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Conserved domains on  [gi|444724463|gb|ELW65066|]
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Peptidyl-prolyl cis-trans isomerase FKBP2 [Tupaia chinensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
279-371 2.50e-50

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 163.91  E-value: 2.50e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  279 CPIKSRKGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERG-APPK 357
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 444724463  358 IPGGATLVFEVELL 371
Cdd:pfam00254  81 IPPNATLVFEVELL 94
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 101-182 1.26e-36

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 127.92  E-value: 1.26e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463   101 ATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQ-LGEMSLEEHSQCE 179
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQhLVEVSFEEHTKCE 80


                   ...
gi 444724463   180 CRP 182
Cdd:smart00141  81 CRP 83
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
279-371 2.50e-50

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 163.91  E-value: 2.50e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  279 CPIKSRKGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERG-APPK 357
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 444724463  358 IPGGATLVFEVELL 371
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 285-373 7.08e-48

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 157.65  E-value: 7.08e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 285 KGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATL 364
Cdd:COG0545   16 AGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNSTL 95


                 ....*....
gi 444724463 365 VFEVELLKI 373
Cdd:COG0545   96 VFEVELLDV 104
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 101-182 1.26e-36

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 127.92  E-value: 1.26e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463   101 ATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQ-LGEMSLEEHSQCE 179
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQhLVEVSFEEHTKCE 80


                   ...
gi 444724463   180 CRP 182
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 101-183 1.91e-32

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 117.09  E-value: 1.91e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 101 ATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRY---PSSQLGEMSLEEHSQ 177
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPkrkPRSKLVEISFEEHTE 80


                 ....*.
gi 444724463 178 CECRPK 183
Cdd:cd00135   81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
103-180 3.04e-28

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 105.45  E-value: 3.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  103 CQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRY----PSSQLGEMSLEEHSQC 178
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYaprrPSPELVEVSFEEHVQC 80


                  ..
gi 444724463  179 EC 180
Cdd:pfam00341  81 EC 82
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 268-373 1.82e-23

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 96.79  E-value: 1.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 268 LQIGVKKRVDHcPIKSRKgDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTgqVIKGWDQGLLGMCEGEKRKLVIPSEL 347
Cdd:PRK11570 104 LQFRVLTQGEG-AIPART-DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHEL 179

                         90       100
                 ....*....|....*....|....*.
gi 444724463 348 GYGERGAPPKIPGGATLVFEVELLKI 373
Cdd:PRK11570 180 AYGERGAGASIPPFSTLVFEVELLEI 205
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 76-185 6.45e-23

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 93.53  E-value: 6.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  76 QASVTQTDAPghqKKVVSWIDVYARATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRM 155
Cdd:PHA02661  24 FSGSTGSSSA---SSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTV 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 444724463 156 QILMIRY-----PSSQLGEMSLEEHSQCECRPKQA 185
Cdd:PHA02661 101 TVMLTSVsgstgATSNFQTISVEEHTKCKCEFKTT 135
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
279-371 2.50e-50

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 163.91  E-value: 2.50e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  279 CPIKSRKGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERG-APPK 357
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGlAGPV 80

                          90
                  ....*....|....
gi 444724463  358 IPGGATLVFEVELL 371
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 285-373 7.08e-48

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 157.65  E-value: 7.08e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 285 KGDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGAPPKIPGGATL 364
Cdd:COG0545   16 AGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNSTL 95


                 ....*....
gi 444724463 365 VFEVELLKI 373
Cdd:COG0545   96 VFEVELLDV 104
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 101-182 1.26e-36

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 127.92  E-value: 1.26e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463   101 ATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQ-LGEMSLEEHSQCE 179
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQhLVEVSFEEHTKCE 80


                   ...
gi 444724463   180 CRP 182
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 101-183 1.91e-32

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 117.09  E-value: 1.91e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 101 ATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRY---PSSQLGEMSLEEHSQ 177
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPkrkPRSKLVEISFEEHTE 80


                 ....*.
gi 444724463 178 CECRPK 183
Cdd:cd00135   81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
103-180 3.04e-28

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 105.45  E-value: 3.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  103 CQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRY----PSSQLGEMSLEEHSQC 178
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYaprrPSPELVEVSFEEHVQC 80


                  ..
gi 444724463  179 EC 180
Cdd:pfam00341  81 EC 82
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 268-373 1.82e-23

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 96.79  E-value: 1.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 268 LQIGVKKRVDHcPIKSRKgDVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTgqVIKGWDQGLLGMCEGEKRKLVIPSEL 347
Cdd:PRK11570 104 LQFRVLTQGEG-AIPART-DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHEL 179

                         90       100
                 ....*....|....*....|....*.
gi 444724463 348 GYGERGAPPKIPGGATLVFEVELLKI 373
Cdd:PRK11570 180 AYGERGAGASIPPFSTLVFEVELLEI 205
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 76-185 6.45e-23

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 93.53  E-value: 6.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463  76 QASVTQTDAPghqKKVVSWIDVYARATCQPREVVVPLTVELMGSVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRM 155
Cdd:PHA02661  24 FSGSTGSSSA---SSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTV 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 444724463 156 QILMIRY-----PSSQLGEMSLEEHSQCECRPKQA 185
Cdd:PHA02661 101 TVMLTSVsgstgATSNFQTISVEEHTKCKCEFKTT 135
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 287-374 5.42e-22

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 94.06  E-value: 5.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 287 DVLHMHYTGKLEDGTEFDSSLPQNQPFVFSLGTgqVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGApPKIPGGATLVF 366
Cdd:PRK10902 165 DTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGV-PGIPANSTLVF 241


                 ....*...
gi 444724463 367 EVELLKIE 374
Cdd:PRK10902 242 DVELLDVK 249
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 285-352 8.70e-21

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 87.46  E-value: 8.70e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 444724463 285 KGDVLHMHYTGKLEDGTEFDSSlPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGER 352
Cdd:COG1047    3 KGDVVTLHYTLKLEDGEVFDST-FEGEPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYGER 69
PRK15095 PRK15095
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 291-352 1.57e-08

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 237908 [Multi-domain]  Cd Length: 156  Bit Score: 53.17  E-value: 1.57e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444724463 291 MHYTGKLEDGTEFDSSLPQNQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGER 352
Cdd:PRK15095  13 VHFTLKLDDGSTAESTRNNGKPALFRLGDGSLSEGLEQQLLGLKVGDKKTFSLEPEAAFGVP 74
Tig COG0544
FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, ...
 282-376 7.35e-07

FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440310 [Multi-domain]  Cd Length: 424  Bit Score: 50.90  E-value: 7.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444724463 282 KSRKGDVLHMHYTGKLeDGTEFDSSLPQNQPFVfsLGTGQVIKGWDQGLLGMCEGEKR--KLVIPSELGYGERgappkip 359
Cdd:COG0544  157 AAEEGDRVTIDFEGTI-DGEEFEGGKAEDYSLE--LGSGSFIPGFEEQLVGMKAGEEKtfEVTFPEDYHAEEL------- 226

                         90
                 ....*....|....*..
gi 444724463 360 GGATLVFEVELLKIERR 376
Cdd:COG0544  227 AGKTATFKVTVKEVKEK 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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