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Conserved domains on  [gi|748446115|gb|AJE60929|]
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wingless, partial [Periplaneta americana]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-124 1.88e-63

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19333:

Pssm-ID: 393294  Cd Length: 311  Bit Score: 195.26  E-value: 1.88e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsgGSGVGGKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19333  165 GSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGN-----------NGNNRGSRRAKKFLLEPENPNHKPPTSKDLVYF 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19333  234 EESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRT 277
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-124 1.88e-63

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 195.26  E-value: 1.88e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsgGSGVGGKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19333  165 GSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGN-----------NGNNRGSRRAKKFLLEPENPNHKPPTSKDLVYF 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19333  234 EESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRT 277
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-125 1.06e-57

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 180.44  E-value: 1.06e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115    1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsggsgvggKKNRynfQLKPYNPDHKPPGTKDLVYL 80
Cdd:pfam00110 170 GSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRR-----------------NKRG---RLVPRNSRFKPPTKNDLVYL 229

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 748446115   81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:pfam00110 230 EKSPDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTR 274
WNT1 smart00097
found in Wnt-1;
1-125 2.06e-53

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 169.42  E-value: 2.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115     1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSlrgqggsggsgvggkknryNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:smart00097 167 GSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGT-------------------NKAPVPKNSTFKPPTETDLVYL 227

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 748446115    81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:smart00097 228 ESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTR 272
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-124 1.88e-63

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 195.26  E-value: 1.88e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsgGSGVGGKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19333  165 GSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGN-----------NGNNRGSRRAKKFLLEPENPNHKPPTSKDLVYF 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19333  234 EESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRT 277
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-125 1.06e-57

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 180.44  E-value: 1.06e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115    1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsggsgvggKKNRynfQLKPYNPDHKPPGTKDLVYL 80
Cdd:pfam00110 170 GSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRR-----------------NKRG---RLVPRNSRFKPPTKNDLVYL 229

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 748446115   81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:pfam00110 230 EKSPDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTR 274
WNT1 smart00097
found in Wnt-1;
1-125 2.06e-53

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 169.42  E-value: 2.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115     1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSlrgqggsggsgvggkknryNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:smart00097 167 GSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGT-------------------NKAPVPKNSTFKPPTETDLVYL 227

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 748446115    81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:smart00097 228 ESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTR 272
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 1-124 2.90e-52

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 166.63  E-value: 2.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsggsgvgGKKNrynfqLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19338  174 GSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSN----------------DGKS-----LIPEGKTIKPPTKEDLVYL 232

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19338  233 EESPDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQT 276
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-125 1.57e-44

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 146.28  E-value: 1.57e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsggsgvggkkNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd13113  151 GSCTTKTCWRQLPSFREIGDYLKEKYDNAVKVKLNN-------------------NGSGLRLVPKRSRFRSPTETDLVYL 211

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd13113  212 EESPDYCEPNPTLGSLGTAGRECNPTSPGPDSCELLCCGRGYRTE 256
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 1-125 1.23e-43

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 144.77  E-value: 1.23e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVsnagslrgqggsggsgvggKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19336  172 GSCELKTCWRAMPTFREVGNILKEKFDGATEVQQ-------------------KRIGSRPVLVPKNPQFKPHTDADLVYL 232

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19336  233 DSSPDFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTR 277
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 1-125 3.74e-43

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 143.58  E-value: 3.74e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSLrgqggsggsgvggkkNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19339  171 GSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRR---------------RRPTFLKLKISRKYKKPRPRDLVYL 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19339  236 EKSPNYCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTH 280
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 1-124 1.64e-39

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 134.05  E-value: 1.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVsnagslrgqggsggsgVGGKKNRYNFQ-LKPYNPDHKPPGTKDLVY 79
Cdd:cd19335  172 GSCELKTCWWAQPDFRKIGDYLKDKYDSASEMVV----------------ERHRESRGWVEtLRPKYKLFKPPTERDLIY 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  80 LEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19335  236 YEESPNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNT 280
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 1-125 4.57e-39

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 132.75  E-value: 4.57e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVmvsnagslrgqggsggsgvggKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19337  177 GSCSLKTCWRQLAPFREVGDRLKDKYDGAVKV---------------------KLNRRGTLLRRRNSRFNKPTKDDLVYL 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19337  236 DDSPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTK 280
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 1-124 3.17e-38

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 130.85  E-value: 3.17e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsggsgvggKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19342  176 GSCELKTCWKAAPDFREVGDILKEKYDHATLVDQSN-----------------LNNGARRRRLTRRKRRRRPPKTDLVYY 238

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19342  239 ERSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNT 282
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 1-125 2.91e-37

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 128.14  E-value: 2.91e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVmvsnagslrgqggsggsgvGGKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19343  167 GSCSVKTCWKALPDLSEVASRLKRKYARAVEV-------------------VSRKVGSRRKLVPKSLKVRPYTKDDLIYL 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19343  228 TKSPDYCLPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTY 272
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 1-124 3.92e-37

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 127.84  E-value: 3.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSLrgqggsggsgvggkknrynfqLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19334  178 GSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTN---------------------LLAANKGHKKPTRSDLVYF 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19334  237 ESSPDYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDT 280
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 1-125 2.08e-35

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 123.11  E-value: 2.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSnagslrgqggsggsgvgGKKNRYnfQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19344  168 GSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIATK-----------------KSKRRL--RRRERRKRKVPISKDELVYI 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19344  229 HKSPNYCVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQ 273
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 1-122 6.93e-30

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 109.00  E-value: 6.93e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASrVMVSNAGSlrgqggsggsgvggkknrynfQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19347  177 GSCSLKTCWLQLADFRKVGDALKEKYDSAA-AMKLNSRG---------------------KLVQVNSRFNPPTTLDLVYI 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGY 122
Cdd:cd19347  235 DPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGY 276
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 1-122 2.04e-29

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 107.76  E-value: 2.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsgGSGVGGKKNRYNfqlkpynpdhkPPGTKDLVYL 80
Cdd:cd19348  177 GSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINR-----------KGKLELVNSRFN-----------PPTAEDLVYI 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGY 122
Cdd:cd19348  235 DPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGY 276
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 1-125 1.71e-28

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 105.52  E-value: 1.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGslrgqggsggsgvggkKNRYNFQLKPYNP-DHKPPGTKDLVY 79
Cdd:cd19349  176 GSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRAS----------------RNKRPTFLKIKKPlSYRKPMDTDLVY 239

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 748446115  80 LEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19349  240 IEKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTH 285
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 1-125 3.78e-28

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 104.71  E-value: 3.78e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGslrgqggsggsgvggKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19350  176 GSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRAS---------------RLRQPTFLKIKKRRSYQKPMETDLVYI 240

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTH 125
Cdd:cd19350  241 ERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTH 285
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 1-122 3.99e-27

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 101.60  E-value: 3.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVmvsnagslrgqggsggsgvgGKKNRYNFQLKPYNPDHKP-PGTKDLVY 79
Cdd:cd19355  164 GSCQLKTCWQVTPEFRTVGSLLKDRFYVATLI--------------------KPHNRNTGQLEPGHAPHRRrASINDLVY 223

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 748446115  80 LEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGY 122
Cdd:cd19355  224 FEKSPDFCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGH 266
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-124 2.16e-26

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 100.01  E-value: 2.16e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVsnagslrgqggsggsgvggkkNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19345  178 GSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVM---------------------NQDGTGFTVANKHFKKPTKNDLVYF 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19345  237 ENSPDYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDT 280
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 1-125 1.06e-25

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 97.74  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNagslrgqggsggsGVGGKKNRYNFQLKPYNPDHKPPGTKDLVYL 80
Cdd:cd19341  161 GSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSEN-------------NAATGGSQLRKGKSGSVKKKSRPRRKDLVYL 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748446115  81 EPSPGFCERNPRLGiqGTHGRQCNDTsigvDGCDLMCCGRGYRTH 125
Cdd:cd19341  228 EKSPSFCRSTRYSP--GTKGRRCLKG----DNCDTLCCGRGYNTQ 266
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 1-124 3.58e-22

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 88.83  E-value: 3.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSnagslrgqggsggsgvggkKNRYNFQLKpyNPDHKPPGTKDLVYL 80
Cdd:cd19346  178 GSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMN-------------------QDGTGFTVA--NKNFRKATKTDLVYF 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRT 124
Cdd:cd19346  237 ENSPDYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDT 280
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 1-122 7.63e-21

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 84.94  E-value: 7.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVmvsnagslrgqggsggsgvggkkNRYNFQLKPYNPDHKPPG-TKDLVY 79
Cdd:cd19356  164 GSCQFKTCWHVTPEFRLVGALLREKFQRAIFI-----------------------NSHNKNSGVFLPRLRPRRlARELVY 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 748446115  80 LEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGY 122
Cdd:cd19356  221 FEKSPDFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGH 263
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 1-103 4.47e-20

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 82.73  E-value: 4.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSLRGQGGSGGSGVGGKKNrynfqlkpynpdhkppgtkDLVYL 80
Cdd:cd19340  155 GSCSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRETNGSRAIKLLNIKKN-------------------DLVYL 215

                         90       100
                 ....*....|....*....|...
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQC 103
Cdd:cd19340  216 EKSPNYCRANVTLGWPGTLGRQC 238
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 1-124 7.78e-18

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 76.86  E-value: 7.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVM-VSNAGSLRGQGGSGGSGVGGKKNRYnfqlkpynpdhkpPGTKDLVY 79
Cdd:cd19354  158 GSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHsVTNDATGETELWSPERHGHTLKGHS-------------PRSTDLVY 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 748446115  80 LEPSPGFCErnPRLGIQGTHGRQCN-DTSigvdgCDLMCCGRGYRT 124
Cdd:cd19354  225 LEDSPSFCR--PSKYSPGTAGRTCSrETN-----CDSLCCGRGYNT 263
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 1-103 2.69e-12

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 61.58  E-value: 2.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSLRGQGGSGGSGVGGKKNRynfqlkpynpdhkppgtKDLVYL 80
Cdd:cd19352  158 GSCTTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISK-----------------KELVHL 220

                         90       100
                 ....*....|....*....|...
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQC 103
Cdd:cd19352  221 EDSPDYCLENKTLGLLGTEGREC 243
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 1-120 2.95e-12

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 61.46  E-value: 2.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSLRGqggsggsgvggkkNRYNFQLKPYNPDHKPPGTkDLVYL 80
Cdd:cd19351  157 GSCSIQTCWLQLADFREIGNYLKVKHDQALKLEMDKRRMRAG-------------NSADNRGAIAEAFGSVAET-ELIYL 222

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 748446115  81 EPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGR 120
Cdd:cd19351  223 EDSPDYCTKNASLGLQGTEGRECLQSGKNLSQWERRSCRR 262
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 1-125 5.28e-12

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 60.82  E-value: 5.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748446115   1 GSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNAGSLRGQGGSGGsgvggkknrynfqlKPYNPDHKP--PGTKDLV 78
Cdd:cd19353  159 GSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPP--------------KKSGAGHSDqiPRTTDLV 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 748446115  79 YLEPSPGFCeRNPRLGiQGTHGRQCNDTSigvdGCDLMCCGRGYRTH 125
Cdd:cd19353  225 YIDDSPSFC-LMSRFS-PGTSGRRCYKDK----NCESICCGRGHNTQ 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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