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Conserved domains on  [gi|254596562|gb|ACT75565|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Dactylopsila trivirgata]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-201 2.33e-117

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 341.10  E-value: 2.33e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00110 259 YPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00110 339 SRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGK 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLTY 201
Cdd:MTH00110 419 LTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-201 2.33e-117

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 341.10  E-value: 2.33e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00110 259 YPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00110 339 SRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGK 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLTY 201
Cdd:MTH00110 419 LTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 3-200 1.17e-31

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 119.42  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:COG1008  278 LAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVLYDRTHTR 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFitsQR---G 159
Cdd:COG1008  358 DIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY---QRvffG 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596562 160 KLTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLT 200
Cdd:COG1008  435 PLKEELAELPDLNPRELAVLAPLAALILLLGLYPQPLLDLI 475
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-140 2.17e-28

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 107.40  E-value: 2.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562    1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA-NTNYERI 79
Cdd:pfam00361 148 QILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRV 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596562   80 HSRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGT 140
Cdd:pfam00361 228 HTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-201 1.14e-27

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 108.49  E-value: 1.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562    4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:TIGR01972 273 AALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRD 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT- 162
Cdd:TIGR01972 353 IAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKRVFFGELSn 432

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 254596562  163 HHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLTY 201
Cdd:TIGR01972 433 PEVAEFPDLNGREIAVLAPLVVLILFLGLYPNPLLDLTE 471
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-201 2.33e-117

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 341.10  E-value: 2.33e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00110 259 YPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00110 339 SRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGK 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLTY 201
Cdd:MTH00110 419 LTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-198 8.25e-90

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 270.53  E-value: 8.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00124 259 YPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSMLFCLANTNYERTH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00124 339 SRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYMFLSTQRGT 418

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILG 198
Cdd:MTH00124 419 LPTHITTIQPTHTREHLLMTLHIIPLLLLILKPELISG 456
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-199 3.44e-86

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 261.39  E-value: 3.44e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00068 259 YPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQTPWSFSGAIILMISHGLTSSALFCLANTNYERTH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00068 339 SRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSLFNWSNWTILITGLGTLITAAYTLYMFLMTQRGP 418

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGL 199
Cdd:MTH00068 419 LPNHLKTLFPTYTREHLLLALHILPMLLLILKPELISGM 457
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-200 9.10e-72

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 224.45  E-value: 9.10e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00127 260 YPFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQTPWGFTGALILMIAHGLTSSALFCLANTNYERTH 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00127 340 SRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSLFNWSPWTLALTGLGTLITAGYSLYMFLMTQRGP 419

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLT 200
Cdd:MTH00127 420 LPDHIIALNPSHTREHLLMALHLLPLLLLILKPELIWGWT 459
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-196 5.96e-66

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 209.03  E-value: 5.96e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00206 255 YFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGSPWGFKGALLLMIAHGLVSSALFCLANLLYERSH 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00206 335 TRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYSLYMFVMTQHGK 414

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFI 196
Cdd:MTH00206 415 TPNHLLSLSPSSTREHLLLFLHLFPVILLILNPNLI 450
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-197 2.53e-53

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 176.70  E-value: 2.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00044 261 FILIVFCCWGALITSIICLRQTDLKALIAYSSVGHMSLVAAGIFSGTNWGINGALILMIAHGLVSSALFCLANILYERSG 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00044 341 TRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIYQLTNSGS 420

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFIL 197
Cdd:MTH00044 421 FPSWISNVSPISSREHLLIFLHLLPLILIIINPNIIL 457
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-199 1.65e-48

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 163.79  E-value: 1.65e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00163 247 YIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIGHGLCSSGLFCLANIIYERLG 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00163 327 SRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSYSQHGK 406

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGL 199
Cdd:MTH00163 407 YYSGLYSCSSGKVREYLLLFLHWLPLNLLILKSDLFMLW 445
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 3-188 1.53e-46

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 157.69  E-value: 1.53e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:MTH00150 220 LISLSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSR 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT 162
Cdd:MTH00150 300 SLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGGSS 379

                        170       180
                 ....*....|....*....|....*.
gi 254596562 163 HHLHTMKPTYTREHILMTLHLIPLLI 188
Cdd:MTH00150 380 SFLKPFNELKSSEMLLLLLHWVPLLL 405
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 2-196 7.25e-43

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 149.12  E-value: 7.25e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   2 PFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHS 81
Cdd:MTH00014 254 PFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWGWQGALAMMIAHGLCSSALFALANMTYETTHT 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  82 RTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKL 161
Cdd:MTH00014 334 RSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYTSTQHGSP 413

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 254596562 162 THHLHTMKPTYTREHILMTLHLIPLLITSI*PKFI 196
Cdd:MTH00014 414 PSFMNPLNLFTPRNHTLMTLHLVPLFILILKPDLI 448
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 3-196 4.14e-42

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 147.05  E-value: 4.14e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:MTH00205 253 FFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAIIMMVAHGLCSSGMFALANVNYERTNSR 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT 162
Cdd:MTH00205 333 SMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQSQHGKVS 412

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254596562 163 HHLHTMKPTYTREHILMTLHLIPLLITSI*PKFI 196
Cdd:MTH00205 413 SQISSFLAISEREYYILILHWFPLNILILKLKIF 446
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 3-200 1.17e-31

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 119.42  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:COG1008  278 LAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVLYDRTHTR 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFitsQR---G 159
Cdd:COG1008  358 DIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY---QRvffG 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596562 160 KLTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLT 200
Cdd:COG1008  435 PLKEELAELPDLNPRELAVLAPLAALILLLGLYPQPLLDLI 475
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-140 2.17e-28

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 107.40  E-value: 2.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562    1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA-NTNYERI 79
Cdd:pfam00361 148 QILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRV 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596562   80 HSRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGT 140
Cdd:pfam00361 228 HTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-201 1.14e-27

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 108.49  E-value: 1.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562    4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:TIGR01972 273 AALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRD 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT- 162
Cdd:TIGR01972 353 IAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKRVFFGELSn 432

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 254596562  163 HHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGLTY 201
Cdd:TIGR01972 433 PEVAEFPDLNGREIAVLAPLVVLILFLGLYPNPLLDLTE 471
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 1-197 1.87e-25

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 102.20  E-value: 1.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:PRK05846 278 PIIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVTLGIFAGNQLGIQGAIFQMISHGLSSAALFLLVGVLYDRLH 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:PRK05846 358 TRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAFIATTGLILAAVYSLWLYQRVMFGP 437

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 254596562 161 LTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFIL 197
Cdd:PRK05846 438 VKNEVAKLKDLNGRELLILLPLVALLLLLGVYPKPLL 474
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 1-199 1.70e-22

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 93.97  E-value: 1.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   1 YPFIV-LSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERI 79
Cdd:MTH00204 275 APLIVmLSVIAVIYGSLTTCRQVDFKRLIAYSSVAHMGLVPLGLFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERH 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  80 HSRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRG 159
Cdd:MTH00204 355 HTRLIKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYLYNRISFG 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 254596562 160 KLTHHLHTMKPTYTREHILMTLHLIPLLITSI*PKFILGL 199
Cdd:MTH00204 435 GGSNYLLFSRDLNRRELLAILPLIIAIFLLGIVPFIIIDL 474
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 4-197 2.30e-21

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 90.75  E-value: 2.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:MTH00226 300 IAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRL 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLTH 163
Cdd:MTH00226 380 IKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVFVCSGVILSAVYSFYFANRVTFGAPGN 459

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254596562 164 HLHTMKPTYTREHILMTLHLIPLLITSI*PKFIL 197
Cdd:MTH00226 460 LITFARDVNRREFYITASMVFFAFLIGIYPIFIL 493
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 2-153 8.54e-21

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 88.96  E-value: 8.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   2 PFI-VLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00217 273 PLIqTLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSHTIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHH 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMF 153
Cdd:MTH00217 353 TRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYLY 425
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 3-160 4.19e-17

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 4.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:MTH00094 216 WIIFSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSMSGKLSGLMMMLAHGYTSTLMFYLIGEFYHISKSR 295

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00094 296 LIYFMNSFFSSSMFFGLIFSLVFLSNSGVPPSLSFFSEFLIISNSFMKNKFSFFFIFFYFLVSFYYSLFLIVSSFMGK 373
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
15-193 6.15e-16

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 75.12  E-value: 6.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  15 SSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL---Q 91
Cdd:PRK06473 286 ASCAIAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILAAVFQMISHGLISALLFLLVGVVYKKTGSRDVDVLRGLlnpE 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  92 MILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLTHHLHTMKPT 171
Cdd:PRK06473 366 RGLPITGSLMILGVMASAGIPGMVGFIAEFLVFRGSFPIFPVQTLLCMIGTGLTAVYFLLLVNRVFFGRLTAELSNLPRV 445

                        170       180
                 ....*....|....*....|..
gi 254596562 172 YTREHILMTLHLIPLLITSI*P 193
Cdd:PRK06473 446 LWSERLPALVLAVLIVVLGIQP 467
ndhD CHL00011
NADH dehydrogenase subunit 4
 11-199 7.07e-14

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 69.20  E-value: 7.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  11 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIhsRTMILAR-- 88
Cdd:CHL00011 288 IIYAASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGAILQIISHGFIGAALFFLAGTSYDRI--RLVYLDEmg 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  89 GLQMILPLMCTWWLLASLANLALPPTINFLSELMV---IVSSFSWSNMSIILL----GTNTVITALYSLHMfitSQRGKL 161
Cdd:CHL00011 366 GIAIPMPKIFTMFSSFSMASLALPGMSGFVAELIVffgIITSQKYLLMPKILItfvmAIGMILTPIYLLSM---LRQMFY 442

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 254596562 162 THHLHTMKPTY-----TREHILMTLHLIPLLITSI*PKFILGL 199
Cdd:CHL00011 443 GYKLFNVPNSYffdsgPRELFISICILLPVIGIGIYPDFVLSL 485
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 21-194 2.40e-13

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 67.75  E-value: 2.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  21 QTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGLQMILPLMCTW 100
Cdd:PRK12561 272 QDNVKRRLAYSSVSHMGFVLLGIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYERTHTLSIPNMGGLAKVMPKTFAL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562 101 WLLASLANLALPPTINFLSELMV---IVSSFSWSN----MSIILLGTNTVITALYSLHM----FITSQRGKLTHH--LHT 167
Cdd:PRK12561 352 FTASSMASLALPGMSGFVSELTVflgITSSDVYSStfrtITILLAAVGLILTPIYLLSMlrrvFYGPRSELLPALavVED 431

                        170       180
                 ....*....|....*....|....*..
gi 254596562 168 MKPtytREHILMTLHLIPLLITSI*PK 194
Cdd:PRK12561 432 AKP---RELFIALSLLVPIIGIGFYPK 455
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 3-157 2.75e-12

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 64.40  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:COG0651  275 LLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNHALAKALLFLAAGAIERATGTR 354

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFS---WSNMSIILLGtnTVITALYSLHMFITSQ 157
Cdd:COG0651  355 DLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEagaWLLAAVLLLS--SLLTLAYFVRIFGRAQ 430
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 4-196 4.07e-12

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 63.96  E-value: 4.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:PRK02546 283 IVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFTDLGTSGAMLQMISHGLIGASLFFLVGATYDRTHTLM 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVS-------SFSWSNMSIILLGTNTVITALYSLHM---- 152
Cdd:PRK02546 363 LDEMGGVGQKMRKMFAMWTACSLASLALPGMSGFVAELMVFVGfatsdayTLPFRVVVVFLAAVGVILTPIYLLSMlrei 442

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 254596562 153 FITSQRGKLTHHlHTMKPTYTREHILMTLHLIPLLITSI*PKFI 196
Cdd:PRK02546 443 FFGPENKELVSH-EKLVDAEPREVFIIACLLVPIIGIGLYPKLV 485
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
5-177 2.68e-10

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 58.57  E-value: 2.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   5 VLSMWGMIMT---SSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHS 81
Cdd:PRK07363 273 GLAIIGTISViygALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTQLSLLGAVAQMISHGLILALLFHLVGIVERKVGT 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  82 RTMILARGLQMI---LPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQR 158
Cdd:PRK07363 353 RDLDVLNGLMNPirgLPLTSALLVLAGMASAGIPGLVGFVAEFIVFQGSFSTFPIPTLLCIVASGLTAVYFVILLNRTCF 432

                        170
                 ....*....|....*....
gi 254596562 159 GKLTHHLHTMKPTYTREHI 177
Cdd:PRK07363 433 GRLDNKLAYYPKVLWSEKI 451
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 3-199 3.31e-10

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 58.40  E-value: 3.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:PRK06458 284 LLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIAFALGIGGPLGIFAALLHMLNHSLTKSAIFFASGNVLQKYGTR 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFS---WSNMSIILLGTNTVITALYslhmfitsqrG 159
Cdd:PRK06458 364 DINVIRGLLKVSPLTGWGLMLGALAIAGMPPFGVFISEFLILTAGLArgpLLIAILLLLLLTLAFAALV----------R 433

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 254596562 160 KLTHHLHTMKPTYTREHILMTLHLIPLLITSI*PkFILGL 199
Cdd:PRK06458 434 RVAGMVFGEPPEAVNRGDLGWLTTSPMFVHLVLV-LVLGL 472
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 2-148 3.42e-09

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 55.27  E-value: 3.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   2 PFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHS 81
Cdd:PRK08375 273 LLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHHALMKGALFLAAGAIEVTYGT 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  82 RTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFS---WSNMSIILLGtnTVITALY 148
Cdd:PRK08375 353 RRLSELSGLGRRMPLTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEagqWLVLAVLLAS--SLLALLY 420
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 3-191 5.06e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 51.90  E-value: 5.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:PRK12667 298 LIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTR 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMvIVSSFSWSNMSI--ILLGTNTVITALYSLHMFITSQRGK 160
Cdd:PRK12667 378 DIDELAGLGRKMPIASFAFLIGALSLVGIPPLNGFFSKLL-LFNALLESGFYLpaLVLLIASAISLVGYFRAWYSLFFGK 456

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254596562 161 LTHHLHTMKptytREHILMTLHLIPLLITSI 191
Cdd:PRK12667 457 PKSGEEVEH----KESPSMSVVILVLALAVL 483
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 11-191 1.51e-07

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 50.54  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  11 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSfmgATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL 90
Cdd:COG1009  286 ALFAALIALAQTDIKRVLAYSTVSQLGYMFLALGVGAYVA---ALFHLLTHAFFKALLFLGAGSVIHATGTRDIRKMGGL 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  91 QMILPLmcTWWLLASLANLAL--PPTINFLSELMVIVSSFSWSNMSIILLGTNTV---ITALYSLHM----FITSQRGKL 161
Cdd:COG1009  363 RKKMPI--TAITFLIGALSLAgiPPFAGFFSKEAILEAALEAGGLGPLLLAVALLgafLTAFYSFRLfflvFFGKPRPKT 440

                        170       180       190
                 ....*....|....*....|....*....|
gi 254596562 162 THHLHtmkptytREHILMTLHLIPLLITSI 191
Cdd:COG1009  441 PKHPH-------ESPWLMTLPLVVLAVLSL 463
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
 4-196 2.44e-06

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 46.89  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   4 IVLSMWGMIMTssicLRQTDLKSLIAYSSVSHMALVIIA---ALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:PRK06525 280 IVTLLYGFLMY----LPQQDMKRLLAYSTITQLGYMFFGlslAILGSRLALEGSIAYIFNHAFAKSLFFLVAGALSYSCG 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITA------LYSLHMFI 154
Cdd:PRK06525 356 TRLLPRLRGVLKKLPLVGVGFCVAALAITGVPPFNGFFSKFPIFAAGFELSVEYWILLPAMVLLLIesvasfAWFLRWFG 435

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 254596562 155 TSQRGKLTHHLHTMKPtytrEHILMTLHLIPLLITSI*PKFI 196
Cdd:PRK06525 436 RVVFGEPSEAVADAAP----LPGSMKLVLIVLIVMSLVSPVI 473
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 4-138 1.27e-04

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 42.06  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:PRK08377 277 IIMATLTVFFAELSALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLAVGYVGITLGGTE 356

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254596562  84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILL 138
Cdd:PRK08377 357 IEKFEGLGKRMPLTALALTIGALSTVGIPLFNVFWSKFRIILAGLSAGYTWPVAL 411
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 3-140 1.92e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 41.26  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:PRK12662 282 FMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALFMVSGSISYHFGTT 361

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596562  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSE---LMVIVSSFSWSNMSIILLGT 140
Cdd:PRK12662 362 KLEDCLNLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKwyiLDAFIKSNAWIGLVVLLVGS 422
PRK12650 PRK12650
DUF4040 family protein;
4-72 3.14e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 40.80  E-value: 3.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254596562   4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA 72
Cdd:PRK12650 276 IIVGMITALMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLAHALFKSSLFMLI 344
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
 11-122 4.02e-04

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 40.67  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  11 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL 90
Cdd:PRK12647 270 MLTGALLAVRQTDLKLILAYSTVSALGTLVMLLGLGSELAIKAAVLFLVAHSLYKGALFMVAGIIDHETGTRDITKLGGL 349

                         90       100       110
                 ....*....|....*....|....*....|...
gi 254596562  91 QMILPLMCTWWLLASLANLALPPTINFLS-ELM 122
Cdd:PRK12647 350 RRAMPITAAAALLAALSMAGLPPLFGFLAkELI 382
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 11-150 8.75e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 39.41  E-value: 8.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  11 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL 90
Cdd:PRK06589 291 IFYSSLKALKTDNIKKILAYSTISQLSLALLSAFILTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKEDQVDKLHGT 370

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254596562  91 QMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSN------MSIILLGTnTVITALYSL 150
Cdd:PRK06589 371 SKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQpwlsiiVMLVVIAS-SILSALYLL 435
PRK12644 PRK12644
putative monovalent cation/H+ antiporter subunit A; Reviewed
 4-69 2.10e-03

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237154 [Multi-domain]  Cd Length: 965  Bit Score: 38.37  E-value: 2.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254596562   4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLF 69
Cdd:PRK12644 271 LVLGLATMLLGGWRALRQHDLKLILAYGTVSQLGFLTVLVGIGTRDAALAGLAMLLAHALFKAALF 336
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
3-65 2.97e-03

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 37.88  E-value: 2.97e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254596562   3 FIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTS 65
Cdd:PRK05777 273 LAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMT 335
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 1-69 3.11e-03

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 37.67  E-value: 3.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254596562   1 YPFIVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLF 69
Cdd:PRK08668 273 YILAWLGNISIIVGTLMAILQEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFNHALFKGLFF 341
PRK07234 PRK07234
putative monovalent cation/H+ antiporter subunit D; Reviewed
 15-94 5.14e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235978 [Multi-domain]  Cd Length: 470  Bit Score: 37.24  E-value: 5.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  15 SSICLRQTDLKSLIAYSSVSHMALVIIAALMqstlsfmgATALMVAHGLTSSMLFCLANTNYERIHS--RTMILARGLQM 92
Cdd:PRK07234 260 VLFALLEKDLKRMLAFSTISQLGFILAAPLV--------GGLYALAHGLVKSTLFLCAGALPSRNFTelISQMLGIGKWI 331


                 ..
gi 254596562  93 IL 94
Cdd:PRK07234 332 PL 333
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 4-69 5.93e-03

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 37.04  E-value: 5.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254596562   4 IVLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLF 69
Cdd:PRK08676 277 IGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLF 342
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 19-65 6.00e-03

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 37.02  E-value: 6.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 254596562  19 LRQTDLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTS 65
Cdd:COG1007  288 LAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMN 334
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
 19-128 8.83e-03

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 36.63  E-value: 8.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596562  19 LRQTDLKSLIAYSSVSHMALVIIA-----------ALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILA 87
Cdd:PRK08667 289 LKEHDLKGLLAYSSIENIGIILMGiglyvifgvygLDTLALLALGGALFHSLNHALFKSLLFLTAGSVVHATGTRNIEKM 368

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 254596562  88 RGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSF 128
Cdd:PRK08667 369 GGLVKLMPYTSALFLVGAVSIAALPPFNGFASELLLYESFF 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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