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Conserved domains on  [gi|38049077|tpg|DAA01863|]
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TPA_exp: regulator of sex-limitation candidate 12 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-64 1.60e-24

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.51  E-value: 1.60e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 38049077     12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFLGLAFSKPHLITFLERRPEPWN 64
Cdd:smart00349   9 YFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 132-212 3.80e-10

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 62.43  E-value: 3.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 132 GEKPYKCEV--CDKAFKYSFSFKQHqRIHTGEKPYKCEVCGKAfncssylgKHQRIHTGEKPYRCEECGRAFTNYSGLTV 209
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 38049077 210 HRK 212
Cdd:COG5189 417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
78-492 7.85e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 7.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077  78 KPYQCKQCGKAFGWKSLLVQHQRIHTGEKPYICKECGKAFNYSST--LKQHQRIHTGEKPYKCevCDKAFKYSFSFKQHQ 155
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 156 RIHTGEKPYKCEvcgkafNCSSYLGKHQRIHTGEKPYR--CEECGRAFTNYSGLTVHRKVHTG-VKPYKCEECGKAFSAR 232
Cdd:COG5048 110 LSSSSSNSNDNN------LLSSHSLPPSSRDPQLPDLLsiSNLRNNPLPGNNSSSVNTPQSNSlHPPLPANSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 233 TTLSKHHRIHTGEKPYKCDECGKTFSVHSTFSKHQRLHTGEKPYKCEECGMAFIGRCILSKHRGTHTGEKPYKCKECGKA 312
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 313 FNCSSSLHQHQQIHRGE-------KLFKCDDCGQAFSCSSYLYKHRR--IHTGM--KPYKCKE--CGKAFNCSSSRNQHQ 379
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 380 RIHIGEKLYKC--DECGQAFTFAS--YLHKHLRIHIGEKLYKCKECGKAFYCFTK-----LIYHWRVHTGEKP--YKCDK 448
Cdd:COG5048 344 LLHTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFkrdsnLSLHIITHLSFRPynCKNPP 423

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 38049077 449 CGKAFSiYSSFMKHQCIHRGEKLCKCNKCEKAFNNCHTLPRHHR 492
Cdd:COG5048 424 CSKSFN-RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-511 6.00e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.00e-03
                          10        20
                  ....*....|....*....|...
gi 38049077   489 RHHRIHTGEKPYNCKDCGKAFTC 511
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-64 1.60e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.51  E-value: 1.60e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 38049077     12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFLGLAFSKPHLITFLERRPEPWN 64
Cdd:smart00349   9 YFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-44 3.93e-14

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 66.34  E-value: 3.93e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 38049077    12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFLG 44
Cdd:pfam01352  10 DFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-43 3.96e-11

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 57.94  E-value: 3.96e-11
                        10        20        30
                ....*....|....*....|....*....|..
gi 38049077  12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFL 43
Cdd:cd07765   9 YFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 132-212 3.80e-10

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 62.43  E-value: 3.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 132 GEKPYKCEV--CDKAFKYSFSFKQHqRIHTGEKPYKCEVCGKAfncssylgKHQRIHTGEKPYRCEECGRAFTNYSGLTV 209
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 38049077 210 HRK 212
Cdd:COG5189 417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
78-492 7.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 7.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077  78 KPYQCKQCGKAFGWKSLLVQHQRIHTGEKPYICKECGKAFNYSST--LKQHQRIHTGEKPYKCevCDKAFKYSFSFKQHQ 155
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 156 RIHTGEKPYKCEvcgkafNCSSYLGKHQRIHTGEKPYR--CEECGRAFTNYSGLTVHRKVHTG-VKPYKCEECGKAFSAR 232
Cdd:COG5048 110 LSSSSSNSNDNN------LLSSHSLPPSSRDPQLPDLLsiSNLRNNPLPGNNSSSVNTPQSNSlHPPLPANSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 233 TTLSKHHRIHTGEKPYKCDECGKTFSVHSTFSKHQRLHTGEKPYKCEECGMAFIGRCILSKHRGTHTGEKPYKCKECGKA 312
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 313 FNCSSSLHQHQQIHRGE-------KLFKCDDCGQAFSCSSYLYKHRR--IHTGM--KPYKCKE--CGKAFNCSSSRNQHQ 379
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 380 RIHIGEKLYKC--DECGQAFTFAS--YLHKHLRIHIGEKLYKCKECGKAFYCFTK-----LIYHWRVHTGEKP--YKCDK 448
Cdd:COG5048 344 LLHTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFkrdsnLSLHIITHLSFRPynCKNPP 423

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 38049077 449 CGKAFSiYSSFMKHQCIHRGEKLCKCNKCEKAFNNCHTLPRHHR 492
Cdd:COG5048 424 CSKSFN-RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
123-147 1.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.04e-04
                          10        20
                  ....*....|....*....|....*
gi 38049077   123 LKQHQRIHTGEKPYKCEVCDKAFKY 147
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-371 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 38049077   346 YLYKHRRIHTGMKPYKCKECGKAFNC 371
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-511 6.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.00e-03
                          10        20
                  ....*....|....*....|...
gi 38049077   489 RHHRIHTGEKPYNCKDCGKAFTC 511
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
12-64 1.60e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.51  E-value: 1.60e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 38049077     12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFLGLAFSKPHLITFLERRPEPWN 64
Cdd:smart00349   9 YFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-44 3.93e-14

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 66.34  E-value: 3.93e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 38049077    12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFLG 44
Cdd:pfam01352  10 DFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 12-43 3.96e-11

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 57.94  E-value: 3.96e-11
                        10        20        30
                ....*....|....*....|....*....|..
gi 38049077  12 DFSAEERECLDSAQWNLYKEVMLENYSHLVFL 43
Cdd:cd07765   9 YFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 132-212 3.80e-10

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 62.43  E-value: 3.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 132 GEKPYKCEV--CDKAFKYSFSFKQHqRIHTGEKPYKCEVCGKAfncssylgKHQRIHTGEKPYRCEECGRAFTNYSGLTV 209
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 38049077 210 HRK 212
Cdd:COG5189 417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
78-492 7.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 7.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077  78 KPYQCKQCGKAFGWKSLLVQHQRIHTGEKPYICKECGKAFNYSST--LKQHQRIHTGEKPYKCevCDKAFKYSFSFKQHQ 155
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 156 RIHTGEKPYKCEvcgkafNCSSYLGKHQRIHTGEKPYR--CEECGRAFTNYSGLTVHRKVHTG-VKPYKCEECGKAFSAR 232
Cdd:COG5048 110 LSSSSSNSNDNN------LLSSHSLPPSSRDPQLPDLLsiSNLRNNPLPGNNSSSVNTPQSNSlHPPLPANSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 233 TTLSKHHRIHTGEKPYKCDECGKTFSVHSTFSKHQRLHTGEKPYKCEECGMAFIGRCILSKHRGTHTGEKPYKCKECGKA 312
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 313 FNCSSSLHQHQQIHRGE-------KLFKCDDCGQAFSCSSYLYKHRR--IHTGM--KPYKCKE--CGKAFNCSSSRNQHQ 379
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 380 RIHIGEKLYKC--DECGQAFTFAS--YLHKHLRIHIGEKLYKCKECGKAFYCFTK-----LIYHWRVHTGEKP--YKCDK 448
Cdd:COG5048 344 LLHTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFkrdsnLSLHIITHLSFRPynCKNPP 423

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 38049077 449 CGKAFSiYSSFMKHQCIHRGEKLCKCNKCEKAFNNCHTLPRHHR 492
Cdd:COG5048 424 CSKSFN-RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-522 2.77e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 118 NYSSTLKQHQRIHTGE----KPYKCEVCDKAFKYSFSFKQHQRIHTGEKPYKCEVCGKAFNCSSY--LGKHQRIHTGEKP 191
Cdd:COG5048  12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPS 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 192 YRCEECGRAFTNY-SGLTVHRKVHTGVKPYKCEECGKAFSARTTLSKHHRIHTGEKPYKCDECGKTFSVHST-FSKHQRL 269
Cdd:COG5048  92 DLNSKSLPLSNSKaSSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 270 HTGEKPYKCEECGMAFIgrcilskHRGTHTGEKPYKCKECGKAFNCSSSLHQHQQIHRGEKLFKCDDCGQAFSCSSYLYK 349
Cdd:COG5048 172 PANSLSKDPSSNLSLLI-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 350 HRRIHTGMKPYKCKECGKAFNCSSSRNQHQRIHIGE-------KLYKCDECGQAFTFASYLHKHLR--IHIGEKL--YKC 418
Cdd:COG5048 245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSC 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 419 KE--CGKAFYCFTKLIYHWRVHTGEKPYKC--DKCGKAFSIYSSFMKHQCIH-------RGEKLCKCNKCEKAFNNCHTL 487
Cdd:COG5048 325 PYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNL 404

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 38049077 488 PRHHRIHTGEKPYNCKD--CGKAFTCTTGLTQHERIH 522
Cdd:COG5048 405 SLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
123-147 1.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.04e-04
                          10        20
                  ....*....|....*....|....*
gi 38049077   123 LKQHQRIHTGEKPYKCEVCDKAFKY 147
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
150-175 4.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 38049077   150 SFKQHQRIHTGEKPYKCEVCGKAFNC 175
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-371 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 38049077   346 YLYKHRRIHTGMKPYKCKECGKAFNC 371
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 198-299 1.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 198 GRAFTNYSGltvHRKVHTGVKPYKCE--ECGKAFSARTTLsKHHRIHTGEKPykcdecgktfSVHSTFS--KHQRLHTGE 273
Cdd:COG5189 331 GERNIDTPS---RMLKVKDGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQ----------KLHENPSpeKMNIFSAKD 396

                        90       100
                ....*....|....*....|....*.
gi 38049077 274 KPYKCEECGMAFIGRCILSKHRGTHT 299
Cdd:COG5189 397 KPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-199 2.35e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077  59 RPEPWNVKTQASVGTYPGSKPYQC--KQCGKAFGWKSLLVQHQRIHTGEKPYICK--ECGKAFNYSSTLKQHQRI--HTG 132
Cdd:COG5048 301 RSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLqqYKD 380

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38049077 133 EKPYK---------CEVCDKAFKYSFSFKQH--QRIHtgekPYKCEVCGKAFNCSSYLGKHQRIHTGEKPYRCEECGR 199
Cdd:COG5048 381 LKNDKksetlsnscIRNFKRDSNLSLHIITHlsFRPY----NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-258 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....
gi 38049077   235 LSKHHRIHTGEKPYKCDECGKTFS 258
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 104-159 2.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.81e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38049077 104 GEKPYICK--ECGKAFNYSSTLKQH-------------------QRIHTGEKPYKCEVCDKAFKYSFSFKQHqRIHT 159
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpspekmNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-315 4.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.69e-03
                          10        20
                  ....*....|....*....|....*
gi 38049077   291 LSKHRGTHTGEKPYKCKECGKAFNC 315
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-511 6.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.00e-03
                          10        20
                  ....*....|....*....|...
gi 38049077   489 RHHRIHTGEKPYNCKDCGKAFTC 511
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
274-530 7.69e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 274 KPYKCEECGMAFIGRCILSKHRGTHTGEKPYKCKECGKAFNCS--SSLHQHQQIHRGEKLFKCDDCGQ------------ 339
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPlsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 340 --------AFSCSSYLYKHRRIH---------TGMKPYKCKEC-GKAFNCSSSRNQHQRIHIGEKLYKCDECGQAFTFAS 401
Cdd:COG5048 112 ssssnsndNNLLSSHSLPPSSRDpqlpdllsiSNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 402 YLHKHLRIHigeklykCKECGKAFYCFTKLIYHWRVHTGEKPYKCDKCGKAF----------SIYSSFMKHQCIHRGEKL 471
Cdd:COG5048 192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspsSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38049077 472 -------------------------CKCNKCEKAFNNCHTLPRH--HRIHTGE--KPYNC--KDCGKAFTCTTGLTQHER 520
Cdd:COG5048 265 lptassqssspnesdsssekgfslpIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                       330
                ....*....|
gi 38049077 521 IHAGEKPYKC 530
Cdd:COG5048 345 LHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-203 8.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.29e-03
                          10        20
                  ....*....|....*....|...
gi 38049077   181 KHQRIHTGEKPYRCEECGRAFTN 203
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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