NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148694863|gb|EDL26810|]
View 

Notch gene homolog 4 (Drosophila), isoform CRA_c [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1599-1803 1.01e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 1.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1678
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1679 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1758
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1759 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1803
Cdd:COG0666   231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1450-1496 2.19e-21

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411988  Cd Length: 92  Bit Score: 90.14  E-value: 2.19e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 148694863 1450 QLIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKALK 1496
Cdd:cd21705    48 QLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGEDAIGLKPLK 92
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1253-1281 1.53e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.53e-08
                           10        20
                   ....*....|....*....|....*....
gi 148694863  1253 QYCRDHFHNGHCEKGCNNAECGWDGGDCR 1281
Cdd:pfam00066    7 PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-470 6.63e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 6.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 148694863  429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE 470
Cdd:cd00054     1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-584 1.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148694863  548 DMDECSST-PCANGGRCRDQPGAFHCECLPGFEGPHCE 584
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-350 4.80e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 4.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148694863  311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGWGGAGCE 350
Cdd:cd00054     1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 7.34e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 7.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 148694863  1207 WKGCPPhSQCWLLFRDGRCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCPY-PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
191-222 1.49e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 148694863   191 DINECFLEPGPCPQGTSCHNTLGSYQCLCPVG 222
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-546 1.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  511 VNECTS-NPCLNQAACHDLLNGFQCLCLPGFTGARCE 546
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148694863  966 DACQSQ-PCHNHGTCTSRPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 926-961 6.20e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYEGQNC 961
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 587-622 1.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  587 VDECLS-DPCPVGASCLDLPGAFFCLCRPGFTGQLCE 622
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 472-508 3.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148694863  472 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGRLCE 508
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-800 4.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQGLHCE 800
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 892-924 1.66e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.66e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 148694863  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQ 924
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1002-1040 5.86e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148694863 1002 DVDECLDR-PCHPSGTaaCHSLANAFYCQCLPGHTGQRCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-723 7.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.42e-04
                          10        20
                  ....*....|....*....|....*...
gi 148694863  696 PCAHGGTCHPQPSGYNCTCPAGYMGLTC 723
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD super family cl08449
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 1.18e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


The actual alignment was detected with superfamily member pfam06816:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 38.65  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 148694863  1291 PSLAL----LVVLRPPaldQQLLALA----RVLSLTLRVGLWVRKDSEGRNMVFPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDP---EELLNNSvqflRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  352 NLDDCAAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLC 387
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-839 3.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148694863  810 SPCRNKATCQDTPRGARCLCSPGYTGSSCQ 839
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP super family cl06639
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1415 3.49e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


The actual alignment was detected with superfamily member pfam07684:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 37.64  E-value: 3.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148694863  1375 AGFVVVMGVDLSRCGPEHpaSRCPWDSGLLLRFLAAMAAVG 1415
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKG 40
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-189 8.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.44e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148694863  158 SANPCANGGVCLATYPQIQCRCPPGFEGHTCE 189
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1599-1803 1.01e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 1.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1678
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1679 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1758
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1759 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1803
Cdd:COG0666   231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1450-1496 2.19e-21

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 90.14  E-value: 2.19e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 148694863 1450 QLIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKALK 1496
Cdd:cd21705    48 QLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGEDAIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1618-1711 4.46e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 4.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863  1618 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDartEDGTTPLMLAARLAVEDLV 1697
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 148694863  1698 EELIAARADVGARD 1711
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1591-1771 1.89e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.64  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1591 GNLEPWEPLLDRGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASR 1670
Cdd:PHA02875   13 GELDIARRLLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1671 QTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTP 1750
Cdd:PHA02875   92 KFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTP 171

                         170       180
                  ....*....|....*....|.
gi 148694863 1751 LFLAAREGAVEVAQLLLELGA 1771
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGA 192
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1253-1281 1.53e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.53e-08
                           10        20
                   ....*....|....*....|....*....
gi 148694863  1253 QYCRDHFHNGHCEKGCNNAECGWDGGDCR 1281
Cdd:pfam00066    7 PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-470 6.63e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 6.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 148694863  429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE 470
Cdd:cd00054     1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-584 1.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148694863  548 DMDECSST-PCANGGRCRDQPGAFHCECLPGFEGPHCE 584
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1252-1280 2.43e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 2.43e-07
                            10        20
                    ....*....|....*....|....*....
gi 148694863   1252 DQYCRDHFHNGHCEKGCNNAECGWDGGDC 1280
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
429-470 3.67e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.67e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 148694863    429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYT-GSRCE 470
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-350 4.80e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 4.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148694863  311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGWGGAGCE 350
Cdd:cd00054     1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1614-1719 5.04e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1614 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHTAVAADAREVCQLLLASRQTTVDARTED------ 1680
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 148694863 1681 -------GTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALH 1719
Cdd:cd22192   129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 7.34e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 7.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 148694863  1207 WKGCPPhSQCWLLFRDGRCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCPY-PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1203-1241 1.05e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 46.94  E-value: 1.05e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863   1203 VPDPWKGCPpHSQCWLLFRDGRCHPQCDSEECLFDGYDC 1241
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
191-222 1.49e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 148694863   191 DINECFLEPGPCPQGTSCHNTLGSYQCLCPVG 222
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-546 1.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  511 VNECTS-NPCLNQAACHDLLNGFQCLCLPGFTGARCE 546
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
548-584 2.99e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.99e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    548 DMDECSST-PCANGGRCRDQPGAFHCECLPGFE-GPHCE 584
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
311-350 3.14e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.14e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 148694863    311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGW-GGAGCE 350
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148694863  966 DACQSQ-PCHNHGTCTSRPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 926-961 6.20e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYEGQNC 961
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
191-229 9.60e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.60e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 148694863    191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVG-QEGPQCK 229
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 587-622 1.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  587 VDECLS-DPCPVGASCLDLPGAFFCLCRPGFTGQLCE 622
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 191-229 1.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148694863  191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCK 229
Cdd:cd00054     1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-546 3.80e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    510 EVNECTS-NPCLNQAACHDLLNGFQCLCLPGFT-GARCE 546
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 472-508 3.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148694863  472 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGRLCE 508
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-800 4.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQGLHCE 800
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
926-961 1.08e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 148694863    926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYE-GQNC 961
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 892-924 1.66e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.66e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 148694863  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQ 924
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 2.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.68e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   968 CQSQPCHNHGTCTSRPGGFHCACPPGFVGLR 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1000 3.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.78e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 148694863    966 DACQS-QPCHNHGTCTSRPGGFHCACPPGFV-GLRCE 1000
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
311-343 3.82e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 3.82e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 148694863   311 DIDECeARGPPRCRNGGTCQNTAGSFHCVCVSG 343
Cdd:pfam07645    1 DVDEC-ATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 930-960 5.32e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 5.32e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   930 CEPNPCHHGSTCVPQPSGYVCQCAPGYEGQN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-800 5.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 5.78e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 148694863    765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQ-GLHCE 800
Cdd:smart00179    2 IDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1002-1040 5.86e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148694863 1002 DVDECLDR-PCHPSGTaaCHSLANAFYCQCLPGHTGQRCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-622 6.07e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 6.07e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    586 EVDECLS-DPCPVGASCLDLPGAFFCLCRPGFT-GQLCE 622
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
472-508 7.31e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.31e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    472 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GRLCE 508
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-723 7.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.42e-04
                          10        20
                  ....*....|....*....|....*...
gi 148694863  696 PCAHGGTCHPQPSGYNCTCPAGYMGLTC 723
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 1.18e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 38.65  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 148694863  1291 PSLAL----LVVLRPPaldQQLLALA----RVLSLTLRVGLWVRKDSEGRNMVFPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDP---EELLNNSvqflRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA pfam07645
Calcium-binding EGF domain;
429-463 1.75e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 148694863   429 DLDECQmaqQGPSPCEHGGSCINTPGSFNCLCLPG 463
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  352 NLDDCAAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLC 387
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 514-544 1.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.93e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   514 CTSNPCLNQAACHDLLNGFQCLCLPGFTGAR 544
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-582 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   552 CSSTPCANGGRCRDQPGAFHCECLPGFEGPH 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
892-924 2.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 148694863    892 EISGLCQNGGLCIDTGSSYFCRCPPGFQ-GKLCQ 924
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-839 3.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148694863  810 SPCRNKATCQDTPRGARCLCSPGYTGSSCQ 839
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1415 3.49e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 37.64  E-value: 3.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148694863  1375 AGFVVVMGVDLSRCGPEHpaSRCPWDSGLLLRFLAAMAAVG 1415
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKG 40
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-381 6.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 6.84e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 148694863    352 NLDDCA-AATCAPGSTCIDRVGSFSCLCPPG 381
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-189 8.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.44e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148694863  158 SANPCANGGVCLATYPQIQCRCPPGFEGHTCE 189
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1599-1803 1.01e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 1.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1678
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1679 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1758
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1759 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1803
Cdd:COG0666   231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1590-1822 8.97e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.63  E-value: 8.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1590 LGNLEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAs 1669
Cdd:COG0666    30 LLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1670 RQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQT 1749
Cdd:COG0666   109 AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGET 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148694863 1750 PLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAA 1822
Cdd:COG0666   189 PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1599-1782 5.57e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.32  E-value: 5.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVGtGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1678
Cdd:COG0666   106 LLEAGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1679 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1758
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263

                         170       180
                  ....*....|....*....|....
gi 148694863 1759 AVEVAQLLLELGAARGLRDQAGLA 1782
Cdd:COG0666   264 AALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1618-1822 6.86e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 6.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1618 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLV 1697
Cdd:COG0666    24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1698 EELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRD 1777
Cdd:COG0666   104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1778 QAGLAPGDVARQRSHWDLLTLLEGAGpttqeARAHARTTPGGGAA 1822
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLEAG-----ADVNAKDNDGKTAL 223
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1450-1496 2.19e-21

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 90.14  E-value: 2.19e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 148694863 1450 QLIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKALK 1496
Cdd:cd21705    48 QLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGEDAIGLKPLK 92
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1556-1718 1.67e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 1.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1556 DVDTCGPDGVTPLMSAVFCGgvqsttgaspqRLGLGNLepwepLLDRGACPQAHTvGTGETPLHLAARFSRPTAARRLLE 1635
Cdd:COG0666   145 DVNAQDNDGNTPLHLAAANG-----------NLEIVKL-----LLEAGADVNARD-NDGETPLHLAAENGHLEIVKLLLE 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1636 AGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGK 1715
Cdd:COG0666   208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286


                  ...
gi 148694863 1716 TAL 1718
Cdd:COG0666   287 TLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1618-1711 4.46e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 4.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863  1618 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDartEDGTTPLMLAARLAVEDLV 1697
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 148694863  1698 EELIAARADVGARD 1711
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1633-1803 1.00e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.08  E-value: 1.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1633 LLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDK 1712
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1713 RGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSH 1792
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         170
                  ....*....|.
gi 148694863 1793 WDLLTLLEGAG 1803
Cdd:COG0666   166 LEIVKLLLEAG 176
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1591-1771 1.89e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.64  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1591 GNLEPWEPLLDRGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASR 1670
Cdd:PHA02875   13 GELDIARRLLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1671 QTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTP 1750
Cdd:PHA02875   92 KFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTP 171

                         170       180
                  ....*....|....*....|.
gi 148694863 1751 LFLAAREGAVEVAQLLLELGA 1771
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGA 192
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1451-1495 7.49e-13

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 65.86  E-value: 7.49e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1451 LIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKAL 1495
Cdd:cd21701    43 LVARKRRRHGTLWFPEGFPRTRASR--RSRRRDPVGQDSVGLKNL 85
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1599-1757 1.03e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.61  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTvDART 1678
Cdd:PHA02878  153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST-DARD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1679 EDGTTPLMLA-ARLAVEDLVEELIAARADVGARDK-RGKTALHwaAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAR 1756
Cdd:PHA02878  232 KCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVK 309


                  .
gi 148694863 1757 E 1757
Cdd:PHA02878  310 Q 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1685-1771 1.48e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 1.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863  1685 LMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQaGADKDAQDSReQTPLFLAAREGAVEVAQ 1764
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNG-RTALHYAARSGHLEIVK 78


                   ....*..
gi 148694863  1765 LLLELGA 1771
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1631-1771 1.76e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.90  E-value: 1.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1631 RRLLEAGANPNQPDRAGRTPLHTAVA---ADAREVCQLLLASrQTTVDARTEDGTTPLMLAARLA-VEDLVEELIAARAD 1706
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHLYLHyssEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148694863 1707 VGARDKRGKTALHWAAAVNNARAA--RSLLQAGADKDAQDSREQTPL--FLAAREGAVEVAQLLLELGA 1771
Cdd:PHA03095  110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGA 178
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1453-1496 2.74e-11

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 61.35  E-value: 2.74e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148694863 1453 RRRRREHGALWLPPGFIrrpQTQQAPHRRRPPLGEDNIGLKALK 1496
Cdd:cd21702    39 RKRRREHGQLWFPEGFK---VSEPSKKKRREPVGEDSVGLKPLK 79
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1599-1756 4.13e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.74  E-value: 4.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVgTGETPLHLAARFSRPTAA--RRLLEAGANPNQPDRAGRTPLHT-AVAADAREVCQLLLASRQTTVD 1675
Cdd:PHA03095  138 LLRKGADVNALDL-YGMTPLAVLLKSRNANVEllRLLIDAGADVYAVDDRFRSLLHHhLQSFKPRARIVRELIRAGCDPA 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1676 ARTEDGTTPLMLAARLAVED--LVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFL 1753
Cdd:PHA03095  217 ATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSL 296


                  ...
gi 148694863 1754 AAR 1756
Cdd:PHA03095  297 MVR 299
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1599-1829 7.71e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.59  E-value: 7.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVgTGETPLHLAARFS-RPTAARRLLEAGANPNQPDRAGRTPLH---TAVAADArEVCQLLLAsRQTTV 1674
Cdd:PHA03095   69 LLEAGADVNAPER-CGFTPLHLYLYNAtTLDVIKLLIKAGADVNAKDKVGRTPLHvylSGFNINP-KVIRLLLR-KGADV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1675 DARTEDGTTPL----------------MLAA---RLAVED------------------LVEELIAARADVGARDKRGKTA 1717
Cdd:PHA03095  146 NALDLYGMTPLavllksrnanvellrlLIDAgadVYAVDDrfrsllhhhlqsfkprarIVRELIRAGCDPAATDMLGNTP 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1718 LHWAAAVNNARAA--RSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDL 1795
Cdd:PHA03095  226 LHSMATGSSCKRSlvLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRA 305

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 148694863 1796 L-TLLEGAGPTTQEARAHARTTPGGGAAPRCRTLS 1829
Cdd:PHA03095  306 VrAALAKNPSAETVAATLNTASVAGGDIPSDATRL 340
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1616-1807 6.96e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.53  E-value: 6.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1616 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLH-----TAVAADAREVCQLLLaSRQTTVDARTEDGTTPLMLAAR 1690
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLL-EYGANVNAPDNNGITPLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1691 LAVED--LVEELIAARADVGARDKRGKTALHWAAAVNNARAARS------------------LLQAGADKDAQDSREQTP 1750
Cdd:PHA03100  116 KKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTP 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148694863 1751 LFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQ 1807
Cdd:PHA03100  196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1451-1495 2.65e-09

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 55.54  E-value: 2.65e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1451 LIRRRRREHGALWLPPGFIRRPQTQQapHRRRPPLGEDNIGLKAL 1495
Cdd:cd21703    40 LVAKRKRKHGPLWFPEGFILNKENSN--RKRREPVGQDAVGMKNL 82
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1614-1719 5.02e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.81  E-value: 5.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1614 GETPLHLAARFS---RPTAARRLLEAGANPNQPDRAGRTPLHTAV-AADAREVCQLLL---ASrqttVDARTEDGTTPL- 1685
Cdd:PHA03095   47 GKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIkagAD----VNAKDKVGRTPLh 122

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 148694863 1686 -MLAARLAVEDLVEELIAARADVGARDKRGKTALH 1719
Cdd:PHA03095  123 vYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLA 157
Ank_4 pfam13637
Ankyrin repeats (many copies);
1616-1667 5.43e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.82  E-value: 5.43e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148694863  1616 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLL 1667
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1633-1771 8.97e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 8.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1633 LLEAGANPNQPDRAGRTPLHTAVAADA--REVCQLLlaSRQTTVDARTEDGTTPLMLAARLAVE-DLVEELIAARADVGA 1709
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSlsRLVPKLL--ERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNA 336

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148694863 1710 RDKRGKTALHWAAAVNNARAAR-SLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGA 1771
Cdd:PHA02876  337 ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399
COG3903 COG3903
Predicted ATPase [General function prediction only];
1585-1904 1.02e-08

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 60.42  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1585 PQRLGLGNLEPWEPLLdRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGAnpnqpDRAGRTPLHTAVAADAREVCQ 1664
Cdd:COG3903   513 DQLAWLARLDAEHDNL-RAALRWALAHGDAELALRLAAALAPFWFLRGLLREGR-----RWLERALAAAGEAAAALAAAA 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1665 LLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGAdkdAQD 1744
Cdd:COG3903   587 ALAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAA 663

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1745 SREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAAPR 1824
Cdd:COG3903   664 AALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAA 743

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1825 CRTLSAGARPRGGGACLQARTWSVDLGARGGKVYARCRSRSGSCGGPTTRGRRFSAGSRGRRGARASQDDWPRDWVALEA 1904
Cdd:COG3903   744 ALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAA 823
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1253-1281 1.53e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.53e-08
                           10        20
                   ....*....|....*....|....*....
gi 148694863  1253 QYCRDHFHNGHCEKGCNNAECGWDGGDCR 1281
Cdd:pfam00066    7 PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1599-1676 3.10e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.76  E-value: 3.10e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148694863 1599 LLDRGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDA 1676
Cdd:PTZ00322  101 LLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1665-1803 3.19e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1665 LLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQD 1744
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148694863 1745 SREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1803
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-470 6.63e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 6.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 148694863  429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE 470
Cdd:cd00054     1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1599-1654 1.07e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 1.07e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 148694863  1599 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTA 1654
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-584 1.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148694863  548 DMDECSST-PCANGGRCRDQPGAFHCECLPGFEGPHCE 584
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1614-1669 1.55e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 1.55e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 148694863  1614 GETPLHLAARFSRPTAARRLLEaGANPNQPDRaGRTPLHTAVAADAREVCQLLLAS 1669
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1614-1718 1.96e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1614 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADaREVCQLLLASRqtTVDARTEDGTTPLMLAARLAV 1693
Cdd:PHA02874  190 GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINNA--SINDQDIDGSTPLHHAINPPC 266

                          90       100
                  ....*....|....*....|....*.
gi 148694863 1694 E-DLVEELIAARADVGARDKRGKTAL 1718
Cdd:PHA02874  267 DiDIIDILLYHKADISIKDNKGENPI 292
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1733-1813 2.18e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 2.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1733 LLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAH 1812
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGAN 180


                  .
gi 148694863 1813 A 1813
Cdd:PTZ00322  181 A 181
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1252-1280 2.43e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 2.43e-07
                            10        20
                    ....*....|....*....|....*....
gi 148694863   1252 DQYCRDHFHNGHCEKGCNNAECGWDGGDC 1280
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
429-470 3.67e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.67e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 148694863    429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYT-GSRCE 470
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1599-1777 4.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.07  E-value: 4.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVgTGETPLHLAARFSRPTA-ARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDAR 1677
Cdd:PHA02876  293 LLERGADVNAKNI-KGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNAR 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1678 TEDGTTPLMLAA--------------RLAVEDL--------------------VEELIAARADVGARDKRGKTALHWAAA 1723
Cdd:PHA02876  372 DYCDKTPIHYAAvrnnvviintlldyGADIEALsqkigtalhfalcgtnpymsVKTLIDRGANVNSKNKDLSTPLHYACK 451

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148694863 1724 VNNARAARS-LLQAGADKDAQDSREQTPLFLAAreGAVEVAQLLLELGAArgLRD 1777
Cdd:PHA02876  452 KNCKLDVIEmLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE--LRD 502
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1451-1493 4.20e-07

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 49.75  E-value: 4.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 148694863 1451 LIRRRRREHGALWLPPGFIRRPQTqqAPHRRRPPLGEDNIGLK 1493
Cdd:cd21704    46 LVARRKREHSTLWFPEGFFLKKES--SNKNRREPVGQDALGMK 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-350 4.80e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 4.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148694863  311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGWGGAGCE 350
Cdd:cd00054     1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1614-1719 5.04e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1614 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHTAVAADAREVCQLLLASRQTTVDARTED------ 1680
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 148694863 1681 -------GTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALH 1719
Cdd:cd22192   129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 7.34e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 7.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 148694863  1207 WKGCPPhSQCWLLFRDGRCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCPY-PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1616-1783 8.67e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 8.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1616 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLasrqttvdartEDGTTPLMLAARLAVED 1695
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----------DNGVDTSILPIPCIEKD 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1696 LVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGL 1775
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185


                  ....*...
gi 148694863 1776 RDQAGLAP 1783
Cdd:PHA02874  186 KDNNGESP 193
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1203-1241 1.05e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 46.94  E-value: 1.05e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863   1203 VPDPWKGCPpHSQCWLLFRDGRCHPQCDSEECLFDGYDC 1241
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
191-222 1.49e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 148694863   191 DINECFLEPGPCPQGTSCHNTLGSYQCLCPVG 222
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-546 1.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  511 VNECTS-NPCLNQAACHDLLNGFQCLCLPGFTGARCE 546
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1599-1771 1.53e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1599 LLDRGACPQAHTVGTgETPLHLAARF-----SRPTAARRLLEAGANPNQPDRAGRTPLHTAVAadaREVCQL----LLAS 1669
Cdd:PHA03100   54 LLDNGADINSSTKNN-STPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS---KKSNSYsiveYLLD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1670 RQTTVDARTEDGTTPLMLAAR------------------LAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAAR 1731
Cdd:PHA03100  130 NGANVNIKNSDGENLLHLYLEsnkidlkilkllidkgvdINAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVK 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 148694863 1732 SLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGA 1771
Cdd:PHA03100  210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
EGF_CA smart00179
Calcium-binding EGF-like domain;
548-584 2.99e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.99e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    548 DMDECSST-PCANGGRCRDQPGAFHCECLPGFE-GPHCE 584
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
311-350 3.14e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.14e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 148694863    311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGW-GGAGCE 350
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.51e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148694863  966 DACQSQ-PCHNHGTCTSRPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 926-961 6.20e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYEGQNC 961
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1615-1751 7.40e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 7.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1615 ETPLHLAARFSRPTAARRLLE-AGANPNQPDRAGRTPLHTAVAADAREVCQLLL-ASRQTTVDARTED---GTTPLMLAA 1689
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMeAAPELVNEPMTSDlyqGETALHIAV 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148694863 1690 RLAVEDLVEELIAARADV------GARDKRGKTAL-----H---WAAAVNNARAARSLLQAGADKDAQDSREQTPL 1751
Cdd:cd22192    98 VNQNLNLVRELIARGADVvspratGTFFRPGPKNLiyygeHplsFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1616-1754 8.09e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 8.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1616 TPLHLAARfsRPTAAR---RLLEAGANPNQPDRAGRTPLHTAV--AADAREVCQLLlaSRQTTVDARTEDGTTPLMLAAR 1690
Cdd:PHA02876  275 TPLHHASQ--APSLSRlvpKLLERGADVNAKNIKGETPLYLMAknGYDTENIRTLI--MLGADVNAADRLYITPLHQAST 350

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148694863 1691 L-AVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLA 1754
Cdd:PHA02876  351 LdRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1591-1718 9.38e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.37  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1591 GNLEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASR 1670
Cdd:PHA02875   79 GDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 148694863 1671 QTTvdaRTED--GTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTAL 1718
Cdd:PHA02875  159 ACL---DIEDccGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
EGF_CA smart00179
Calcium-binding EGF-like domain;
191-229 9.60e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.60e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 148694863    191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVG-QEGPQCK 229
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 587-622 1.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  587 VDECLS-DPCPVGASCLDLPGAFFCLCRPGFTGQLCE 622
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 191-229 1.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148694863  191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCK 229
Cdd:cd00054     1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1633-1688 2.11e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 2.11e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 148694863  1633 LLEAG-ANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQtTVDARTEDGTTPLMLA 1688
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1556-1644 2.15e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 2.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863  1556 DVDTCGPDGVTPLMSAVFCGGVQSTtgaspqRLglgnlepwepLLDrgaCPQAHTVGTGETPLHLAARFSRPTAARRLLE 1635
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIV------KL----------LLE---HADVNLKDNGRTALHYAARSGHLEIVKLLLE 82


                   ....*....
gi 148694863  1636 AGANPNQPD 1644
Cdd:pfam12796   83 KGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1586-1824 2.28e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.29  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1586 QRLGLGNLEPWEPLLDRGACPQAHTVGTgETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADArevcql 1665
Cdd:PHA02876  151 ERIQQDELLIAEMLLEGGADVNAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN------ 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1666 lLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARA--DVGARDKRGKTALHWAAAVNN-ARAARSLLQAGADKDA 1742
Cdd:PHA02876  224 -IDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1743 QDSREQTPLFLAAREG-AVEVAQLLLELGAARGLRDQAGLAPGDVAR--QRSHWDLLTLLE-GAgptTQEARAHARTTPG 1818
Cdd:PHA02876  303 KNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLElGA---NVNARDYCDKTPI 379


                  ....*.
gi 148694863 1819 GGAAPR 1824
Cdd:PHA02876  380 HYAAVR 385
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1733-1773 2.39e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 2.39e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148694863  1733 LLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAAR 1773
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 1597-1719 2.65e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.90  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1597 EPLLDRGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAR--EVCQLLLASRQTTV 1674
Cdd:PHA02946   56 EELLHRGYSPN-ETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKIN 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 148694863 1675 DARTEDGTTPLmLAARLAVEDLVEELIAARADVGARDKRGKTALH 1719
Cdd:PHA02946  135 NSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIH 178
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1619-1700 3.08e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1619 HLAARfSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLL--ASRQTTVDartEDGTTPLMLAARLAVEDL 1696
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLefGADPTLLD---KDGKTPLELAEENGFREV 163


                  ....
gi 148694863 1697 VEEL 1700
Cdd:PTZ00322  164 VQLL 167
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-546 3.80e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    510 EVNECTS-NPCLNQAACHDLLNGFQCLCLPGFT-GARCE 546
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 472-508 3.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148694863  472 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGRLCE 508
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-800 4.16e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQGLHCE 800
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1666-1719 5.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 5.59e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 148694863  1666 LLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALH 1719
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1590-1768 6.70e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.95  E-value: 6.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1590 LGNLEPWEPLLDRGACPQAHTVG-TGETPLHLAARFSRPT---AARRLLEAGANPNQPDR-----------AGRTPLHTA 1654
Cdd:cd21882     1 LEELLGLLECLRWYLTDSAYQRGaTGKTCLHKAALNLNDGvneAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1655 VAADAREVCQLLLAsRQTTVDARTED-------------GTTPLMLAARLAVEDLVEELI---AARADVGARDKRGKTAL 1718
Cdd:cd21882    81 IENRNLNLVRLLVE-NGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVL 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148694863 1719 HWAAAVNNARAARS---------LLQAGADKDAQDSREQ-------TPLFLAAREGAVEVAQLLLE 1768
Cdd:cd21882   160 HALVLQADNTPENSafvcqmynlLLSYGAHLDPTQQLEEipnhqglTPLKLAAVEGKIVMFQHILQ 225
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1617-1783 7.52e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.57  E-value: 7.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1617 PLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAS-------------------------RQ 1671
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSinkcsvfytlvaikdafnnrnveifKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1672 TTVDARTEDGTTPLMLAARLAVEDLVEE-----LIAARADVGARDK-RGKTALHWAAAVNNARAARSLLQAGADKDAQDS 1745
Cdd:PHA02878  120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 148694863 1746 REQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAP 1783
Cdd:PHA02878  200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237
EGF_CA smart00179
Calcium-binding EGF-like domain;
926-961 1.08e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 148694863    926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYE-GQNC 961
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1614-1645 1.63e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 1.63e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 148694863  1614 GETPLHLAA-RFSRPTAARRLLEAGANPNQPDR 1645
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 892-924 1.66e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.66e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 148694863  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQ 924
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 1453-1933 1.97e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 46.79  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1453 RRRRREH-------GALWLPPGFIRRPQTQQAPHRRRPPL------GEDNIGLKALKPEAEVDEDGVAMCSGPEEGEAEE 1519
Cdd:COG3321   824 RRGEDELaqlltalAQLWVAGVPVDWSALYPGRGRRRVPLptypfqREDAAAALLAAALAAALAAAAALGALLLAALAAA 903

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1520 TASASRCQLWPlnsgcgeLPQAAMLTPPQECESEVLDVDTCGPDGVTPLMSAVFCGGVQSTTGASPQRLGLGNLEPWEPL 1599
Cdd:COG3321   904 LAAALLALAAA-------AAAALALAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAA 976

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1600 LDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTE 1679
Cdd:COG3321   977 AAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAA 1056

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1680 DGTTPLMLAARLAVEDLVEELI-AARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1758
Cdd:COG3321  1057 AAAALALALAALLLLAALAELAlAAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAA 1136

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1759 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAAPRCRTLSAGARPRGGG 1838
Cdd:COG3321  1137 AAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAAL 1216

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1839 ACLQARTWSVDLGARGGKVYARCRSRSGSCGGPTTRGRRFSAGSRGRRGARASQDDWPRDWVALEACGSACSAPIPPPSL 1918
Cdd:COG3321  1217 AAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAA 1296

                         490
                  ....*....|....*
gi 148694863 1919 TPSPERGSPQVAWGL 1933
Cdd:COG3321  1297 ALAALLAAAAAAAAA 1311
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 2.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.68e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   968 CQSQPCHNHGTCTSRPGGFHCACPPGFVGLR 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1615-1787 3.38e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1615 ETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLaSRQTTVDARTEDGTTPLMLAARLAVE 1694
Cdd:PHA02874  125 KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL-EKGAYANVKDNNGESPLHNAAEYGDY 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1695 DLVEELIAARADVGARDKRGKTALHwaAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAR-EGAVEVAQLLLELGAAR 1773
Cdd:PHA02874  204 ACIKLLIDHGNHIMNKCKNGFTPLH--NAIIHNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281

                         170
                  ....*....|....
gi 148694863 1774 GLRDQAGLAPGDVA 1787
Cdd:PHA02874  282 SIKDNKGENPIDTA 295
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1000 3.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.78e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 148694863    966 DACQS-QPCHNHGTCTSRPGGFHCACPPGFV-GLRCE 1000
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
311-343 3.82e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 3.82e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 148694863   311 DIDECeARGPPRCRNGGTCQNTAGSFHCVCVSG 343
Cdd:pfam07645    1 DVDEC-ATGTHNCPANTVCVNTIGSFECRCPDG 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1700-1767 4.59e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 4.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148694863 1700 LIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLL 1767
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 930-960 5.32e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 5.32e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   930 CEPNPCHHGSTCVPQPSGYVCQCAPGYEGQN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-800 5.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 5.78e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 148694863    765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQ-GLHCE 800
Cdd:smart00179    2 IDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1002-1040 5.86e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148694863 1002 DVDECLDR-PCHPSGTaaCHSLANAFYCQCLPGHTGQRCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-622 6.07e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 6.07e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    586 EVDECLS-DPCPVGASCLDLPGAFFCLCRPGFT-GQLCE 622
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1633-1771 6.74e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1633 LLEAGANPNQPDRAGRTPLHTAvAADAREVCQLLLASRQTTVDARTEDGTTPLMLA---------------ARLAVEDLV 1697
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIA-ASKGYEDCVLVLLKHACNVHIRDANGNTALWNAisakhhkifrilyhfASISDPHAA 622

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148694863 1698 EELI---AARADVGArdkrgktalhwaaavnnaraARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGA 1771
Cdd:PLN03192  623 GDLLctaAKRNDLTA--------------------MKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
EGF_CA smart00179
Calcium-binding EGF-like domain;
472-508 7.31e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.31e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148694863    472 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GRLCE 508
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-723 7.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.42e-04
                          10        20
                  ....*....|....*....|....*...
gi 148694863  696 PCAHGGTCHPQPSGYNCTCPAGYMGLTC 723
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1614-1641 8.20e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 8.20e-04
                           10        20
                   ....*....|....*....|....*...
gi 148694863  1614 GETPLHLAARFSRPTAARRLLEAGANPN 1641
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
1733-1787 9.41e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 9.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 148694863  1733 LLQAG-ADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVA 1787
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 1.18e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 38.65  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 148694863  1291 PSLAL----LVVLRPPaldQQLLALA----RVLSLTLRVGLWVRKDSEGRNMVFPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDP---EELLNNSvqflRELSTVLRTNVRFKKDENGNPMIYPWYG 56
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
1621-1851 1.23e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 43.46  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1621 AARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEEL 1700
Cdd:COG0515   252 EERYQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAAAAAA 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1701 IAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAG 1780
Cdd:COG0515   332 AAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAAAAAAA 411

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148694863 1781 LAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAAPRCRTLSAGARPRGGGACLQARTWSVDLG 1851
Cdd:COG0515   412 AAAAAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAAAAAAAAAAAPLLAALLAAAALAAAAAAAALALA 482
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1591-1783 1.41e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1591 GNLEPWEPLLDRGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLaSR 1670
Cdd:PHA02874  135 GDLESIKMLFEYGADVNIEDD-NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI-DH 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1671 QTTVDARTEDGTTPL---MLAARLAVEDLVEEliaarADVGARDKRGKTALHWA-AAVNNARAARSLLQAGADKDAQDSR 1746
Cdd:PHA02874  213 GNHIMNKCKNGFTPLhnaIIHNRSAIELLINN-----ASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNK 287

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 148694863 1747 EQTPLFLAARegAVEVAQLLLELGAARGLRDQAGLAP 1783
Cdd:PHA02874  288 GENPIDTAFK--YINKDPVIKDIIANAVLIKEADKLK 322
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1680-1712 1.49e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 148694863  1680 DGTTPLMLAA-RLAVEDLVEELIAARADVGARDK 1712
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 440-468 1.64e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*....
gi 148694863  440 PSPCEHGGSCINTPGSFNCLCLPGYTGSR 468
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA pfam07645
Calcium-binding EGF domain;
429-463 1.75e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 148694863   429 DLDECQmaqQGPSPCEHGGSCINTPGSFNCLCLPG 463
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1685-1771 1.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148694863 1685 LMLAARLAVEDlVEELIAARADVGARDKRGKTALHWAAAVNNARAA---RSLLQAGADKDAQDSREQTPLFLAAREGAVE 1761
Cdd:PHA03095   19 LLNASNVTVEE-VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90
                  ....*....|.
gi 148694863 1762 -VAQLLLELGA 1771
Cdd:PHA03095   98 dVIKLLIKAGA 108
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 148694863  352 NLDDCAAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLC 387
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 514-544 1.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.93e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   514 CTSNPCLNQAACHDLLNGFQCLCLPGFTGAR 544
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-582 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148694863   552 CSSTPCANGGRCRDQPGAFHCECLPGFEGPH 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 440-468 2.37e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.37e-03
                           10        20
                   ....*....|....*....|....*....
gi 148694863   440 PSPCEHGGSCINTPGSFNCLCLPGYTGSR 468
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 969-998 2.38e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.38e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148694863  969 QSQPCHNHGTCTSRPGGFHCACPPGFVGLR 998
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
892-924 2.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 148694863    892 EISGLCQNGGLCIDTGSSYFCRCPPGFQ-GKLCQ 924
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
1716-1767 3.15e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 3.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148694863  1716 TALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLL 1767
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-839 3.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.44e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148694863  810 SPCRNKATCQDTPRGARCLCSPGYTGSSCQ 839
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1415 3.49e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 37.64  E-value: 3.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148694863  1375 AGFVVVMGVDLSRCGPEHpaSRCPWDSGLLLRFLAAMAAVG 1415
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKG 40
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 892-921 4.99e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 4.99e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148694863  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGK 921
Cdd:cd00053     3 AASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-381 6.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 6.84e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 148694863    352 NLDDCA-AATCAPGSTCIDRVGSFSCLCPPG 381
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 931-960 6.98e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 6.98e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148694863  931 EPNPCHHGSTCVPQPSGYVCQCAPGYEGQN 960
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-189 8.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.44e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148694863  158 SANPCANGGVCLATYPQIQCRCPPGFEGHTCE 189
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH