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Conserved domains on  [gi|119624834|gb|EAX04429|]
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leucine rich repeat containing 1, isoform CRA_a [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-192 1.54e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  52 PEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119624834 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLNQL 192
Cdd:COG4886  186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-192 1.54e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  52 PEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119624834 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLNQL 192
Cdd:COG4886  186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-197 3.06e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.83  E-value: 3.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  26 YVPEEIYryarsleELLLDANQLRELPEQFFQLVKlrKLGLSDNEIQRLPPEIANFMQlvELDVSRNEIPEIPESISfcK 105
Cdd:PRK15370 196 CIPEQIT-------TLILDNNELKSLPENLQGNIK--TLYANSNQLTSIPATLPDTIQ--EMELSINRITELPERLP--S 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 106 ALQVADFSGNPLTRLPESFPElqNLTCLSVNDISLQSLPEN----IGNLY---------------NLASLELRENLLTYL 166
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHlpsgITHLNvqsnsltalpetlppGLKTLEAGENALTSL 340

                        170       180       190
                 ....*....|....*....|....*....|.
gi 119624834 167 PDSLTQlrRLEELDLGNNEIYNLNQLEPSYI 197
Cdd:PRK15370 341 PASLPP--ELQVLDVSKNQITVLPETLPPTI 369
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-180 6.64e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 6.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  35 ARSLEELLLDANQLRELpEQFFQLVKLRKLGLSDNEIQRLppE-IANFMQLVELDVSRNEIPEiPESISF--------CK 105
Cdd:cd21340   45 LTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV--EgLENLTNLEELHIENQRLPP-GEKLTFdprslaalSN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 106 ALQVADFSGNPLTRLpESFPELQNLTCL--SVNDIS-LQSLPENIGNLYNLASLELRENLLTYLP---DSL-TQLRRLEE 178
Cdd:cd21340  121 SLRVLNISGNNIDSL-EPLAPLRNLEQLdaSNNQISdLEELLDLLSSWPSLRELDLTGNPVCKKPkyrDKIiLASKSLEV 199


                 ..
gi 119624834 179 LD 180
Cdd:cd21340  200 LD 201
LRR_8 pfam13855
Leucine rich repeat;
36-94 2.32e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 2.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119624834   36 RSLEELLLDANQLREL-PEQFFQLVKLRKLGLSDNEIQRLPPE-IANFMQLVELDVSRNEI 94
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-192 1.54e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  52 PEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119624834 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLNQL 192
Cdd:COG4886  186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL 246
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-197 3.06e-20

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.83  E-value: 3.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  26 YVPEEIYryarsleELLLDANQLRELPEQFFQLVKlrKLGLSDNEIQRLPPEIANFMQlvELDVSRNEIPEIPESISfcK 105
Cdd:PRK15370 196 CIPEQIT-------TLILDNNELKSLPENLQGNIK--TLYANSNQLTSIPATLPDTIQ--EMELSINRITELPERLP--S 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 106 ALQVADFSGNPLTRLPESFPElqNLTCLSVNDISLQSLPEN----IGNLY---------------NLASLELRENLLTYL 166
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHlpsgITHLNvqsnsltalpetlppGLKTLEAGENALTSL 340

                        170       180       190
                 ....*....|....*....|....*....|.
gi 119624834 167 PDSLTQlrRLEELDLGNNEIYNLNQLEPSYI 197
Cdd:PRK15370 341 PASLPP--ELQVLDVSKNQITVLPETLPPTI 369
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
14-196 1.02e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  14 VESIDKRHCSLVYVPEeiyRYARSLEELLLDANQLRELPEQFFQlvKLRKLGLSDNEIQRLPPEIANfmQLVELDVSRNE 93
Cdd:PRK15370 243 IQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNS 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  94 IPEIPESISFCKALQVADfsGNPLTRLPESF-PELQNLTcLSVNDISLqsLPENIGNlyNLASLELRENLLTYLPDSLTQ 172
Cdd:PRK15370 316 LTALPETLPPGLKTLEAG--ENALTSLPASLpPELQVLD-VSKNQITV--LPETLPP--TITTLDVSRNALTNLPENLPA 388

                        170       180
                 ....*....|....*....|....
gi 119624834 173 lrRLEELDLGNNEIYNLNQLEPSY 196
Cdd:PRK15370 389 --ALQIMQASRNNLVRLPESLPHF 410
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-163 4.61e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 4.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  37 SLEELLLDANQ-LRELPeQFFQLVKLRKLGLSDNEIQ-RLPPEIANFMQLVELDVSRNEIP-EIPESISFCKALQVADFS 113
Cdd:PLN00113 453 SLQMLSLARNKfFGGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLS 531

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119624834 114 GNPLT-RLPESFPELQNLTC--LSVNDISlQSLPENIGNLYNLASLELRENLL 163
Cdd:PLN00113 532 HNQLSgQIPASFSEMPVLSQldLSQNQLS-GEIPKNLGNVESLVQVNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-194 1.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPpEIANFMQLVELDVSRNEIPEIPESISFcKALQVADFSGNP 116
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQ 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119624834 117 LTRLP-ESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLNQLEP 194
Cdd:COG4886  284 LTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-186 1.66e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  36 RSLEELLLDANQLR-ELPEQFFQLVKLRKLGLSDNEIQ-RLPPEIANFMQLVELDVSRNEI-PEIPESiSFCKALQVADF 112
Cdd:PLN00113 404 RSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFfGGLPDS-FGSKRLENLDL 482

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119624834 113 SGNPLT-RLPE---SFPELQNLTcLSVNDISlQSLPENIGNLYNLASLELRENLLT-YLPDSLTQLRRLEELDLGNNEI 186
Cdd:PLN00113 483 SRNQFSgAVPRklgSLSELMQLK-LSENKLS-GEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQL 559
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-180 6.64e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 6.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  35 ARSLEELLLDANQLRELpEQFFQLVKLRKLGLSDNEIQRLppE-IANFMQLVELDVSRNEIPEiPESISF--------CK 105
Cdd:cd21340   45 LTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV--EgLENLTNLEELHIENQRLPP-GEKLTFdprslaalSN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 106 ALQVADFSGNPLTRLpESFPELQNLTCL--SVNDIS-LQSLPENIGNLYNLASLELRENLLTYLP---DSL-TQLRRLEE 178
Cdd:cd21340  121 SLRVLNISGNNIDSL-EPLAPLRNLEQLdaSNNQISdLEELLDLLSSWPSLRELDLTGNPVCKKPkyrDKIiLASKSLEV 199


                 ..
gi 119624834 179 LD 180
Cdd:cd21340  200 LD 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-184 8.58e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 8.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  38 LEELLLDANQLR-ELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVEL--DVSRNEIPEIPESISFCKALQVADFSG 114
Cdd:PLN00113 262 LQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIlhLFSNNFTGKIPVALTSLPRLQVLQLWS 341

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119624834 115 NPLT-RLPESFPELQNLTCLSVNDISLQS-LPENIGNLYNLASLELRENLL-TYLPDSLTQLRRLEELDLGNN 184
Cdd:PLN00113 342 NKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDN 414
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
38-186 9.11e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.23  E-value: 9.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  38 LEELLLDANQLRELPEQFFQLVKL-----------------RKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100
Cdd:PRK15387 304 LQELSVSDNQLASLPALPSELCKLwaynnqltslptlpsglQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSG 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 101 IsfcKALQVadfSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEnignlyNLASLELRENLLTYLPDSLTQLRRLEELD 180
Cdd:PRK15387 384 L---KELIV---SGNRLTSLPVLPSELKELMVSGNRLTSLPMLPS------GLLSLSVYRNQLTRLPESLIHLSSETTVN 451


                 ....*.
gi 119624834 181 LGNNEI 186
Cdd:PRK15387 452 LEGNPL 457
PLN03150 PLN03150
hypothetical protein; Provisional
 41-123 5.41e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 5.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  41 LLLDANQLR-ELPEQFFQLVKLRKLGLSDNEIQ-RLPPEIANFMQLVELDVSRNEIP-EIPESISFCKALQVADFSGNPL 117
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*..
gi 119624834 118 T-RLPES 123
Cdd:PLN03150 503 SgRVPAA 509
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 27-184 1.20e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  27 VPEEIYRYARSLEELLLDANQLR-ELPEQFFQLvkLRKLGLSDNEIQ-RLPPEIANFMQLVELDVSRNEIP-EIPESISF 103
Cdd:PLN00113 109 IPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPN--LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTN 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 104 CKALQVADFSGNPLT-RLPESFPELQNLTC--LSVNDIS---------LQSL--------------PENIGNLYNLASLE 157
Cdd:PLN00113 187 LTSLEFLTLASNQLVgQIPRELGQMKSLKWiyLGYNNLSgeipyeiggLTSLnhldlvynnltgpiPSSLGNLKNLQYLF 266

                        170       180
                 ....*....|....*....|....*...
gi 119624834 158 LRENLLT-YLPDSLTQLRRLEELDLGNN 184
Cdd:PLN00113 267 LYQNKLSgPIPPSIFSLQKLISLDLSDN 294
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-188 3.21e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 3.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  38 LEELLLDANQLR-ELPEQFFQLV-KLRKLGLSDNEIQRLPPEiaNFMQLVE-LDVSRNEIP-EIPESISFCKALQVADFS 113
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTGSIPR--GSIPNLEtLDLSNNMLSgEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119624834 114 GNPLT-RLPESFPELQNLTCLSVNDISLQ-SLPENIGNLYNLASLEL-RENLLTYLPDSLTQLRRLEELDLgnneIYN 188
Cdd:PLN00113 173 GNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDL----VYN 246
PLN03150 PLN03150
hypothetical protein; Provisional
 64-148 3.67e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  64 LGLsDNEIQR--LPPEIANFMQLVELDVSRNEIP-EIPESISFCKALQVADFSGNPLT-RLPESFPELQNLTCLSVNDIS 139
Cdd:PLN03150 423 LGL-DNQGLRgfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNS 501

                         90
                 ....*....|
gi 119624834 140 LQS-LPENIG 148
Cdd:PLN03150 502 LSGrVPAALG 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-186 4.74e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 4.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  38 LEELLLDANQLR-ELPEQFFQLVKLRKLGLSDNEIQ-RLPPEIANFMQLVELDVSRNEIP-EIPESISFCKALQVADFSG 114
Cdd:PLN00113 334 LQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQD 413

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119624834 115 NPLT-RLPESFPELQNLTCLsvnDISLQSLPENIGNL-YNLASLEL----RENLLTYLPDSLTQlRRLEELDLGNNEI 186
Cdd:PLN00113 414 NSFSgELPSEFTKLPLVYFL---DISNNNLQGRINSRkWDMPSLQMlslaRNKFFGGLPDSFGS-KRLENLDLSRNQF 487
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
38-189 7.01e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 7.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPeianfmQLVELDVSRNEIPEIPESIS-FCKALQVadfsGNP 116
Cdd:PRK15387 264 LLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPP------GLQELSVSDNQLASLPALPSeLCKLWAY----NNQ 333

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119624834 117 LTRLPESFPELQNLtclSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQL----RRLEELDLGNNEIYNL 189
Cdd:PRK15387 334 LTSLPTLPSGLQEL---SVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELivsgNRLTSLPVLPSELKEL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
41-192 1.72e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  41 LLLDANQLRELPEQffqLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIsfCKALqvadFSGNPLTRL 120
Cdd:PRK15387 227 LVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGL--CKLW----IFGNQLTSL 297

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119624834 121 PESFPELQNltcLSVNDISLQSLPENIGNLYNLASLelrENLLTYLPdslTQLRRLEELDLGNNEIYNLNQL 192
Cdd:PRK15387 298 PVLPPGLQE---LSVSDNQLASLPALPSELCKLWAY---NNQLTSLP---TLPSGLQELSVSDNQLASLPTL 360
LRR_8 pfam13855
Leucine rich repeat;
36-94 2.32e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 2.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119624834   36 RSLEELLLDANQLREL-PEQFFQLVKLRKLGLSDNEIQRLPPE-IANFMQLVELDVSRNEI 94
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
128-186 3.02e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 3.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119624834  128 QNLTCLSVNDISLQSL-PENIGNLYNLASLELRENLLTYL-PDSLTQLRRLEELDLGNNEI 186
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
18-118 3.34e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  18 DKRHCSLVYVPEEIYRY-------------ARSLEELLLDANQLRELPeqfFQLVKLRKLGLSDNEIQRLPPEIANfmqL 84
Cdd:PRK15387 351 DNQLASLPTLPSELYKLwaynnrltslpalPSGLKELIVSGNRLTSLP---VLPSELKELMVSGNRLTSLPMLPSG---L 424

                         90       100       110
                 ....*....|....*....|....*....|....
gi 119624834  85 VELDVSRNEIPEIPESISFCKALQVADFSGNPLT 118
Cdd:PRK15387 425 LSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 33-186 7.09e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 7.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834  33 RYARSLEELLLDANQLRELPE------QFFQ-LVKLRKLGLSDNEIQR-LPPEIANFMQ---LVELDVSRNEIPEIPESI 101
Cdd:cd00116   48 RPQPSLKELCLSLNETGRIPRglqsllQGLTkGCGLQELDLSDNALGPdGCGVLESLLRsssLQELKLNNNGLGDRGLRL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119624834 102 SfCKALQ-------VADFSGNPLT-----RLPESFPELQNLTCLSV--NDIS---LQSLPENIGNLYNLASLELRENLLT 164
Cdd:cd00116  128 L-AKGLKdlppaleKLVLGRNRLEgasceALAKALRANRDLKELNLanNGIGdagIRALAEGLKANCNLEVLDLNNNGLT 206

                        170       180
                 ....*....|....*....|....*..
gi 119624834 165 -----YLPDSLTQLRRLEELDLGNNEI 186
Cdd:cd00116  207 degasALAETLASLKSLEVLNLGDNNL 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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