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Conserved domains on  [gi|330426196|gb|AEC15947|]
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small T-antigen [JC polyomavirus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-151 3.34e-74

Small T antigen; Reviewed


:

Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 219.16  E-value: 3.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330426196   7 REESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPDFGTWNSSE----- 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSEeedvp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330426196  82 ---VGCDFPPNSDTLYCKEWPNCATNPSVHCPCLMCMLKLRHRNRKFLRSSPLVWIDCYCFDCFRQWFGCDLT 151
Cdd:PHA03102  81 sgyVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRLKQKLRPEPLVWGECYCYKCFRQWFGLDIT 153
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-151 3.34e-74

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 219.16  E-value: 3.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330426196   7 REESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPDFGTWNSSE----- 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSEeedvp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330426196  82 ---VGCDFPPNSDTLYCKEWPNCATNPSVHCPCLMCMLKLRHRNRKFLRSSPLVWIDCYCFDCFRQWFGCDLT 151
Cdd:PHA03102  81 sgyVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRLKQKLRPEPLVWGECYCYKCFRQWFGLDIT 153
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 83-172 1.29e-42

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 137.13  E-value: 1.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330426196   83 GCDFPPNSDTLYCKEWPNCATNPSVHCPCLMCMLKLRHRNR-KFLRSSPLVWIDCYCFDCFRQWFGCDLTQEALHCWEKV 161
Cdd:pfam02380   3 GATFGDKYDALYCKDWPTCLKNVSSNCNCILCLLRKQHKNRkKFLRKPPLVWGECYCYDCYRQWFGLPLTEETLFLWAQI 82

                          90
                  ....*....|.
gi 330426196  162 LGDTPYRDLKL 172
Cdd:pfam02380  83 IANTPFRDLKL 93
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 1.64e-10

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 53.78  E-value: 1.64e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330426196    11 MELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD-----EDKMKRMNFLYKKMEQGVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 7.40e-06

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 41.38  E-value: 7.40e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 330426196  12 ELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD----EDKMKRMNFLYK 60
Cdd:cd06257    1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-56 1.22e-04

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 39.32  E-value: 1.22e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 330426196  15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGG-----DEDKMKRMN 56
Cdd:COG2214    9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLN 53
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-151 3.34e-74

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 219.16  E-value: 3.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330426196   7 REESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPDFGTWNSSE----- 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSEeedvp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330426196  82 ---VGCDFPPNSDTLYCKEWPNCATNPSVHCPCLMCMLKLRHRNRKFLRSSPLVWIDCYCFDCFRQWFGCDLT 151
Cdd:PHA03102  81 sgyVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRLKQKLRPEPLVWGECYCYKCFRQWFGLDIT 153
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 83-172 1.29e-42

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 137.13  E-value: 1.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330426196   83 GCDFPPNSDTLYCKEWPNCATNPSVHCPCLMCMLKLRHRNR-KFLRSSPLVWIDCYCFDCFRQWFGCDLTQEALHCWEKV 161
Cdd:pfam02380   3 GATFGDKYDALYCKDWPTCLKNVSSNCNCILCLLRKQHKNRkKFLRKPPLVWGECYCYDCYRQWFGLPLTEETLFLWAQI 82

                          90
                  ....*....|.
gi 330426196  162 LGDTPYRDLKL 172
Cdd:pfam02380  83 IANTPFRDLKL 93
PHA02624 PHA02624
large T antigen; Provisional
 1-98 1.05e-40

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 144.74  E-value: 1.05e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330426196   1 MDKVLNREESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPdFGTWNSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90
                 ....*....|....*...
gi 330426196  81 EVgcdfpPNSDTLYCKEW 98
Cdd:PHA02624  80 EI-----PTYGTPEWEQW 92
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 1.64e-10

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 53.78  E-value: 1.64e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330426196    11 MELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD-----EDKMKRMNFLYKKMEQGVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 7.40e-06

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 41.38  E-value: 7.40e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 330426196  12 ELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD----EDKMKRMNFLYK 60
Cdd:cd06257    1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 15-59 7.80e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 38.99  E-value: 7.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 330426196   15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKG----GDEDKMKRMNFLY 59
Cdd:pfam00226   4 EILGVSPDA--SDEEIKKAYRKLALKYHPDKNpgdpEAEEKFKEINEAY 50
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-56 1.22e-04

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 39.32  E-value: 1.22e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 330426196  15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGG-----DEDKMKRMN 56
Cdd:COG2214    9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLN 53
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 15-56 1.65e-04

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 39.69  E-value: 1.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 330426196  15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD----EDKMKRMN 56
Cdd:COG0484    4 EILGVSRDA--SAEEIKKAYRKLAKKYHPDRNPGdpeaEEKFKEIN 47
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
11-55 5.71e-04

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 36.70  E-value: 5.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 330426196  11 MELMD---LLGLDRSAwgNIPVMRKAYLKKCKELHPDK--GGDEDKMKRM 55
Cdd:COG1076    1 MQLDDafeLLGLPPDA--DDAELKRAYRKLQREHHPDRlaAGLPEEEQRL 48
SEC63 COG5407
Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular ...
 15-56 1.51e-03

Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 444165 [Multi-domain]  Cd Length: 61  Bit Score: 35.36  E-value: 1.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 330426196  15 DLLGLDRSAWGNipVMRKAYLKKCKELHPDKGGD----EDKMKRMN 56
Cdd:COG5407    4 EVLGVAKTASAD--EIKKAYRKLAKKYHPDRNKGdpkaEERFKEIN 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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