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Conserved domains on  [gi|54887382|gb|AAH35810|]
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Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 [Homo sapiens]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 63-142 6.49e-30

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467105  Cd Length: 83  Bit Score: 105.11  E-value: 6.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54887382  63 LRCYTCKSLPRDERCNLTQNCSHGQT-CTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPW 141
Cdd:cd23575   3 LKCYTCVSAHSNSDCLTETNCSSSDTyCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVSGA 82


                .
gi 54887382 142 Q 142
Cdd:cd23575  83 Q 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 63-142 6.49e-30

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 105.11  E-value: 6.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54887382  63 LRCYTCKSLPRDERCNLTQNCSHGQT-CTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPW 141
Cdd:cd23575   3 LKCYTCVSAHSNSDCLTETNCSSSDTyCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVSGA 82


                .
gi 54887382 142 Q 142
Cdd:cd23575  83 Q 83
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 63-140 3.37e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 35.20  E-value: 3.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54887382     63 LRCYTCKSlprdercNLTQNCSHGQTC--------TTLIAHGNTESGLLTTHSTWCTDSCQPITKT---VEGTQVTMTCC 131
Cdd:smart00134   1 LQCYSCTG-------NPDSSCSSEEECrspddvclTVVAEVISDSRGSVVYKGCATSPICPGSHGYeinLTIAFLKVSCC 73


                   ....*....
gi 54887382    132 QSSLCNVPP 140
Cdd:smart00134  74 QTDLCNAAG 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 63-142 6.49e-30

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 105.11  E-value: 6.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54887382  63 LRCYTCKSLPRDERCNLTQNCSHGQT-CTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPW 141
Cdd:cd23575   3 LKCYTCVSAHSNSDCLTETNCSSSDTyCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVSCCQTDLCNVSGA 82


                .
gi 54887382 142 Q 142
Cdd:cd23575  83 Q 83
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 63-138 1.64e-06

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 43.97  E-value: 1.64e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 54887382  63 LRCYTCKSLPRDERCNLTQNCSH-GQTCTTLIAhgnTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNV 138
Cdd:cd23573   3 LQCYTCKAQLSNSNCQTETPCREnAKACKTDVI---RAVGLLKVISKECSSSCTEDYQDYFVGKRNITCCSTDLCNV 76
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 63-137 6.95e-06

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 42.31  E-value: 6.95e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 54887382  63 LRCYTCKSLPRdeRCNLTQNCSHGQ-TCTTLiahgntESGLLTTHSTWCTDSC--QPITKTVEGTQVTMTCCQSSLCN 137
Cdd:cd23554   1 LKCYNCPNPTS--NCNTNVTCSSNLdACLIV------KAGNRIYRQCWKYSDCnfDFISERFGESNFKYRCCQKDLCN 70
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 63-137 1.62e-03

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 35.79  E-value: 1.62e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 54887382  63 LRCYTCKSLPRDERCNLTQNCSHGQT-CTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCN 137
Cdd:cd23543   3 LYCYTCENQSSNWNCLKPTKCSDNDKyCVTTVASGGTGSSSGVRITKKCSPKCPETNVNIGIASVSTSCCQSSLCN 78
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 63-140 3.37e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 35.20  E-value: 3.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54887382     63 LRCYTCKSlprdercNLTQNCSHGQTC--------TTLIAHGNTESGLLTTHSTWCTDSCQPITKT---VEGTQVTMTCC 131
Cdd:smart00134   1 LQCYSCTG-------NPDSSCSSEEECrspddvclTVVAEVISDSRGSVVYKGCATSPICPGSHGYeinLTIAFLKVSCC 73


                   ....*....
gi 54887382    132 QSSLCNVPP 140
Cdd:smart00134  74 QTDLCNAAG 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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