3.13e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 78.53 E-value: 3.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 42 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 119
Cdd:cd00200 124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 120 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 199
Cdd:cd00200 192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263
|
170 180
....*....|....*....|....*.
3JPX_A 200 VLSADYDLLGEKIMSCGMDHSLKLWR 225
Cdd:cd00200 264 VTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
123-399 |
2.70e-10 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 61.47 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 123 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 202
Cdd:COG2319 50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRWLGDlils 282
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG----------------------------HSGAVTSVAFSPD---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 283 kscenaivcwkpgkmeddidkikpsesnvtilGRFdysqcdiwymrfsmdfwqkmLALGNQVGKLYVWDLEvedphKAKC 362
Cdd:COG2319 174 --------------------------------GKL--------------------LASGSDDGTVRLWDLA-----TGKL 196
|
250 260 270
....*....|....*....|....*....|....*...
3JPX_A 363 -TTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:COG2319 197 lRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWD 232
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
193-399 |
6.41e-06 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 47.33 E-value: 6.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 193 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINskrmmnaikesydynpnkTNRPFISQKIHFPDFSTrdihrnyVDC 272
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE------------------TGELLRTLKGHTGPVRD-------VAA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 273 VRWlGDLILSKSCENAIVCWKPGKmeddidkikpSESNVTILGrfdySQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDL 352
Cdd:cd00200 60 SAD-GTYLASGSSDKTIRLWDLET----------GECVRTLTG----HTSYVSSVAFSPD--GRILSSSSRDKTIKVWDV 122
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
3JPX_A 353 EVEDPhkakCTTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:cd00200 123 ETGKC----LTTLRGHT--DWVNSVAFSPDGTFVASSSQDGTIKLWD 163
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
140-180 |
8.86e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.60 E-value: 8.86e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
3JPX_A 140 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
141-180 |
4.05e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.71 E-value: 4.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|
3JPX_A 141 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
128-230 |
1.09e-03 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 41.09 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 128 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 202
Cdd:PTZ00420 51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130
|
90 100 110
....*....|....*....|....*....|
3JPX_A 203 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 230
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
144-370 |
3.24e-03 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 39.49 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 144 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIfggVEGHRDEVLSADYDLLGEKIMSCGMDHSLkl 223
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKKL-- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JPX_A 224 wRINSKRMMNAIKESYDYNPNKTNRPFISQKihfpdfstrdihrnyVDCVRWLGdliLSKSCENAIVCWKPGKMEDDIDK 303
Cdd:PTZ00421 193 -NIIDPRDGTIVSSVEAHASAKSQRCLWAKR---------------KDLIITLG---CSKSQQRQIMLWDTRKMASPYST 253
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3JPX_A 304 IKPSESNVTILGRFDySQCDIWYMRFSMDFWQKMLALGNQvGKLYVWDLEVEDPHKAKCT----TLTHHKC 370
Cdd:PTZ00421 254 VDLDQSSALFIPFFD-EDTNLLYIGSKGEGNIRCFELMNE-RLTFCSSYSSVEPHKGLCMmpkwSLDTRKC 322
|
|
| |
