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Conserved domains on  [gi|47226153|emb|CAG08300|]
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unnamed protein product, partial [Tetraodon nigroviridis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 487-943 2.56e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 452.16  E-value: 2.56e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    487 RPVVHIGSTLQVTPNNIDRDKIkeQCDMSLPSCSNFAARACFSYTAHPEsFSPKLILDYTFEADIKRKKaRLPPRVDFLG 566
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKK--NCTLTGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    567 ----VPRGRLELPGQKRKICTDIELRLLRDFKDWLHAIPISVTASLG--DSTQWTSERVTPVLDLFQPKYTVSEINItNR 640
Cdd:pfam08441   77 sqqpSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRvdPRAPSDLPGLKPILDQNQPSTVQEQANF-LK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    641 GCGSDNICQSNLSLEYRFCSRQMensksvfrslsrkDGVAVITpTEEDIALEMTVTNrGGDDAHQTRSIISLPDTLHYSS 720
Cdd:pfam08441  156 DCGEDNVCVPDLQLSAKFDSRES-------------DEPLLLG-DDNDLALEITVTN-LGEDAYEAELYVTLPPGLDYSG 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    721 VVTTASEPKVDCTANDKGT--LIDCELGNPIEKDAEVTFYVMLTTSGISLSTKAVNISLQLQTTSTQV--LKPVEASAKV 796
Cdd:pfam08441  221 VRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsnSNPVSLKVPV 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    797 FFELKLQLYGVARPSQVsFGRSLEGKSTIN--SVEEIGALVQYEFRITNLGRSlkYFTNASLNIFWPKENSLGKWLLYLT 874
Cdd:pfam08441  301 VAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLYLL 377

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47226153    875 QTsnTGVQSVPCSPVKEINPLKNVKGL-SRKKREAELEALTSGDFSFLPTKRK----YKTLTCADGLRCVEICC 943
Cdd:pfam08441  378 DV--QGQGKGECSPQNEINPLNLTQSLeSSKPLRTSRVHHVVKRRDVLKSEKAtqtaSVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 394-444 3.83e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 59.31  E-value: 3.83e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47226153     394 SMFGLAVENIGDINQDNYGDIAVGAPYDGS----GRVYLYCGSSTGINKNAAQVL 444
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 334-372 9.38e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.52  E-value: 9.38e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47226153    334 FGYDVAVVDLNGDGWEDLAVGAPQFYKKEklfGGAVYVY 372
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 452-494 8.77e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 8.77e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47226153     452 TLFGYSLSGNLDVDDNQYPDLAVGS-LSDSVFVYRARPVVHIGS 494
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 487-943 2.56e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 452.16  E-value: 2.56e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    487 RPVVHIGSTLQVTPNNIDRDKIkeQCDMSLPSCSNFAARACFSYTAHPEsFSPKLILDYTFEADIKRKKaRLPPRVDFLG 566
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKK--NCTLTGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    567 ----VPRGRLELPGQKRKICTDIELRLLRDFKDWLHAIPISVTASLG--DSTQWTSERVTPVLDLFQPKYTVSEINItNR 640
Cdd:pfam08441   77 sqqpSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRvdPRAPSDLPGLKPILDQNQPSTVQEQANF-LK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    641 GCGSDNICQSNLSLEYRFCSRQMensksvfrslsrkDGVAVITpTEEDIALEMTVTNrGGDDAHQTRSIISLPDTLHYSS 720
Cdd:pfam08441  156 DCGEDNVCVPDLQLSAKFDSRES-------------DEPLLLG-DDNDLALEITVTN-LGEDAYEAELYVTLPPGLDYSG 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    721 VVTTASEPKVDCTANDKGT--LIDCELGNPIEKDAEVTFYVMLTTSGISLSTKAVNISLQLQTTSTQV--LKPVEASAKV 796
Cdd:pfam08441  221 VRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsnSNPVSLKVPV 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    797 FFELKLQLYGVARPSQVsFGRSLEGKSTIN--SVEEIGALVQYEFRITNLGRSlkYFTNASLNIFWPKENSLGKWLLYLT 874
Cdd:pfam08441  301 VAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLYLL 377

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47226153    875 QTsnTGVQSVPCSPVKEINPLKNVKGL-SRKKREAELEALTSGDFSFLPTKRK----YKTLTCADGLRCVEICC 943
Cdd:pfam08441  378 DV--QGQGKGECSPQNEINPLNLTQSLeSSKPLRTSRVHHVVKRRDVLKSEKAtqtaSVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 394-444 3.83e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 59.31  E-value: 3.83e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47226153     394 SMFGLAVENIGDINQDNYGDIAVGAPYDGS----GRVYLYCGSSTGINKNAAQVL 444
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 334-372 9.38e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.52  E-value: 9.38e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47226153    334 FGYDVAVVDLNGDGWEDLAVGAPQFYKKEklfGGAVYVY 372
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 332-386 7.42e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.46  E-value: 7.42e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 47226153     332 SSFGYDVA-VVDLNGDGWEDLAVGAPQFYkkEKLFGGAVYVYINN-NGKNWEKINPI 386
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSsGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 396-429 2.76e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 42.11  E-value: 2.76e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47226153    396 FGLAVEnIGDINQDNYGDIAVGAPY---DGSGRVYLY 429
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGeggAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 452-494 8.77e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 8.77e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47226153     452 TLFGYSLSGNLDVDDNQYPDLAVGS-LSDSVFVYRARPVVHIGS 494
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 487-943 2.56e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 452.16  E-value: 2.56e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    487 RPVVHIGSTLQVTPNNIDRDKIkeQCDMSLPSCSNFAARACFSYTAHPEsFSPKLILDYTFEADIKRKKaRLPPRVDFLG 566
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKK--NCTLTGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    567 ----VPRGRLELPGQKRKICTDIELRLLRDFKDWLHAIPISVTASLG--DSTQWTSERVTPVLDLFQPKYTVSEINItNR 640
Cdd:pfam08441   77 sqqpSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRvdPRAPSDLPGLKPILDQNQPSTVQEQANF-LK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    641 GCGSDNICQSNLSLEYRFCSRQMensksvfrslsrkDGVAVITpTEEDIALEMTVTNrGGDDAHQTRSIISLPDTLHYSS 720
Cdd:pfam08441  156 DCGEDNVCVPDLQLSAKFDSRES-------------DEPLLLG-DDNDLALEITVTN-LGEDAYEAELYVTLPPGLDYSG 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    721 VVTTASEPKVDCTANDKGT--LIDCELGNPIEKDAEVTFYVMLTTSGISLSTKAVNISLQLQTTSTQV--LKPVEASAKV 796
Cdd:pfam08441  221 VRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsnSNPVSLKVPV 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47226153    797 FFELKLQLYGVARPSQVsFGRSLEGKSTIN--SVEEIGALVQYEFRITNLGRSlkYFTNASLNIFWPKENSLGKWLLYLT 874
Cdd:pfam08441  301 VAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLYLL 377

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47226153    875 QTsnTGVQSVPCSPVKEINPLKNVKGL-SRKKREAELEALTSGDFSFLPTKRK----YKTLTCADGLRCVEICC 943
Cdd:pfam08441  378 DV--QGQGKGECSPQNEINPLNLTQSLeSSKPLRTSRVHHVVKRRDVLKSEKAtqtaSVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 394-444 3.83e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 59.31  E-value: 3.83e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47226153     394 SMFGLAVENIGDINQDNYGDIAVGAPYDGS----GRVYLYCGSSTGINKNAAQVL 444
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 334-372 9.38e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.52  E-value: 9.38e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47226153    334 FGYDVAVVDLNGDGWEDLAVGAPQFYKKEklfGGAVYVY 372
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 332-386 7.42e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.46  E-value: 7.42e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 47226153     332 SSFGYDVA-VVDLNGDGWEDLAVGAPQFYkkEKLFGGAVYVYINN-NGKNWEKINPI 386
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSsGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 342-416 7.94e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 49.92  E-value: 7.94e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47226153    342 DLNGDGWEDLAVGAPqfykkeklfgGAVYVYINNNGKNWEKINPIrLLGQQSSMFGLAVeniGDINQDNYGDIAV 416
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNGDGTFTFITSV-SLGGGGGGLSVAV---GDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 396-429 2.76e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 42.11  E-value: 2.76e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47226153    396 FGLAVEnIGDINQDNYGDIAVGAPY---DGSGRVYLY 429
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGeggAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 452-494 8.77e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 8.77e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 47226153     452 TLFGYSLSGNLDVDDNQYPDLAVGS-LSDSVFVYRARPVVHIGS 494
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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