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Conserved domains on  [gi|436408815|pdb|4FQT|B]
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Chain B, Anopheles Gambiae Odorant Binding protein 1

Protein Classification

pheromone/general odorant binding protein( domain architecture ID 10476671)

pheromone/general odorant binding protein (PBP/GOBP) is olfaction-related protein characterized by six conserved cysteines that are paired in three disulfide bridges

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBP_GOBP pfam01395
PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous ...
 13-116 3.21e-19

PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).


:

Pssm-ID: 460193  Cd Length: 109  Bit Score: 76.37  E-value: 3.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B         13 PELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMH-M 91
Cdd:pfam01395   4 EEQKEKIKQARKECAKELGVSDEDVEKLKKGEFPDDDETKCYIRCVLKKLGLMDDDGGLNKDVLLEQLEPVLDDEKAKeI 83

                          90       100
                  ....*....|....*....|....*
4FQT_B         92 GKRCLYPEGETLCDKAFWLHKCWKQ 116
Cdd:pfam01395  84 IEKCQAGAVKDPCETAYKLFKCFYK 108
 
Name Accession Description Interval E-value
PBP_GOBP pfam01395
PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous ...
 13-116 3.21e-19

PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).


Pssm-ID: 460193  Cd Length: 109  Bit Score: 76.37  E-value: 3.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B         13 PELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMH-M 91
Cdd:pfam01395   4 EEQKEKIKQARKECAKELGVSDEDVEKLKKGEFPDDDETKCYIRCVLKKLGLMDDDGGLNKDVLLEQLEPVLDDEKAKeI 83

                          90       100
                  ....*....|....*....|....*
4FQT_B         92 GKRCLYPEGETLCDKAFWLHKCWKQ 116
Cdd:pfam01395  84 IEKCQAGAVKDPCETAYKLFKCFYK 108
PBP_GOBP cd23992
pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; ...
 19-114 1.07e-17

pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; Arthropod Odorant Binding Proteins (OBPs) extract odorants at the air-lymph interface and carry them to the olfactory receptors. In insects, OBPs are located in the antennal sensillary lymph. OBPs that bind insects' specific pheromones are called Pheromone Binding Proteins (PBPs), and OBPs that bind general odorant molecules are sometimes called General OBPs (GOPBs). The family includes PBPs and GOBPs mainly from insects, which are distinct from the vertebrate OBPs. PBPs are male-specific and associate with pheromone-sensitive neurons and GOBPs. GOBPs share a high level of sequence similarity with the PBPs. They may carry odorants rather than pheromones.


Pssm-ID: 467938  Cd Length: 99  Bit Score: 72.19  E-value: 1.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B       19 LKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGD-VHLEKLHDSLPSSMHDIAMHMGKRCLY 97
Cdd:cd23992   2 LKEAHEECAKETGVSEEDLEKLKKGEFPDDEKLKCFLACVLKKLGLMDDDGNkFNLEKLLEDFKKEDKEKVKEIVEKCKK 81

                        90
                ....*....|....*...
4FQT_B       98 PEGET-LCDKAFWLHKCW 114
Cdd:cd23992  82 EVGKDdPCETAYKLAKCF 99
PhBP smart00708
Insect pheromone/odorant binding protein domains;
22-118 2.07e-14

Insect pheromone/odorant binding protein domains;


Pssm-ID: 214783  Cd Length: 103  Bit Score: 63.99  E-value: 2.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B          22 LHDICLGKTGVTEEAIKKF--SDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSS--MHDIAMHMGKRCL- 96
Cdd:smart00708   1 TREECKKELGVSEADLADFvkFWREDYPDEKVKCYIKCVLKKLGLMDDDGKFDAEKLLEQLKADdeMAEELEDIIEKCEk 80

                           90       100
                   ....*....|....*....|...
4FQT_B          97 -YPEGETLCDKAFWLHKCWKQSD 118
Cdd:smart00708  81 kKGTEEDPCDTAYRVAKCFKKAI 103
 
Name Accession Description Interval E-value
PBP_GOBP pfam01395
PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous ...
 13-116 3.21e-19

PBP/GOBP family; The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).


Pssm-ID: 460193  Cd Length: 109  Bit Score: 76.37  E-value: 3.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B         13 PELLEALKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSSMHDIAMH-M 91
Cdd:pfam01395   4 EEQKEKIKQARKECAKELGVSDEDVEKLKKGEFPDDDETKCYIRCVLKKLGLMDDDGGLNKDVLLEQLEPVLDDEKAKeI 83

                          90       100
                  ....*....|....*....|....*
4FQT_B         92 GKRCLYPEGETLCDKAFWLHKCWKQ 116
Cdd:pfam01395  84 IEKCQAGAVKDPCETAYKLFKCFYK 108
PBP_GOBP cd23992
pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; ...
 19-114 1.07e-17

pheromone binding protein/general-odorant binding protein (PBP/GOBP) family proteins; Arthropod Odorant Binding Proteins (OBPs) extract odorants at the air-lymph interface and carry them to the olfactory receptors. In insects, OBPs are located in the antennal sensillary lymph. OBPs that bind insects' specific pheromones are called Pheromone Binding Proteins (PBPs), and OBPs that bind general odorant molecules are sometimes called General OBPs (GOPBs). The family includes PBPs and GOBPs mainly from insects, which are distinct from the vertebrate OBPs. PBPs are male-specific and associate with pheromone-sensitive neurons and GOBPs. GOBPs share a high level of sequence similarity with the PBPs. They may carry odorants rather than pheromones.


Pssm-ID: 467938  Cd Length: 99  Bit Score: 72.19  E-value: 1.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B       19 LKPLHDICLGKTGVTEEAIKKFSDEEIHEDEKLKCYMNCLFHEAKVVDDNGD-VHLEKLHDSLPSSMHDIAMHMGKRCLY 97
Cdd:cd23992   2 LKEAHEECAKETGVSEEDLEKLKKGEFPDDEKLKCFLACVLKKLGLMDDDGNkFNLEKLLEDFKKEDKEKVKEIVEKCKK 81

                        90
                ....*....|....*...
4FQT_B       98 PEGET-LCDKAFWLHKCW 114
Cdd:cd23992  82 EVGKDdPCETAYKLAKCF 99
PhBP smart00708
Insect pheromone/odorant binding protein domains;
22-118 2.07e-14

Insect pheromone/odorant binding protein domains;


Pssm-ID: 214783  Cd Length: 103  Bit Score: 63.99  E-value: 2.07e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FQT_B          22 LHDICLGKTGVTEEAIKKF--SDEEIHEDEKLKCYMNCLFHEAKVVDDNGDVHLEKLHDSLPSS--MHDIAMHMGKRCL- 96
Cdd:smart00708   1 TREECKKELGVSEADLADFvkFWREDYPDEKVKCYIKCVLKKLGLMDDDGKFDAEKLLEQLKADdeMAEELEDIIEKCEk 80

                           90       100
                   ....*....|....*....|...
4FQT_B          97 -YPEGETLCDKAFWLHKCWKQSD 118
Cdd:smart00708  81 kKGTEEDPCDTAYRVAKCFKKAI 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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