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Conserved domains on  [gi|1471766851|gb|AXU41059|]
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desmin, partial [Homo sapiens]

Protein Classification

Filament_head and Filament domain-containing protein( domain architecture ID 12057322)

Filament_head and Filament domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Filament super family cl25641
Intermediate filament protein;
107-192 6.50e-23

Intermediate filament protein;


The actual alignment was detected with superfamily member pfam00038:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 93.06  E-value: 6.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471766851 107 NEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRL---KGREPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNL 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELrqkKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80


                  ....*....
gi 1471766851 184 LDDLQRLKA 192
Cdd:pfam00038  81 RLAAEDFRQ 89
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 9-106 2.65e-09

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


:

Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 52.01  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471766851   9 QRVSSYRRTFGGapgfplgsplssPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGglgslRARRLGTTRTPSSYG--AG 86
Cdd:pfam04732   1 YSSSSYRRMFGD------------SSSSRPSYSSSSGSRSVSSRSYSRSSSSSPSS-----SSRRSSRSSSRSSYPslAA 63

                          90       100
                  ....*....|....*....|
gi 1471766851  87 ELLDFSLADAVNQEFLTTRT 106
Cdd:pfam04732  64 DSLDFSLADALNQEFKATRT 83
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
107-192 6.50e-23

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 93.06  E-value: 6.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471766851 107 NEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRL---KGREPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNL 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELrqkKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80


                  ....*....
gi 1471766851 184 LDDLQRLKA 192
Cdd:pfam00038  81 RLAAEDFRQ 89
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 9-106 2.65e-09

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 52.01  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471766851   9 QRVSSYRRTFGGapgfplgsplssPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGglgslRARRLGTTRTPSSYG--AG 86
Cdd:pfam04732   1 YSSSSYRRMFGD------------SSSSRPSYSSSSGSRSVSSRSYSRSSSSSPSS-----SSRRSSRSSSRSSYPslAA 63

                          90       100
                  ....*....|....*....|
gi 1471766851  87 ELLDFSLADAVNQEFLTTRT 106
Cdd:pfam04732  64 DSLDFSLADALNQEFKATRT 83
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
107-192 6.50e-23

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 93.06  E-value: 6.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471766851 107 NEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRL---KGREPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNL 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELrqkKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80


                  ....*....
gi 1471766851 184 LDDLQRLKA 192
Cdd:pfam00038  81 RLAAEDFRQ 89
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 9-106 2.65e-09

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 52.01  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471766851   9 QRVSSYRRTFGGapgfplgsplssPVFPRAGFGSKGSSSSVTSRVYQVSRTSGGAGglgslRARRLGTTRTPSSYG--AG 86
Cdd:pfam04732   1 YSSSSYRRMFGD------------SSSSRPSYSSSSGSRSVSSRSYSRSSSSSPSS-----SSRRSSRSSSRSSYPslAA 63

                          90       100
                  ....*....|....*....|
gi 1471766851  87 ELLDFSLADAVNQEFLTTRT 106
Cdd:pfam04732  64 DSLDFSLADALNQEFKATRT 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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