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Conserved domains on  [gi|33115113|gb|AAN85130|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Mus musculus]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.45e-41

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 9.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.45e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 9.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
5-98 8.79e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 63.74  E-value: 8.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113    5 FFNLTMAFSLSLLGtLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNT 84
Cdd:pfam00420  3 LLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|....
gi 33115113   85 YGTDYVQNLNLLQC 98
Cdd:pfam00420 82 HGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 5.57e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.81  E-value: 5.57e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113 12 FSLSLLGtLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:COG0713 14 FAIGLYG-VLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


               ....*
gi 33115113 92 NLNLL 96
Cdd:COG0713 93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.45e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 129.67  E-value: 9.45e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 7.39e-26

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 91.83  E-value: 7.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.10e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 88.87  E-value: 1.10e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.14e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 79.65  E-value: 4.14e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
5-98 8.79e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 63.74  E-value: 8.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113    5 FFNLTMAFSLSLLGtLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNT 84
Cdd:pfam00420  3 LLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|....
gi 33115113   85 YGTDYVQNLNLLQC 98
Cdd:pfam00420 82 HGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 2.87e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 54.56  E-value: 2.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   4 TFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSN 83
Cdd:MTH00181  1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                        90
                ....*....|...
gi 33115113  84 TYGTDYVQNLNLL 96
Cdd:MTH00181 81 THGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 2.94e-11

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 54.54  E-value: 2.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 33115113  81 VSNTYGTDYVQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 3-98 4.86e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 48.82  E-value: 4.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   3 STFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSmpIPITILVFAACEAAVGLALLVKVS 82
Cdd:MTH00188  4 SMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELY--LSLVLLTFAACEASVGLALLVSLI 81

                        90
                ....*....|....*.
gi 33115113  83 NTYGTDYVQNLNLLQC 98
Cdd:MTH00188 82 RSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 7.90e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 43.30  E-value: 7.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   9 TMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMtsVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 33115113  89 YVQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.06e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 40.50  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   1 MPSTFFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMpIPITILVFAACEAAVGLALLVK 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 33115113  81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 5-92 3.95e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 38.60  E-value: 3.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113   5 FFNLTMAFSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPitILVFAACEAAVGLALLVKVSNT 84
Cdd:MTH00162  4 LLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLF--FLTFSVCEGALGLSILVSMIRS 81


                ....*...
gi 33115113  85 YGTDYVQN 92
Cdd:MTH00162 82 HGNDYFSS 89
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 2.60e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 36.93  E-value: 2.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113  12 FSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:MTH00180 13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                ....*.
gi 33115113  92 NLNLLQ 97
Cdd:MTH00180 93 SLNLLR 98
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 5.57e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.81  E-value: 5.57e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113 12 FSLSLLGtLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:COG0713 14 FAIGLYG-VLTRRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


               ....*
gi 33115113 92 NLNLL 96
Cdd:COG0713 93 DLNEL 97
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.86e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 34.65  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33115113  12 FSLSLLGTLMFRSHLMSTLLCLEGMVLSLFIMTSVTSLNSNSMSSMPIPITILVFAACEAAVGLALLVKVSNTYGTDYVQ 91
Cdd:MTH00001 13 FLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTISLK 92


                ....*.
gi 33115113  92 NLNLLQ 97
Cdd:MTH00001 93 SLNSLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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