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Conserved domains on  [gi|19071307|gb|AAL84196|]
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adenylate kinase, partial [Enterococcus faecium]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11478412)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0016310|GO:0046872
PubMed:  2841070
SCOP:  3002021

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-145 7.18e-92

adenylate kinase; Reviewed


:

Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 265.09  E-value: 7.18e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK00279  17 AKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEAL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:PRK00279  97 DEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGE-ELIQR 160
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-145 7.18e-92

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 265.09  E-value: 7.18e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK00279  17 AKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEAL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:PRK00279  97 DEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGE-ELIQR 160
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-145 6.28e-90

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 260.06  E-value: 6.28e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307   1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:COG0563  17 AKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEAL 96

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307  81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:COG0563  97 DELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGG-ELVQR 160
ADK pfam00406
Adenylate kinase;
1-145 1.21e-75

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 222.95  E-value: 1.21e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:pfam00406  13 AEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEAL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307    81 DAMLKDlNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDrCGGHEFYQR 145
Cdd:pfam00406  93 EELLER-GIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDD-VTGEPLVQR 155
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-145 3.24e-70

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 210.17  E-value: 3.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAE-PDTEKGFLLDGFPRTLDQAKA 79
Cdd:TIGR01351  16 AKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENGFILDGFPRTLSQAEA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19071307    80 LDAMLKDlnkKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDtCDRCGGHEFYQR 145
Cdd:TIGR01351  96 LDALLEE---PIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPG-CDDCTGELLVQR 157
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-145 4.76e-63

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 191.30  E-value: 4.76e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307   1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:cd01428  16 AERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEAL 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307  81 DAMLKDlNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKifnptkvedTCDRCGGHEFYQR 145
Cdd:cd01428  96 DELLDE-GIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL---------GKDDVTGEPLSQR 150
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-145 7.18e-92

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 265.09  E-value: 7.18e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK00279  17 AKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEAL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:PRK00279  97 DEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGE-ELIQR 160
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-145 6.28e-90

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 260.06  E-value: 6.28e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307   1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:COG0563  17 AKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEAL 96

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307  81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:COG0563  97 DELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGG-ELVQR 160
ADK pfam00406
Adenylate kinase;
1-145 1.21e-75

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 222.95  E-value: 1.21e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:pfam00406  13 AEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEAL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307    81 DAMLKDlNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDrCGGHEFYQR 145
Cdd:pfam00406  93 EELLER-GIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDD-VTGEPLVQR 155
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-145 3.24e-70

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 210.17  E-value: 3.24e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAE-PDTEKGFLLDGFPRTLDQAKA 79
Cdd:TIGR01351  16 AKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENGFILDGFPRTLSQAEA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19071307    80 LDAMLKDlnkKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDtCDRCGGHEFYQR 145
Cdd:TIGR01351  96 LDALLEE---PIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPG-CDDCTGELLVQR 157
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-145 4.76e-63

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 191.30  E-value: 4.76e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307   1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:cd01428  16 AERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEAL 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19071307  81 DAMLKDlNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKifnptkvedTCDRCGGHEFYQR 145
Cdd:cd01428  96 DELLDE-GIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL---------GKDDVTGEPLSQR 150
adk PRK02496
adenylate kinase; Provisional
 1-111 2.09e-45

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 146.43  E-value: 2.09e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK02496  18 AVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFL 97

                         90       100       110
                 ....*....|....*....|....*....|.
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGR 111
Cdd:PRK02496  98 DELLQEIGQSGERVVNLDVPDDVVVERLLAR 128
PRK14528 PRK14528
adenylate kinase; Provisional
 1-113 1.71e-43

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 141.69  E-value: 1.71e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK14528  18 AKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADAL 97

                         90       100       110
                 ....*....|....*....|....*....|...
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRFI 113
Cdd:PRK14528  98 DALLKNEGKSIDKAINLEVPDGELLKRLLGRAE 130
PLN02674 PLN02674
adenylate kinase
 4-145 1.84e-40

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 135.40  E-value: 1.84e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    4 IIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKALDAM 83
Cdd:PLN02674  51 IKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAQKLDEM 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19071307   84 LKDLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTcDRCGGHEFYQR 145
Cdd:PLN02674 131 LAKQGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGV-DDVTGEPLIQR 191
PRK14530 PRK14530
adenylate kinase; Provisional
 3-145 3.48e-40

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 133.76  E-value: 3.48e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    3 KIIDAYGIPHISTGDMFRAAMQNETA-LGLE---AKSYMDKGALVPDEVTNGIVKERLAEPDtekGFLLDGFPRTLDQAK 78
Cdd:PRK14530  22 NLAEEFGVEHVTTGDALRANKQMDISdMDTEydtPGEYMDAGELVPDAVVNEIVEEALSDAD---GFVLDGYPRNLEQAE 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19071307   79 ALDAMlKDLnkkiDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:PRK14530  99 YLESI-TDL----DVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGG-ELIQR 159
PRK13808 PRK13808
adenylate kinase; Provisional
 1-111 1.84e-38

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 132.70  E-value: 1.84e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK13808  17 AQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANGFILDGFPRTVPQAEAL 96

                         90       100       110
                 ....*....|....*....|....*....|.
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGR 111
Cdd:PRK13808  97 DALLKDKQLKLDAVVELRVNEGALLARVETR 127
PRK14526 PRK14526
adenylate kinase; Provisional
 12-145 9.82e-36

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 122.27  E-value: 9.82e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307   12 HISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKALDAMLKDLNkki 91
Cdd:PRK14526  28 HISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKALDKFLPNIK--- 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19071307   92 daVIDIHVGEEILVERLAGRFICSNCGatyhKIFN----PTKVEDTCDRCGGhEFYQR 145
Cdd:PRK14526 105 --IINFLIDEELLIKRLSGRRICKSCN----NIFNiytlPTKEKGICDVCKG-DLYQR 155
PRK14532 PRK14532
adenylate kinase; Provisional
 1-112 1.17e-35

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 121.47  E-value: 1.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:PRK14532  17 AKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGGAIFDGFPRTVAQAEAL 96

                         90       100       110
                 ....*....|....*....|....*....|..
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGRF 112
Cdd:PRK14532  97 DKMLASRGQKIDVVIRLKVDDEALIERIVKRF 128
PLN02842 PLN02842
nucleotide kinase
 2-136 3.68e-32

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 118.81  E-value: 3.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    2 EKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDT-EKGFLLDGFPRTLDQAKAL 80
Cdd:PLN02842  15 ELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAkEKGWLLDGYPRSFAQAQSL 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19071307   81 DAmlkdLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIFNPTKVEDTCDR 136
Cdd:PLN02842  95 EK----LKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIKAR 146
PRK14531 PRK14531
adenylate kinase; Provisional
 1-111 2.01e-31

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 110.67  E-value: 2.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEkGFLLDGFPRTLDQAKAL 80
Cdd:PRK14531  19 AARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSG-GWLLDGFPRTVAQAEAL 97

                         90       100       110
                 ....*....|....*....|....*....|.
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGR 111
Cdd:PRK14531  98 EPLLEELKQPIEAVVLLELDDAVLIERLLAR 128
PLN02459 PLN02459
probable adenylate kinase
 1-121 1.59e-30

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 110.32  E-value: 1.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERL--AEPDTEKGFLLDGFPRTLDQAK 78
Cdd:PLN02459  46 ASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLeaGEEEGESGFILDGFPRTVRQAE 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 19071307   79 ALDAMlkdlnKKIDAVIDIHVGEEILVERLAGRFICSNCGATY 121
Cdd:PLN02459 126 ILEGV-----TDIDLVVNLKLREEVLVEKCLGRRICSECGKNF 163
PRK14529 PRK14529
adenylate kinase; Provisional
 6-139 6.08e-30

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 107.88  E-value: 6.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    6 DAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEpDTEKGFLLDGFPRTLDQAKALDAMLK 85
Cdd:PRK14529  22 KKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQ-DGKNGWLLDGFPRNKVQAEKLWEALQ 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19071307   86 DLNKKIDAVIDIHVGEEILVERLAGRFICSNCGATYHKIF-NPTK-VEDTCDRCGG 139
Cdd:PRK14529 101 KEGMKLDYVIEILLPREVAKNRIMGRRLCKNDNNHPNNIFiDAIKpDGDVCRVCGG 156
AAA_17 pfam13207
AAA domain;
1-111 9.54e-29

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 102.32  E-value: 9.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     1 AEKIIDAYGIPHISTGDMFRAAMQNETalGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:pfam13207  12 LKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDGHPRIKTPAGYL 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 19071307    81 DAMLKDLNKKI--DAVIDIHVGEEILVERLAGR 111
Cdd:pfam13207  90 PGLPVEVLRELkpDAIILLEADPEEILERRLKD 122
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-145 3.11e-28

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 103.73  E-value: 3.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEP--DTEKGFLLDGFPRTLDQAK 78
Cdd:PTZ00088  23 AEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVtdDCFKGFILDGFPRNLKQCK 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19071307   79 ALDAMlkdlnKKIDAVIDIHVGEEILVERLAGRFICSNCGatyhKIFNPTKVEDT------------CDRCGGHEFYQR 145
Cdd:PTZ00088 103 ELGKI-----TNIDLFVNIYLPRNILIKKLLGRRICNTCN----RNFNIAHIRSDpydmppilppadCEGCKGNPKLQK 172
PRK14527 PRK14527
adenylate kinase; Provisional
 1-111 6.12e-28

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 101.79  E-value: 6.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    1 AEKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKgFLLDGFPRTLDQAKAL 80
Cdd:PRK14527  23 AERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVR-VIFDGFPRTLAQAEAL 101

                         90       100       110
                 ....*....|....*....|....*....|.
gi 19071307   81 DAMLKDLNKKIDAVIDIHVGEEILVERLAGR 111
Cdd:PRK14527 102 DRLLEELGARLLAVVLLEVPDEELIRRIVER 132
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 2-111 7.53e-20

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 81.02  E-value: 7.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     2 EKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKER-LAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:TIGR01360  21 EKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAmVAALGTSKGFLIDGYPREVKQGEEF 100

                          90       100       110
                  ....*....|....*....|....*....|.
gi 19071307    81 DAMLKDlnkkIDAVIDIHVGEEILVERLAGR 111
Cdd:TIGR01360 101 ERRIGP----PTLVLYFDCSEDTMVKRLLKR 127
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 2-111 4.46e-19

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 78.95  E-value: 4.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307     2 EKIIDAYGIPHISTGDMFRAAMQNE-TALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKGFLLDGFPRTLDQAKAL 80
Cdd:TIGR01359  17 AKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLIDGFPRNEENLEAW 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 19071307    81 DAMLKDlNKKIDAVIDIHVGEEILVERLAGR 111
Cdd:TIGR01359  97 EKLMDN-KVNFKFVLFFDCPEETMIKRLLKR 126
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 111-145 9.47e-15

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 63.63  E-value: 9.47e-15
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19071307   111 RFICSNCGATYHKIFNPTKVEDTCDRCGGhEFYQR 145
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGG-ELVQR 34
PLN02200 PLN02200
adenylate kinase family protein
 2-111 1.13e-11

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 59.91  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19071307    2 EKIIDAYGIPHISTGDMFRAAMQNETALGLEAKSYMDKGALVPDEVTNGIVKERLAEPDTEKgFLLDGFPRTLDQAKALD 81
Cdd:PLN02200  61 EKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK-FLIDGFPRTEENRIAFE 139

                         90       100       110
                 ....*....|....*....|....*....|
gi 19071307   82 AMLKdlnKKIDAVIDIHVGEEILVERLAGR 111
Cdd:PLN02200 140 RIIG---AEPNVVLFFDCPEEEMVKRVLNR 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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