sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes; sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes; sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
549-785
3.87e-45
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 163.59 E-value: 3.87e-45
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
980-1297
8.45e-44
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 159.74 E-value: 8.45e-44
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1345-1602
1.04e-41
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 153.96 E-value: 1.04e-41
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
107-485
9.26e-29
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 116.60 E-value: 9.26e-29
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1290-1339
3.18e-15
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
:
Pssm-ID: 240441 Cd Length: 54 Bit Score: 71.44 E-value: 3.18e-15
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1618-1651
1.34e-03
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
The actual alignment was detected with superfamily member pfam16905:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 38.40 E-value: 1.34e-03
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
549-785
3.87e-45
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 163.59 E-value: 3.87e-45
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
980-1297
8.45e-44
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 159.74 E-value: 8.45e-44
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1345-1602
1.04e-41
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 153.96 E-value: 1.04e-41
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
107-485
9.26e-29
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 116.60 E-value: 9.26e-29
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1290-1339
3.18e-15
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 71.44 E-value: 3.18e-15
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1618-1651
1.34e-03
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 38.40 E-value: 1.34e-03
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
549-785
3.87e-45
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 163.59 E-value: 3.87e-45
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
980-1297
8.45e-44
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 159.74 E-value: 8.45e-44
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1345-1602
1.04e-41
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 153.96 E-value: 1.04e-41
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
107-485
9.26e-29
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 116.60 E-value: 9.26e-29
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1290-1339
3.18e-15
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 71.44 E-value: 3.18e-15
Polycystin cation channel; This family contains the cation channel region from group II of ...
1401-1602
2.08e-04
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 44.57 E-value: 2.08e-04
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1618-1651
1.34e-03
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 38.40 E-value: 1.34e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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