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Conserved domains on  [gi|119599064|gb|EAW78658|]
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interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), isoform CRA_c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL12 super family cl03854
Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer ...
 51-126 2.71e-38

Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses.


The actual alignment was detected with superfamily member pfam03039:

Pssm-ID: 460785  Cd Length: 214  Bit Score: 128.45  E-value: 2.71e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119599064   51 DHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTK 126
Cdd:pfam03039  12 QHLSLARNLPIQSPPPMHQYCLGHSQNLLTATETLLQKARKLLEYYSCTEEEIDHEDITKDKTSTVKACLPLELKK 87
 
Name Accession Description Interval E-value
IL12 pfam03039
Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer ...
 51-126 2.71e-38

Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses.


Pssm-ID: 460785  Cd Length: 214  Bit Score: 128.45  E-value: 2.71e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119599064   51 DHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTK 126
Cdd:pfam03039  12 QHLSLARNLPIQSPPPMHQYCLGHSQNLLTATETLLQKARKLLEYYSCTEEEIDHEDITKDKTSTVKACLPLELKK 87
 
Name Accession Description Interval E-value
IL12 pfam03039
Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer ...
 51-126 2.71e-38

Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses.


Pssm-ID: 460785  Cd Length: 214  Bit Score: 128.45  E-value: 2.71e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119599064   51 DHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTK 126
Cdd:pfam03039  12 QHLSLARNLPIQSPPPMHQYCLGHSQNLLTATETLLQKARKLLEYYSCTEEEIDHEDITKDKTSTVKACLPLELKK 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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