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Conserved domains on  [gi|528525333|emb|CCQ32622|]
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carbonic anhydrase [Halorhabdus tiamatea SARL4B]

Protein Classification

carbonic anhydrase( domain architecture ID 10658772)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-198 2.33e-34

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


:

Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 119.92  E-value: 2.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333    28 DGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   108 TYDALTdglseppgieysvGLLVPHLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPESVD-----VVGVVY 182
Cdd:smart00947  78 ALDDEP-------------GLIDNWLERIRPARERALEELGDVDALEELNVRDQVENLRTSPAIREAVAkgklkVHGWVY 144

                          170
                   ....*....|....*.
gi 528525333   183 DFQDrydgrrGEVHVV 198
Cdd:smart00947 145 DIET------GKLEVL 154
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-198 2.33e-34

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 119.92  E-value: 2.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333    28 DGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   108 TYDALTdglseppgieysvGLLVPHLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPESVD-----VVGVVY 182
Cdd:smart00947  78 ALDDEP-------------GLIDNWLERIRPARERALEELGDVDALEELNVRDQVENLRTSPAIREAVAkgklkVHGWVY 144

                          170
                   ....*....|....*.
gi 528525333   183 DFQDrydgrrGEVHVV 198
Cdd:smart00947 145 DIET------GKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-186 2.60e-34

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 119.92  E-value: 2.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   34 AVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTATYDAlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFD-TGPGDLFVVRNAGNLVPPYDLN---VLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528525333  114 DGLSEPPGIEYSVGLLVPHLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPESVD-----VVGVVYDFQD 186
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTFPIVREAVAkgklkIHGWVYDLET 153
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
8-204 6.34e-34

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 120.27  E-value: 6.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   8 MLAGN----DDHARAFDDQFDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVL 83
Cdd:COG0288    7 LLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGNVVPPYDPG---VLASIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  84 YPIEHTGTETAVIVGHTGCGAVTATYDALTdgLSEPPGIEYSVGLLVPHLRAGVEALPEELERERaIDHLVEYNVDRQVE 163
Cdd:COG0288   83 YAVEVLGVKLIVVLGHSGCGAVKAALDGLE--LEELGLIGNWLRHIRPAVERVRAELPAADGEER-LDRLVELNVREQVE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 528525333 164 FLQNSPDIPESVD-----VVGVVYDFQDrydgrrGEVHVVNVDGET 204
Cdd:COG0288  160 NLRTSPIVREAVAagklkVHGWVYDLAT------GRVEFLDPEGGG 199
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-198 1.41e-17

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 75.61  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  30 QRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTAty 109
Cdd:cd00382    1 QKPKALIIGCSDSRVPPELIFG-LGPGDLFVVRNAGNLVPPYDLD---VLASLEYAVEVLGVKHIIVCGHTDCGAVKA-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333 110 daltdglseppgieysvgllvphlragvealpeelereraidhLVEYNVDRQVEFLQNSPDI-----PESVDVVGVVYDF 184
Cdd:cd00382   75 -------------------------------------------LVEENVREQVENLRSHPLIqeavaPGELKVHGWVYDI 111

                        170
                 ....*....|....
gi 528525333 185 QDrydgrrGEVHVV 198
Cdd:cd00382  112 ET------GKLEVL 119
PRK10437 PRK10437
carbonic anhydrase; Provisional
 1-204 1.14e-12

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 64.57  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   1 MRDVfVSMLAGNDDHARAFDDQ----FDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIqHVDGEA 76
Cdd:PRK10437   1 MKDI-DTLISNNALWSKMLVEEdpgfFEKLAQAQKPRFLWIGCSDSRVPAERLTG-LEPGELFVHRNVANLVI-HTDLNC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  77 VVSgdVLYPIEHTGTETAVIVGHTGCGAVTATYDALTDGLseppgieysVGLLVPHLRA---GVEALPEELERERAIDHL 153
Cdd:PRK10437  78 LSV--VQYAVDVLEVEHIIICGHYGCGGVQAAVENPELGL---------INNWLLHIRDiwfKHSSLLGEMPQERRLDTL 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528525333 154 VEYNVDRQV------EFLQNSPDIPESVDVVGVVYDFQdryDGRRGEVHVVNVDGET 204
Cdd:PRK10437 147 CELNVMEQVynlghsTIMQSAWKRGQKVTIHGWAYGIH---DGLLRDLDVTATNRET 200
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-198 2.33e-34

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 119.92  E-value: 2.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333    28 DGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   108 TYDALTdglseppgieysvGLLVPHLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPESVD-----VVGVVY 182
Cdd:smart00947  78 ALDDEP-------------GLIDNWLERIRPARERALEELGDVDALEELNVRDQVENLRTSPAIREAVAkgklkVHGWVY 144

                          170
                   ....*....|....*.
gi 528525333   183 DFQDrydgrrGEVHVV 198
Cdd:smart00947 145 DIET------GKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-186 2.60e-34

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 119.92  E-value: 2.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   34 AVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTATYDAlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFD-TGPGDLFVVRNAGNLVPPYDLN---VLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528525333  114 DGLSEPPGIEYSVGLLVPHLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPESVD-----VVGVVYDFQD 186
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTFPIVREAVAkgklkIHGWVYDLET 153
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
8-204 6.34e-34

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 120.27  E-value: 6.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   8 MLAGN----DDHARAFDDQFDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVL 83
Cdd:COG0288    7 LLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGNVVPPYDPG---VLASIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  84 YPIEHTGTETAVIVGHTGCGAVTATYDALTdgLSEPPGIEYSVGLLVPHLRAGVEALPEELERERaIDHLVEYNVDRQVE 163
Cdd:COG0288   83 YAVEVLGVKLIVVLGHSGCGAVKAALDGLE--LEELGLIGNWLRHIRPAVERVRAELPAADGEER-LDRLVELNVREQVE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 528525333 164 FLQNSPDIPESVD-----VVGVVYDFQDrydgrrGEVHVVNVDGET 204
Cdd:COG0288  160 NLRTSPIVREAVAagklkVHGWVYDLAT------GRVEFLDPEGGG 199
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-198 1.41e-17

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 75.61  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  30 QRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGeavVSGDVLYPIEHTGTETAVIVGHTGCGAVTAty 109
Cdd:cd00382    1 QKPKALIIGCSDSRVPPELIFG-LGPGDLFVVRNAGNLVPPYDLD---VLASLEYAVEVLGVKHIIVCGHTDCGAVKA-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333 110 daltdglseppgieysvgllvphlragvealpeelereraidhLVEYNVDRQVEFLQNSPDI-----PESVDVVGVVYDF 184
Cdd:cd00382   75 -------------------------------------------LVEENVREQVENLRSHPLIqeavaPGELKVHGWVYDI 111

                        170
                 ....*....|....
gi 528525333 185 QDrydgrrGEVHVV 198
Cdd:cd00382  112 ET------GKLEVL 119
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 21-197 2.39e-16

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 74.11  E-value: 2.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  21 DQFDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRV--IQHVDGEAVVSGDVLYPIEHTGTETAVIVG 98
Cdd:cd00884   15 ELFEKLAKGQSPKALFIACSDSRVVPALITQ-TQPGELFVVRNVGNLVppYEPDGGFHGTSAAIEYAVAVLKVEHIVVCG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  99 HTGCGAVTATYDaLTDGLSEPPGIEYSVGLLVPhLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPESVD-- 176
Cdd:cd00884   94 HSDCGGIRALLS-PEDLLDKLPFIGKWLRIAEP-AKEVVLAELSHADFDDQLRALEKENVLLSLENLLTYPFVRERLEag 171

                        170       180
                 ....*....|....*....|....
gi 528525333 177 ---VVGVVYDFQDrydgrrGEVHV 197
Cdd:cd00884  172 tlsLHGWYYDIET------GELYA 189
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 23-186 4.28e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 70.67  E-value: 4.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  23 FDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGEAVVsgdVLYPIEHTGTETAVIVGHTGC 102
Cdd:cd00883   16 FPRLAKGQTPEYLWIGCSDSRVPENTILG-LLPGEVFVHRNIANLVSPTDLNCLSV---LQYAVDVLKVKHIIVCGHYGC 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333 103 GAVTAtydALTDglseppgieYSVGLLVPHL---RAGVEALPEELE----RERAIDHLVEYNVDRQVEFLQNSPDIPESV 175
Cdd:cd00883   92 GGVKA---ALTG---------KRLGLLDNWLrpiRDVYRLHAAELDaledEEERVDRLVELNVVEQVKNLCKTPIVQDAW 159

                        170
                 ....*....|....*..
gi 528525333 176 D------VVGVVYDFQD 186
Cdd:cd00883  160 KrgqeleVHGWVYDLGD 176
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 8-108 5.51e-14

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 66.78  E-value: 5.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   8 MLAGND-------DHARAFDDQFDAVQDGQRPDAVTVTCSDSRVLADHAWgNARPGHLFTVSNIGNrviqhvdgeaVVSG 80
Cdd:cd03378    8 LKEGNKrfvsgkpLHPDQDLARRRELAKGQKPFAVILSCSDSRVPPEIIF-DQGLGDLFVVRVAGN----------IVDD 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 528525333  81 DVL----YPIEHTGTETAVIVGHTGCGAVTAT 108
Cdd:cd03378   77 DVLgsleYAVEVLGVPLVVVLGHESCGAVAAA 108
PRK10437 PRK10437
carbonic anhydrase; Provisional
 1-204 1.14e-12

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 64.57  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333   1 MRDVfVSMLAGNDDHARAFDDQ----FDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIqHVDGEA 76
Cdd:PRK10437   1 MKDI-DTLISNNALWSKMLVEEdpgfFEKLAQAQKPRFLWIGCSDSRVPAERLTG-LEPGELFVHRNVANLVI-HTDLNC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  77 VVSgdVLYPIEHTGTETAVIVGHTGCGAVTATYDALTDGLseppgieysVGLLVPHLRA---GVEALPEELERERAIDHL 153
Cdd:PRK10437  78 LSV--VQYAVDVLEVEHIIICGHYGCGGVQAAVENPELGL---------INNWLLHIRDiwfKHSSLLGEMPQERRLDTL 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 528525333 154 VEYNVDRQV------EFLQNSPDIPESVDVVGVVYDFQdryDGRRGEVHVVNVDGET 204
Cdd:PRK10437 147 CELNVMEQVynlghsTIMQSAWKRGQKVTIHGWAYGIH---DGLLRDLDVTATNRET 200
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-183 3.56e-12

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 61.88  E-value: 3.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  37 VTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGEAVVSGDVLypiehtGTETAVIVGHTGCGAVTATYDALTDGL 116
Cdd:cd03379    8 VTCMDARLDPEKALG-LKLGDAKVIRNAGGRVTDDAIRSLVVSVYLL------GTREIIVIHHTDCGMLTFTDEELKEKM 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528525333 117 SEPpGIEYSVGLLVPHLRAGvealpeelererAIDHLVEyNVDRQVEFLQNSPDIPESVDVVGVVYD 183
Cdd:cd03379   81 KER-GIAEAYGGIDKEFWFL------------GFDDLEE-SVREDVERIRNHPLIPDDVPVHGYVYD 133
PLN00416 PLN00416
carbonate dehydratase
 23-105 2.02e-09

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 56.20  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  23 FDAVQDGQRPDAVTVTCSDSRVLADHAWgNARPGHLFTVSNIGNRV-----IQHVDgeavVSGDVLYPIEHTGTETAVIV 97
Cdd:PLN00416  71 FNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVppfdqKRHSG----VGAAVEYAVVHLKVENILVI 145


                 ....*...
gi 528525333  98 GHTGCGAV 105
Cdd:PLN00416 146 GHSCCGGI 153
PLN03006 PLN03006
carbonate dehydratase
 21-186 3.72e-09

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 55.52  E-value: 3.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  21 DQFDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGEAVVSGDVLYPIEHTGTETAVIVGHT 100
Cdd:PLN03006 102 EHYKNLADAQAPKFLVIACADSRVCPSAVLG-FQPGDAFTVRNIANLVPPYESGPTETKAALEFSVNTLNVENILVIGHS 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333 101 GCGAVTATYDALTDGLSEppGIEYSVGLLVPHLRAGVEALPEELERERAIDHLVEYNVDRQVEFLQNSPDIPE-----SV 175
Cdd:PLN03006 181 RCGGIQALMKMEDEGDSR--SFIHNWVVVGKKAKESTKAVASNLHFDHQCQHCEKASINHSLERLLGYPWIEEkvrqgSL 258

                        170
                 ....*....|.
gi 528525333 176 DVVGVVYDFQD 186
Cdd:PLN03006 259 SLHGGYYNFVD 269
PLN02154 PLN02154
carbonic anhydrase
 21-107 1.56e-08

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 53.60  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  21 DQFDAVQDGQRPDAVTVTCSDSRVLADHAWGnARPGHLFTVSNIGNRVIQHVDGEAVVSGDVLYPIEHTGTETAVIVGHT 100
Cdd:PLN02154  96 EKFKALAIAQSPKVMVIGCADSRVCPSYVLG-FQPGEAFTIRNVANLVTPVQNGPTETNSALEFAVTTLQVENIIVMGHS 174


                 ....*..
gi 528525333 101 GCGAVTA 107
Cdd:PLN02154 175 NCGGIAA 181
PLN03014 PLN03014
carbonic anhydrase
 29-131 3.91e-08

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 52.81  E-value: 3.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  29 GQRPDAVTVTCSDSRVLADHAWgNARPGHLFTVSNIGNRVIQHVDGE-AVVSGDVLYPIEHTGTETAVIVGHTGCGAVTA 107
Cdd:PLN03014 157 GQSPKYMVFACSDSRVCPSHVL-DFQPGDAFVVRNIANMVPPFDKVKyGGVGAAIEYAVLHLKVENIVVIGHSACGGIKG 235

                         90       100
                 ....*....|....*....|....
gi 528525333 108 TYDALTDGLSEPPGIEYSVGLLVP 131
Cdd:PLN03014 236 LMSFPLDGNNSTDFIEDWVKICLP 259
PLN03019 PLN03019
carbonic anhydrase
 29-131 6.97e-08

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 52.07  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  29 GQRPDAVTVTCSDSRVLADHAWgNARPGHLFTVSNIGNRVIQHVDGE-AVVSGDVLYPIEHTGTETAVIVGHTGCGAVTA 107
Cdd:PLN03019 152 GQSPKYMVFACSDSRVCPSHVL-DFHPGDAFVVRNIANMVPPFDKVKyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKG 230

                         90       100
                 ....*....|....*....|....
gi 528525333 108 TYDALTDGLSEPPGIEYSVGLLVP 131
Cdd:PLN03019 231 LMSFPLDGNNSTDFIEDWVKICLP 254
PRK15219 PRK15219
carbonic anhydrase; Provisional
 28-183 5.66e-05

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 42.90  E-value: 5.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333  28 DGQRPDAVTVTCSDSRVladhawgnarPGHLFTVSNIGNRVIQHVDGEaVVSGDVLYPIEH----TGTETAVIVGHTGCG 103
Cdd:PRK15219  86 AGQYPAAVILSCIDSRA----------PAEIILDTGIGETFNSRVAGN-ISNDDLLGSMEFacavAGAKVVLVMGHTACG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528525333 104 AVTATYDALTDG-LSeppgieysvGLLvPHLRAGVEALPEELER----ERAIDHLVEYNVDRQVEFLQ-NSPDIPE---- 173
Cdd:PRK15219 155 AVKGAIDNVELGnLT---------GLL-DRIKPAIEVTEFDGERssknYKFVDAVARKNVELTIENIRkNSPILRKleqe 224

                        170
                 ....*....|.
gi 528525333 174 -SVDVVGVVYD 183
Cdd:PRK15219 225 gKIKIVGSMYN 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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