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Conserved domains on  [gi|339475362|gb|EGP90454|]
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hypothetical protein MYCGRDRAFT_84691 [Zymoseptoria tritici IPO323]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 541-629 2.16e-31

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


:

Pssm-ID: 211321  Cd Length: 85  Bit Score: 116.89  E-value: 2.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 541 KIHITLETRSGNKTVTKVSGLEAYHINARPLADELRKTCAGSTSVEPLAGASKknereVMEVMVQGPQKDTVLKAL-ERR 619
Cdd:cd11608    1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKK-----GVEVQVQGNQVKFVAKLLtEKY 75

                         90
                 ....*....|
gi 339475362 620 GVDKRWVEVL 629
Cdd:cd11608   76 GVPKKYIDGL 85
PUA_eIF2d-like cd21156
PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; ...
 120-202 1.77e-19

PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Most members of this eukaryotic translation initiation factor 2D (eIF2d)-like family of eukaryotic proteins also contain a domain homologous to the translation initiation factor eIF1/SUI1, and a short uncharacterized N-terminal domain. eIF2D may function as a cytosolic GTP-independent initiation factor which delivers Met-tRNA (and non-initiating tRNAs) to the 40S ribosomal subunit. The family member from Drosophila melanogaster has been named ligatin, and this alias has been adopted for other family members as well, which are not homologous to the vertebrate ligatin (LGTN) that is a trafficking receptor for phosphoglycoproteins.


:

Pssm-ID: 409298 [Multi-domain]  Cd Length: 82  Bit Score: 83.00  E-value: 1.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 120 VPLVHTHEFVMQKLQGGADLMTPGLAAGPPFPPKAKKDTIVAIASTDRPtVPMAMGFCAIDvcALDKV-QGAKGHAVENM 198
Cdd:cd21156    2 LPVFTTHPPVSEKLLGGADLMLPGVIVPPPGLPPFEKGSLVAVAVLGNP-APVAVGRAAMS--SEDMYaSGMKGKGVEVL 78


                 ....
gi 339475362 199 HWVG 202
Cdd:cd21156   79 HTYG 82
Pre-PUA super family cl38935
Pre-PUA-like domain; This Pre-PUA-like domain is found in a wide variety of proteins including ...
 2-117 1.22e-11

Pre-PUA-like domain; This Pre-PUA-like domain is found in a wide variety of proteins including the eukaryotic translation initiation factor 2D, where it is found at the N-terminus.


The actual alignment was detected with superfamily member pfam17832:

Pssm-ID: 436077  Cd Length: 86  Bit Score: 61.05  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362    2 FKKKPTIKPLANLKSSDRRKLADQIIQDYELDLQQADDsqtpeqkaeataarttlrntLLPANTQSCRFLTTYGpdlrqa 81
Cdd:pfam17832   1 FKKPFKVKSNTQLKSSDRRKLRAKLLEQFPSLEEQLDE--------------------LLPKKEEVIVIKLHTE------ 54

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 339475362   82 SGTLYVgsqdeHEARVLWFQ-IEGRIYPSIYTLWRNP 117
Cdd:pfam17832  55 HVSLYS-----VDGEPLFFQvRDGPLYPTLYLLWKYP 86
 
Name Accession Description Interval E-value
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 541-629 2.16e-31

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 116.89  E-value: 2.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 541 KIHITLETRSGNKTVTKVSGLEAYHINARPLADELRKTCAGSTSVEPLAGASKknereVMEVMVQGPQKDTVLKAL-ERR 619
Cdd:cd11608    1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKK-----GVEVQVQGNQVKFVAKLLtEKY 75

                         90
                 ....*....|
gi 339475362 620 GVDKRWVEVL 629
Cdd:cd11608   76 GVPKKYIDGL 85
SUI1 pfam01253
Translation initiation factor SUI1;
539-621 6.30e-23

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 92.50  E-value: 6.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362  539 PPKIHITLETRSGNKTVTKVSGLEAYHINARPLADELRKTCAGSTSVEplagaskKNEREvMEVMVQGPQKDTVLKALER 618
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVV-------KDGGG-EEIQVQGDQRDKVAELLTE 72


                  ...
gi 339475362  619 RGV 621
Cdd:pfam01253  73 KGI 75
PUA_eIF2d-like cd21156
PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; ...
 120-202 1.77e-19

PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Most members of this eukaryotic translation initiation factor 2D (eIF2d)-like family of eukaryotic proteins also contain a domain homologous to the translation initiation factor eIF1/SUI1, and a short uncharacterized N-terminal domain. eIF2D may function as a cytosolic GTP-independent initiation factor which delivers Met-tRNA (and non-initiating tRNAs) to the 40S ribosomal subunit. The family member from Drosophila melanogaster has been named ligatin, and this alias has been adopted for other family members as well, which are not homologous to the vertebrate ligatin (LGTN) that is a trafficking receptor for phosphoglycoproteins.


Pssm-ID: 409298 [Multi-domain]  Cd Length: 82  Bit Score: 83.00  E-value: 1.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 120 VPLVHTHEFVMQKLQGGADLMTPGLAAGPPFPPKAKKDTIVAIASTDRPtVPMAMGFCAIDvcALDKV-QGAKGHAVENM 198
Cdd:cd21156    2 LPVFTTHPPVSEKLLGGADLMLPGVIVPPPGLPPFEKGSLVAVAVLGNP-APVAVGRAAMS--SEDMYaSGMKGKGVEVL 78


                 ....
gi 339475362 199 HWVG 202
Cdd:cd21156   79 HTYG 82
Pre-PUA pfam17832
Pre-PUA-like domain; This Pre-PUA-like domain is found in a wide variety of proteins including ...
 2-117 1.22e-11

Pre-PUA-like domain; This Pre-PUA-like domain is found in a wide variety of proteins including the eukaryotic translation initiation factor 2D, where it is found at the N-terminus.


Pssm-ID: 436077  Cd Length: 86  Bit Score: 61.05  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362    2 FKKKPTIKPLANLKSSDRRKLADQIIQDYELDLQQADDsqtpeqkaeataarttlrntLLPANTQSCRFLTTYGpdlrqa 81
Cdd:pfam17832   1 FKKPFKVKSNTQLKSSDRRKLRAKLLEQFPSLEEQLDE--------------------LLPKKEEVIVIKLHTE------ 54

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 339475362   82 SGTLYVgsqdeHEARVLWFQ-IEGRIYPSIYTLWRNP 117
Cdd:pfam17832  55 HVSLYS-----VDGEPLFFQvRDGPLYPTLYLLWKYP 86
Tma20 COG2016
Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ...
 100-206 3.98e-08

Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441619 [Multi-domain]  Cd Length: 154  Bit Score: 52.86  E-value: 3.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 100 FQIEGRIYPSIYTLWRNPNVVPLVHTHE----FVMqklqGGADLMTPG-LAAGPPFppkaKKDTIVAIA--STDRPtvpM 172
Cdd:COG2016   53 FKVDDEPFPTLRGLLKYPPEKPVVTVDMgavkFVS----NGADVMRPGiVEADGEI----KEGDIVVIVeeKHGKP---L 121

                         90       100       110
                 ....*....|....*....|....*....|....
gi 339475362 173 AMGFCAIDvcALDKVQGAKGHAVENMHWVGDELW 206
Cdd:COG2016  122 AVGRALVD--GEEMVEGKKGKAVKNLHHVGDKLW 153
unchar_dom_2 TIGR00451
uncharacterized domain 2; This uncharacterized domain is found a number of enzymes and ...
 97-203 1.89e-07

uncharacterized domain 2; This uncharacterized domain is found a number of enzymes and uncharacterized proteins, often at the C-terminus. It is found in some but not all members of a family of related tRNA-guanine transglycosylases (tgt), which exchange a guanine base for some modified base without breaking the phosphodiester backbone of the tRNA. It is also found in rRNA pseudouridine synthase, another enzyme of RNA base modification not otherwise homologous to tgt. It is found, again at the C-terminus, in two putative glutamate 5-kinases. It is also found in a family of small, uncharacterized archaeal proteins consisting mostly of this domain.


Pssm-ID: 129543 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362   97 VLWFQIEGRIYPSIYTLWRNPNVVPLVHTHEFVMQKLQGGADLMTPGLA-AGPPFPpkaKKDTIVAIASTDRPtvPMAMG 175
Cdd:TIGR00451   7 PLYFIYDDKVIPSLKGALKLMEDKKIVVVDNGAVKFLKNGADVMRPGIVdADEDIK---EGDDVVVVDENKDR--PLAVG 81

                          90       100
                  ....*....|....*....|....*...
gi 339475362  176 FCAIDvcALDKVQGAKGHAVENMHWVGD 203
Cdd:TIGR00451  82 IALMS--GEEMKEMDKGKAVKNIHHIGD 107
PRK14560 PRK14560
putative RNA-binding protein; Provisional
 73-210 8.55e-07

putative RNA-binding protein; Provisional


Pssm-ID: 237757 [Multi-domain]  Cd Length: 160  Bit Score: 49.08  E-value: 8.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362  73 TYGPDLRQASGTLYVGSQDEHEA-----RVLWFQIEGRIYPSIYTLWRNPNVVPLVHTHEFVMQKLQGGADLMTPG-LAA 146
Cdd:PRK14560  24 KFGVDIDGKDAVEEVETDKKEEIylvdgEPLFFKVDDELFPTLRGALKLKPEKRRVVVDAGAVKFVSNGADVMAPGiVEA 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339475362 147 GPPFppkaKKDTIVAIAsTDRPTVPMAMGFCAIDvcALDKVQGAKGHAVENMHWVGDELWSYSV 210
Cdd:PRK14560 104 DEDI----KEGDIVFVV-EETHGKPLAVGRALMD--GDEMVEEKKGKAVKNIHHVGDEIWEFEV 160
 
Name Accession Description Interval E-value
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 541-629 2.16e-31

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 116.89  E-value: 2.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 541 KIHITLETRSGNKTVTKVSGLEAYHINARPLADELRKTCAGSTSVEPLAGASKknereVMEVMVQGPQKDTVLKAL-ERR 619
Cdd:cd11608    1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSPLPGKKK-----GVEVQVQGNQVKFVAKLLtEKY 75

                         90
                 ....*....|
gi 339475362 620 GVDKRWVEVL 629
Cdd:cd11608   76 GVPKKYIDGL 85
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 541-629 3.10e-26

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 102.12  E-value: 3.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 541 KIHITLETRSGNKTVTKVSGLEAYhINARPLADELRKTCAGSTSVEPlagaskknerEVMEVMVQGPQKDTVLKALERRG 620
Cdd:cd00474    1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVEG----------EKMEIEIQGDHTDQIIVALEEKG 69


                 ....*....
gi 339475362 621 VDKRWVEVL 629
Cdd:cd00474   70 IDKDWVELL 78
SUI1 pfam01253
Translation initiation factor SUI1;
539-621 6.30e-23

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 92.50  E-value: 6.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362  539 PPKIHITLETRSGNKTVTKVSGLEAYHINARPLADELRKTCAGSTSVEplagaskKNEREvMEVMVQGPQKDTVLKALER 618
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVV-------KDGGG-EEIQVQGDQRDKVAELLTE 72


                  ...
gi 339475362  619 RGV 621
Cdd:pfam01253  73 KGI 75
PUA_eIF2d-like cd21156
PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; ...
 120-202 1.77e-19

PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Most members of this eukaryotic translation initiation factor 2D (eIF2d)-like family of eukaryotic proteins also contain a domain homologous to the translation initiation factor eIF1/SUI1, and a short uncharacterized N-terminal domain. eIF2D may function as a cytosolic GTP-independent initiation factor which delivers Met-tRNA (and non-initiating tRNAs) to the 40S ribosomal subunit. The family member from Drosophila melanogaster has been named ligatin, and this alias has been adopted for other family members as well, which are not homologous to the vertebrate ligatin (LGTN) that is a trafficking receptor for phosphoglycoproteins.


Pssm-ID: 409298 [Multi-domain]  Cd Length: 82  Bit Score: 83.00  E-value: 1.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 120 VPLVHTHEFVMQKLQGGADLMTPGLAAGPPFPPKAKKDTIVAIASTDRPtVPMAMGFCAIDvcALDKV-QGAKGHAVENM 198
Cdd:cd21156    2 LPVFTTHPPVSEKLLGGADLMLPGVIVPPPGLPPFEKGSLVAVAVLGNP-APVAVGRAAMS--SEDMYaSGMKGKGVEVL 78


                 ....
gi 339475362 199 HWVG 202
Cdd:cd21156   79 HTYG 82
Pre-PUA pfam17832
Pre-PUA-like domain; This Pre-PUA-like domain is found in a wide variety of proteins including ...
 2-117 1.22e-11

Pre-PUA-like domain; This Pre-PUA-like domain is found in a wide variety of proteins including the eukaryotic translation initiation factor 2D, where it is found at the N-terminus.


Pssm-ID: 436077  Cd Length: 86  Bit Score: 61.05  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362    2 FKKKPTIKPLANLKSSDRRKLADQIIQDYELDLQQADDsqtpeqkaeataarttlrntLLPANTQSCRFLTTYGpdlrqa 81
Cdd:pfam17832   1 FKKPFKVKSNTQLKSSDRRKLRAKLLEQFPSLEEQLDE--------------------LLPKKEEVIVIKLHTE------ 54

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 339475362   82 SGTLYVgsqdeHEARVLWFQ-IEGRIYPSIYTLWRNP 117
Cdd:pfam17832  55 HVSLYS-----VDGEPLFFQvRDGPLYPTLYLLWKYP 86
PUA_MCTS-1-like cd21155
PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins; The ...
 122-206 5.85e-11

PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins; The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Members of this eukaryotic family, labelled MCT-1 (malignant T cell-amplified sequence 1) or MCTS-1 (multiple copies T-cell lymphoma-1), contain a single PUA domain. They may play roles in the regulation of the cell cycle; human MCT-1 has been characterized for its oncogenic potential. MCT-1/MCTS1 expression is a new poor-prognosis marker in patients with aggressive breast cancers, and thus the MCT-1 pathway is a novel and promising therapeutic target for triple-negative breast cancer (TNBC).


Pssm-ID: 409297  Cd Length: 97  Bit Score: 59.42  E-value: 5.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 122 LVHTHEFVMQKLQ----------GGADLMTPGL-AAGPPFPPKAKKDTIVAIastdrptvpMAMG---FCAIDVCAL--D 185
Cdd:cd21155    5 LLHKYPFMLPKVQvdkgaikfvlSGANIMCPGLtSPGGKLPDDVEKGTVVAI---------MAEGkehALAIGITKMssE 75

                         90       100
                 ....*....|....*....|..
gi 339475362 186 KVQGA-KGHAVENMHWVGDELW 206
Cdd:cd21155   76 DIKKVnKGIGIENIHYLGDGLW 97
Tma20 COG2016
Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ...
 100-206 3.98e-08

Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441619 [Multi-domain]  Cd Length: 154  Bit Score: 52.86  E-value: 3.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 100 FQIEGRIYPSIYTLWRNPNVVPLVHTHE----FVMqklqGGADLMTPG-LAAGPPFppkaKKDTIVAIA--STDRPtvpM 172
Cdd:COG2016   53 FKVDDEPFPTLRGLLKYPPEKPVVTVDMgavkFVS----NGADVMRPGiVEADGEI----KEGDIVVIVeeKHGKP---L 121

                         90       100       110
                 ....*....|....*....|....*....|....
gi 339475362 173 AMGFCAIDvcALDKVQGAKGHAVENMHWVGDELW 206
Cdd:COG2016  122 AVGRALVD--GEEMVEGKKGKAVKNLHHVGDKLW 153
unchar_dom_2 TIGR00451
uncharacterized domain 2; This uncharacterized domain is found a number of enzymes and ...
 97-203 1.89e-07

uncharacterized domain 2; This uncharacterized domain is found a number of enzymes and uncharacterized proteins, often at the C-terminus. It is found in some but not all members of a family of related tRNA-guanine transglycosylases (tgt), which exchange a guanine base for some modified base without breaking the phosphodiester backbone of the tRNA. It is also found in rRNA pseudouridine synthase, another enzyme of RNA base modification not otherwise homologous to tgt. It is found, again at the C-terminus, in two putative glutamate 5-kinases. It is also found in a family of small, uncharacterized archaeal proteins consisting mostly of this domain.


Pssm-ID: 129543 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362   97 VLWFQIEGRIYPSIYTLWRNPNVVPLVHTHEFVMQKLQGGADLMTPGLA-AGPPFPpkaKKDTIVAIASTDRPtvPMAMG 175
Cdd:TIGR00451   7 PLYFIYDDKVIPSLKGALKLMEDKKIVVVDNGAVKFLKNGADVMRPGIVdADEDIK---EGDDVVVVDENKDR--PLAVG 81

                          90       100
                  ....*....|....*....|....*...
gi 339475362  176 FCAIDvcALDKVQGAKGHAVENMHWVGD 203
Cdd:TIGR00451  82 IALMS--GEEMKEMDKGKAVKNIHHIGD 107
arCOG00985 TIGR03684
arCOG04150 universal archaeal PUA-domain protein; This universal archaeal protein contains a ...
 96-206 3.48e-07

arCOG04150 universal archaeal PUA-domain protein; This universal archaeal protein contains a domain possibly associated with RNA binding (pfam01472, TIGR00451).


Pssm-ID: 274723 [Multi-domain]  Cd Length: 150  Bit Score: 49.91  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362   96 RVLWFQIEGRIYPSIYTLWRNPNVVPLVHTHEFVMQKLQGGADLMTPG-LAAGPPFppkAKKDTIVAIASTDRptVPMAM 174
Cdd:TIGR03684  45 KPLLFEVDGRLFPTLYGLLELNPDKNVVVVDEGAVKFIINGADIMAPGiVEADPSI---KEGDIVFVVDETHG--KPLAV 119

                          90       100       110
                  ....*....|....*....|....*....|..
gi 339475362  175 GFCAIDvcALDKVQGAKGHAVENMHWVGDELW 206
Cdd:TIGR03684 120 GIALMD--AEEMVEEKKGKAVKNIHHVGDKIW 149
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 541-621 7.80e-07

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 47.09  E-value: 7.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362 541 KIHITLETRS-GNKTVTKVSGLEAYHINARPLADELRKTCAgstsveplAGASKKNErevmEVMVQGPQKDTVLKALERR 619
Cdd:cd11567    2 KVRVRLEKRGrGGKTVTVIEGLPLSEEDLKELAKELKKKCG--------CGGTVKDG----EIELQGDHREKIKELLEKK 69


                 ..
gi 339475362 620 GV 621
Cdd:cd11567   70 GF 71
PRK14560 PRK14560
putative RNA-binding protein; Provisional
 73-210 8.55e-07

putative RNA-binding protein; Provisional


Pssm-ID: 237757 [Multi-domain]  Cd Length: 160  Bit Score: 49.08  E-value: 8.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339475362  73 TYGPDLRQASGTLYVGSQDEHEA-----RVLWFQIEGRIYPSIYTLWRNPNVVPLVHTHEFVMQKLQGGADLMTPG-LAA 146
Cdd:PRK14560  24 KFGVDIDGKDAVEEVETDKKEEIylvdgEPLFFKVDDELFPTLRGALKLKPEKRRVVVDAGAVKFVSNGADVMAPGiVEA 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339475362 147 GPPFppkaKKDTIVAIAsTDRPTVPMAMGFCAIDvcALDKVQGAKGHAVENMHWVGDELWSYSV 210
Cdd:PRK14560 104 DEDI----KEGDIVFVV-EETHGKPLAVGRALMD--GDEMVEEKKGKAVKNIHHVGDEIWEFEV 160
PUA_MJ1432-like cd21154
PUA RNA-binding domain of MJ1432, TA1423, PH0734, and similar proteins; The RNA-binding PUA ...
 136-208 9.84e-06

PUA RNA-binding domain of MJ1432, TA1423, PH0734, and similar proteins; The RNA-binding PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was detected in a number of proteins involved in RNA metabolism. Members of this mostly archaeal family have not been characterized functionally; they may bind to RNA. This family includes Pyrococcus horikoshii PH0734 where the N-terminal domain may modulate the binding target of the C-terminal PUA domain using its characteristic electropositive surface.


Pssm-ID: 409296 [Multi-domain]  Cd Length: 84  Bit Score: 44.03  E-value: 9.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 339475362 136 GADLMTPGLAAgppFPPKAKKDTIVAIAsTDRPTVPMAMGFCAIDvcALDKVQGAKGHAVENMHWVGDELWSY 208
Cdd:cd21154   18 GADVMRPGIVE---ADEEIKKGDIVVVV-DERHGKPLAVGIALMS--GEEMVEMKKGKAVKNLHYVGDKIWKL 84
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 540-606 2.81e-05

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 42.93  E-value: 2.81e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 339475362 540 PKIHITLETRSGNKTVTKVSGLEAYHINARPLADELRKTCAGSTSVeplagasKKNEREVMEVMVQG 606
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASV-------TKGAEGKDEIVIQG 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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