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Conserved domains on  [gi|90183453|gb|ABD90819|]
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tyrosine precursor, partial [Tachycnemis seychellensis]

Protein Classification

EGF_Lam and Tyrosinase domain-containing protein( domain architecture ID 11079609)

EGF_Lam and Tyrosinase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tyrosinase super family cl02830
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 113-176 2.26e-09

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


The actual alignment was detected with superfamily member pfam00264:

Pssm-ID: 470683  Cd Length: 209  Bit Score: 54.40  E-value: 2.26e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90183453   113 NVYDLFVWLHYYASRDAFleggevwenidfAHEAPGFLPWHRFFLLLWEREIQKVAG--DENFTIP 176
Cdd:pfam00264   2 SSYDDFAAIHGIPFTPWP------------IHGNGLFLPWHRYYLLLFEQALREECGyaDPTGTLP 55
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 30-51 1.32e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.10  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|..
gi 90183453    30 TCQCQGNFMGYHCGECKFGYTG 51
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGYYG 40
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 113-176 2.26e-09

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 54.40  E-value: 2.26e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90183453   113 NVYDLFVWLHYYASRDAFleggevwenidfAHEAPGFLPWHRFFLLLWEREIQKVAG--DENFTIP 176
Cdd:pfam00264   2 SSYDDFAAIHGIPFTPWP------------IHGNGLFLPWHRYYLLLFEQALREECGyaDPTGTLP 55
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 30-51 1.32e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.10  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|..
gi 90183453    30 TCQCQGNFMGYHCGECKFGYTG 51
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 31-52 2.56e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 34.64  E-value: 2.56e-03
                        10        20
                ....*....|....*....|..
gi 90183453  31 CQCQGNFMGYHCGECKFGYTGP 52
Cdd:cd00055  21 CECKPNTTGRRCDRCAPGYYGL 42
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 113-176 2.26e-09

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 54.40  E-value: 2.26e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90183453   113 NVYDLFVWLHYYASRDAFleggevwenidfAHEAPGFLPWHRFFLLLWEREIQKVAG--DENFTIP 176
Cdd:pfam00264   2 SSYDDFAAIHGIPFTPWP------------IHGNGLFLPWHRYYLLLFEQALREECGyaDPTGTLP 55
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 30-51 1.32e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.10  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|..
gi 90183453    30 TCQCQGNFMGYHCGECKFGYTG 51
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 31-52 2.56e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 34.64  E-value: 2.56e-03
                        10        20
                ....*....|....*....|..
gi 90183453  31 CQCQGNFMGYHCGECKFGYTGP 52
Cdd:cd00055  21 CECKPNTTGRRCDRCAPGYYGL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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