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Conserved domains on  [gi|116283383|gb|AAH19577|]
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CDK5RAP2 protein, partial [Homo sapiens]

Protein Classification

Cnn_1N and PRK12704 domain-containing protein( domain architecture ID 10546816)

Cnn_1N and PRK12704 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 61-129 1.70e-18

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


:

Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 77.95  E-value: 1.70e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116283383   61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASK 129
Cdd:pfam07989   1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAEK 69
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 141-314 1.71e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  141 EIQRVKEDARKKVQQVEdlltkRILLLEKDVTAAQAELEKAFA--------GTETEKAL-RLRLESKLSEMKKMHEGDLA 211
Cdd:pfam17380 297 EQERLRQEKEEKAREVE-----RRRKLEEAEKARQAEMDRQAAiyaeqermAMERERELeRIRQEERKRELERIRQEEIA 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  212 MALV-LDEKDRLIEE-----------------LKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLcaapREEKERE 273
Cdd:pfam17380 372 MEISrMRELERLQMErqqknervrqeleaarkVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRL----EEERARE 447

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 116283383  274 TEAAQMEHQkERNSFQERIQALEEDLREKEREIATEKKKKK 314
Cdd:pfam17380 448 MERVRLEEQ-ERQQQVERLRQQEEERKRKKLELEKEKRDRK 487
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 61-129 1.70e-18

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 77.95  E-value: 1.70e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116283383   61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASK 129
Cdd:pfam07989   1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAEK 69
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 141-314 1.71e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  141 EIQRVKEDARKKVQQVEdlltkRILLLEKDVTAAQAELEKAFA--------GTETEKAL-RLRLESKLSEMKKMHEGDLA 211
Cdd:pfam17380 297 EQERLRQEKEEKAREVE-----RRRKLEEAEKARQAEMDRQAAiyaeqermAMERERELeRIRQEERKRELERIRQEEIA 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  212 MALV-LDEKDRLIEE-----------------LKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLcaapREEKERE 273
Cdd:pfam17380 372 MEISrMRELERLQMErqqknervrqeleaarkVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRL----EEERARE 447

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 116283383  274 TEAAQMEHQkERNSFQERIQALEEDLREKEREIATEKKKKK 314
Cdd:pfam17380 448 MERVRLEEQ-ERQQQVERLRQQEEERKRKKLELEKEKRDRK 487
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 105-314 1.74e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383 105 ELKVEVESLKRELQEREQLLIKASKAVESLAEAggseiQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAfag 184
Cdd:COG1196  243 ELEAELEELEAELEELEAELAELEAELEELRLE-----LEELELELEEAQAEEYELLAELARLEQDIARLEERRREL--- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383 185 TETEKALRLRLESKLSEMKKMHEgdlAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMacpdenvssgelrglca 264
Cdd:COG1196  315 EERLEELEEELAELEEELEELEE---ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL----------------- 374

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 116283383 265 APREEKERETEAAQMEHQKERNSFQERIQALEEDLREKEREIATEKKKKK 314
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 107-307 2.68e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383   107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKdvtaaQAELEKAFAGTE 186
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE-----LAELEEKLEELK 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383   187 TE-KALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSgELRGLCAA 265
Cdd:TIGR02168  351 EElESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ-EIEELLKK 429

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 116283383   266 PREEKERETEAAQMEHQKERNSFQERIQALEEDLREKEREIA 307
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 61-129 1.70e-18

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 77.95  E-value: 1.70e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116283383   61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASK 129
Cdd:pfam07989   1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAEK 69
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 141-314 1.71e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  141 EIQRVKEDARKKVQQVEdlltkRILLLEKDVTAAQAELEKAFA--------GTETEKAL-RLRLESKLSEMKKMHEGDLA 211
Cdd:pfam17380 297 EQERLRQEKEEKAREVE-----RRRKLEEAEKARQAEMDRQAAiyaeqermAMERERELeRIRQEERKRELERIRQEEIA 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  212 MALV-LDEKDRLIEE-----------------LKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLcaapREEKERE 273
Cdd:pfam17380 372 MEISrMRELERLQMErqqknervrqeleaarkVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRL----EEERARE 447

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 116283383  274 TEAAQMEHQkERNSFQERIQALEEDLREKEREIATEKKKKK 314
Cdd:pfam17380 448 MERVRLEEQ-ERQQQVERLRQQEEERKRKKLELEKEKRDRK 487
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 105-314 1.74e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383 105 ELKVEVESLKRELQEREQLLIKASKAVESLAEAggseiQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAfag 184
Cdd:COG1196  243 ELEAELEELEAELEELEAELAELEAELEELRLE-----LEELELELEEAQAEEYELLAELARLEQDIARLEERRREL--- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383 185 TETEKALRLRLESKLSEMKKMHEgdlAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMacpdenvssgelrglca 264
Cdd:COG1196  315 EERLEELEEELAELEEELEELEE---ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL----------------- 374

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 116283383 265 APREEKERETEAAQMEHQKERNSFQERIQALEEDLREKEREIATEKKKKK 314
Cdd:COG1196  375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 107-307 2.68e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383   107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKdvtaaQAELEKAFAGTE 186
Cdd:TIGR02168  276 VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE-----LAELEEKLEELK 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383   187 TE-KALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSgELRGLCAA 265
Cdd:TIGR02168  351 EElESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ-EIEELLKK 429

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 116283383   266 PREEKERETEAAQMEHQKERNSFQERIQALEEDLREKEREIA 307
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 86-303 5.14e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 38.65  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383   86 ERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGS----------EIQRVKEDARK---- 151
Cdd:pfam10174 460 EREDRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKkdsklksleiAVEQKKEECSKlenq 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  152 --KVQQVEDL------LTKRILLLEKDV-------TAAQAELEK---AFAGTETEKALRlrlESKLSEMKKMHEGDLAMA 213
Cdd:pfam10174 540 lkKAHNAEEAvrtnpeINDRIRLLEQEVarykeesGKAQAEVERllgILREVENEKNDK---DKKIAELESLTLRQMKEQ 616

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283383  214 LVLDEKDRLIEELKLSlKSKEALIQCLKEEKSQMACPDENVSSgELRGLCAAPREE----KERETEAAQMEHQKER---N 286
Cdd:pfam10174 617 NKKVANIKHGQQEMKK-KGAQLLEEARRREDNLADNSQQLQLE-ELMGALEKTRQEldatKARLSSTQQSLAEKDGhltN 694

                         250
                  ....*....|....*..
gi 116283383  287 SFQERIQALEEDLREKE 303
Cdd:pfam10174 695 LRAERRKQLEEILEMKQ 711
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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