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Conserved domains on  [gi|33340035|gb|AAQ14493|]
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polymeric immunoglobulin receptor precursor [Gallus gallus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 253-354 1.13e-33

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 124.05  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 253 QGKHTIFGVKGSSATIDCHYDPTKNYSLKYLCKWRTTGCARIIDNTGFLPGpyeGRVAMFDNPKNGTFSIVLNQLSSRDE 332
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKEDA 78

                        90       100
                ....*....|....*....|..
gi 33340035 333 GFYWCMTDDHRERRTSKELKIV 354
Cdd:cd05716  79 GWYWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 360-457 6.77e-33

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 121.74  E-value: 6.77e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 360 LTGKEEVQAEVGSRVDLTCSYPCKYYSYEKYWCKWSRDGCTPLTSSDQSHPGLDVS--CDTANKTLILSLDPVTVEDQGW 437
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGRISltDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 33340035 438 YWCGVKHNGHYGETMAVSLQ 457
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 33-136 1.28e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 101.32  E-value: 1.28e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035  33 GPQQVYGLIDGSVSIKCFYPPTtvNRHDRKYWCRESSRSCLTVVSTSGYRArgyQGRVTIIDFPEQGIMLVNISQLTLAD 112
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|....
gi 33340035 113 QGTYQCGIGLNGkGLSNRVSLDIS 136
Cdd:cd05716  78 AGWYWCGVGDDG-DRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 142-243 2.99e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 91.69  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 142 PEEAELFYVELQGSVSMACDFGEDYASTRKFLCKMEKSGCRNIIDTYGKIDSdfqGRILLSNENTEGAFSVMITQVDWED 221
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|..
gi 33340035 222 AGLYLCGVGSYGEYGETKELDL 243
Cdd:cd05716  78 AGWYWCGVGDDGDRGLTVQVKL 99
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 253-354 1.13e-33

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 124.05  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 253 QGKHTIFGVKGSSATIDCHYDPTKNYSLKYLCKWRTTGCARIIDNTGFLPGpyeGRVAMFDNPKNGTFSIVLNQLSSRDE 332
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKEDA 78

                        90       100
                ....*....|....*....|..
gi 33340035 333 GFYWCMTDDHRERRTSKELKIV 354
Cdd:cd05716  79 GWYWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 360-457 6.77e-33

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 121.74  E-value: 6.77e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 360 LTGKEEVQAEVGSRVDLTCSYPCKYYSYEKYWCKWSRDGCTPLTSSDQSHPGLDVS--CDTANKTLILSLDPVTVEDQGW 437
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGRISltDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 33340035 438 YWCGVKHNGHYGETMAVSLQ 457
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 33-136 1.28e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 101.32  E-value: 1.28e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035  33 GPQQVYGLIDGSVSIKCFYPPTtvNRHDRKYWCRESSRSCLTVVSTSGYRArgyQGRVTIIDFPEQGIMLVNISQLTLAD 112
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|....
gi 33340035 113 QGTYQCGIGLNGkGLSNRVSLDIS 136
Cdd:cd05716  78 AGWYWCGVGDDG-DRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 142-243 2.99e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 91.69  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 142 PEEAELFYVELQGSVSMACDFGEDYASTRKFLCKMEKSGCRNIIDTYGKIDSdfqGRILLSNENTEGAFSVMITQVDWED 221
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|..
gi 33340035 222 AGLYLCGVGSYGEYGETKELDL 243
Cdd:cd05716  78 AGWYWCGVGDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 43-126 9.62e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.79  E-value: 9.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035    43 GSVSIKCFYPPTTVNRHDRKYWCRESS---RSCLTVVSTSGYRARGYQGRVTIIDFPEQGIMLVNISQLTLADQGTYQCG 119
Cdd:pfam07686  12 GSVTLPCTYSSSMSEASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCA 91


                  ....*..
gi 33340035   120 IGLNGKG 126
Cdd:pfam07686  92 VIPSGEG 98
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 364-458 6.97e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.28  E-value: 6.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035    364 EEVQAEVGSRVDLTCSYPckyySYEKYWCKWSRDGCTPLTSSDqshpGLDVSCDTANKTLILSldPVTVEDQGWYWCGVk 443
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS----GSPPPEVTWYKQGGKLLAESG----RFSVSRSGSTSTLTIS--NVTPEDSGTYTCAA- 70

                           90
                   ....*....|....*
gi 33340035    444 HNGHYGETMAVSLQV 458
Cdd:smart00410  71 TNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 253-353 8.38e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.14  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   253 QGKHTIFGVKGSSATIDCHYDPTKNY--SLKYLCKWRTTG-----CARIIDNTGflPGPYEGRVAMFDNPKNGTFSIVLN 325
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEasTSVYWYRQPPGKgptflIAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLTIQ 78

                          90       100
                  ....*....|....*....|....*...
gi 33340035   326 QLSSRDEGFYWCMTDDHRERRTSKELKI 353
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFGKGTRL 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 150-246 1.07e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.76  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   150 VELQGSVSMACDF--GEDYASTRKFLCKMEKSGCRNIIDTYGKIDSD---FQGRILLSNENTEGAFSVMITQVDWEDAGL 224
Cdd:pfam07686   8 VALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEegvKKGRFSGRGDPSNGDGSLTIQNLTLSDSGT 87

                          90       100
                  ....*....|....*....|..
gi 33340035   225 YLCGVGSYGEYGETKELDLHVY 246
Cdd:pfam07686  88 YTCAVIPSGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 361-458 1.82e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   361 TGKEEVQAEVGSRVDLTCSYP--CKYYSYEKYWCKWSRDG---CTPLTSSDQSHPGLD-----VSCDTANKTLILSLDPV 430
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssMSEASTSVYWYRQPPGKgptFLIAYYSNGSEEGVKkgrfsGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 33340035   431 TVEDQGWYWCGVKHNGHYGETMAVSLQV 458
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 263-338 4.69e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 4.69e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33340035    263 GSSATIDCHYDPTKNYSLKylckWRTTGCARIIdntgflpgpYEGRVAMFDNpkNGTFSIVLNQLSSRDEGFYWCM 338
Cdd:smart00410   9 GESVTLSCEASGSPPPEVT----WYKQGGKLLA---------ESGRFSVSRS--GSTSTLTISNVTPEDSGTYTCA 69
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-133 8.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 8.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035     34 PQQVYGLIDGSVSIKCFYPPttvNRHDRKYWCRESsrscLTVVStsgyrargYQGRVTIIDFPEQGIMlvNISQLTLADQ 113
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG---SPPPEVTWYKQG----GKLLA--------ESGRFSVSRSGSTSTL--TISNVTPEDS 63

                           90       100
                   ....*....|....*....|
gi 33340035    114 GTYQCGIGLNGKGLSNRVSL 133
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTL 83
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 253-354 1.13e-33

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 124.05  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 253 QGKHTIFGVKGSSATIDCHYDPTKNYSLKYLCKWRTTGCARIIDNTGFLPGpyeGRVAMFDNPKNGTFSIVLNQLSSRDE 332
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKEDA 78

                        90       100
                ....*....|....*....|..
gi 33340035 333 GFYWCMTDDHRERRTSKELKIV 354
Cdd:cd05716  79 GWYWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 360-457 6.77e-33

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 121.74  E-value: 6.77e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 360 LTGKEEVQAEVGSRVDLTCSYPCKYYSYEKYWCKWSRDGCTPLTSSDQSHPGLDVS--CDTANKTLILSLDPVTVEDQGW 437
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGRISltDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 33340035 438 YWCGVKHNGHYGETMAVSLQ 457
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 33-136 1.28e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 101.32  E-value: 1.28e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035  33 GPQQVYGLIDGSVSIKCFYPPTtvNRHDRKYWCRESSRSCLTVVSTSGYRArgyQGRVTIIDFPEQGIMLVNISQLTLAD 112
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|....
gi 33340035 113 QGTYQCGIGLNGkGLSNRVSLDIS 136
Cdd:cd05716  78 AGWYWCGVGDDG-DRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 142-243 2.99e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 91.69  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 142 PEEAELFYVELQGSVSMACDFGEDYASTRKFLCKMEKSGCRNIIDTYGKIDSdfqGRILLSNENTEGAFSVMITQVDWED 221
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                        90       100
                ....*....|....*....|..
gi 33340035 222 AGLYLCGVGSYGEYGETKELDL 243
Cdd:cd05716  78 AGWYWCGVGDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 43-126 9.62e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.79  E-value: 9.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035    43 GSVSIKCFYPPTTVNRHDRKYWCRESS---RSCLTVVSTSGYRARGYQGRVTIIDFPEQGIMLVNISQLTLADQGTYQCG 119
Cdd:pfam07686  12 GSVTLPCTYSSSMSEASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCA 91


                  ....*..
gi 33340035   120 IGLNGKG 126
Cdd:pfam07686  92 VIPSGEG 98
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 364-458 6.97e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.28  E-value: 6.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035    364 EEVQAEVGSRVDLTCSYPckyySYEKYWCKWSRDGCTPLTSSDqshpGLDVSCDTANKTLILSldPVTVEDQGWYWCGVk 443
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS----GSPPPEVTWYKQGGKLLAESG----RFSVSRSGSTSTLTIS--NVTPEDSGTYTCAA- 70

                           90
                   ....*....|....*
gi 33340035    444 HNGHYGETMAVSLQV 458
Cdd:smart00410  71 TNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 253-353 8.38e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.14  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   253 QGKHTIFGVKGSSATIDCHYDPTKNY--SLKYLCKWRTTG-----CARIIDNTGflPGPYEGRVAMFDNPKNGTFSIVLN 325
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEasTSVYWYRQPPGKgptflIAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLTIQ 78

                          90       100
                  ....*....|....*....|....*...
gi 33340035   326 QLSSRDEGFYWCMTDDHRERRTSKELKI 353
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFGKGTRL 106
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 37-136 8.97e-06

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 45.34  E-value: 8.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035  37 VYGLIDGSVSIKCFY------PPTTV--NRHDRKYWCR-------ESSRSCLTVVSTSGYRARG--YQGRVTIIDFPE-Q 98
Cdd:cd05901   7 VHGSLSGSVVLPCRFstlptlPPSYNitSEFLRIKWTKiqvdkngKDHKETTVLVAQNGIIKIGqeYMGRVSVPSHPEdQ 86

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33340035  99 GIMLVNISQLTLADQGTYQCGIGLNGKGLSNRVSLDIS 136
Cdd:cd05901  87 GDASLTIVKLRASDAGVYRCEVMHGIEDTQDTVSLDVS 124
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 150-246 1.07e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.76  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   150 VELQGSVSMACDF--GEDYASTRKFLCKMEKSGCRNIIDTYGKIDSD---FQGRILLSNENTEGAFSVMITQVDWEDAGL 224
Cdd:pfam07686   8 VALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEegvKKGRFSGRGDPSNGDGSLTIQNLTLSDSGT 87

                          90       100
                  ....*....|....*....|..
gi 33340035   225 YLCGVGSYGEYGETKELDLHVY 246
Cdd:pfam07686  88 YTCAVIPSGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 361-458 1.82e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   361 TGKEEVQAEVGSRVDLTCSYP--CKYYSYEKYWCKWSRDG---CTPLTSSDQSHPGLD-----VSCDTANKTLILSLDPV 430
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssMSEASTSVYWYRQPPGKgptFLIAYYSNGSEEGVKkgrfsGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 33340035   431 TVEDQGWYWCGVKHNGHYGETMAVSLQV 458
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRLTV 108
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 363-440 4.28e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 4.28e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33340035   363 KEEVQAEVGSRVDLTCSypCKYYSYEKYWckWSRDGcTPLTSSDQSHPGLDvscdtaNKTLILSLDPVTVEDQGWYWC 440
Cdd:pfam13927   8 PSSVTVREGETVTLTCE--ATGSPPPTIT--WYKNG-EPISSGSTRSRSLS------GSNSTLTISNVTRSDAGTYTC 74
IgC2_CD160 cd21392
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ...
 367-443 1.33e-03

Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


Pssm-ID: 409621  Cd Length: 119  Bit Score: 38.93  E-value: 1.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 367 QAEVGSRVDLTCSYPCKYYSYEK---YWCKWSRDGCTPLTSSDQSHPGLDVSCDTANKT---LILSLDPVTVEDQGWYWC 440
Cdd:cd21392   8 ASQEGGRLNLTCTVWHKKEEAEGlivFWCKDRSNDCSPETSLKQLRLKRDPESDGVTERssqLVFTINQVTPSDSGTYQC 87


                ...
gi 33340035 441 GVK 443
Cdd:cd21392  88 CAR 90
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 253-355 2.23e-03

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 38.28  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035 253 QGKHTIFGVKGSSATIDCHYDPTKNYSlKYLCKW---RTTGCARII--DNTG--FLPGPYEGRVAMFDNPKnGTFSIVLN 325
Cdd:cd16089   4 EGPESITGPWKGSVNLPCTYVPEEGYT-QVLVKWlvqRDSDPVTIFlrDSSGdhIQQAKYRGRLEVSKDTP-GDVSLQLD 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33340035 326 QLSSRDEGFY-----WCMTDDH---RERRTskELKIVE 355
Cdd:cd16089  82 TLEMDDRGHYtcqvtWQTPDGNlivREKTT--ELRVQK 117
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 253-342 3.53e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.17  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035   253 QGKHTIFGVKGSSATIDCHYDP-TKNYSLKylckWRTTGCARIidntgflpgpyEGRVAMFDNPKNGTFSIVLNQLSSRD 331
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTgSPGPDVT----WSKEGGTLI-----------ESLKVKHDNGRTTQSSLLISNVTKED 65

                          90
                  ....*....|.
gi 33340035   332 EGFYWCMTDDH 342
Cdd:pfam00047  66 AGTYTCVVNNP 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 263-338 4.69e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 4.69e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33340035    263 GSSATIDCHYDPTKNYSLKylckWRTTGCARIIdntgflpgpYEGRVAMFDNpkNGTFSIVLNQLSSRDEGFYWCM 338
Cdd:smart00410   9 GESVTLSCEASGSPPPEVT----WYKQGGKLLA---------ESGRFSVSRS--GSTSTLTISNVTPEDSGTYTCA 69
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-133 8.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 8.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33340035     34 PQQVYGLIDGSVSIKCFYPPttvNRHDRKYWCRESsrscLTVVStsgyrargYQGRVTIIDFPEQGIMlvNISQLTLADQ 113
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG---SPPPEVTWYKQG----GKLLA--------ESGRFSVSRSGSTSTL--TISNVTPEDS 63

                           90       100
                   ....*....|....*....|
gi 33340035    114 GTYQCGIGLNGKGLSNRVSL 133
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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