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Conserved domains on  [gi|292630720|sp|B7PP17|]
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RecName: Full=Anamorsin homolog; AltName: Full=Fe-S cluster assembly protein DRE2 homolog

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIAPIN1 super family cl37720
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 203-265 6.91e-30

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


The actual alignment was detected with superfamily member pfam05093:

Pssm-ID: 398662  Cd Length: 99  Bit Score: 108.13  E-value: 6.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630720  203 GEKKRKACKNCTCGLAEELDKEAAAK------------------------VQPK-SSCGNCYLGDAFRCASCPYKGLPAF 257
Cdd:pfam05093  12 GKKRRKACKDCTCGLKELEEAEDAAQralqdkalgkvkfteddlteidftVQGKtGSCGSCALGDAFRCSGCPYLGLPAF 91


                  ....*...
gi 292630720  258 KPGEKIVL 265
Cdd:pfam05093  92 KPGEEVTI 99
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 203-265 6.91e-30

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 108.13  E-value: 6.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630720  203 GEKKRKACKNCTCGLAEELDKEAAAK------------------------VQPK-SSCGNCYLGDAFRCASCPYKGLPAF 257
Cdd:pfam05093  12 GKKRRKACKDCTCGLKELEEAEDAAQralqdkalgkvkfteddlteidftVQGKtGSCGSCALGDAFRCSGCPYLGLPAF 91


                  ....*...
gi 292630720  258 KPGEKIVL 265
Cdd:pfam05093  92 KPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
172-268 2.21e-22

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 93.67  E-value: 2.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630720 172 DRDVELVDPDQLISEEDFKKpdpSTLKASCGGE--KKRKACKNCTCGLAEELDKEAAAKVQPK----------------- 232
Cdd:COG5636  158 DTDPRTIMEDELLDEDSEDK---AIQRSECPPSktKKKRACKDCTCGLKEEEENEIVRTRQDKvvkftedelteidftid 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 292630720 233 ----SSCGNCYLGDAFRCASCPYKGLPAFKPGEKIVLSED 268
Cdd:COG5636  235 gkkvSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMN 274
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 203-265 6.91e-30

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 108.13  E-value: 6.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630720  203 GEKKRKACKNCTCGLAEELDKEAAAK------------------------VQPK-SSCGNCYLGDAFRCASCPYKGLPAF 257
Cdd:pfam05093  12 GKKRRKACKDCTCGLKELEEAEDAAQralqdkalgkvkfteddlteidftVQGKtGSCGSCALGDAFRCSGCPYLGLPAF 91


                  ....*...
gi 292630720  258 KPGEKIVL 265
Cdd:pfam05093  92 KPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
172-268 2.21e-22

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 93.67  E-value: 2.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630720 172 DRDVELVDPDQLISEEDFKKpdpSTLKASCGGE--KKRKACKNCTCGLAEELDKEAAAKVQPK----------------- 232
Cdd:COG5636  158 DTDPRTIMEDELLDEDSEDK---AIQRSECPPSktKKKRACKDCTCGLKEEEENEIVRTRQDKvvkftedelteidftid 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 292630720 233 ----SSCGNCYLGDAFRCASCPYKGLPAFKPGEKIVLSED 268
Cdd:COG5636  235 gkkvSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMN 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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