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Conserved domains on  [gi|119359273|emb|CAL91840|]
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unnamed protein product, partial [Xenopus sp.]

Protein Classification

minichromosome maintenance family protein( domain architecture ID 1003676)

minichromosome maintenance (MCM) family protein similar to minichromosome maintenance protein, a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication, and MCM domain-containing protein 2 (mcmdc2), which plays an important role in meiotic recombination and associated DNA double-strand break repair

Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 1-66 2.36e-46

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member cd17760:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 299  Bit Score: 148.85  E-value: 2.36e-46
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDSGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17760   48 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDGGEWNLEAGALVLADGGLCCIDEFN 113
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 1-66 2.36e-46

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 148.85  E-value: 2.36e-46
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDSGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17760   48 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDGGEWNLEAGALVLADGGLCCIDEFN 113
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 1-65 3.05e-38

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 133.00  E-value: 3.05e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD---SGEWNLEAGALVLADGGLCCIDEF 65
Cdd:COG1241  322 GDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDdfgTGRWTLEAGALVLADGGLACIDEL 389
MCM pfam00493
MCM P-loop domain;
1-66 6.68e-37

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 122.25  E-value: 6.68e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273    1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:pfam00493  64 GDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFD 131
MCM smart00350
minichromosome maintenance proteins;
1-65 7.63e-32

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 114.28  E-value: 7.63e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119359273     1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEF 65
Cdd:smart00350 243 GDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEF 309
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 1-66 9.39e-22

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 86.20  E-value: 9.39e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADGGLCCIDEFN 66
Cdd:PTZ00111 499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELD 567
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 1-66 2.36e-46

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 148.85  E-value: 2.36e-46
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDSGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17760   48 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDGGEWNLEAGALVLADGGLCCIDEFN 113
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 1-65 3.05e-38

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 133.00  E-value: 3.05e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD---SGEWNLEAGALVLADGGLCCIDEF 65
Cdd:COG1241  322 GDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDdfgTGRWTLEAGALVLADGGLACIDEL 389
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 1-66 3.77e-37

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 125.15  E-value: 3.77e-37
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDS--GEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17706   48 GDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGLTAAVVRDSetGEWYLEAGALVLADGGVCCIDEFD 115
MCM pfam00493
MCM P-loop domain;
1-66 6.68e-37

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 122.25  E-value: 6.68e-37
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273    1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:pfam00493  64 GDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFD 131
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 1-66 3.03e-32

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 112.46  E-value: 3.03e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17757   48 GDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGLTAAVVRDeeTGDFVIEAGALMLADNGICCIDEFD 115
MCM smart00350
minichromosome maintenance proteins;
1-65 7.63e-32

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 114.28  E-value: 7.63e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119359273     1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEF 65
Cdd:smart00350 243 GDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEF 309
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 1-66 3.18e-30

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 107.53  E-value: 3.18e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17753   48 GDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTASVRKDpvTKEWTLEGGALVLADKGVCLIDEFD 115
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 1-66 5.05e-30

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 106.77  E-value: 5.05e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17761   49 GDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGLTAAVVRDegTGEWYLEAGALVLADKGIAVVDEID 116
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 1-66 2.11e-28

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 102.49  E-value: 2.11e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17758   47 GDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLTAAVMKDpvTGEMTLEGGALVLADQGICCIDEFD 114
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 1-66 6.72e-28

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 101.31  E-value: 6.72e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDS--GEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17756   48 GDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGLTASVMRDPstREFYLEGGAMVLADGGVVCIDEFD 115
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 1-66 8.08e-28

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 100.97  E-value: 8.08e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17755   49 GDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVGLTAYVTRDpdTKQLVLESGALVLSDGGICCIDEFD 116
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 1-66 4.37e-23

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 87.97  E-value: 4.37e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17759   50 GDPGLGKSQMLQAACNIAPRGVYVCGNTTTTSGLTVTLTKDgrSGDFALEAGALVLGDQGICGIDEFD 117
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 1-66 2.77e-22

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 85.98  E-value: 2.77e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLT--VTAVKDSGEWNLEAGALVLADGGLCCIDEFN 66
Cdd:cd17754   48 GDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGLTaaVTTDQETGERRLEAGAMVLADRGVVCIDEFD 115
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 1-66 9.39e-22

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 86.20  E-value: 9.39e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119359273   1 GDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADGGLCCIDEFN 66
Cdd:PTZ00111 499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELD 567
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1-66 2.62e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 41.51  E-value: 2.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119359273    1 GDPGTGKSQFLK-YAAKITPRSVLTAGIgstSAGLTVTAVKdsGEWNLEAGALVLADGGL---------CCIDEFN 66
Cdd:pfam07728   6 GPPGTGKTELAErLAAALSNRPVFYVQL---TRDTTEEDLF--GRRNIDPGGASWVDGPLvraaregeiAVLDEIN 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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