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Conserved domains on  [gi|2072555799|pdb|7CIX|A]
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Chain A, Agmatine N-acetyltransferase

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
36-188 1.93e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 53.94  E-value: 1.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A       36 LTAGTHPPEPEAADKEFLLSNVPFGTCFVALHEGRIVAAVVAGPKDSHEPEHmaeearkyaggkwgsilhllsavetatd 115
Cdd:COG3153  15 LLRAAFGPGREAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDIDGEGP---------------------------- 66

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7CIX_A      116 vcrrfsvpsCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDcTSVYAARLVQRLGYQLINTLRY 188
Cdd:COG3153  67 ---------ALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLL-GDPSLLPFYERFGFRPAGELGL 129
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
36-188 1.93e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 53.94  E-value: 1.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A       36 LTAGTHPPEPEAADKEFLLSNVPFGTCFVALHEGRIVAAVVAGPKDSHEPEHmaeearkyaggkwgsilhllsavetatd 115
Cdd:COG3153  15 LLRAAFGPGREAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDIDGEGP---------------------------- 66

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7CIX_A      116 vcrrfsvpsCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDcTSVYAARLVQRLGYQLINTLRY 188
Cdd:COG3153  67 ---------ALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLL-GDPSLLPFYERFGFRPAGELGL 129
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 33-180 2.96e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 44.82  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A         33 EEPLTAGTHPPEPEAADKEFLLSNVPFGTCFVALHEGRIVAAVVAGPKDSHEPehmaeearkyaggkwgsilhllsavet 112
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPP--------------------------- 58

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A        113 atdvcrrfsvpsCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDCTS--VYAARLVQRLGY 180
Cdd:pfam00583  59 ------------VGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAAdnLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 116-165 8.22e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.57  E-value: 8.22e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
7CIX_A      116 VCRRFSVPSCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVD 165
Cdd:cd04301  16 LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
36-188 1.93e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 53.94  E-value: 1.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A       36 LTAGTHPPEPEAADKEFLLSNVPFGTCFVALHEGRIVAAVVAGPKDSHEPEHmaeearkyaggkwgsilhllsavetatd 115
Cdd:COG3153  15 LLRAAFGPGREAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDIDGEGP---------------------------- 66

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7CIX_A      116 vcrrfsvpsCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDcTSVYAARLVQRLGYQLINTLRY 188
Cdd:COG3153  67 ---------ALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLL-GDPSLLPFYERFGFRPAGELGL 129
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
26-193 1.99e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 51.92  E-value: 1.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A       26 LLAHYYPEEPLTAGTHPPEPEAADKEFLLSNVPFGTCFVALHEGRIVAAVVAGPkdshepeHMAEEARKYAGgkwgsilh 105
Cdd:COG1247  18 IYNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASLGP-------FRPRPAYRGTA-------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A      106 llsavetatdvcrrfsvpsclhVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDCTSVYAA--RLVQRLGYQLI 183
Cdd:COG1247  83 ----------------------EESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEAsiALYEKLGFEEV 140

                       170
                ....*....|
7CIX_A      184 NTLRYVDHLD 193
Cdd:COG1247 141 GTLPEVGFKF 150
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 116-187 3.31e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 46.96  E-value: 3.31e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
7CIX_A      116 VCRRFSVPSCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDC--TSVYAARLVQRLGYQLINTLR 187
Cdd:COG0456   4 LLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVreDNEAAIALYEKLGFEEVGERP 77
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
123-189 1.32e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 44.90  E-value: 1.32e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
7CIX_A      123 PSCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVS--VDCTSVYAARLVQRLGYQLINTLRYV 189
Cdd:COG3393  13 PGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFlyVDADNPAARRLYERLGFRPVGEYATV 81
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 127-183 1.43e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 46.14  E-value: 1.43e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
7CIX_A      127 HVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDcTSVYAARLVQRLGYQLI 183
Cdd:COG1246  54 ELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL-TTSAAIHFYEKLGFEEI 109
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 33-180 2.96e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 44.82  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A         33 EEPLTAGTHPPEPEAADKEFLLSNVPFGTCFVALHEGRIVAAVVAGPKDSHEPehmaeearkyaggkwgsilhllsavet 112
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPP--------------------------- 58

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7CIX_A        113 atdvcrrfsvpsCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDCTS--VYAARLVQRLGY 180
Cdd:pfam00583  59 ------------VGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAAdnLAAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 116-181 5.49e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 40.52  E-value: 5.49e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
7CIX_A        116 VCRRFSVPSCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDcTSVYAARLVQRLGYQ 181
Cdd:pfam13508  19 ALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELE-TTNRAAAFYEKLGFE 83
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 127-192 5.90e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 41.49  E-value: 5.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
7CIX_A        127 HVHALGVDPQLRGRNLGGRLMETVAQRGR--DLGHQLVSVDcTSVYAARLVQRLGYQLINTLRYVDHL 192
Cdd:pfam13673  53 HISLLFVDPDYQGQGIGKALLEAVEDYAEkdGIKLSELTVN-ASPYAVPFYEKLGFRATGPEQEFNGI 119
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 116-165 8.22e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.57  E-value: 8.22e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
7CIX_A      116 VCRRFSVPSCLHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVD 165
Cdd:cd04301  16 LSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
133-181 1.57e-03

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 37.47  E-value: 1.57e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
7CIX_A      133 VDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDCtSVYAARLVQRLGYQ 181
Cdd:COG2153  66 VLPEYRGQGLGRALMEAAIEEARERGARRIVLSA-QAHAVGFYEKLGFV 113
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 126-192 2.96e-03

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 36.57  E-value: 2.96e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
7CIX_A      126 LHVHALGVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVDCTSVY--AARLVQRLGYQLINtlRYVDHL 192
Cdd:COG0454  59 LELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNpaAIRFYERLGFKEIE--RYVAYV 125
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 130-189 3.46e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 35.38  E-value: 3.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
7CIX_A        130 ALGVDPQLRGRNLGGRLMETVAQRGRDLGHQ-LVSVDCTSVYAARLVQRLGYQLINTLRYV 189
Cdd:pfam08445  26 ALQTLPEHRRRGLGSRLVAALARGIAERGITpFAVVVAGNTPSRRLYEKLGFRKIDETYWV 86
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 132-177 9.80e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 34.03  E-value: 9.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
7CIX_A        132 GVDPQLRGRNLGGRLMETVAQRGRDLGHQLVSVdCTsvYAARLVQR 177
Cdd:pfam14542  30 EVPPALRGQGIASKLVKAALDDAREEGLKIVPL-CS--YVAAYLEK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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