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Conserved domains on  [gi|524810911|emb|CDF04724|]
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aTPase family associated with various cellular activities (AAA) [Megasphaera elsdenii CAG:570]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 17-139 1.45e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


:

Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 64.70  E-value: 1.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911    17 GEVPLLVGETGIGKTSLARELAA---KNDWSLVGIDGNLLKEGEIGGLPTVEAGTTIYAVH--HKLRKIDEEIAKGRTVL 91
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARelgPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSgeLRLRLALALARKLKPDV 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 524810911    92 LFIDEINR-CDHAVQQELMNLILNREINGYVLSPSVHIIAAMNPADSYD 139
Cdd:smart00382  82 LILDEITSlLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLG 130
McrB super family cl34253
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 21-260 3.74e-08

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


The actual alignment was detected with superfamily member COG1401:

Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 54.78  E-value: 3.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAakndWSLVGIDGNLLK----------EGEIGGLPTVEAGTTIYAVHHKLRKIDEEIAK--GR 88
Cdd:COG1401  225 ILAGPPGTGKTYLARRLA----EALGGEDNGRIEfvqfhpswsyEDFLLGYRPSLDEGKYEPTPGIFLRFCLKAEKnpDK 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  89 TVLLFIDEINRCDhaVQQ---ELMNLI------------LNREINGYVLS--PSVHIIAAMNPAD-SYDYevveMDAAQQ 150
Cdd:COG1401  301 PYVLIIDEINRAN--VEKyfgELLSLLesdkrgeelsieLPYSGEGEEFSipPNLYIIGTMNTDDrSLAL----SDKALR 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911 151 NRFVWLYMEADYLQWLDwastagieEKVMEFISTFPEYLDKTNEDDINATPRSYERISKLYHIYKQDPSAIPQGVFYNVI 230
Cdd:COG1401  375 RRFTFEFLDPDLDKLSN--------EEVVDLLEELNEILEKRDFQIGHRALLLLDGLLSGDLDLLLLLLLLLLELLLLLL 446

                        250       260       270
                 ....*....|....*....|....*....|
gi 524810911 231 RGNVGKLIAQEFVHFVTSDAQPLIAYDDVF 260
Cdd:COG1401  447 DKLDLLGMAEFEDRLELSEYLPLLLRASLE 476
 
Name Accession Description Interval E-value
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 17-139 1.45e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 64.70  E-value: 1.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911    17 GEVPLLVGETGIGKTSLARELAA---KNDWSLVGIDGNLLKEGEIGGLPTVEAGTTIYAVH--HKLRKIDEEIAKGRTVL 91
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARelgPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSgeLRLRLALALARKLKPDV 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 524810911    92 LFIDEINR-CDHAVQQELMNLILNREINGYVLSPSVHIIAAMNPADSYD 139
Cdd:smart00382  82 LILDEITSlLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLG 130
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 21-153 4.83e-12

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 62.70  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911   21 LLVGETGIGKTSLARELAAK-NDWSLVGIDGN-LLKEGEIGGLPTVEAGTTIYaVHHKLRKIDEEiakGRtvLLFIDEIN 98
Cdd:pfam07728   3 LLVGPPGTGKTELAERLAAAlSNRPVFYVQLTrDTTEEDLFGRRNIDPGGASW-VDGPLVRAARE---GE--IAVLDEIN 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 524810911   99 RCDHAVQQELMNLILNREI---NG----YVLSPSVHIIAAMNPAdsyDYEVVEMDAAQQNRF 153
Cdd:pfam07728  77 RANPDVLNSLLSLLDERRLllpDGgelvKAAPDGFRLIATMNPL---DRGLNELSPALRSRF 135
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 20-139 2.51e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 58.31  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  20 PLLVGETGIGKTSLARELA---AKNDWSLVGIDGNLLKEGEIGGlptveagttIYAVHHKLRKIDEEIAKGRTVLLFIDE 96
Cdd:cd00009   22 LLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASDLLEGLVVA---------ELFGHFLVRLLFELAEKAKPGVLFIDE 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 524810911  97 INRCDHAVQQELMNlILNREINGYVLSPSVHIIAAMNPADSYD 139
Cdd:cd00009   93 IDSLSRGAQNALLR-VLETLNDLRIDRENVRVIGATNRPLLGD 134
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 21-260 3.74e-08

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 54.78  E-value: 3.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAakndWSLVGIDGNLLK----------EGEIGGLPTVEAGTTIYAVHHKLRKIDEEIAK--GR 88
Cdd:COG1401  225 ILAGPPGTGKTYLARRLA----EALGGEDNGRIEfvqfhpswsyEDFLLGYRPSLDEGKYEPTPGIFLRFCLKAEKnpDK 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  89 TVLLFIDEINRCDhaVQQ---ELMNLI------------LNREINGYVLS--PSVHIIAAMNPAD-SYDYevveMDAAQQ 150
Cdd:COG1401  301 PYVLIIDEINRAN--VEKyfgELLSLLesdkrgeelsieLPYSGEGEEFSipPNLYIIGTMNTDDrSLAL----SDKALR 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911 151 NRFVWLYMEADYLQWLDwastagieEKVMEFISTFPEYLDKTNEDDINATPRSYERISKLYHIYKQDPSAIPQGVFYNVI 230
Cdd:COG1401  375 RRFTFEFLDPDLDKLSN--------EEVVDLLEELNEILEKRDFQIGHRALLLLDGLLSGDLDLLLLLLLLLLELLLLLL 446

                        250       260       270
                 ....*....|....*....|....*....|
gi 524810911 231 RGNVGKLIAQEFVHFVTSDAQPLIAYDDVF 260
Cdd:COG1401  447 DKLDLLGMAEFEDRLELSEYLPLLLRASLE 476
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 21-153 2.89e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.16  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAkndwslvGIDGNL--------LKEGEIgglptveAGTTIYAvhhkLRKIDEEIAKGR--TV 90
Cdd:COG0714   35 LLEGVPGVGKTTLAKALAR-------ALGLPFiriqftpdLLPSDI-------LGTYIYD----QQTGEFEFRPGPlfAN 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 524810911  91 LLFIDEINRCDHAVQQELMNLILNRE--ING--YVLSPSVHIIAAMNPADSYD-YEVVEmdaAQQNRF 153
Cdd:COG0714   97 VLLADEINRAPPKTQSALLEAMEERQvtIPGgtYKLPEPFLVIATQNPIEQEGtYPLPE---AQLDRF 161
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 20-98 1.80e-04

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 43.29  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  20 PLLVGETGIGKTSLARELAakndWSLVgidgnllkEGEIgglPTVEAGTTIYAV---------------HHKLRKIDEEI 84
Cdd:PRK11034 210 PLLVGESGVGKTAIAEGLA----WRIV--------QGDV---PEVMADCTIYSLdigsllagtkyrgdfEKRFKALLKQL 274

                         90
                 ....*....|....
gi 524810911  85 AKGRTVLLFIDEIN 98
Cdd:PRK11034 275 EQDTNSILFIDEIH 288
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 21-55 1.34e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 38.63  E-value: 1.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 524810911  21 LLVGETGIGKTSLARELAAKNDWSLVGIDGNLLKE 55
Cdd:NF033453  20 LLVGPPGSGKTALLRELAAKRGAPVINVNLELSRR 54
 
Name Accession Description Interval E-value
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 17-139 1.45e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 64.70  E-value: 1.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911    17 GEVPLLVGETGIGKTSLARELAA---KNDWSLVGIDGNLLKEGEIGGLPTVEAGTTIYAVH--HKLRKIDEEIAKGRTVL 91
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARelgPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSgeLRLRLALALARKLKPDV 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 524810911    92 LFIDEINR-CDHAVQQELMNLILNREINGYVLSPSVHIIAAMNPADSYD 139
Cdd:smart00382  82 LILDEITSlLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLG 130
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 21-153 4.83e-12

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 62.70  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911   21 LLVGETGIGKTSLARELAAK-NDWSLVGIDGN-LLKEGEIGGLPTVEAGTTIYaVHHKLRKIDEEiakGRtvLLFIDEIN 98
Cdd:pfam07728   3 LLVGPPGTGKTELAERLAAAlSNRPVFYVQLTrDTTEEDLFGRRNIDPGGASW-VDGPLVRAARE---GE--IAVLDEIN 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 524810911   99 RCDHAVQQELMNLILNREI---NG----YVLSPSVHIIAAMNPAdsyDYEVVEMDAAQQNRF 153
Cdd:pfam07728  77 RANPDVLNSLLSLLDERRLllpDGgelvKAAPDGFRLIATMNPL---DRGLNELSPALRSRF 135
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 20-139 2.51e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 58.31  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  20 PLLVGETGIGKTSLARELA---AKNDWSLVGIDGNLLKEGEIGGlptveagttIYAVHHKLRKIDEEIAKGRTVLLFIDE 96
Cdd:cd00009   22 LLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASDLLEGLVVA---------ELFGHFLVRLLFELAEKAKPGVLFIDE 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 524810911  97 INRCDHAVQQELMNlILNREINGYVLSPSVHIIAAMNPADSYD 139
Cdd:cd00009   93 IDSLSRGAQNALLR-VLETLNDLRIDRENVRVIGATNRPLLGD 134
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 21-260 3.74e-08

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 54.78  E-value: 3.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAakndWSLVGIDGNLLK----------EGEIGGLPTVEAGTTIYAVHHKLRKIDEEIAK--GR 88
Cdd:COG1401  225 ILAGPPGTGKTYLARRLA----EALGGEDNGRIEfvqfhpswsyEDFLLGYRPSLDEGKYEPTPGIFLRFCLKAEKnpDK 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  89 TVLLFIDEINRCDhaVQQ---ELMNLI------------LNREINGYVLS--PSVHIIAAMNPAD-SYDYevveMDAAQQ 150
Cdd:COG1401  301 PYVLIIDEINRAN--VEKyfgELLSLLesdkrgeelsieLPYSGEGEEFSipPNLYIIGTMNTDDrSLAL----SDKALR 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911 151 NRFVWLYMEADYLQWLDwastagieEKVMEFISTFPEYLDKTNEDDINATPRSYERISKLYHIYKQDPSAIPQGVFYNVI 230
Cdd:COG1401  375 RRFTFEFLDPDLDKLSN--------EEVVDLLEELNEILEKRDFQIGHRALLLLDGLLSGDLDLLLLLLLLLLELLLLLL 446

                        250       260       270
                 ....*....|....*....|....*....|
gi 524810911 231 RGNVGKLIAQEFVHFVTSDAQPLIAYDDVF 260
Cdd:COG1401  447 DKLDLLGMAEFEDRLELSEYLPLLLRASLE 476
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 21-139 1.02e-07

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 50.28  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911   21 LLVGETGIGKTSLARELAAKNDWSLVGIDGNLLKEGEIGglptveagttiyAVHHKLRKIDEEIAKGRTVLLFIDEI--- 97
Cdd:pfam00004   2 LLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVG------------ESEKRLRELFEAAKKLAPCVIFIDEIdal 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 524810911   98 ----NRCDHAVQQELMNLILNrEINGY-VLSPSVHIIAAMNPADSYD 139
Cdd:pfam00004  70 agsrGSGGDSESRRVVNQLLT-ELDGFtSSNSKVIVIAATNRPDKLD 115
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 21-139 2.67e-06

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 46.89  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAKNDWSLVGIDGNLLKEGEIGGlptveagttiyaVHHKLRKIDEEIAKGRTVLLFIDEI--- 97
Cdd:cd19481   30 LLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGE------------SEKNLRKIFERARRLAPCILFIDEIdai 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 524810911  98 -----NRCDHAVQQELMNLILNrEINGYVLSPSVHIIAAMNPADSYD 139
Cdd:cd19481   98 grkrdSSGESGELRRVLNQLLT-ELDGVNSRSKVLVIAATNRPDLLD 143
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 21-139 2.15e-05

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 44.20  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAKNDWSLVGIDGnllkegeigglPTVE---AGTTiyavHHKLRKIDEEIAKGRTVLLFIDEI 97
Cdd:cd19503   38 LLHGPPGTGKTLLARAVANEAGANFLSISG-----------PSIVskyLGES----EKNLREIFEEARSHAPSIIFIDEI 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 524810911  98 N-------RCDHAVQQELMNLILNReINGYVLSPSVHIIAAMNPADSYD 139
Cdd:cd19503  103 DalapkreEDQREVERRVVAQLLTL-MDGMSSRGKVVVIAATNRPDAID 150
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 21-153 2.89e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.16  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAkndwslvGIDGNL--------LKEGEIgglptveAGTTIYAvhhkLRKIDEEIAKGR--TV 90
Cdd:COG0714   35 LLEGVPGVGKTTLAKALAR-------ALGLPFiriqftpdLLPSDI-------LGTYIYD----QQTGEFEFRPGPlfAN 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 524810911  91 LLFIDEINRCDHAVQQELMNLILNRE--ING--YVLSPSVHIIAAMNPADSYD-YEVVEmdaAQQNRF 153
Cdd:COG0714   97 VLLADEINRAPPKTQSALLEAMEERQvtIPGgtYKLPEPFLVIATQNPIEQEGtYPLPE---AQLDRF 161
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 7-139 1.76e-04

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 43.07  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911   7 FKSVELVLKAGEVP----LLVGETGIGKTSLARELAAKNDWSLVGIDGN-----LLKEGEigglptveagttiyavhHKL 77
Cdd:COG1222   98 LKNPELFRKYGIEPpkgvLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSelvskYIGEGA-----------------RNV 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  78 RKIDEEIAKGRTVLLFIDEI--------NRCDHAVQQELMNLILNrEINGYVLSPSVHIIAAMNPADSYD 139
Cdd:COG1222  161 REVFELAREKAPSIIFIDEIdaiaarrtDDGTSGEVQRTVNQLLA-ELDGFESRGDVLIIAATNRPDLLD 229
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 20-98 1.80e-04

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 43.29  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  20 PLLVGETGIGKTSLARELAakndWSLVgidgnllkEGEIgglPTVEAGTTIYAV---------------HHKLRKIDEEI 84
Cdd:PRK11034 210 PLLVGESGVGKTAIAEGLA----WRIV--------QGDV---PEVMADCTIYSLdigsllagtkyrgdfEKRFKALLKQL 274

                         90
                 ....*....|....
gi 524810911  85 AKGRTVLLFIDEIN 98
Cdd:PRK11034 275 EQDTNSILFIDEIH 288
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 21-55 1.34e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 38.63  E-value: 1.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 524810911  21 LLVGETGIGKTSLARELAAKNDWSLVGIDGNLLKE 55
Cdd:NF033453  20 LLVGPPGSGKTALLRELAAKRGAPVINVNLELSRR 54
clpC CHL00095
Clp protease ATP binding subunit
 20-97 1.39e-03

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 40.81  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  20 PLLVGETGIGKTSLARELA---AKNDWSLVGIDGNLLkEGEIGglpTVEAGTT-IYAVHHKLRKIDEEIAKGRTVLLFID 95
Cdd:CHL00095 203 PILIGEPGVGKTAIAEGLAqriVNRDVPDILEDKLVI-TLDIG---LLLAGTKyRGEFEERLKRIFDEIQENNNIILVID 278


                 ..
gi 524810911  96 EI 97
Cdd:CHL00095 279 EV 280
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 21-139 1.41e-03

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 38.96  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAKNDWSLVGIDGNLLKEGEIGglptveagttiyAVHHKLRKIDEEIAKGRTVLLFIDEI--- 97
Cdd:cd19519   38 LLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAG------------ESESNLRKAFEEAEKNAPAIIFIDEIdai 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 524810911  98 --------NRCDHAVQQELMNLILNREINGYVLspsvhIIAAMNPADSYD 139
Cdd:cd19519  106 apkrekthGEVERRIVSQLLTLMDGLKQRAHVI-----VMAATNRPNSID 150
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 21-111 1.49e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 38.44  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911   21 LLVGETGIGKTSLARELAAKNDWSLVGID---GNLLKEGEIGGLPTVEAGTTIYAVHHKLrkIDEEIAKGRTVLlfIDEI 97
Cdd:pfam13671   3 LLVGLPGSGKSTLARRLLEELGAVRLSSDderKRLFGEGRPSISYYTDATDRTYERLHEL--ARIALRAGRPVI--LDAT 78

                          90
                  ....*....|....
gi 524810911   98 NrCDHAVQQELMNL 111
Cdd:pfam13671  79 N-LRRDERARLLAL 91
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 21-112 2.54e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 38.31  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAK---NDWSLVGIDGNLLKEGE-----IGGLPtveagttIYAVHHKLRKIDEEIAKGRTVLL 92
Cdd:cd19499   45 LFLGPTGVGKTELAKALAELlfgDEDNLIRIDMSEYMEKHsvsrlIGAPP-------GYVGYTEGGQLTEAVRRKPYSVV 117

                         90       100
                 ....*....|....*....|
gi 524810911  93 FIDEINRCDHAVQQELMNLI 112
Cdd:cd19499  118 LLDEIEKAHPDVQNLLLQVL 137
AAA_22 pfam13401
AAA domain;
21-113 4.22e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 36.94  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911   21 LLVGETGIGKTSLARELAAKNDW--------------SLVGIDGNLLKEGEIGGLPTVEAGTTIYAVHHKLRkideeiAK 86
Cdd:pfam13401   9 VLTGESGTGKTTLLRRLLEQLPEvrdsvvfvdlpsgtSPKDLLRALLRALGLPLSGRLSKEELLAALQQLLL------AL 82

                          90       100
                  ....*....|....*....|....*..
gi 524810911   87 GRTVLLFIDEInrcdHAVQQELMNLIL 113
Cdd:pfam13401  83 AVAVVLIIDEA----QHLSLEALEELR 105
MK0520 COG2401
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ...
 7-39 5.81e-03

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];


Pssm-ID: 441957 [Multi-domain]  Cd Length: 222  Bit Score: 37.63  E-value: 5.81e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 524810911   7 FKSVELVLKAGEVPLLVGETGIGKTSLARELAA 39
Cdd:COG2401   46 LRDLNLEIEPGEIVLIVGASGSGKSTLLRLLAG 78
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 21-139 7.49e-03

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 36.93  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524810911  21 LLVGETGIGKTSLARELAAKNDWSLVGIDGNLLKEGEIGGLPTVEAGTTIYAVHHKlrkideeiakgrTVLLFIDEINRC 100
Cdd:cd19502   41 LLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGARLVRELFEMAREKA------------PSIIFIDEIDAI 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 524810911 101 -----------DHAVQQELMNLIlnREINGYVLSPSVHIIAAMNPADSYD 139
Cdd:cd19502  109 gakrfdsgtggDREVQRTMLELL--NQLDGFDPRGNIKVIMATNRPDILD 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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