|
Name |
Accession |
Description |
Interval |
E-value |
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
8-478 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 830.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 8 LHDRALHLLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQN 87
Cdd:COG0514 1 LRDDALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 88 GVRAAFLNSTLLPHEAREVEDALLRGDLDLLYVAPERLLMPRTLDLLERAPVALFAIDEAHCVSQWGHDFRPEYQQLSVL 167
Cdd:COG0514 81 GIRAAFLNSSLSAEERREVLRALRAGELKLLYVAPERLLNPRFLELLRRLKISLFAIDEAHCISQWGHDFRPDYRRLGEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 168 AERFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFDRPNIQYRV--GLKDSPKTQLLHFIREeHPGDAGIVYCLS 245
Cdd:COG0514 161 RERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVvpKPPDDKLAQLLDFLKE-HPGGSGIVYCLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 246 RKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETG 325
Cdd:COG0514 240 RKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 326 RAGRDGLPSTAWMVYGLSDVVNVRRMLAQSDAPEEVKRVEASKLDALLTYCEAATCRRQVLLHYFGEELSEPCGNCDVCL 405
Cdd:COG0514 320 RAGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVERAKLDAMLAYAETTGCRRQFLLRYFGEELAEPCGNCDNCL 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
4Q47_A 406 NPPRVRDLTREAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKEHDEKLWRSVLRQLV 478
Cdd:COG0514 400 GPPETFDGTEAAQKALSCVYRTGQRFGAGHVIDVLRGSKNEKIRQFGHDKLSTYGIGKDLSDKEWRSVIRQLL 472
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
15-516 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 729.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 15 LLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVRAAFL 94
Cdd:TIGR01389 4 VLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAAAYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 95 NSTLLPHEAREVEDALLRGDLDLLYVAPERLLMPRTLDLLERAPVALFAIDEAHCVSQWGHDFRPEYQQLSVLAERFPEL 174
Cdd:TIGR01389 84 NSTLSAKEQQDIEKALVNGELKLLYVAPERLEQDYFLNMLQRIPIALVAVDEAHCVSQWGHDFRPEYQRLGSLAERFPQV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 175 PRVALTATADERTRADIKSVLRLEDAPQFVSSFDRPNIQYRVGLKDSPKTQLLHFIREeHPGDAGIVYCLSRKSVEETAK 254
Cdd:TIGR01389 164 PRIALTATADAETRQDIRELLRLADANEFITSFDRPNLRFSVVKKNNKQKFLLDYLKK-HRGQSGIIYASSRKKVEELAE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 255 WLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDGLPS 334
Cdd:TIGR01389 243 RLESQGISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMPGNLESYYQEAGRAGRDGLPA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 335 TAWMVYGLSDVVNVRRMLAQSDAPEEVKRVEASKLDALLTYCEAATCRRQVLLHYFGEELSEPCGNCDVCLNPPRVRDLT 414
Cdd:TIGR01389 323 EAILLYSPADIALLKRRIEQSEADDDYKQIEREKLRAMIAYCETQTCRRAYILRYFGENEVEPCGNCDNCLDPPKSYDAT 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 415 REAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKEHDEKLWRSVLRQLVSLGYLSADD--HFGLR 492
Cdd:TIGR01389 403 VEAQKALSCVYRMGQRFGVGYIIEVLRGSKNDKILQKGHDQLSTYGIGKDYTQKEWRSLIDQLIAEGLLTENDeiYIGLQ 482
|
490 500
....*....|....*....|....
4Q47_A 493 ATGKSRGILKEGQKLLLREDTLLP 516
Cdd:TIGR01389 483 LTEAARKVLKNEVEVLLRPFKVVA 506
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
1-516 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 595.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 1 MTAAPAALHDRALHLLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQ 80
Cdd:PRK11057 2 AQAEVLNLESLAKQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 81 VDTLRQNGVRAAFLNSTLLPHEAREVEDALLRGDLDLLYVAPERLLMPRTLDLLERAPVALFAIDEAHCVSQWGHDFRPE 160
Cdd:PRK11057 82 VDQLLANGVAAACLNSTQTREQQLEVMAGCRTGQIKLLYIAPERLMMDNFLEHLAHWNPALLAVDEAHCISQWGHDFRPE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 161 YQQLSVLAERFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFDRPNIQYRVGLKDSPKTQLLHFIREEHpGDAGI 240
Cdd:PRK11057 162 YAALGQLRQRFPTLPFMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYTLVEKFKPLDQLMRYVQEQR-GKSGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 241 VYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGY 320
Cdd:PRK11057 241 IYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 321 YQETGRAGRDGLPSTAWMVYGLSDVVNVRRMLAQSDAPEEvKRVEASKLDALLTYCEAATCRRQVLLHYFGEELSEPCGN 400
Cdd:PRK11057 321 YQETGRAGRDGLPAEAMLFYDPADMAWLRRCLEEKPAGQQ-QDIERHKLNAMGAFAEAQTCRRLVLLNYFGEGRQEPCGN 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 401 CDVCLNPPRVRDLTREAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKEHDEKLWRSVLRQLVSL 480
Cdd:PRK11057 400 CDICLDPPKQYDGLEDAQKALSCIYRVNQRFGMGYVVEVLRGANNQRIRDYGHDKLKVYGIGRDKSHEHWVSVIRQLIHL 479
|
490 500 510 520
....*....|....*....|....*....|....*....|.
4Q47_A 481 GYLSAD--DHFGLRATGKSRGILKEGQKLLL---REDTLLP 516
Cdd:PRK11057 480 GLVTQNiaQHSALQLTEAARPVLRGEVSLQLavpRIVALKP 520
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
16-464 |
0e+00 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 521.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 16 LQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVRAAFLN 95
Cdd:TIGR00614 3 LKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATFLN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 96 STLLPHEAREVEDALLRGDLDLLYVAPERLLMPRTL--DLLERAPVALFAIDEAHCVSQWGHDFRPEYQQLSVLAERFPE 173
Cdd:TIGR00614 83 SAQTKEQQLNVLTDLKDGKIKLLYVTPEKISASNRLlqTLEERKGITLIAVDEAHCISQWGHDFRPDYKALGSLKQKFPN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 174 LPRVALTATADERTRADIKSVLRLEDAPQFVSSFDRPNIQYRVGLKDS-PKTQLLHFIREEHPGDAGIVYCLSRKSVEET 252
Cdd:TIGR00614 163 VPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTPkILEDLLRFIRKEFEGKSGIIYCPSRKKVEQV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 253 AKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDGL 332
Cdd:TIGR00614 243 AAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQESGRAGRDGL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 333 PSTAWMVYGLSDVVNVRRMLAQSdaPEEVKRVEASKLDALLTYC-EAATCRRQVLLHYFGEEL----------SEPCGNC 401
Cdd:TIGR00614 323 PSECHLFYAPADMNRLRRLLMEE--PDGNFRTYKLKLYEMMEYClNSSTCRRLILLSYFGEKGfnksfcimgtEKCCDNC 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
4Q47_A 402 DVCLN------PPRVRDLTREAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKE 464
Cdd:TIGR00614 401 CKRLDyktkdvTDKVYDFGPQAQKALSAVGRLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLYGRGKD 469
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
19-510 |
1.45e-112 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 360.75 E-value: 1.45e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 19 IWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVRAAFLNSTL 98
Cdd:PLN03137 455 VFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMNLLQANIPAASLSAGM 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 99 LPHEAREV--EDALLRGDLDLLYVAPERL----LMPRTLDLLE-RAPVALFAIDEAHCVSQWGHDFRPEYQQLSVLAERF 171
Cdd:PLN03137 535 EWAEQLEIlqELSSEYSKYKLLYVTPEKVaksdSLLRHLENLNsRGLLARFVIDEAHCVSQWGHDFRPDYQGLGILKQKF 614
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 172 PELPRVALTATADERTRADIKSVLRLEDAPQFVSSFDRPNIQYRVglkdSPKTQ-----LLHFIREEHPGDAGIVYCLSR 246
Cdd:PLN03137 615 PNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSV----VPKTKkcledIDKFIKENHFDECGIIYCLSR 690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 247 KSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGR 326
Cdd:PLN03137 691 MDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGR 770
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 327 AGRDGLPSTAWMVYGLSDVVNVRRMLAQSDAPEE-----VKRVEAS---------KLDALLTYCE-AATCRRQVLLHYFG 391
Cdd:PLN03137 771 AGRDGQRSSCVLYYSYSDYIRVKHMISQGGVEQSpmamgYNRMASSgriletnteNLLRMVSYCEnEVDCRRFLQLVHFG 850
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 392 EEL-SEPCGN-CDVCLNPPRV--RDLTREAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKeHDE 467
Cdd:PLN03137 851 EKFdSTNCKKtCDNCSSSKSLidKDVTEIARQLVELVKLTGERFSSAHILEVYRGSLNQYVKKHRHETLSLHGAGK-HLS 929
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
4Q47_A 468 KLWRS-VLRQLVSLGYLSAD----DHFGLRAT------GKSRGILKEGQKLLLR 510
Cdd:PLN03137 930 KGEASrILHYLVTEDILAEDvkksDLYGSVSSllkvneSKAYKLFSGGQTIIMR 983
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
13-208 |
1.67e-103 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 308.69 E-value: 1.67e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 13 LHLLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVRAA 92
Cdd:cd17920 1 EQILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 93 FLNSTLLPHEAREVEDALLRGDLDLLYVAPERLLMPRTLDLLERAP----VALFAIDEAHCVSQWGHDFRPEYQQLSVLA 168
Cdd:cd17920 81 ALNSTLSPEEKREVLLRIKNGQYKLLYVTPERLLSPDFLELLQRLPerkrLALIVVDEAHCVSQWGHDFRPDYLRLGRLR 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
4Q47_A 169 ERFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFD 208
Cdd:cd17920 161 RALPGVPILALTATATPEVREDILKRLGLRNPVIFRASFD 200
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
209-340 |
4.66e-73 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 228.25 E-value: 4.66e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 209 RPNIQYRVGLKDSPKTQLLH--FIREEHPGDAGIVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEE 286
Cdd:cd18794 1 RPNLFYSVRPKDKKDEKLDLlkRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
4Q47_A 287 GVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDGLPSTAWMVY 340
Cdd:cd18794 81 IQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
13-208 |
1.89e-66 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 213.27 E-value: 1.89e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 13 LHLLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLL----RPGTGIVVSPLIALMKDQVDTLrQNG 88
Cdd:cd18018 1 LKLLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLlrrrGPGLTLVVSPLIALMKDQVDAL-PRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 89 VRAAFLNSTLLPHEAREVEDALLRGDLDLLYVAPERLLMPRTL-DLLERAPVALFAIDEAHCVSQWGHDFRPEYQQL-SV 166
Cdd:cd18018 80 IKAAALNSSLTREERRRILEKLRAGEVKILYVSPERLVNESFReLLRQTPPISLLVVDEAHCISEWSHNFRPDYLRLcRV 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
4Q47_A 167 LAERFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFD 208
Cdd:cd18018 160 LRELLGAPPVLALTATATKRVVEDIASHLGIPESGVVRGPLY 201
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
9-208 |
9.89e-64 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 206.83 E-value: 9.89e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 9 HDRALHLLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNG 88
Cdd:cd18015 3 SGKVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKKLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 89 VRAAFLNSTLLPHEAREVEDALLRGD--LDLLYVAPERLLMP-RTLDLLERA----PVALFAIDEAHCVSQWGHDFRPEY 161
Cdd:cd18015 83 ISATMLNASSSKEHVKWVHAALTDKNseLKLLYVTPEKIAKSkRFMSKLEKAynagRLARIAIDEVHCCSQWGHDFRPDY 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
4Q47_A 162 QQLSVLAERFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFD 208
Cdd:cd18015 163 KKLGILKRQFPNVPILGLTATATSKVLKDVQKILCIQKCLTFTASFN 209
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
11-208 |
1.44e-56 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 188.11 E-value: 1.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 11 RALHLLQTIWGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVR 90
Cdd:cd18016 4 EMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 91 AAFLNSTLLPHEAREVEDALLRGD--LDLLYVAPERL-----LMPRTLDLLERAPVALFAIDEAHCVSQWGHDFRPEYQQ 163
Cdd:cd18016 84 ATYLTGDKTDAEATKIYLQLSKKDpiIKLLYVTPEKIsasnrLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPDYKR 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
4Q47_A 164 LSVLAERFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFD 208
Cdd:cd18016 164 LNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
13-208 |
5.73e-56 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 185.75 E-value: 5.73e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 13 LHLLQTIWGYPAFRGVQGEIVQQVAEGG-NALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVRA 91
Cdd:cd18017 1 LNALNEYFGHSSFRPVQWKVIRSVLEERrDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 92 AFLNStllpHEAREVEDALLRGDLDLLYVAPERLLmpRTLDLLE--RAPVALFAIDEAHCVSQWGHDFRPEYQQLSVLAE 169
Cdd:cd18017 81 CFLGS----AQSQNVLDDIKMGKIRVIYVTPEFVS--KGLELLQqlRNGITLIAIDEAHCVSQWGHDFRSSYRHLGSIRN 154
|
170 180 190
....*....|....*....|....*....|....*....
4Q47_A 170 RFPELPRVALTATADERTRADIKSVLRLEDAPQFVSSFD 208
Cdd:cd18017 155 RLPNVPIVALTATATPSVRDDIIKNLNLRNPQITCTSFD 193
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
16-210 |
7.99e-49 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 167.26 E-value: 7.99e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 16 LQTIWGYPAFRG-VQGEIVQQVAEG-GNALVLMPTGGGKSLCYQLPSLLRPGTGIVVSPLIALMKDQVDTLRQNGVRAAF 93
Cdd:cd18014 4 LKKVFGHSDFKSpLQEKATMAVVKGnKDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIRVDS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 94 LNSTL-LPHEAREVEDalLRGD---LDLLYVAPERLLMP---RTLD-LLERAPVALFAIDEAHCVSQWGHDFRPEYQQLS 165
Cdd:cd18014 84 LNSKLsAQERKRIIAD--LESEkpqTKFLYITPEMAATSsfqPLLSsLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLG 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
4Q47_A 166 VLAERFPELPRVALTATADERTRADIKSVLRLEdapQFVSSFDRP 210
Cdd:cd18014 162 ALRSRYGHVPWVALTATATPQVQEDIFAQLRLK---KPVAIFKTP 203
|
|
| DpdF |
NF041063 |
protein DpdF; |
14-351 |
1.87e-47 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 176.64 E-value: 1.87e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 14 HLLQTIWGYPAFRGV-QGEIVQQVA---EGGNALVLMPTGGGKSLCYQLPSLLRPGTG---IVVSPLIALMKDQVDTLRQ 86
Cdd:NF041063 129 PFLAEALGFTHYRSPgQREAVRAALlapPGSTLIVNLPTGSGKSLVAQAPALLASRQGgltLVVVPTVALAIDQERRARE 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 87 NGVRAAFLNSTL------LPHEARE-VEDALLRGDLDLLYVAPERL---LMPRTLDLLERAPVALFAIDEAHCVSQWGHD 156
Cdd:NF041063 209 LLRRAGPDLGGPlawhggLSAEERAaIRQRIRDGTQRILFTSPESLtgsLRPALFDAAEAGLLRYLVVDEAHLVDQWGDG 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 157 FRPEYQQLSVL------AERFPELPR-VALTATADERTRADIKSVLRLEDAPQFVS-SFDRPNIQYRVGLKDSPKT---Q 225
Cdd:NF041063 289 FRPEFQLLAGLrrsllrLAPSGRPFRtLLLSATLTESTLDTLETLFGPPGPFIVVSaVQLRPEPAYWVAKCDSEEErreR 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 226 LLHFIReeH-PGDAgIVYCLSRKSVEETAKWLQAQGIDALA-YHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKP 303
Cdd:NF041063 369 VLEALR--HlPRPL-ILYVTKVEDAEAWLQRLRAAGFRRVAlFHGDTPDAERERLIEQWRENELDIVVATSAFGLGMDKS 445
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
4Q47_A 304 NVRFVAHLDLPKSMEGYYQETGRAGRDGLPSTAWMVYGLSDVVNVRRM 351
Cdd:NF041063 446 DVRTVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLDIAKSL 493
|
|
| RQC |
pfam09382 |
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ... |
407-512 |
3.90e-36 |
|
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 462780 [Multi-domain] Cd Length: 108 Bit Score: 129.97 E-value: 3.90e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 407 PPRVRDLTREAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKEHDEKLWRSVLRQLVSLGYLSAD 486
Cdd:pfam09382 1 PPETVDVTEEAQKILSCVYRTGQRFGAGHLIDVLRGSKNKKIRQLGHDKLSTFGIGKDLSKKEWRRIIRQLIAEGYLEVD 80
|
90 100
....*....|....*....|....*...
4Q47_A 487 D--HFGLRATGKSRGILKEGQKLLLRED 512
Cdd:pfam09382 81 IefYSVLKLTPKAREVLKGEEKVMLRVP 108
|
|
| RQC |
smart00956 |
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ... |
412-501 |
1.47e-32 |
|
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 214936 [Multi-domain] Cd Length: 92 Bit Score: 119.50 E-value: 1.47e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 412 DLTREAQMALSATIRTGNRFGAAHLTDVLLGRETDKVLAQGHHQLPTFGVGKEHDEKLWRSVLRQLVSLGYLSADDHF-- 489
Cdd:smart00956 1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKGHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLREDGGRyp 80
|
90
....*....|..
4Q47_A 490 GLRATGKSRGIL 501
Cdd:smart00956 81 YLKLTEKARPVL 92
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
342-405 |
1.54e-24 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 96.59 E-value: 1.54e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
4Q47_A 342 LSDVVNVRRMLAQSDAPEEVKRVEASKLDALLTYCEAAT-CRRQVLLHYFGEEL-SEPCGNCDVCL 405
Cdd:pfam16124 1 YQDVVRLRFLIEQSEADEERKEVELQKLQAMVAYCENTTdCRRKQLLRYFGEEFdSEPCGNCDNCL 66
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
28-185 |
6.35e-23 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 95.39 E-value: 6.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 28 VQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSL------LRPGTGIVVSPLIALMKDQVDTLRQNGVRAAFLNSTLLPH 101
Cdd:pfam00270 3 IQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLLGG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 102 EAREVEDALLRGdLDLLYVAPERLlmprtLDLLERAP----VALFAIDEAHCVSQWGhdFRPEYQQlsvLAERFPELPR- 176
Cdd:pfam00270 83 DSRKEQLEKLKG-PDILVGTPGRL-----LDLLQERKllknLKLLVLDEAHRLLDMG--FGPDLEE---ILRRLPKKRQi 151
|
....*....
4Q47_A 177 VALTATADE 185
Cdd:pfam00270 152 LLLSATLPR 160
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
250-331 |
1.45e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 91.50 E-value: 1.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 250 EETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGR 329
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
4Q47_A 330 DG 331
Cdd:smart00490 81 AG 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
21-216 |
1.55e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.55 E-value: 1.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 21 GYPAFRGVQGEIVQQVAEG-GNALVLMPTGGGKSLCYQLPSLLR-----PGTGIVVSPLIALMKDQVDTLRQNGVRAAFL 94
Cdd:smart00487 5 GFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAlkrgkGGRVLVLVPTRELAEQWAEELKKLGPSLGLK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 95 NSTLL-PHEAREVEDALLRGDLDLLYVAPERLLMPRTLDLLERAPVALFAIDEAHCVSQWGhdFRPEYQQLsvLAERFPE 173
Cdd:smart00487 85 VVGLYgGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG--FGDQLEKL--LKLLPKN 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
4Q47_A 174 LPRVALTATADERTRADIKSVLRLedaPQFVSSFDRPNIQYRV 216
Cdd:smart00487 161 VQLLLLSATPPEEIENLLELFLND---PVFIDVGFTPLEPIEQ 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
223-331 |
4.25e-20 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 85.34 E-value: 4.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 223 KTQLLHFIREEHPGDAGIVYCLSRKSVEETaKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDK 302
Cdd:pfam00271 2 KLEALLELLKKERGGKVLIFSQTKKTLEAE-LLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDL 80
|
90 100
....*....|....*....|....*....
4Q47_A 303 PNVRFVAHLDLPKSMEGYYQETGRAGRDG 331
Cdd:pfam00271 81 PDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
37-327 |
1.81e-16 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 82.38 E-value: 1.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 37 AEGGNALVLMPTGGGKSL----CYQlpSLLRPGTGIVVSPLIALMKDQVDTLRQngvraaFLNSTLLPHEAREVEDALLR 112
Cdd:COG1061 98 RGGGRGLVVAPTGTGKTVlalaLAA--ELLRGKRVLVLVPRRELLEQWAEELRR------FLGDPLAGGGKKDSDAPITV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 113 GDLDLLYVAPERLLMPRTLDLLerapvalfAIDEAHcvsqwgHDFRPEYQQLsvlAERFPELPRVALTAT---ADERTRA 189
Cdd:COG1061 170 ATYQSLARRAHLDELGDRFGLV--------IIDEAH------HAGAPSYRRI---LEAFPAAYRLGLTATpfrSDGREIL 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 190 -----DIKSVLRLEDA--------PQFVSSFDR------------PNIQYRVGLKDSPKTQLLHFIREEHPGD-AGIVYC 243
Cdd:COG1061 233 lflfdGIVYEYSLKEAiedgylapPEYYGIRVDltderaeydalsERLREALAADAERKDKILRELLREHPDDrKTLVFC 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 244 LSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQE 323
Cdd:COG1061 313 SSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQR 392
|
....
4Q47_A 324 TGRA 327
Cdd:COG1061 393 LGRG 396
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
223-332 |
2.40e-16 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 75.62 E-value: 2.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 223 KTQLLHFIREEHPGDAGIVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCAT-VAfGMGID 301
Cdd:cd18787 14 KLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVLVATdVA-ARGLD 92
|
90 100 110
....*....|....*....|....*....|....
4Q47_A 302 KPNVRFVAHLDLPKSMEGYYQ---ETGRAGRDGL 332
Cdd:cd18787 93 IPGVDHVINYDLPRDAEDYVHrigRTGRAGRKGT 126
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
28-332 |
1.13e-15 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 79.04 E-value: 1.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 28 VQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSLLR-----PGT--GIVVSP---LIALMKDQVDTL-RQNGVRAAflns 96
Cdd:COG0513 28 IQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRldpsrPRApqALILAPtreLALQVAEELRKLaKYLGLRVA---- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 97 TLLPHEAREVEDALLRGDLDLLyVA-PERLLmprtlDLLER-----APVALFAIDEAhcvsqwghD------FRPEyqqL 164
Cdd:COG0513 104 TVYGGVSIGRQIRALKRGVDIV-VAtPGRLL-----DLIERgaldlSGVETLVLDEA--------DrmldmgFIED---I 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 165 SVLAERFPELPRVAL-TATADERTRADIKSVLRledAPQFVS----SFDRPNIQ---YRVGLKDspKTQLL-HFIREEHP 235
Cdd:COG0513 167 ERILKLLPKERQTLLfSATMPPEIRKLAKRYLK---NPVRIEvapeNATAETIEqryYLVDKRD--KLELLrRLLRDEDP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 236 gDAGIVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCAT-VAfGMGIDKPNVRFVAHLDLP 314
Cdd:COG0513 242 -ERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATdVA-ARGIDIDDVSHVINYDLP 319
|
330 340
....*....|....*....|..
4Q47_A 315 KSMEgYYQ----ETGRAGRDGL 332
Cdd:COG0513 320 EDPE-DYVhrigRTGRAGAEGT 340
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
39-182 |
1.32e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.90 E-value: 1.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 39 GGNALVLMPTGGGKSLCYQLPSLLR---PGTGI-VVSPLIALMKDQ---VDTLRQNGVRAAFLNSTLLPHEAREVEdall 111
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLllkKGKKVlVLVPTKALALQTaerLRELFGPGIRVAVLVGGSSAEEREKNK---- 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
4Q47_A 112 RGDLDLLYVAPERLLMPRT-LDLLERAPVALFAIDEAHCVSQWGHDFRPEYQQlsVLAERFPELPRVALTAT 182
Cdd:cd00046 77 LGDADIIIATPDMLLNLLLrEDRLFLKDLKLIIVDEAHALLIDSRGALILDLA--VRKAGLKNAQVILLSAT 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
29-339 |
3.77e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 69.09 E-value: 3.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 29 QGEIVQQVAEGGNALVLMPTGGGKSLCYQLP---SLL--RPGTGIVVSPLIALMKDQVDTLRQ------NGVRAAflnsT 97
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPvleALLedPGATALYLYPTKALARDQLRRLRElaealgLGVRVA----T 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 98 L---LPHEAREveDALLRGDL-----DLLYVAperlLMPRTL---DLLERapVALFAIDEAHC---V--SQWGHDFRpey 161
Cdd:COG1205 137 YdgdTPPEERR--WIREHPDIvltnpDMLHYG----LLPHHTrwaRFFRN--LRYVVIDEAHTyrgVfgSHVANVLR--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 162 qQLSVLAERFPELPR-VALTAT-------ADERTRADIKSVLrlED-APQ----FVssFDRPNIqYRVGLKDSPKTQ--- 225
Cdd:COG1205 206 -RLRRICRHYGSDPQfILASATignpaehAERLTGRPVTVVD--EDgSPRgertFV--LWNPPL-VDDGIRRSALAEaar 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 226 -LLHFIREEHPGdagIVYCLSRKSVEETAKWLQAQ------GIDALAYHAGLSSTERNNVQERFLNEE--GVIvcATVAF 296
Cdd:COG1205 280 lLADLVREGLRT---LVFTRSRRGAELLARYARRAlrepdlADRVAAYRAGYLPEERREIERGLRSGEllGVV--STNAL 354
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
4Q47_A 297 GMGIDkpnvrfVAHLDL------PKSMEGYYQETGRAGRDGLPSTAWMV 339
Cdd:COG1205 355 ELGID------IGGLDAvvlagyPGTRASFWQQAGRAGRRGQDSLVVLV 397
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
48-331 |
1.10e-11 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 67.11 E-value: 1.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 48 TGGGKSLCYQLPS--------LLRPGTGIVVSPLiALMKDQVDTLRQNGVRaaFLNSTLLPHEA-------REVEDALLR 112
Cdd:PTZ00110 176 TGSGKTLAFLLPAivhinaqpLLRYGDGPIVLVL-APTRELAEQIREQCNK--FGASSKIRNTVayggvpkRGQIYALRR 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 113 GdLDLLYVAPERLLmprtlDLLER-----APVALFAIDEAHCVSQWGhdFRPEYQQLsvLAERFPELPRVALTATADERT 187
Cdd:PTZ00110 253 G-VEILIACPGRLI-----DFLESnvtnlRRVTYLVLDEADRMLDMG--FEPQIRKI--VSQIRPDRQTLMWSATWPKEV 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 188 RADIKSVLRLEDAPQFVSSFDRP---NIQYRVGLKD--SPKTQLLHFIRE-EHPGDAGIVYCLSRKSVEETAKWLQAQGI 261
Cdd:PTZ00110 323 QSLARDLCKEEPVHVNVGSLDLTachNIKQEVFVVEehEKRGKLKMLLQRiMRDGDKILIFVETKKGADFLTKELRLDGW 402
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 262 DALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDG 331
Cdd:PTZ00110 403 PALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAG 472
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
28-332 |
1.81e-11 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 66.46 E-value: 1.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 28 VQGEIVQQ-VAEGGNALVLMPTGGGKSLCYQLP---SLLRPGTGIVVSPLIALMKDQVDTLRQN----GVRAAFlnSTLl 99
Cdd:COG1204 26 PQAEALEAgLLEGKNLVVSAPTASGKTLIAELAilkALLNGGKALYIVPLRALASEKYREFKRDfeelGIKVGV--STG- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 100 pheAREVEDALLrGDLDLLYVAPERllmprtLDLLER------APVALFAIDEAHCVsqwGHDFR-PEYQQ-LSVLAERF 171
Cdd:COG1204 103 ---DYDSDDEWL-GRYDILVATPEK------LDSLLRngpswlRDVDLVVVDEAHLI---DDESRgPTLEVlLARLRRLN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 172 PELPRVALTATADertraDIKSVLRLEDAPQFVSSFdRPN-------IQYRVGLKDSPKTQL-------LHFIREehpGD 237
Cdd:COG1204 170 PEAQIVALSATIG-----NAEEIAEWLDAELVKSDW-RPVplnegvlYDGVLRFDDGSRRSKdptlalaLDLLEE---GG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 238 AGIVYCLSRKSVEETAKWLqAQGI-----------------------------DALAY---------HAGLSSTERNNVQ 279
Cdd:COG1204 241 QVLVFVSSRRDAESLAKKL-ADELkrrltpeereeleelaeellevseethtnEKLADclekgvafhHAGLPSELRRLVE 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
4Q47_A 280 ERFlnEEGVI--VCATVAFGMGIDKP-------NVRFVAHLDLPkSMEgYYQETGRAGRDGL 332
Cdd:COG1204 320 DAF--REGLIkvLVATPTLAAGVNLParrviirDTKRGGMVPIP-VLE-FKQMAGRAGRPGY 377
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
240-339 |
2.02e-10 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 59.19 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 240 IVYCLSRKSVEETAKWLQAQGIDAL-------AYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLD 312
Cdd:cd18797 39 IVFCRSRKLAELLLRYLKARLVEEGplaskvaSYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
|
90 100
....*....|....*....|....*..
4Q47_A 313 LPKSMEGYYQETGRAGRDGLPSTAWMV 339
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDSLVILV 145
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
223-336 |
3.62e-10 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 61.88 E-value: 3.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 223 KTQLL-HFIREEHPGDAgIVYCLSRKSVEETAKWLQAQGIDAlAYHAG-LSSTERNNVQERFLNEEGVIVCAT-VAfGMG 299
Cdd:PRK11192 232 KTALLcHLLKQPEVTRS-IVFVRTRERVHELAGWLRKAGINC-CYLEGeMVQAKRNEAIKRLTDGRVNVLVATdVA-ARG 308
|
90 100 110
....*....|....*....|....*....|....*..
4Q47_A 300 IDKPNVRFVAHLDLPKSMEGYYQETGRAGRDGLPSTA 336
Cdd:PRK11192 309 IDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTA 345
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
240-332 |
4.54e-09 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 55.25 E-value: 4.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 240 IVYCLSRKSVEETAKWLqaQGIdalAY-HAGLSSTERNNVQERFLneEGVI--VCATVAFGMGIDKPnvrfvAHL----- 311
Cdd:cd18795 47 LVFCSSRKECEKTAKDL--AGI---AFhHAGLTREDRELVEELFR--EGLIkvLVATSTLAAGVNLP-----ARTviikg 114
|
90 100 110
....*....|....*....|....*....|.
4Q47_A 312 ----------DLPKSMegYYQETGRAGRDGL 332
Cdd:cd18795 115 tqrydgkgyrELSPLE--YLQMIGRAGRPGF 143
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
1-336 |
6.43e-09 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 58.26 E-value: 6.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 1 MTAAPAALHDRALHLLQTIwGYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLP-----SLLRPG--------TG 67
Cdd:PLN00206 121 LSFSSCGLPPKLLLNLETA-GYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPiisrcCTIRSGhpseqrnpLA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 68 IVVSP---LIALMKDQVDTLrqnGVRAAFLNSTLLPHEAREVEDALLRGDLDLLYVAPERLLmprtlDLLER-----APV 139
Cdd:PLN00206 200 MVLTPtreLCVQVEDQAKVL---GKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLI-----DLLSKhdielDNV 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 140 ALFAIDEAHCVSQWGhdFRPEYQQLSvlaeRFPELPRVAL-TATADERTRADIKSVLRledAPQFVS--SFDRPNI---Q 213
Cdd:PLN00206 272 SVLVLDEVDCMLERG--FRDQVMQIF----QALSQPQVLLfSATVSPEVEKFASSLAK---DIILISigNPNRPNKavkQ 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 214 YRVGLKDSPKTQLLHFI--REEHPGDAGIVYCLSRKSVEETAKWLQ-AQGIDALAYHAGLSSTERNNVQERFLNEEGVIV 290
Cdd:PLN00206 343 LAIWVETKQKKQKLFDIlkSKQHFKPPAVVFVSSRLGADLLANAITvVTGLKALSIHGEKSMKERREVMKSFLVGEVPVI 422
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
4Q47_A 291 CATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDGLPSTA 336
Cdd:PLN00206 423 VATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTA 468
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
289-331 |
1.17e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.94 E-value: 1.17e-08
10 20 30 40
....*....|....*....|....*....|....*....|...
4Q47_A 289 IVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDG 331
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
29-148 |
2.63e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 53.74 E-value: 2.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 29 QGEIVQQVAEGGNALVLMPTGGGKSLCYQLP---SLLR-PG-TGIVVSPLIALMKDQVDTLRQ------NGVRAAFLN-S 96
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPileALLRdPGsRALYLYPTKALAQDQLRSLRElleqlgLGIRVATYDgD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
4Q47_A 97 TllPHEAREvedALLRGDLDLLYVAP---ERLLMP---RTLDLLERapVALFAIDEAH 148
Cdd:cd17923 85 T--PREERR---AIIRNPPRILLTNPdmlHYALLPhhdRWARFLRN--LRYVVLDEAH 135
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
240-329 |
5.36e-07 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 52.59 E-value: 5.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 240 IVYCLSRKSVEETAKWLqaqGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKP--NVRF------VAHL 311
Cdd:COG1202 431 IIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPasQVIFdslamgIEWL 507
|
90
....*....|....*...
4Q47_A 312 dlpkSMEGYYQETGRAGR 329
Cdd:COG1202 508 ----SVQEFHQMLGRAGR 521
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
240-331 |
3.47e-06 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 49.44 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 240 IVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEG 319
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPEN 350
|
90
....*....|..
4Q47_A 320 YYQETGRAGRDG 331
Cdd:PTZ00424 351 YIHRIGRSGRFG 362
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
21-331 |
1.05e-04 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 44.84 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 21 GYPAFRGVQGEIVQQVAEGGNALVLMPTGGGKSLCYQLPSL------LRPGTGIVVSPLIALMKDQVDTLRQNGVRAAFL 94
Cdd:PRK11634 25 GYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLhnldpeLKAPQILVLAPTRELAVQVAEAMTDFSKHMRGV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 95 NSTLLPHEAR-EVEDALLRGDLDLLYVAPERLL--MPR-TLDLLERAPVALfaiDEAHCVSQWGHdfrpeYQQLSVLAER 170
Cdd:PRK11634 105 NVVALYGGQRyDVQLRALRQGPQIVVGTPGRLLdhLKRgTLDLSKLSGLVL---DEADEMLRMGF-----IEDVETIMAQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 171 FPELPRVAL-TATADERTRADIKsvlRLEDAPQFV----SSFDRPNI-QYRVGLKDSPKTQLLHFIREEHPGDAGIVYCL 244
Cdd:PRK11634 177 IPEGHQTALfSATMPEAIRRITR---RFMKEPQEVriqsSVTTRPDIsQSYWTVWGMRKNEALVRFLEAEDFDAAIIFVR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 245 SRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQET 324
Cdd:PRK11634 254 TKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRI 333
|
....*..
4Q47_A 325 GRAGRDG 331
Cdd:PRK11634 334 GRTGRAG 340
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
239-329 |
1.26e-04 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 41.39 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 239 GIVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERN-NVQERFLNEEG---VIVCATVaFGMGIDKPNVRFVAHLDLP 314
Cdd:cd18799 9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGdEALILLFFGELkppILVTVDL-LTTGVDIPEVDNVVFLRPT 87
|
90
....*....|....*
4Q47_A 315 KSMEGYYQETGRAGR 329
Cdd:cd18799 88 ESRTLFLQMLGRGLR 102
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
39-182 |
1.30e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 42.57 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 39 GGNALVLMPTGGGKSLCYQLPSLLR------PGTGIV-VSPLIALMKDQVDTLRqngvraAFLNSTLL--PHEAR----- 104
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSladepeKGVQVLyISPLKALINDQERRLE------EPLDEIDLeiPVAVRhgdts 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 105 -EVEDALLRGDLDLLYVAPERL-LM---PRTLDLLerAPVALFAIDEAHCV--SQWGhdfrpeyQQLSVLAERF-----P 172
Cdd:cd17922 75 qSEKAKQLKNPPGILITTPESLeLLlvnKKLRELF--AGLRYVVVDEIHALlgSKRG-------VQLELLLERLrkltgR 145
|
170
....*....|
4Q47_A 173 ELPRVALTAT 182
Cdd:cd17922 146 PLRRIGLSAT 155
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
28-76 |
1.03e-03 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 40.01 E-value: 1.03e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
4Q47_A 28 VQGEIVQQ-VAEGGNALVLMPTGGGKSLCYQL---PSLLRPGTGIVVSPLIAL 76
Cdd:cd18028 5 PQAEAVRAgLLKGENLLISIPTASGKTLIAEMamvNTLLEGGKALYLVPLRAL 57
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
220-373 |
1.69e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 40.98 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 220 DSPKTQ-LLHFIREEH-PGDAGIVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEG--VIVCATVA 295
Cdd:COG0553 531 RSAKLEaLLELLEELLaEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEapVFLISLKA 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 296 FGMGIdkpNVRF---VAHLDL---PKSMEgyyQETGRAGRdglpstawmvYGLSDVVNVRRMLAQsDAPEEvkrveasKL 369
Cdd:COG0553 611 GGEGL---NLTAadhVIHYDLwwnPAVEE---QAIDRAHR----------IGQTRDVQVYKLVAE-GTIEE-------KI 666
|
....
4Q47_A 370 DALL 373
Cdd:COG0553 667 LELL 670
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
38-184 |
2.48e-03 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 39.17 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 38 EGGNALVLMPTGGGKSLCYQLpSLLR-----PGTGIVVSPLIAL----MKDQVDTLRQNGVRAAFLNSTllphearEVED 108
Cdd:cd17921 16 SGDSVLVSAPTSSGKTLIAEL-AILRalatsGGKAVYIAPTRALvnqkEADLRERFGPLGKNVGLLTGD-------PSVN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 109 ALLRGDLDLLYVAPERL-LMPRTLDLLERAPVALFAIDEAHCVSQwghdfrPEY-----QQLSVLAERFPELPRVALTAT 182
Cdd:cd17921 88 KLLLAEADILVATPEKLdLLLRNGGERLIQDVRLVVVDEAHLIGD------GERgvvleLLLSRLLRINKNARFVGLSAT 161
|
..
4Q47_A 183 AD 184
Cdd:cd17921 162 LP 163
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
116-331 |
3.95e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 39.90 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 116 DLLYVAPERLLmprtlDLLERAPVAL-----FAIDEAHCVSQWGhdFRPEYQQLSVLAERFPELPRVALTATADErtraD 190
Cdd:PRK01297 215 DILVATPGRLL-----DFNQRGEVHLdmvevMVLDEADRMLDMG--FIPQVRQIIRQTPRKEERQTLLFSATFTD----D 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 191 IKSVLR--------LEDAPQFVSSFDRPNIQYRVGLKDspKTQLLHFIREEHPGDAGIVYCLSRKSVEETAKWLQAQGID 262
Cdd:PRK01297 284 VMNLAKqwttdpaiVEIEPENVASDTVEQHVYAVAGSD--KYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGIN 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
4Q47_A 263 ALAYHAGLSSTERNNVQERFLNEEGVIVCATVAFGMGIDKPNVRFVAHLDLPKSMEGYYQETGRAGRDG 331
Cdd:PRK01297 362 AAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAG 430
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
221-301 |
4.52e-03 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 37.46 E-value: 4.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 221 SPK-TQLLHFIRE-EHPGDAGIVYCLSRKSVEETAKWLQAQGIDALAYHAGLSSTERNNVQERFLNEEG--VIVCATVAF 296
Cdd:cd18793 10 SGKlEALLELLEElREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKAG 89
|
....*
4Q47_A 297 GMGID 301
Cdd:cd18793 90 GVGLN 94
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
219-341 |
7.49e-03 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 37.25 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Q47_A 219 KDSPKTQLLHFIREEHP--GDAGIVY-------CLSRKSVEETAKWLQAQGIDA-LAY-HAGLSSTERNNVQERFLNEEG 287
Cdd:cd18792 8 PHDDLDLVYEAIERELArgGQVYYVYprieeseKLDLKSIEALAEELKELVPEArVALlHGKMTEDEKEAVMLEFREGEY 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
4Q47_A 288 -VIVCATVaFGMGIDKPNV---------RF-VAHLdlpksmegyYQETGRAGRDGLPSTAWMVYG 341
Cdd:cd18792 88 dILVSTTV-IEVGIDVPNAntmiiedadRFgLSQL---------HQLRGRVGRGKHQSYCYLLYP 142
|
|
| |
