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Conserved domains on  [gi|307168143|gb|EFN61422|]
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Sodium channel protein para [Camponotus floridanus]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11999295)

sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1651-1901 2.11e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 202.11  E-value: 2.11e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1651 FDMIIMLFIGLNMLTMTLDHY-QQSETFSNVLDYLNMIFIVIFTSECLMKIFA--LRYHYFKEPWNLFDFVVVILSILGL 1727
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYfQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1728 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KD 1805
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1806 KSGLDDVYNFKTFGQSMILLFQMSTSAGWDGVLDGIINEEdcqepnneigypgncgSSTIGIAYLLSYLVISFLIVINMY 1885
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 307168143  1886 IAVILENYSQATEDVQ 1901
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1286-1601 2.90e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 190.17  E-value: 2.90e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1286 NKYFETAVITMILLSSLALALEDVHLQQRPvLQDILYYMDRIFTVIFFLEMLIKWLALGFSK-YFTNAWCWLDFIIVMLS 1364
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1365 LINLGAVWAGAadIPAFRSMRTLRALRPLRAVSRWEGMRVslinfvaslcgaggiqafktmrtlralrplramsrmqgmr 1444
Cdd:pfam00520   80 LISLVLSSVGS--LSGLRVLRLLRLLRLLRLIRRLEGLRT---------------------------------------- 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1445 vVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYYKCVDVNkttlsyeiipdrnacfaenytweNSPMNFDHVGK 1524
Cdd:pfam00520  118 -LVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPD-----------------------NGRTNFDNFPN 173
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 307168143  1525 AYLCLFQVATFKGWIQIMNDAIDSREasiidkqpiretNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1601
Cdd:pfam00520  174 AFLWLFQTMTTEGWGDIMYDTIDGKG------------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
796-1007 2.65e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 170.14  E-value: 2.65e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   796 DPFVELFITLCIVVNTLFMALDHHDMDKD-MERILKSGNYFFTATFAIEATMKLIAMSPKY-YFQEGWNIFDFIIVAL-- 871
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   872 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDNVh 950
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307168143   951 lfpDEEMPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLV-GDVSCIPFFLATVVIGN 1007
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGkGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
140-425 6.19e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 168.98  E-value: 6.19e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   140 HPLFSLFIITTILVNCILMIM--------PTTPTIESTEVIFTGIYTFESAVKVMARGFIlqpFTYLRDAWNWLDFVVIA 211
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   212 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 287
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   288 kciknfpedgswgnltaENWErfvsnetnwyvdeaknmplcgnssgagqclpgytclqgygdNPNYGYTSFDTFGWALLS 367
Cdd:pfam00520  156 -----------------KTWE-----------------------------------------NPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307168143   368 AFRLMTQDYWENLYQLVLRSAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK 425
Cdd:pfam00520  178 LFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
538-720 4.99e-34

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 432199  Cd Length: 163  Bit Score: 129.11  E-value: 4.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   538 ASLSLPGSPFNLRRSSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSE-ENGTIVVPVyy 616
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR------------------DAGSENDFADDENSTFEDSEsRRGSLFVPR-- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   617 anLGSRHSSYTSHASRLSyTSHGDLAFPGIR-------GIDSI---GKQLTKQE-QILRNRTNKQTTPANGHVTDtnqks 685
Cdd:pfam11933   59 --RHERRSSYQSQASRSS-RSHPGLPQNGKRhstvdcnGVVSLvggGPEPTSPGgLLLPEVIIDKAGTGDSTTTT----- 130
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 307168143   686 yhfETDLEDPMGKTKQQDNPFIE-PSQQHTVVDMKD 720
Cdd:pfam11933  131 ---EEELRKRRSSSYQLSMDYLEePFQRQRAVSAAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1033-1282 1.94e-32

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 428983  Cd Length: 195  Bit Score: 125.92  E-value: 1.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1033 DNDTNKIAEAIDRIARFINWIKRNILNI------------------AKLMRAKFTNQISDQApgegpsnsWKEDGIDRDG 1094
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFccrlclepqlpekkpldeSKDARSKLTNQIANHT--------KKAPGGGGKY 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1095 DLDLADGELdayrdkksaKELNQLEVA--IGEGmeftihgdlknklknklcmnntkviansinhhdyrlDNDYINQNEDD 1172
Cdd:pfam06512   73 ELDEGHMDF---------ITNPNLTVCvpIAEG------------------------------------ESDLENEEDDD 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1173 TISNKSYgshknrafkDESHKGSMDSLNGEekkDASKEDLEqegedledegeegeevdIDIIQAEEDPIQ-------DNY 1245
Cdd:pfam06512  108 ESSQSSD---------EEKSKQQEQLEDDD---SSSSEGST-----------------VDLQDPEEELEKipeeaeeLKE 158
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 307168143  1246 PSDCCPENCYKKFPFLAGDDDAPFWQGWANLRLKTFR 1282
Cdd:pfam06512  159 PEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1591-1643 1.03e-27

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 106.88  E-value: 1.03e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 307168143 1591 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGNKKPLKAIPRPRWRPQGIVF 1643
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1912-1959 8.77e-06

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 435642  Cd Length: 54  Bit Score: 44.58  E-value: 8.77e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 307168143  1912 YYEIWQQFDPDGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IVSMDIP 1959
Cdd:pfam16905    2 FVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1651-1901 2.11e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 202.11  E-value: 2.11e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1651 FDMIIMLFIGLNMLTMTLDHY-QQSETFSNVLDYLNMIFIVIFTSECLMKIFA--LRYHYFKEPWNLFDFVVVILSILGL 1727
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYfQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1728 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KD 1805
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1806 KSGLDDVYNFKTFGQSMILLFQMSTSAGWDGVLDGIINEEdcqepnneigypgncgSSTIGIAYLLSYLVISFLIVINMY 1885
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 307168143  1886 IAVILENYSQATEDVQ 1901
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1286-1601 2.90e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 190.17  E-value: 2.90e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1286 NKYFETAVITMILLSSLALALEDVHLQQRPvLQDILYYMDRIFTVIFFLEMLIKWLALGFSK-YFTNAWCWLDFIIVMLS 1364
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1365 LINLGAVWAGAadIPAFRSMRTLRALRPLRAVSRWEGMRVslinfvaslcgaggiqafktmrtlralrplramsrmqgmr 1444
Cdd:pfam00520   80 LISLVLSSVGS--LSGLRVLRLLRLLRLLRLIRRLEGLRT---------------------------------------- 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1445 vVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYYKCVDVNkttlsyeiipdrnacfaenytweNSPMNFDHVGK 1524
Cdd:pfam00520  118 -LVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPD-----------------------NGRTNFDNFPN 173
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 307168143  1525 AYLCLFQVATFKGWIQIMNDAIDSREasiidkqpiretNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1601
Cdd:pfam00520  174 AFLWLFQTMTTEGWGDIMYDTIDGKG------------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
796-1007 2.65e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 170.14  E-value: 2.65e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   796 DPFVELFITLCIVVNTLFMALDHHDMDKD-MERILKSGNYFFTATFAIEATMKLIAMSPKY-YFQEGWNIFDFIIVAL-- 871
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   872 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDNVh 950
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307168143   951 lfpDEEMPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLV-GDVSCIPFFLATVVIGN 1007
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGkGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
140-425 6.19e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 168.98  E-value: 6.19e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   140 HPLFSLFIITTILVNCILMIM--------PTTPTIESTEVIFTGIYTFESAVKVMARGFIlqpFTYLRDAWNWLDFVVIA 211
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   212 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 287
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   288 kciknfpedgswgnltaENWErfvsnetnwyvdeaknmplcgnssgagqclpgytclqgygdNPNYGYTSFDTFGWALLS 367
Cdd:pfam00520  156 -----------------KTWE-----------------------------------------NPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307168143   368 AFRLMTQDYWENLYQLVLRSAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK 425
Cdd:pfam00520  178 LFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
538-720 4.99e-34

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 432199  Cd Length: 163  Bit Score: 129.11  E-value: 4.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   538 ASLSLPGSPFNLRRSSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSE-ENGTIVVPVyy 616
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR------------------DAGSENDFADDENSTFEDSEsRRGSLFVPR-- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   617 anLGSRHSSYTSHASRLSyTSHGDLAFPGIR-------GIDSI---GKQLTKQE-QILRNRTNKQTTPANGHVTDtnqks 685
Cdd:pfam11933   59 --RHERRSSYQSQASRSS-RSHPGLPQNGKRhstvdcnGVVSLvggGPEPTSPGgLLLPEVIIDKAGTGDSTTTT----- 130
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 307168143   686 yhfETDLEDPMGKTKQQDNPFIE-PSQQHTVVDMKD 720
Cdd:pfam11933  131 ---EEELRKRRSSSYQLSMDYLEePFQRQRAVSAAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1033-1282 1.94e-32

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 125.92  E-value: 1.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1033 DNDTNKIAEAIDRIARFINWIKRNILNI------------------AKLMRAKFTNQISDQApgegpsnsWKEDGIDRDG 1094
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFccrlclepqlpekkpldeSKDARSKLTNQIANHT--------KKAPGGGGKY 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1095 DLDLADGELdayrdkksaKELNQLEVA--IGEGmeftihgdlknklknklcmnntkviansinhhdyrlDNDYINQNEDD 1172
Cdd:pfam06512   73 ELDEGHMDF---------ITNPNLTVCvpIAEG------------------------------------ESDLENEEDDD 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1173 TISNKSYgshknrafkDESHKGSMDSLNGEekkDASKEDLEqegedledegeegeevdIDIIQAEEDPIQ-------DNY 1245
Cdd:pfam06512  108 ESSQSSD---------EEKSKQQEQLEDDD---SSSSEGST-----------------VDLQDPEEELEKipeeaeeLKE 158
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 307168143  1246 PSDCCPENCYKKFPFLAGDDDAPFWQGWANLRLKTFR 1282
Cdd:pfam06512  159 PEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1591-1643 1.03e-27

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 106.88  E-value: 1.03e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 307168143 1591 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGNKKPLKAIPRPRWRPQGIVF 1643
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1912-1959 8.77e-06

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 435642  Cd Length: 54  Bit Score: 44.58  E-value: 8.77e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 307168143  1912 YYEIWQQFDPDGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IVSMDIP 1959
Cdd:pfam16905    2 FVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1651-1901 2.11e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 202.11  E-value: 2.11e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1651 FDMIIMLFIGLNMLTMTLDHY-QQSETFSNVLDYLNMIFIVIFTSECLMKIFA--LRYHYFKEPWNLFDFVVVILSILGL 1727
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYfQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1728 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KD 1805
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1806 KSGLDDVYNFKTFGQSMILLFQMSTSAGWDGVLDGIINEEdcqepnneigypgncgSSTIGIAYLLSYLVISFLIVINMY 1885
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 307168143  1886 IAVILENYSQATEDVQ 1901
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1286-1601 2.90e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 190.17  E-value: 2.90e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1286 NKYFETAVITMILLSSLALALEDVHLQQRPvLQDILYYMDRIFTVIFFLEMLIKWLALGFSK-YFTNAWCWLDFIIVMLS 1364
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1365 LINLGAVWAGAadIPAFRSMRTLRALRPLRAVSRWEGMRVslinfvaslcgaggiqafktmrtlralrplramsrmqgmr 1444
Cdd:pfam00520   80 LISLVLSSVGS--LSGLRVLRLLRLLRLLRLIRRLEGLRT---------------------------------------- 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1445 vVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYYKCVDVNkttlsyeiipdrnacfaenytweNSPMNFDHVGK 1524
Cdd:pfam00520  118 -LVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPD-----------------------NGRTNFDNFPN 173
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 307168143  1525 AYLCLFQVATFKGWIQIMNDAIDSREasiidkqpiretNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1601
Cdd:pfam00520  174 AFLWLFQTMTTEGWGDIMYDTIDGKG------------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
796-1007 2.65e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 170.14  E-value: 2.65e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   796 DPFVELFITLCIVVNTLFMALDHHDMDKD-MERILKSGNYFFTATFAIEATMKLIAMSPKY-YFQEGWNIFDFIIVAL-- 871
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   872 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDNVh 950
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307168143   951 lfpDEEMPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMLV-GDVSCIPFFLATVVIGN 1007
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGkGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
140-425 6.19e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 168.98  E-value: 6.19e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   140 HPLFSLFIITTILVNCILMIM--------PTTPTIESTEVIFTGIYTFESAVKVMARGFIlqpFTYLRDAWNWLDFVVIA 211
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   212 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 287
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   288 kciknfpedgswgnltaENWErfvsnetnwyvdeaknmplcgnssgagqclpgytclqgygdNPNYGYTSFDTFGWALLS 367
Cdd:pfam00520  156 -----------------KTWE-----------------------------------------NPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 307168143   368 AFRLMTQDYWENLYQLVLRSAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK 425
Cdd:pfam00520  178 LFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
538-720 4.99e-34

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 432199  Cd Length: 163  Bit Score: 129.11  E-value: 4.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   538 ASLSLPGSPFNLRRSSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSE-ENGTIVVPVyy 616
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR------------------DAGSENDFADDENSTFEDSEsRRGSLFVPR-- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   617 anLGSRHSSYTSHASRLSyTSHGDLAFPGIR-------GIDSI---GKQLTKQE-QILRNRTNKQTTPANGHVTDtnqks 685
Cdd:pfam11933   59 --RHERRSSYQSQASRSS-RSHPGLPQNGKRhstvdcnGVVSLvggGPEPTSPGgLLLPEVIIDKAGTGDSTTTT----- 130
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 307168143   686 yhfETDLEDPMGKTKQQDNPFIE-PSQQHTVVDMKD 720
Cdd:pfam11933  131 ---EEELRKRRSSSYQLSMDYLEePFQRQRAVSAAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1033-1282 1.94e-32

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 125.92  E-value: 1.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1033 DNDTNKIAEAIDRIARFINWIKRNILNI------------------AKLMRAKFTNQISDQApgegpsnsWKEDGIDRDG 1094
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFccrlclepqlpekkpldeSKDARSKLTNQIANHT--------KKAPGGGGKY 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1095 DLDLADGELdayrdkksaKELNQLEVA--IGEGmeftihgdlknklknklcmnntkviansinhhdyrlDNDYINQNEDD 1172
Cdd:pfam06512   73 ELDEGHMDF---------ITNPNLTVCvpIAEG------------------------------------ESDLENEEDDD 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1173 TISNKSYgshknrafkDESHKGSMDSLNGEekkDASKEDLEqegedledegeegeevdIDIIQAEEDPIQ-------DNY 1245
Cdd:pfam06512  108 ESSQSSD---------EEKSKQQEQLEDDD---SSSSEGST-----------------VDLQDPEEELEKipeeaeeLKE 158
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 307168143  1246 PSDCCPENCYKKFPFLAGDDDAPFWQGWANLRLKTFR 1282
Cdd:pfam06512  159 PEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1591-1643 1.03e-27

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 106.88  E-value: 1.03e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 307168143 1591 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGNKKPLKAIPRPRWRPQGIVF 1643
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1687-1894 6.79e-11

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 66.60  E-value: 6.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1687 IFIVIFTSECLMKIFALRYHYFKEPWNLFDFVVVILSILGLVLSdiIEKYFVSPTLLRVV-----------RVAKVGRVL 1755
Cdd:pfam08016  218 VFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLVDRLIKSVeaspvtfidfdRVAQLDNLY 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143  1756 RLVKG----------------AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFmhvkdKSGLDdvyNFKTFG 1819
Cdd:pfam08016  296 RIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLF-----GTQAP---NFSNFV 367
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 307168143  1820 QSMILLFQMSTSAgwdgvldgiineedcqEPNNEIGYpgncGSSTIGIAYLLSYLVISFLIVINMYIAVILENYS 1894
Cdd:pfam08016  368 KSILTLFRTILGD----------------FGYNEIFS----GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 422
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1912-1959 8.77e-06

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 435642  Cd Length: 54  Bit Score: 44.58  E-value: 8.77e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 307168143  1912 YYEIWQQFDPDGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IVSMDIP 1959
Cdd:pfam16905    2 FVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
884-978 4.20e-04

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 45.03  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307168143   884 LSVLRSFRLLRVFKlakswpTLNLLISIMGRTVGALGNLTFVLCIIIFIFAVMGMQLFGKNYvdnvhlfpdeemprWNFT 963
Cdd:pfam08016  305 LTWLKLFKVLRFNK------TMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA--------------PNFS 364
                           90
                   ....*....|....*
gi 307168143   964 DFMHSFMIVFRVLCG 978
Cdd:pfam08016  365 NFVKSILTLFRTILG 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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