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Conserved domains on  [gi|188504146|gb|ACD56191|]
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EGH, partial [Drosophila simulans]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10614002)

glycosyltransferase family 2 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; similar to Drosophila melanogaster beta-1,4-mannosyltransferase egh that has a proposed role in glycosphingolipid biosynthesis

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  10521532|12691742|9445404

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 72-219 1.77e-43

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


:

Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 144.40  E-value: 1.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188504146   72 WIVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYAneNVVNWLTTLADSFRvSDDMGKLRLQFKLFHKPLFSWkGSY 151
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASPEVAIIQGPILPM--NVGNYLEELAALFF-ADDHGKSIPVRMALGRVLPFV-GSG 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188504146  152 VVTQVSAERSVSFDNgiDGSVAEDCFFAMRAFSQGYTFNFIEGE-MYEKSPFTLLDFLQQRKRWLQGIL 219
Cdd:pfam13632  77 AFLRRSALQEVGGWD--DGSVSEDFDFGLRLQRAGYRVRFAPYSaVYEKSPLTFRDFLRQRRRWAYGCL 143
 
Name Accession Description Interval E-value
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 72-219 1.77e-43

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 144.40  E-value: 1.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188504146   72 WIVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYAneNVVNWLTTLADSFRvSDDMGKLRLQFKLFHKPLFSWkGSY 151
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASPEVAIIQGPILPM--NVGNYLEELAALFF-ADDHGKSIPVRMALGRVLPFV-GSG 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188504146  152 VVTQVSAERSVSFDNgiDGSVAEDCFFAMRAFSQGYTFNFIEGE-MYEKSPFTLLDFLQQRKRWLQGIL 219
Cdd:pfam13632  77 AFLRRSALQEVGGWD--DGSVSEDFDFGLRLQRAGYRVRFAPYSaVYEKSPLTFRDFLRQRRRWAYGCL 143
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 169-219 2.41e-05

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 43.96  E-value: 2.41e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 188504146 169 DGSVAEDCFFAMRAFSQGYTFNFIEG-EMYEKSPFTLLDFLQQRKRWLQGIL 219
Cdd:COG1215  163 EDTLGEDLDLSLRLLRAGYRIVYVPDaVVYEEAPETLRALFRQRRRWARGGL 214
CESA_like_2 cd06427
CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) ...
 171-217 1.61e-04

CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.


Pssm-ID: 133049 [Multi-domain]  Cd Length: 241  Bit Score: 41.47  E-value: 1.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 188504146 171 SVAEDCFFAMRAFSQGYTFNFIEGEMYEKSPFTLLDFLQQRKRWLQG 217
Cdd:cd06427  183 NVTEDADLGLRLARAGYRTGVLNSTTLEEANNALGNWIRQRSRWIKG 229
 
Name Accession Description Interval E-value
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 72-219 1.77e-43

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 144.40  E-value: 1.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188504146   72 WIVHLDEETLLTENSVRGIINFVLDGKHPFGQGLITYAneNVVNWLTTLADSFRvSDDMGKLRLQFKLFHKPLFSWkGSY 151
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASPEVAIIQGPILPM--NVGNYLEELAALFF-ADDHGKSIPVRMALGRVLPFV-GSG 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188504146  152 VVTQVSAERSVSFDNgiDGSVAEDCFFAMRAFSQGYTFNFIEGE-MYEKSPFTLLDFLQQRKRWLQGIL 219
Cdd:pfam13632  77 AFLRRSALQEVGGWD--DGSVSEDFDFGLRLQRAGYRVRFAPYSaVYEKSPLTFRDFLRQRRRWAYGCL 143
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 169-219 2.41e-05

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 43.96  E-value: 2.41e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 188504146 169 DGSVAEDCFFAMRAFSQGYTFNFIEG-EMYEKSPFTLLDFLQQRKRWLQGIL 219
Cdd:COG1215  163 EDTLGEDLDLSLRLLRAGYRIVYVPDaVVYEEAPETLRALFRQRRRWARGGL 214
CESA_like_2 cd06427
CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) ...
 171-217 1.61e-04

CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.


Pssm-ID: 133049 [Multi-domain]  Cd Length: 241  Bit Score: 41.47  E-value: 1.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 188504146 171 SVAEDCFFAMRAFSQGYTFNFIEGEMYEKSPFTLLDFLQQRKRWLQG 217
Cdd:cd06427  183 NVTEDADLGLRLARAGYRTGVLNSTTLEEANNALGNWIRQRSRWIKG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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