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Conserved domains on  [gi|29292650|dbj|BAC66431|]
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large T [JC polyomavirus]

Protein Classification

PHA02624 family protein( domain architecture ID 11476056)

PHA02624 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02624 PHA02624
large T antigen; Provisional
 1-636 0e+00

large T antigen; Provisional


:

Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 1143.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650    1 MDKVLNREESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPdFGTWNSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   81 EVPTYGTDEWESWWNTFNEKWDEDLFCHEEMFASDDENT---------------GSQHSTPPKKKKKVEDPKDFPVDLHA 145
Cdd:PHA02624  80 EIPTYGTPEWEQWWEEFNEKWDEDLFCDEELSSSDDEDEppppspppsqeeesqSSSQATPPKKKKKNPAPNDFPSCLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  146 FLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKYSVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKLCTFSFLICK 225
Cdd:PHA02624 160 FLSHAIFSNKTLTCFLIYTTKEKAELLYKKLLEKFNPTFISRHSYDGGALLFIITPGKHRVSAVNNFCKKHCTVSFLICK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  226 GVNKEYLFYSALCRQPYAVVEESIQGGLKEHDFNPEEPEEtKQVSWKLVTQYALDTKCEDVFLLMGMYLDFQENPLQCKK 305
Cdd:PHA02624 240 GVKKEYELYSALCRDPFKLLEESIPGGLKEYEFNPEEEEE-KQVNWKLITDFALETNCDDVLLLLGLYLEFAVPPEECKK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  306 CEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTVAAKQRVDSIHMTREEMLVERFNFLLDKMDLIFgaHGNAVL 385
Cdd:PHA02624 319 CQKKKLKTHFKYHEKHHENAKLFLDSKNQKTICQQAVDGVLAKRRVKLLTMTREELLAERFKKLLDKMDEIF--KGSVDI 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  386 EQYMAGVAWIHCLLPQMDTVIYEFLKCIVLNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVG 465
Cdd:PHA02624 397 LQYMAGVAWLHCLLPNFDDVIYDILKLIVENVPKRRYWLFKGPVNSGKTTLAAALLDLCGGKSLNVNCPPDKLNFELGCA 476

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  466 IDQFMVVFEDVKGTGAESRDLPSGQGISNLDCLRDYLDGSVKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQARFVRQ 545
Cdd:PHA02624 477 IDQFMVVFEDVKGQPADNKDLPSGQGMNNLDNLRDYLDGSVPVNLEKKHLNKRSQIFPPGIVTMNEYLIPQTVKARFAKV 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  546 IDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRPVADFAAAIHERIVQWKERLDLEISMYTFSTMKANVGMGRP 625
Cdd:PHA02624 557 LDFKPKPYLKKSLKKNEYLLEKRILQSGETLLLLLIWYRPVEDFAEEIQEKVVTWKERLDKEVSDTTFATMKENIHEGKD 636

                        650
                 ....*....|.
gi 29292650  626 ILDFPREEDSE 636
Cdd:PHA02624 637 PLEKIVEEDSD 647
 
Name Accession Description Interval E-value
PHA02624 PHA02624
large T antigen; Provisional
 1-636 0e+00

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 1143.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650    1 MDKVLNREESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPdFGTWNSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   81 EVPTYGTDEWESWWNTFNEKWDEDLFCHEEMFASDDENT---------------GSQHSTPPKKKKKVEDPKDFPVDLHA 145
Cdd:PHA02624  80 EIPTYGTPEWEQWWEEFNEKWDEDLFCDEELSSSDDEDEppppspppsqeeesqSSSQATPPKKKKKNPAPNDFPSCLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  146 FLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKYSVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKLCTFSFLICK 225
Cdd:PHA02624 160 FLSHAIFSNKTLTCFLIYTTKEKAELLYKKLLEKFNPTFISRHSYDGGALLFIITPGKHRVSAVNNFCKKHCTVSFLICK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  226 GVNKEYLFYSALCRQPYAVVEESIQGGLKEHDFNPEEPEEtKQVSWKLVTQYALDTKCEDVFLLMGMYLDFQENPLQCKK 305
Cdd:PHA02624 240 GVKKEYELYSALCRDPFKLLEESIPGGLKEYEFNPEEEEE-KQVNWKLITDFALETNCDDVLLLLGLYLEFAVPPEECKK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  306 CEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTVAAKQRVDSIHMTREEMLVERFNFLLDKMDLIFgaHGNAVL 385
Cdd:PHA02624 319 CQKKKLKTHFKYHEKHHENAKLFLDSKNQKTICQQAVDGVLAKRRVKLLTMTREELLAERFKKLLDKMDEIF--KGSVDI 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  386 EQYMAGVAWIHCLLPQMDTVIYEFLKCIVLNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVG 465
Cdd:PHA02624 397 LQYMAGVAWLHCLLPNFDDVIYDILKLIVENVPKRRYWLFKGPVNSGKTTLAAALLDLCGGKSLNVNCPPDKLNFELGCA 476

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  466 IDQFMVVFEDVKGTGAESRDLPSGQGISNLDCLRDYLDGSVKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQARFVRQ 545
Cdd:PHA02624 477 IDQFMVVFEDVKGQPADNKDLPSGQGMNNLDNLRDYLDGSVPVNLEKKHLNKRSQIFPPGIVTMNEYLIPQTVKARFAKV 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  546 IDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRPVADFAAAIHERIVQWKERLDLEISMYTFSTMKANVGMGRP 625
Cdd:PHA02624 557 LDFKPKPYLKKSLKKNEYLLEKRILQSGETLLLLLIWYRPVEDFAEEIQEKVVTWKERLDKEVSDTTFATMKENIHEGKD 636

                        650
                 ....*....|.
gi 29292650  626 ILDFPREEDSE 636
Cdd:PHA02624 637 PLEKIVEEDSD 647
Polyoma_lg_T_C pfam06431
Polyomavirus large T antigen C-terminus;
266-679 0e+00

Polyomavirus large T antigen C-terminus;


Pssm-ID: 283968  Cd Length: 417  Bit Score: 899.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   266 TKQVSWKLVTQYALDTKCEDVFLLMGMYLDFQENPLQCKKCEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTV 345
Cdd:pfam06431   1 TKQVSWKLVTEYAMETKCEDVFLLLGMYLEFQYNFEMCKKCIKKDQPSHFKYHEKHYANAAIFADSKNQKSICQQAVDTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   346 AAKQRVDSIHMTREEMLVERFNFLLDKMDLIFGAHGNAVLEQYMAGVAWIHCLLPQMDTVIYEFLKCIVLNIPKKRYWLF 425
Cdd:pfam06431  81 LAKKRVDSLHMTREEMLTERFNDLLDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIYDFLKCIVYNIPKKRYWLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   426 KGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVGIDQFMVVFEDVKGTGAESRDLPSGQGISNLDCLRDYLDGS 505
Cdd:pfam06431 161 KGPIDSGKTTLAAALLDLCGGKALNVNLPLERLNFELGVAIDQFMVVFEDVKGTGAESRDLPSGHGINNLDNLRDYLDGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   506 VKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQARFVRQIDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRP 585
Cdd:pfam06431 241 VKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVRQIDFRPKDYLRKSLERSEFLLEKRILQSGMTLLLLLIWFRP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   586 VADFAAAIHERIVQWKERLDLEISMYTFSTMKANVGMGRPILDFPREEDSEAEDSGHGSSTESQSQCFSQVSEASGADTQ 665
Cdd:pfam06431 321 VADFAQSIQSRIVEWKERLDKEISMYTFSKMKFNVAMGIGILDWLREEDSEDEDSGHGSSTESQSQCKSQVSHESGIDSQ 400

                         410
                  ....*....|....
gi 29292650   666 EHCTYHICKGFQCF 679
Cdd:pfam06431 401 SQGSFHACKGFQCF 414
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 2.72e-09

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 53.39  E-value: 2.72e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29292650     11 MELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD-----EDKMKRMNFLYKKMEQGVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 9.46e-05

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 40.61  E-value: 9.46e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 29292650  12 ELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD----EDKMKRMNFLYK 60
Cdd:cd06257   1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-56 7.25e-04

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 39.32  E-value: 7.25e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 29292650  15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGG-----DEDKMKRMN 56
Cdd:COG2214   9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLN 53
 
Name Accession Description Interval E-value
PHA02624 PHA02624
large T antigen; Provisional
 1-636 0e+00

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 1143.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650    1 MDKVLNREESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPdFGTWNSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   81 EVPTYGTDEWESWWNTFNEKWDEDLFCHEEMFASDDENT---------------GSQHSTPPKKKKKVEDPKDFPVDLHA 145
Cdd:PHA02624  80 EIPTYGTPEWEQWWEEFNEKWDEDLFCDEELSSSDDEDEppppspppsqeeesqSSSQATPPKKKKKNPAPNDFPSCLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  146 FLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKYSVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKLCTFSFLICK 225
Cdd:PHA02624 160 FLSHAIFSNKTLTCFLIYTTKEKAELLYKKLLEKFNPTFISRHSYDGGALLFIITPGKHRVSAVNNFCKKHCTVSFLICK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  226 GVNKEYLFYSALCRQPYAVVEESIQGGLKEHDFNPEEPEEtKQVSWKLVTQYALDTKCEDVFLLMGMYLDFQENPLQCKK 305
Cdd:PHA02624 240 GVKKEYELYSALCRDPFKLLEESIPGGLKEYEFNPEEEEE-KQVNWKLITDFALETNCDDVLLLLGLYLEFAVPPEECKK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  306 CEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTVAAKQRVDSIHMTREEMLVERFNFLLDKMDLIFgaHGNAVL 385
Cdd:PHA02624 319 CQKKKLKTHFKYHEKHHENAKLFLDSKNQKTICQQAVDGVLAKRRVKLLTMTREELLAERFKKLLDKMDEIF--KGSVDI 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  386 EQYMAGVAWIHCLLPQMDTVIYEFLKCIVLNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVG 465
Cdd:PHA02624 397 LQYMAGVAWLHCLLPNFDDVIYDILKLIVENVPKRRYWLFKGPVNSGKTTLAAALLDLCGGKSLNVNCPPDKLNFELGCA 476

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  466 IDQFMVVFEDVKGTGAESRDLPSGQGISNLDCLRDYLDGSVKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQARFVRQ 545
Cdd:PHA02624 477 IDQFMVVFEDVKGQPADNKDLPSGQGMNNLDNLRDYLDGSVPVNLEKKHLNKRSQIFPPGIVTMNEYLIPQTVKARFAKV 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650  546 IDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRPVADFAAAIHERIVQWKERLDLEISMYTFSTMKANVGMGRP 625
Cdd:PHA02624 557 LDFKPKPYLKKSLKKNEYLLEKRILQSGETLLLLLIWYRPVEDFAEEIQEKVVTWKERLDKEVSDTTFATMKENIHEGKD 636

                        650
                 ....*....|.
gi 29292650  626 ILDFPREEDSE 636
Cdd:PHA02624 637 PLEKIVEEDSD 647
Polyoma_lg_T_C pfam06431
Polyomavirus large T antigen C-terminus;
266-679 0e+00

Polyomavirus large T antigen C-terminus;


Pssm-ID: 283968  Cd Length: 417  Bit Score: 899.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   266 TKQVSWKLVTQYALDTKCEDVFLLMGMYLDFQENPLQCKKCEKKDQPNHFNHHEKHYYNAQIFADSKNQKSICQQAVDTV 345
Cdd:pfam06431   1 TKQVSWKLVTEYAMETKCEDVFLLLGMYLEFQYNFEMCKKCIKKDQPSHFKYHEKHYANAAIFADSKNQKSICQQAVDTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   346 AAKQRVDSIHMTREEMLVERFNFLLDKMDLIFGAHGNAVLEQYMAGVAWIHCLLPQMDTVIYEFLKCIVLNIPKKRYWLF 425
Cdd:pfam06431  81 LAKKRVDSLHMTREEMLTERFNDLLDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIYDFLKCIVYNIPKKRYWLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   426 KGPIDSGKTTLAAALLDLCGGKSLNVNMPLERLNFELGVGIDQFMVVFEDVKGTGAESRDLPSGQGISNLDCLRDYLDGS 505
Cdd:pfam06431 161 KGPIDSGKTTLAAALLDLCGGKALNVNLPLERLNFELGVAIDQFMVVFEDVKGTGAESRDLPSGHGINNLDNLRDYLDGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   506 VKVNLERKHQNKRTQVFPPGIVTMNEYSVPRTLQARFVRQIDFRPKAYLRKSLSCSEYLLEKRILQSGMTLLLLLIWFRP 585
Cdd:pfam06431 241 VKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVRQIDFRPKDYLRKSLERSEFLLEKRILQSGMTLLLLLIWFRP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   586 VADFAAAIHERIVQWKERLDLEISMYTFSTMKANVGMGRPILDFPREEDSEAEDSGHGSSTESQSQCFSQVSEASGADTQ 665
Cdd:pfam06431 321 VADFAQSIQSRIVEWKERLDKEISMYTFSKMKFNVAMGIGILDWLREEDSEDEDSGHGSSTESQSQCKSQVSHESGIDSQ 400

                         410
                  ....*....|....
gi 29292650   666 EHCTYHICKGFQCF 679
Cdd:pfam06431 401 SQGSFHACKGFQCF 414
T_Ag_DNA_bind pfam02217
Origin of replication binding protein; This domain of large T antigen binds to the SV40 origin ...
 137-230 5.91e-52

Origin of replication binding protein; This domain of large T antigen binds to the SV40 origin of DNA replication.


Pssm-ID: 280395  Cd Length: 94  Bit Score: 174.42  E-value: 5.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650   137 KDFPVDLHAFLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKYSVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKL 216
Cdd:pfam02217   1 IDFPADLEAYLSHAISSNKTPNCFLIYTTKEKLQQLYPKLMEKFSPTFHSLAHWGGGYALFIITPTKHRVSAVKNFCKKH 80

                          90
                  ....*....|....
gi 29292650   217 CTFSFLICKGVNKE 230
Cdd:pfam02217  81 CTVSFLIVKGVKKP 94
PHA03102 PHA03102
Small T antigen; Reviewed
 7-108 4.72e-40

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 144.04  E-value: 4.72e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650    7 REESMELMDLLGLDRSAWGNIPVMRKAYLKKCKELHPDKGGDEDKMKRMNFLYKKMEQGVKVAHQPDFGTWNSSevptyg 86
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSS------ 74

                         90       100
                 ....*....|....*....|....*..
gi 29292650   87 tdEWESWWN-----TFNEKWDEDLFCH 108
Cdd:PHA03102  75 --EEEDVPSgyvgaTFGDRVNALYCKD 99
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 2.72e-09

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 53.39  E-value: 2.72e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29292650     11 MELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD-----EDKMKRMNFLYKKMEQGVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 9.46e-05

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 40.61  E-value: 9.46e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 29292650  12 ELMDLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD----EDKMKRMNFLYK 60
Cdd:cd06257   1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 15-59 6.74e-04

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 38.22  E-value: 6.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 29292650    15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKG----GDEDKMKRMNFLY 59
Cdd:pfam00226   4 EILGVSPDA--SDEEIKKAYRKLALKYHPDKNpgdpEAEEKFKEINEAY 50
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-56 7.25e-04

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 39.32  E-value: 7.25e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 29292650  15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGG-----DEDKMKRMN 56
Cdd:COG2214   9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLN 53
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 15-56 1.18e-03

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 39.69  E-value: 1.18e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 29292650  15 DLLGLDRSAwgNIPVMRKAYLKKCKELHPDKGGD----EDKMKRMN 56
Cdd:COG0484   4 EILGVSRDA--SAEEIKKAYRKLAKKYHPDRNPGdpeaEEKFKEIN 47
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 406-504 2.42e-03

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 39.26  E-value: 2.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29292650 406 IYEFLKC----IVLNIPKKRYWLFKGPIDSGKTTLAAAL-----LDLCGGKSLNVNMPLERLNFELGVGIDQFMVVFEDV 476
Cdd:cd19510   5 LKDFIKNedwyNDRGIPYRRGYLLYGPPGTGKSSFIAALageldYDICDLNLSEVVLTDDRLNHLLNTAPKQSIILLEDI 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 29292650 477 ----KGTGAESRDLPSGQGISN--LDCLRDYLDG 504
Cdd:cd19510  85 daafESREHNKKNPSAYGGLSRvtFSGLLNALDG 118
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
11-55 3.03e-03

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 36.70  E-value: 3.03e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 29292650  11 MELMD---LLGLDRSAwgNIPVMRKAYLKKCKELHPDK--GGDEDKMKRM 55
Cdd:COG1076   1 MQLDDafeLLGLPPDA--DDAELKRAYRKLQREHHPDRlaAGLPEEEQRL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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