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Conserved domains on  [gi|544590880|gb|AGW24855|]
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IRS [Anatid alphaherpesvirus 1]

Protein Classification

PHA03307 family protein( domain architecture ID 11476204)

PHA03307 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3-1549 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1425.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880    3 KTQYPDFTDLIEAAASADCSFMSNISSIDIQhgiqgPNTPLIDESQYLLDDSRCLIDNVMNAAAMAATTKPMETVnrgdg 82
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGDA-----ADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTG----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880   83 rlyldymgpplsdaaftkplqPNPGP-TEIDSSDEEPTTCGNLNPIKEATPPKMQSPSQGMRQKGDTTPKGVVRAEGGPK 161
Cdd:PHA03307   71 ---------------------PPPGPgTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPS 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  162 TGSDLQKKRKSEYKLGRGGKTMAKKPGVNKTKVAAGGKNYAGIADVIDIGESEEECSDNGGAAVGVKKPRSATAGRPSAP 241
Cdd:PHA03307  130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  242 DKPIASPARSPTAAPPKNTARRRHRSPSSSASPPPARCADSGRTMTPKSSPTSVTSAGWYRSPARspqtGVVERSGPPST 321
Cdd:PHA03307  210 SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG----WNGPSSRPGPA 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  322 SPRSAPRGRSPPALPIVSCCSPAAS-PRRSVDRGRSRSSSSSSTSSSSSSSDGSSVSRGPSPDRPPTPKRPPPSFIPSAP 400
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPGSGPAPSsPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSP 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  401 KKRRPAmqrkkdnaeqrspktdlsklfsqqltHPPTSNTAASKATGTVKRKGKQPVRRAVQQEETEQQPQTMEQPTMLAN 480
Cdd:PHA03307  366 RKRPRP--------------------------SRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDA 419

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  481 SprestqyqhpssddtidlvscepppaannafyqrprrgrgrrpsamkrvssssagaescmsiGVPEMPTMNGPLLMTNG 560
Cdd:PHA03307  420 G--------------------------------------------------------------AASGAFYARYPLLTPSG 437

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  561 DPWPGSEPPPPGKVRYGGTGDYRQGLWDEPEIRYARERYAESRGPVAVFVGEMGDSSKQYDALVKALYSNSFDAMGWIQC 640
Cdd:PHA03307  438 EPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQN 517

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  641 NKITGEDLLLEQVCQKQCNlrGGTGSGSFITGSVARPLPHIGDAMAAGNALWGLPHVAAAVAMSRRYDKVQKQFLQMSLR 720
Cdd:PHA03307  518 PKLTGPDQALDQFCQKKFQ--APRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLR 595

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  721 RAYAYMLFPAKAVDASAsltddissiyrrmnavrrsmreateglqtvtvrgdsqiepqntpqstDHLATEQSAADPDFCD 800
Cdd:PHA03307  596 RAYAPMAYPENAADTGA-----------------------------------------------GAAAPAPAAPRPDAAA 628

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  801 PEHASDYSTEELADACVLACNAVIEVLLECFGGAGNIPGISslELDAACPSAQLHRHHVQLLSWIKDLKLLPICINAMRL 880
Cdd:PHA03307  629 AGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGLA--FPRPACPPRALEACPARLESWLRELRDLRDAVYLARL 706

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  881 RGELSSSQGIESCVMALRAVGTVISTVRPFVNFSVDRARRRYSAWNLTEALFSAPSGNGsakingAKLSWVLSHLTPKDK 960
Cdd:PHA03307  707 RGDLPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVP------AKLAEALALLEPAEP 780

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  961 QTSPLVWPiasktidkYMTSGSGIQQDGGSKRKDQTRSVACQTNCHKQDRERKIDGANRVnkqcqqiPGSERANGKGEQP 1040
Cdd:PHA03307  781 QRGAGSSP--------PVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSES-------SGPARPPGAAARP 845

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1041 RRFASK--RKSMPVQALPRDGIDNGADDVHGPPQTKRHSVPSNGSGAYAQTDDTAPKDRDRPDGLPKhqniqnskkdnqt 1118
Cdd:PHA03307  846 PPARSSesSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK------------- 912

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1119 elpwtlpsvkaLGPMPQGGPHPRGGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARV 1198
Cdd:PHA03307  913 -----------LGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFDPEALAEI 981

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1199 AARRGGSHVEGRLY-GPLRVTDPLRKQCAWMNQIPDPEDVKVVIMYCPLVGEELSAAP---VASCMPMWSDEKGGLSFLL 1274
Cdd:PHA03307  982 AARCGGPPPRSGSAfGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPapdASPGGPAWSPERGGLSFLL 1061

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1275 AALCDRLCSYGSHAWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAIS 1354
Cdd:PHA03307 1062 AALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPAVS 1141

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1355 SYHSYIKATITPQAHGAHRWPDCEAMSRVVMTSRGIVGPGVFARVEAAFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTR 1434
Cdd:PHA03307 1142 QYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRTR 1221

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1435 VPMTPREYRGLVLPQYD-RKDMAFQADGLSIRGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRKHPFETPDDIPEVVR 1513
Cdd:PHA03307 1222 VPLPPREYRQAVLPALDgCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVVR 1301

                        1530      1540      1550
                  ....*....|....*....|....*....|....*...
gi 544590880 1514 SYCAAALLEPQMEGNVCAVNPNTIQRG--QRPPTITWE 1549
Cdd:PHA03307 1302 AFCRAALLEPDPEAPPLVLPPSAAAEAahARAPRVTWA 1339
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3-1549 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1425.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880    3 KTQYPDFTDLIEAAASADCSFMSNISSIDIQhgiqgPNTPLIDESQYLLDDSRCLIDNVMNAAAMAATTKPMETVnrgdg 82
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGDA-----ADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTG----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880   83 rlyldymgpplsdaaftkplqPNPGP-TEIDSSDEEPTTCGNLNPIKEATPPKMQSPSQGMRQKGDTTPKGVVRAEGGPK 161
Cdd:PHA03307   71 ---------------------PPPGPgTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPS 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  162 TGSDLQKKRKSEYKLGRGGKTMAKKPGVNKTKVAAGGKNYAGIADVIDIGESEEECSDNGGAAVGVKKPRSATAGRPSAP 241
Cdd:PHA03307  130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  242 DKPIASPARSPTAAPPKNTARRRHRSPSSSASPPPARCADSGRTMTPKSSPTSVTSAGWYRSPARspqtGVVERSGPPST 321
Cdd:PHA03307  210 SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG----WNGPSSRPGPA 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  322 SPRSAPRGRSPPALPIVSCCSPAAS-PRRSVDRGRSRSSSSSSTSSSSSSSDGSSVSRGPSPDRPPTPKRPPPSFIPSAP 400
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPGSGPAPSsPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSP 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  401 KKRRPAmqrkkdnaeqrspktdlsklfsqqltHPPTSNTAASKATGTVKRKGKQPVRRAVQQEETEQQPQTMEQPTMLAN 480
Cdd:PHA03307  366 RKRPRP--------------------------SRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDA 419

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  481 SprestqyqhpssddtidlvscepppaannafyqrprrgrgrrpsamkrvssssagaescmsiGVPEMPTMNGPLLMTNG 560
Cdd:PHA03307  420 G--------------------------------------------------------------AASGAFYARYPLLTPSG 437

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  561 DPWPGSEPPPPGKVRYGGTGDYRQGLWDEPEIRYARERYAESRGPVAVFVGEMGDSSKQYDALVKALYSNSFDAMGWIQC 640
Cdd:PHA03307  438 EPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQN 517

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  641 NKITGEDLLLEQVCQKQCNlrGGTGSGSFITGSVARPLPHIGDAMAAGNALWGLPHVAAAVAMSRRYDKVQKQFLQMSLR 720
Cdd:PHA03307  518 PKLTGPDQALDQFCQKKFQ--APRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLR 595

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  721 RAYAYMLFPAKAVDASAsltddissiyrrmnavrrsmreateglqtvtvrgdsqiepqntpqstDHLATEQSAADPDFCD 800
Cdd:PHA03307  596 RAYAPMAYPENAADTGA-----------------------------------------------GAAAPAPAAPRPDAAA 628

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  801 PEHASDYSTEELADACVLACNAVIEVLLECFGGAGNIPGISslELDAACPSAQLHRHHVQLLSWIKDLKLLPICINAMRL 880
Cdd:PHA03307  629 AGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGLA--FPRPACPPRALEACPARLESWLRELRDLRDAVYLARL 706

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  881 RGELSSSQGIESCVMALRAVGTVISTVRPFVNFSVDRARRRYSAWNLTEALFSAPSGNGsakingAKLSWVLSHLTPKDK 960
Cdd:PHA03307  707 RGDLPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVP------AKLAEALALLEPAEP 780

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  961 QTSPLVWPiasktidkYMTSGSGIQQDGGSKRKDQTRSVACQTNCHKQDRERKIDGANRVnkqcqqiPGSERANGKGEQP 1040
Cdd:PHA03307  781 QRGAGSSP--------PVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSES-------SGPARPPGAAARP 845

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1041 RRFASK--RKSMPVQALPRDGIDNGADDVHGPPQTKRHSVPSNGSGAYAQTDDTAPKDRDRPDGLPKhqniqnskkdnqt 1118
Cdd:PHA03307  846 PPARSSesSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK------------- 912

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1119 elpwtlpsvkaLGPMPQGGPHPRGGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARV 1198
Cdd:PHA03307  913 -----------LGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFDPEALAEI 981

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1199 AARRGGSHVEGRLY-GPLRVTDPLRKQCAWMNQIPDPEDVKVVIMYCPLVGEELSAAP---VASCMPMWSDEKGGLSFLL 1274
Cdd:PHA03307  982 AARCGGPPPRSGSAfGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPapdASPGGPAWSPERGGLSFLL 1061

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1275 AALCDRLCSYGSHAWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAIS 1354
Cdd:PHA03307 1062 AALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPAVS 1141

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1355 SYHSYIKATITPQAHGAHRWPDCEAMSRVVMTSRGIVGPGVFARVEAAFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTR 1434
Cdd:PHA03307 1142 QYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRTR 1221

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1435 VPMTPREYRGLVLPQYD-RKDMAFQADGLSIRGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRKHPFETPDDIPEVVR 1513
Cdd:PHA03307 1222 VPLPPREYRQAVLPALDgCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVVR 1301

                        1530      1540      1550
                  ....*....|....*....|....*....|....*...
gi 544590880 1514 SYCAAALLEPQMEGNVCAVNPNTIQRG--QRPPTITWE 1549
Cdd:PHA03307 1302 AFCRAALLEPDPEAPPLVLPPSAAAEAahARAPRVTWA 1339
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 1142-1558 5.57e-147

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 458.31  E-value: 5.57e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1142 GGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARVAARRGG--------------SHV 1207
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANalpgggdynsneiiTSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1208 EGRLYGPLRVTDPLRKQCAWMNQIPDPEDVKVVIMYCPLVGEELSAAPVASCMPMWSDEKGGLSFLLAALCDRLCSYGSH 1287
Cdd:pfam03585   81 ASRAFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPPKWSNKRGGLSFLLAALSNRLCLPKTS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1288 AWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAISSYHSYIKATITPQ 1367
Cdd:pfam03585  161 AWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCIISPR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1368 AHGAHRWPDCEAMSRVVMTSRGIVGPGVFARVEAAFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTRVPMTPREYRGLVL 1447
Cdd:pfam03585  241 SQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRAAVL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1448 PQYD-RKDMAFQADGLSIRGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRKHPFETPD--DIPeVVRSYCAAALLEPQ 1524
Cdd:pfam03585  321 PVFDgCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSflHVP-TARNFCRSALLEPD 399

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 544590880  1525 MEGNVCAVNPNTIQ---------RGQRP--PTITWELCHGGSRAT 1558
Cdd:pfam03585  400 PEARPLVLHIPEGTcsalaedmvASALPpcPRITWGQGFGHEEGG 444
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3-1549 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1425.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880    3 KTQYPDFTDLIEAAASADCSFMSNISSIDIQhgiqgPNTPLIDESQYLLDDSRCLIDNVMNAAAMAATTKPMETVnrgdg 82
Cdd:PHA03307    1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGDA-----ADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTG----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880   83 rlyldymgpplsdaaftkplqPNPGP-TEIDSSDEEPTTCGNLNPIKEATPPKMQSPSQGMRQKGDTTPKGVVRAEGGPK 161
Cdd:PHA03307   71 ---------------------PPPGPgTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPS 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  162 TGSDLQKKRKSEYKLGRGGKTMAKKPGVNKTKVAAGGKNYAGIADVIDIGESEEECSDNGGAAVGVKKPRSATAGRPSAP 241
Cdd:PHA03307  130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  242 DKPIASPARSPTAAPPKNTARRRHRSPSSSASPPPARCADSGRTMTPKSSPTSVTSAGWYRSPARspqtGVVERSGPPST 321
Cdd:PHA03307  210 SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG----WNGPSSRPGPA 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  322 SPRSAPRGRSPPALPIVSCCSPAAS-PRRSVDRGRSRSSSSSSTSSSSSSSDGSSVSRGPSPDRPPTPKRPPPSFIPSAP 400
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPGSGPAPSsPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSP 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  401 KKRRPAmqrkkdnaeqrspktdlsklfsqqltHPPTSNTAASKATGTVKRKGKQPVRRAVQQEETEQQPQTMEQPTMLAN 480
Cdd:PHA03307  366 RKRPRP--------------------------SRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDA 419

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  481 SprestqyqhpssddtidlvscepppaannafyqrprrgrgrrpsamkrvssssagaescmsiGVPEMPTMNGPLLMTNG 560
Cdd:PHA03307  420 G--------------------------------------------------------------AASGAFYARYPLLTPSG 437

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  561 DPWPGSEPPPPGKVRYGGTGDYRQGLWDEPEIRYARERYAESRGPVAVFVGEMGDSSKQYDALVKALYSNSFDAMGWIQC 640
Cdd:PHA03307  438 EPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQN 517

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  641 NKITGEDLLLEQVCQKQCNlrGGTGSGSFITGSVARPLPHIGDAMAAGNALWGLPHVAAAVAMSRRYDKVQKQFLQMSLR 720
Cdd:PHA03307  518 PKLTGPDQALDQFCQKKFQ--APRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLR 595

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  721 RAYAYMLFPAKAVDASAsltddissiyrrmnavrrsmreateglqtvtvrgdsqiepqntpqstDHLATEQSAADPDFCD 800
Cdd:PHA03307  596 RAYAPMAYPENAADTGA-----------------------------------------------GAAAPAPAAPRPDAAA 628

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  801 PEHASDYSTEELADACVLACNAVIEVLLECFGGAGNIPGISslELDAACPSAQLHRHHVQLLSWIKDLKLLPICINAMRL 880
Cdd:PHA03307  629 AGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGLA--FPRPACPPRALEACPARLESWLRELRDLRDAVYLARL 706

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  881 RGELSSSQGIESCVMALRAVGTVISTVRPFVNFSVDRARRRYSAWNLTEALFSAPSGNGsakingAKLSWVLSHLTPKDK 960
Cdd:PHA03307  707 RGDLPVAGGREERVAAVRAVSLVARTVAPLVRYSPRRARARASAWDITDALFSNPSLVP------AKLAEALALLEPAEP 780

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  961 QTSPLVWPiasktidkYMTSGSGIQQDGGSKRKDQTRSVACQTNCHKQDRERKIDGANRVnkqcqqiPGSERANGKGEQP 1040
Cdd:PHA03307  781 QRGAGSSP--------PVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSES-------SGPARPPGAAARP 845

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1041 RRFASK--RKSMPVQALPRDGIDNGADDVHGPPQTKRHSVPSNGSGAYAQTDDTAPKDRDRPDGLPKhqniqnskkdnqt 1118
Cdd:PHA03307  846 PPARSSesSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK------------- 912

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1119 elpwtlpsvkaLGPMPQGGPHPRGGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARV 1198
Cdd:PHA03307  913 -----------LGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALAFDPEALAEI 981

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1199 AARRGGSHVEGRLY-GPLRVTDPLRKQCAWMNQIPDPEDVKVVIMYCPLVGEELSAAP---VASCMPMWSDEKGGLSFLL 1274
Cdd:PHA03307  982 AARCGGPPPRSGSAfGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPapdASPGGPAWSPERGGLSFLL 1061

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1275 AALCDRLCSYGSHAWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAIS 1354
Cdd:PHA03307 1062 AALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPEDWPADGPAVS 1141

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1355 SYHSYIKATITPQAHGAHRWPDCEAMSRVVMTSRGIVGPGVFARVEAAFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTR 1434
Cdd:PHA03307 1142 QYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTVRTRLGPRTR 1221

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1435 VPMTPREYRGLVLPQYD-RKDMAFQADGLSIRGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRKHPFETPDDIPEVVR 1513
Cdd:PHA03307 1222 VPLPPREYRQAVLPALDgCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAGPDELPAVVR 1301

                        1530      1540      1550
                  ....*....|....*....|....*....|....*...
gi 544590880 1514 SYCAAALLEPQMEGNVCAVNPNTIQRG--QRPPTITWE 1549
Cdd:PHA03307 1302 AFCRAALLEPDPEAPPLVLPPSAAAEAahARAPRVTWA 1339
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 1142-1558 5.57e-147

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 458.31  E-value: 5.57e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1142 GGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARVAARRGG--------------SHV 1207
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANalpgggdynsneiiTSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1208 EGRLYGPLRVTDPLRKQCAWMNQIPDPEDVKVVIMYCPLVGEELSAAPVASCMPMWSDEKGGLSFLLAALCDRLCSYGSH 1287
Cdd:pfam03585   81 ASRAFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLFCVPAPDTPPKWSNKRGGLSFLLAALSNRLCLPKTS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1288 AWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAISSYHSYIKATITPQ 1367
Cdd:pfam03585  161 AWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCIISPR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1368 AHGAHRWPDCEAMSRVVMTSRGIVGPGVFARVEAAFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTRVPMTPREYRGLVL 1447
Cdd:pfam03585  241 SQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRAAVL 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  1448 PQYD-RKDMAFQADGLSIRGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRKHPFETPD--DIPeVVRSYCAAALLEPQ 1524
Cdd:pfam03585  321 PVFDgCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSflHVP-TARNFCRSALLEPD 399

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 544590880  1525 MEGNVCAVNPNTIQ---------RGQRP--PTITWELCHGGSRAT 1558
Cdd:pfam03585  400 PEARPLVLHIPEGTcsalaedmvASALPpcPRITWGQGFGHEEGG 444
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 572-732 2.02e-60

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 204.29  E-value: 2.02e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880   572 GKVRYGGTGDYRQGLWDEPEIRYARERYAESRGPVAVFVGEMGDSSKQYDALVKALYSNSFDAMGWIQCNKITGEDLLLE 651
Cdd:pfam03584    5 GRVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYTPDAEPLGWLQNPRLNPGDVALN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880   652 QVCQKqcNLRGGTGSGSFITGSVARPLPHIGDAMAAGNALWGLPHVAAAVAMSRRYDKVQKQFLQMSLRRAYAYMLFPAK 731
Cdd:pfam03584   85 QICQK--ISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPLAFPEN 162


                   .
gi 544590880   732 A 732
Cdd:pfam03584  163 A 163
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 576-1370 1.51e-17

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 89.48  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  576 YGGTGdYRQGLWDEPEIRYARERYAESRGPVAVFVGEMGDSSKQYDALVKALYSNSFDAMGW-IQCNKITGEDlllEQVC 654
Cdd:PHA03308  365 YHGSG-YRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLERLVEEFMVHPLSRVSYgYGGPKLSPRD---KRLC 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  655 QkQCNLRG-GTGSGSFITGSVARPLPHIGDAMAAGNALWGLPHVAAAVAMSRRYDKVQKQFLQMSLRRAYAYMLFPAKAV 733
Cdd:PHA03308  441 E-LCALRGpGSSEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAALRRAFVPFVFPGAAV 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  734 DASASLTDDISSIYRRMNAVRRSMREateglqtvtvrgdsqiepqntpqstdhlaTEQSAADPDFCDPEHASDYSTEELA 813
Cdd:PHA03308  520 DPTAASASGDHPVLVGARRIARATRE-----------------------------LEAAAKEPPAATPEKLSSSALLRHT 570

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  814 DACVLACNAVIEVL--LECFGGAGNiPGISSLELDAAcpsaqLHRHHVQLLSWikdLKLLPICINAMRLR-----GELSS 886
Cdd:PHA03308  571 RTCIVAAADLMAALtaIDCPPVTIN-PAKRRPDLYQA-----LSRAPKTVFTW---ERAMPYCAASLWSRlvigsLPLPS 641

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  887 SQGIESCVMALRAVGTVIST-----VRPFVNFSVdrarrrySAWNLTEALFSAPSGNGSAKINGAKLSWVLSHLTPKDKQ 961
Cdd:PHA03308  642 TDDVTLLVEAMEAAVGVLGCsdegdVRPSIAYAA-------SGWRMIATMLGDDSAPGSEHVTDDCPADDDTHHHDRRKR 714

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  962 TS----------PLVWPIASKTIDKYMTSGSGIQQDGGSKRKDQTRSVACQTNCHKQ----------DRERKIDGANRVN 1021
Cdd:PHA03308  715 RGgrrttcrydlPPGTPDRAAHLLLYGSPGGGDGAEPSAAQESPANPWPRAPPCDEQeplsvspygpEPDRPPDDDFETR 794

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1022 KQCQQIPGSERANgkgEQPRRFASKrKSMPVQALPrDGIDNGAddvhgpPQTKRHS-------VPSNGSGAYAQTDDTAP 1094
Cdd:PHA03308  795 KGLKRKSSEDHAD---PIPEGNATK-KTCGLQGLP-DSLPPAV------PETDRDNpllppcpITPEGPPCPPREEPQQP 863

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1095 KDRDRPDGLPKH-QNIQNSKKDNQTELPWTLPSVKALGPMPQGGPHPRGGYRRVPTGITHTPLPTESARSTYCQ-PDIVA 1172
Cdd:PHA03308  864 QEPQEPQSPSFHiSEIGEALFHSTPVSPTILFAPEGFIPNQGDVYRPHGKNLGVALSAGEPYVPAHRARPALERlANYLR 943

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1173 ELLDDP------MFPPNWKPALMFDPEALARVAARRGGSHVEGRLYgplrvtdpLRKQCAWMNQIPDPEDVKVVIMYCPL 1246
Cdd:PHA03308  944 GLSSGPagsysaTGPADWLPAFARDPVALGEFCKRISPVNRGGRCV--------LEERLSWTLRHPADKIYDLIILVSER 1015

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880 1247 V-GEELSAApvascmpmwsdekgglsFLLAALCDRLCSYGSHAWAGNWTG-----VPDISALNSRGVLLLSVRDLGFAGA 1320
Cdd:PHA03308 1016 ApGEFLERA-----------------YAYAALCGRACMPGGACWPESWTRgeypyIPPDEKDPGRSVAILCTTDLGYAGA 1078

                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|...
gi 544590880 1321 VEYLCLR-LGSAHKRLIFLDTIDTVDWPA-DGPAI-SSYHSYIKATITPQAHG 1370
Cdd:PHA03308 1079 VEWMLERaLSTSGRACVVVDARDPGDEDSrSGPRIpTGRRGVVYARTSPPSHA 1131
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 574-772 1.55e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 66.42  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  574 VRYGGTGdYRQGLWDEPEIRYARERYAESRGPVAVFVGEMGDSSKQYDALVKALY----SNSFDAMGWIQCNKITGEdll 649
Cdd:PHA03309  638 VYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMlqplSRVSHSYGGSRLNKTEKN--- 713

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  650 LEQVC---------QKQCNLRGGTGSGSFITG--SVARPLPHIGDAMAAGNALWGLPHVAAAVAMSRRYDKVQKQFLQMS 718
Cdd:PHA03309  714 LCKIClppdggddrDGGGKSRGGRGGGSKDASrtAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSC 793

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 544590880  719 LRRAYAYMLFPAKAVDASASLTDDISSIYRRMNAvrrSMREATEGLQTVTVRGD 772
Cdd:PHA03309  794 LRLAFAPLVFPGASPPVGADDSPWPTSPIRECAA---ALREGFRALNDIRAEQD 844
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 218-334 4.14e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544590880  218 SDNGGAAVGVKKPRSATAGRPSAPDKPIASPARSPTAAPPKNTARRRHRSPSSSASPPPARCADSGRTM-TPKSSPTSVT 296
Cdd:PRK07764  595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASdGGDGWPAKAG 674

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 544590880  297 SAGWYRSPARSPQTGVVERSGPPSTSPRSAPRGRSPPA 334
Cdd:PRK07764  675 GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG 712
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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