|
Name |
Accession |
Description |
Interval |
E-value |
| LRR19-TM |
pfam15176 |
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ... |
251-364 |
7.48e-68 |
|
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes. :
Pssm-ID: 464545 Cd Length: 115 Bit Score: 208.99 E-value: 7.48e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 251 LTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSE 330
Cdd:pfam15176 2 LTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNPD 81
|
90 100 110
....*....|....*....|....*....|....
gi 26329279 331 DTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364
Cdd:pfam15176 82 DTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-155 |
8.94e-13 |
|
Leucine rich repeat; :
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 8.94e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 96 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLI 155
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
45-174 |
5.72e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription]; The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.33 E-value: 5.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRITlnaADSRVLQMYSLLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886 113 TNLESLDLSGNQLT---DLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKEL 187
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 26329279 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886 188 DLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNN 238
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
174-211 |
5.35e-07 |
|
Leucine rich repeat C-terminal domain; :
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 45.88 E-value: 5.35e-07
10 20 30
....*....|....*....|....*....|....*...
gi 26329279 174 NPWNCTCGLLELHNWLNTSNVTLENENMtMCSYPDELK 211
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLR 37
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR19-TM |
pfam15176 |
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ... |
251-364 |
7.48e-68 |
|
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.
Pssm-ID: 464545 Cd Length: 115 Bit Score: 208.99 E-value: 7.48e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 251 LTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSE 330
Cdd:pfam15176 2 LTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNPD 81
|
90 100 110
....*....|....*....|....*....|....
gi 26329279 331 DTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364
Cdd:pfam15176 82 DTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-155 |
8.94e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 8.94e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 96 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLI 155
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
45-174 |
5.72e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.33 E-value: 5.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRITlnaADSRVLQMYSLLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886 113 TNLESLDLSGNQLT---DLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKEL 187
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 26329279 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886 188 DLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNN 238
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
174-211 |
5.35e-07 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 45.88 E-value: 5.35e-07
10 20 30
....*....|....*....|....*....|....*...
gi 26329279 174 NPWNCTCGLLELHNWLNTSNVTLENENMtMCSYPDELK 211
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLR 37
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
45-175 |
8.48e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.40 E-value: 8.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRITLNAAdsrvLQMYSLLTELYLMENNIIALYNssFRNLLNLEILNICGNSISVI-------------- 110
Cdd:cd21340 24 KNLKVLYLYDNKITKIEN----LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhi 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 111 --QQ-----------GSFVGL-NELKQLFLCQNKILQLNPdtFVPLNNLKVLNLQGNLIRLFDA-----PQLPHLEILTL 171
Cdd:cd21340 98 enQRlppgekltfdpRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEElldllSSWPSLRELDL 175
|
....
gi 26329279 172 DGNP 175
Cdd:cd21340 176 TGNP 179
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
142-235 |
8.59e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 44.69 E-value: 8.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 142 LNNLKVLNLQ-GNLIRLFDAPQLphleilTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSAP- 219
Cdd:TIGR00864 2 ISNNKISTIEeGICANLCNLSEI------DLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPl 75
|
90
....*....|....*.
gi 26329279 220 FTTECHSTFISTITED 235
Cdd:TIGR00864 76 LDSGCDEEYVACLKDN 91
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
45-156 |
2.59e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 39.39 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRIT----LNAADSrvLQMYSLLTELYLMENNI-----IALYnSSFRNLLNLEILNICGNSISViqQG-- 113
Cdd:COG5238 292 TTLTSLDLSVNRIGdegaIALAEG--LQGNKTLHTLNLAYNGIgaqgaIALA-KALQENTTLHSLDLSDNQIGD--EGai 366
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 26329279 114 ----SFVGLNELKQLFLCQNKIlqlNPDTFVPL------NNLKVLNLQGNLIR 156
Cdd:COG5238 367 alakYLEGNTTLRELNLGKNNI---GKQGAEALidalqtNRLHTLILDGNLIG 416
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
47-153 |
5.94e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 38.68 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 47 VTILDLSYNRITLNAaDSRVLQMYSLlTELYLMENNIIALYNSSFRNLlNLEILNICGNSISVIQQGSFVGLNELKQLFL 126
Cdd:PLN00113 430 VYFLDISNNNLQGRI-NSRKWDMPSL-QMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506
|
90 100
....*....|....*....|....*..
gi 26329279 127 CQNKILQLNPDTFVPLNNLKVLNLQGN 153
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHN 533
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR19-TM |
pfam15176 |
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ... |
251-364 |
7.48e-68 |
|
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.
Pssm-ID: 464545 Cd Length: 115 Bit Score: 208.99 E-value: 7.48e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 251 LTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSE 330
Cdd:pfam15176 2 LTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNPD 81
|
90 100 110
....*....|....*....|....*....|....
gi 26329279 331 DTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364
Cdd:pfam15176 82 DTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-155 |
8.94e-13 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 8.94e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 96 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLI 155
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
45-174 |
5.72e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.33 E-value: 5.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRITlnaADSRVLQMYSLLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886 113 TNLESLDLSGNQLT---DLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKEL 187
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 26329279 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886 188 DLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNN 238
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
73-131 |
5.66e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 5.66e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 26329279 73 LTELYLMENNIIALYNSSFRNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKI 131
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
45-174 |
2.93e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.94 E-value: 2.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRITLNAADsrvlqmyslLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886 96 TNLTELDLSGNEELSNLTN---------LESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSL 164
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 26329279 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886 165 DLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPlgNLTNLEELDLSGN 215
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
174-211 |
5.35e-07 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 45.88 E-value: 5.35e-07
10 20 30
....*....|....*....|....*....|....*...
gi 26329279 174 NPWNCTCGLLELHNWLNTSNVTLENENMtMCSYPDELK 211
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLR 37
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
45-175 |
8.48e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.40 E-value: 8.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRITLNAAdsrvLQMYSLLTELYLMENNIIALYNssFRNLLNLEILNICGNSISVI-------------- 110
Cdd:cd21340 24 KNLKVLYLYDNKITKIEN----LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhi 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 111 --QQ-----------GSFVGL-NELKQLFLCQNKILQLNPdtFVPLNNLKVLNLQGNLIRLFDA-----PQLPHLEILTL 171
Cdd:cd21340 98 enQRlppgekltfdpRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEElldllSSWPSLRELDL 175
|
....
gi 26329279 172 DGNP 175
Cdd:cd21340 176 TGNP 179
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
8-175 |
1.39e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.93 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 8 FWLFSMLLPSVKSQASETEVPCNFSRRNYTLIPEGISTNVTILDLSYNRITLNAADSRVLQMYSLLTELYLMENNIIAL- 86
Cdd:COG4886 25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLs 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 87 YNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQLFLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLP 164
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEElgNLT 182
|
170
....*....|.
gi 26329279 165 HLEILTLDGNP 175
Cdd:COG4886 183 NLKELDLSNNQ 193
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
120-175 |
2.16e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 2.16e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 26329279 120 ELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLIRLFDAP---QLPHLEILTLDGNP 175
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsGLPSLRYLDLSGNR 60
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
142-235 |
8.59e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 44.69 E-value: 8.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 142 LNNLKVLNLQ-GNLIRLFDAPQLphleilTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSAP- 219
Cdd:TIGR00864 2 ISNNKISTIEeGICANLCNLSEI------DLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPl 75
|
90
....*....|....*.
gi 26329279 220 FTTECHSTFISTITED 235
Cdd:TIGR00864 76 LDSGCDEEYVACLKDN 91
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
45-156 |
2.59e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 39.39 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 45 TNVTILDLSYNRIT----LNAADSrvLQMYSLLTELYLMENNI-----IALYnSSFRNLLNLEILNICGNSISViqQG-- 113
Cdd:COG5238 292 TTLTSLDLSVNRIGdegaIALAEG--LQGNKTLHTLNLAYNGIgaqgaIALA-KALQENTTLHSLDLSDNQIGD--EGai 366
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 26329279 114 ----SFVGLNELKQLFLCQNKIlqlNPDTFVPL------NNLKVLNLQGNLIR 156
Cdd:COG5238 367 alakYLEGNTTLRELNLGKNNI---GKQGAEALidalqtNRLHTLILDGNLIG 416
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
47-153 |
5.94e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 38.68 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329279 47 VTILDLSYNRITLNAaDSRVLQMYSLlTELYLMENNIIALYNSSFRNLlNLEILNICGNSISVIQQGSFVGLNELKQLFL 126
Cdd:PLN00113 430 VYFLDISNNNLQGRI-NSRKWDMPSL-QMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506
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90 100
....*....|....*....|....*..
gi 26329279 127 CQNKILQLNPDTFVPLNNLKVLNLQGN 153
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHN 533
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