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Conserved domains on  [gi|12620891|gb|AAG61125|]
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AHL synthase [Burkholderia cepacia]

Protein Classification

acyl-homoserine-lactone synthase( domain architecture ID 10008134)

acyl-homoserine-lactone (AHL) synthase is involved in regulating the expression of virulence genes in a process known as quorum-sensing; similar to Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI and RhlI

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 1-191 5.84e-58

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


:

Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 180.90  E-value: 5.84e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891   1 MQTFVHEEGRLPHELAADLGRYRRRVFVEQLGWALPSANvSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLK 80
Cdd:COG3916   1 FEIISADNLHLHPELLDEMFRLRHRVFVEELGWEVPVPD-GLEIDQYDDPSAHYLLAHDEDGRVVGCVRLLPTTGPYMLE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891  81 SLFADLIaEDMPLPQSAAVWELSRFAATDDE----GGPGNAEWAVRPMLAAVVECAAQLGARQLIGVTFASMERLFRRIG 156
Cdd:COG3916  80 DVFPDLL-DGGPAPRRPDIWEISRFAVDKDFrrrlGERARRPRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLG 158

                       170       180       190
                ....*....|....*....|....*....|....*
gi 12620891 157 IHAHRAGPPKQVDGRLVVACWIDIDPQTFAALGIE 191
Cdd:COG3916 159 WPFEPLGPPVEIGGERAPAYLIDVDEETLARLRIS 193
 
Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 1-191 5.84e-58

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 180.90  E-value: 5.84e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891   1 MQTFVHEEGRLPHELAADLGRYRRRVFVEQLGWALPSANvSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLK 80
Cdd:COG3916   1 FEIISADNLHLHPELLDEMFRLRHRVFVEELGWEVPVPD-GLEIDQYDDPSAHYLLAHDEDGRVVGCVRLLPTTGPYMLE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891  81 SLFADLIaEDMPLPQSAAVWELSRFAATDDE----GGPGNAEWAVRPMLAAVVECAAQLGARQLIGVTFASMERLFRRIG 156
Cdd:COG3916  80 DVFPDLL-DGGPAPRRPDIWEISRFAVDKDFrrrlGERARRPRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLG 158

                       170       180       190
                ....*....|....*....|....*....|....*
gi 12620891 157 IHAHRAGPPKQVDGRLVVACWIDIDPQTFAALGIE 191
Cdd:COG3916 159 WPFEPLGPPVEIGGERAPAYLIDVDEETLARLRIS 193
Autoind_synth pfam00765
Autoinducer synthase;
18-188 1.53e-20

Autoinducer synthase;


Pssm-ID: 366292  Cd Length: 182  Bit Score: 84.49  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891    18 DLGRYRRRVFVEQLGWALPSANvSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLKSLFADLIaEDMPLPQSA 97
Cdd:pfam00765  11 EMFRLRKRVFKDRLGWDVQIIQ-GMERDQYDNLDPTYLLGVKDEGRVIGCVRLLETKGPNMLTGTFSSYL-DGENIPRSG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891    98 AVWELSRFAATDD--EGGPGNAEWAVRPML-AAVVECAAQLGARQLIGVTFASMERLFRRIGIHAHRAGPPKQVDGRLVV 174
Cdd:pfam00765  89 NYWESSRFCVDTDlvSGRAGNSIAPATSTLfLGMIEYAMSAGYTGIVTIVDHPMLRILKRSGWPISYVGQPLSEGKEKAY 168

                         170
                  ....*....|....
gi 12620891   175 ACWIDIDPQTFAAL 188
Cdd:pfam00765 169 AALLPCDDESVEAL 182
PRK13834 PRK13834
putative autoinducer synthesis protein; Provisional
 21-188 6.99e-16

putative autoinducer synthesis protein; Provisional


Pssm-ID: 172361  Cd Length: 207  Bit Score: 72.41  E-value: 6.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891   21 RYRRRVFVEQLGWALpSANVSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLKSLFADLIAeDMPLPQSAAVW 100
Cdd:PRK13834  23 RLRARVFGGRLGWDV-SITDGEERDQFDDLKPTYILAISDSGRVAGCARLLPAIGPTMLAQVFPQLLP-AGRLNAHPAMI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891  101 ELSRFA--ATDDEG-GPGNAEWAVRPMLAAVVECAAQLGARQLIGVTFASMERLFRRIGIHAHRAGPPKQVDGRLVVACW 177
Cdd:PRK13834 101 ESSRFCvdTALAEGrGGGQLHEATLTMFAGIIEWSMANGYTEIVTATDLRFERILARAGWPMQRLGEPKAIGNTMAVAGI 180

                        170
                 ....*....|.
gi 12620891  178 IDIDPQTFAAL 188
Cdd:PRK13834 181 LPADRDSFERV 191
 
Name Accession Description Interval E-value
LasI COG3916
N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction ...
 1-191 5.84e-58

N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis) [Signal transduction mechanisms];


Pssm-ID: 443121 [Multi-domain]  Cd Length: 201  Bit Score: 180.90  E-value: 5.84e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891   1 MQTFVHEEGRLPHELAADLGRYRRRVFVEQLGWALPSANvSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLK 80
Cdd:COG3916   1 FEIISADNLHLHPELLDEMFRLRHRVFVEELGWEVPVPD-GLEIDQYDDPSAHYLLAHDEDGRVVGCVRLLPTTGPYMLE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891  81 SLFADLIaEDMPLPQSAAVWELSRFAATDDE----GGPGNAEWAVRPMLAAVVECAAQLGARQLIGVTFASMERLFRRIG 156
Cdd:COG3916  80 DVFPDLL-DGGPAPRRPDIWEISRFAVDKDFrrrlGERARRPRVALALFLAMVEYALENGITHLVAVMEPRLERLLRRLG 158

                       170       180       190
                ....*....|....*....|....*....|....*
gi 12620891 157 IHAHRAGPPKQVDGRLVVACWIDIDPQTFAALGIE 191
Cdd:COG3916 159 WPFEPLGPPVEIGGERAPAYLIDVDEETLARLRIS 193
Autoind_synth pfam00765
Autoinducer synthase;
18-188 1.53e-20

Autoinducer synthase;


Pssm-ID: 366292  Cd Length: 182  Bit Score: 84.49  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891    18 DLGRYRRRVFVEQLGWALPSANvSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLKSLFADLIaEDMPLPQSA 97
Cdd:pfam00765  11 EMFRLRKRVFKDRLGWDVQIIQ-GMERDQYDNLDPTYLLGVKDEGRVIGCVRLLETKGPNMLTGTFSSYL-DGENIPRSG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891    98 AVWELSRFAATDD--EGGPGNAEWAVRPML-AAVVECAAQLGARQLIGVTFASMERLFRRIGIHAHRAGPPKQVDGRLVV 174
Cdd:pfam00765  89 NYWESSRFCVDTDlvSGRAGNSIAPATSTLfLGMIEYAMSAGYTGIVTIVDHPMLRILKRSGWPISYVGQPLSEGKEKAY 168

                         170
                  ....*....|....
gi 12620891   175 ACWIDIDPQTFAAL 188
Cdd:pfam00765 169 AALLPCDDESVEAL 182
PRK13834 PRK13834
putative autoinducer synthesis protein; Provisional
 21-188 6.99e-16

putative autoinducer synthesis protein; Provisional


Pssm-ID: 172361  Cd Length: 207  Bit Score: 72.41  E-value: 6.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891   21 RYRRRVFVEQLGWALpSANVSFERDQFDRDDTVYVFARNADGDMCGCARLLPTTRPYLLKSLFADLIAeDMPLPQSAAVW 100
Cdd:PRK13834  23 RLRARVFGGRLGWDV-SITDGEERDQFDDLKPTYILAISDSGRVAGCARLLPAIGPTMLAQVFPQLLP-AGRLNAHPAMI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891  101 ELSRFA--ATDDEG-GPGNAEWAVRPMLAAVVECAAQLGARQLIGVTFASMERLFRRIGIHAHRAGPPKQVDGRLVVACW 177
Cdd:PRK13834 101 ESSRFCvdTALAEGrGGGQLHEATLTMFAGIIEWSMANGYTEIVTATDLRFERILARAGWPMQRLGEPKAIGNTMAVAGI 180

                        170
                 ....*....|.
gi 12620891  178 IDIDPQTFAAL 188
Cdd:PRK13834 181 LPADRDSFERV 191
Acetyltransf_5 pfam13444
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 23-106 4.15e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions.


Pssm-ID: 463880  Cd Length: 102  Bit Score: 35.28  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12620891    23 RRRVFVEQLGWALPSANVSFERDQFDrDDTVYVFARNAD-GDMCGCARLLPTTRPYLLKSLFADL---IAEDMPLPQSAA 98
Cdd:pfam13444   2 RYRVFREEMGATGPAALPGLDIDRFD-AYCDHLLVWDDDtGEVVGTYRLLPPDAASGLGGFYSATefdLSALLALRGRLL 80


                  ....*...
gi 12620891    99 vwELSRFA 106
Cdd:pfam13444  81 --ELGRSC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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