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Conserved domains on  [gi|26330464|dbj|BAC28962|]
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unnamed protein product [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10640301)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Homo sapiens collagen and calcium-binding EGF domain-containing protein 1

CATH:  2.10.25.10
Gene Ontology:  GO:0005509|GO:0005515
PubMed:  3282918|2288911|7606779

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
135-176 1.46e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 1.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 26330464    135 DIDECATSNTTLCAHICINTMGSYHCECREGYIledDGRTCT 176
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
135-176 1.46e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 1.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 26330464    135 DIDECATSNTTLCAHICINTMGSYHCECREGYIledDGRTCT 176
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 139-175 6.20e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.39  E-value: 6.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 26330464   139 CATSNTtLCAHICINTMGSYHCECREGYILEDDGRTC 175
Cdd:pfam14670   1 CSVNNG-GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 135-176 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 1.22e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 26330464 135 DIDECATSNTTLCAHICINTMGSYHCECREGYIleddGRTCT 176
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
135-176 1.46e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 1.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 26330464    135 DIDECATSNTTLCAHICINTMGSYHCECREGYIledDGRTCT 176
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 139-175 6.20e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.39  E-value: 6.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 26330464   139 CATSNTtLCAHICINTMGSYHCECREGYILEDDGRTC 175
Cdd:pfam14670   1 CSVNNG-GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 135-176 1.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 1.22e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 26330464 135 DIDECATSNTTLCAHICINTMGSYHCECREGYIleddGRTCT 176
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 133-174 1.28e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 1.28e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 26330464 133 CLDIDECATSNTTlCAHICINTMGSYHCECREGYILEDDGRT 174
Cdd:cd01475 184 CVVPDLCATLSHV-CQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
135-165 5.56e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 5.56e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 26330464   135 DIDECATSnTTLCAH--ICINTMGSYHCECREG 165
Cdd:pfam07645   1 DVDECATG-THNCPAntVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 141-175 6.79e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 6.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 26330464   141 TSNTTLCAH--ICINTMGSYHCECREGYILedDGRTC 175
Cdd:pfam12947   2 SDNNGGCHPnaTCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 138-169 1.61e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 1.61e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 26330464 138 ECATSNTTLCAHICINTMGSYHCECREGYILE 169
Cdd:cd00053   1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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