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Conserved domains on  [gi|557725336|dbj|GAD95993|]
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CRAL/TRIO domain protein [Paecilomyces variotii No. 5]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10510166)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to phosphatidylinositol transfer proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CRAL_TRIO pfam00650
CRAL/TRIO domain;
200-344 1.49e-49

CRAL/TRIO domain;


:

Pssm-ID: 425800 [Multi-domain]  Cd Length: 150  Bit Score: 166.65  E-value: 1.49e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  200 MGKSFVHGIDKEGRPISIVRVKTHKIGAHSNEAVEKFTVHQIETARLAL-QGNVETVVLIFDMTGFTLANMD---YQPVK 275
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVYVLERAILLMeEGQVEGLTVIIDMKGLSLSNMDwwpISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  276 FIIKCFEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYGVKD-LEKFIDRGNIIKELGG 344
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEeLEKYIPPEQLPKEYGG 150
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
102-153 8.59e-15

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


:

Pssm-ID: 427494  Cd Length: 53  Bit Score: 68.45  E-value: 8.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557725336  102 KDFQQTIADKTPEQLRQTLWaMVKKDHPDVLLLRFLRARKWDVNKAVIMLIS 153
Cdd:pfam03765   3 DELLELLKDEDEETDREKFW-LTREDHDDACLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
CRAL_TRIO pfam00650
CRAL/TRIO domain;
200-344 1.49e-49

CRAL/TRIO domain;


Pssm-ID: 425800 [Multi-domain]  Cd Length: 150  Bit Score: 166.65  E-value: 1.49e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  200 MGKSFVHGIDKEGRPISIVRVKTHKIGAHSNEAVEKFTVHQIETARLAL-QGNVETVVLIFDMTGFTLANMD---YQPVK 275
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVYVLERAILLMeEGQVEGLTVIIDMKGLSLSNMDwwpISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  276 FIIKCFEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYGVKD-LEKFIDRGNIIKELGG 344
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEeLEKYIPPEQLPKEYGG 150
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
195-347 7.10e-33

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 122.41  E-value: 7.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336   195 IAQYKMGKSFVHGIDKEGRPISIVRVKTHKIGAHSNEAVEKFTVHQIETA--RLALQGNVETVVLIFDMTGFTLANMDYQ 272
Cdd:smart00516   2 LELLKAYIPGGRGYDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKIlqEEKKTGGIEGFTVIFDLKGLSMSNPDLS 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557725336   273 PVKFIIKCFEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYG--VKDLEKFIDRGNIIKELGGDDP 347
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNdsKEELLEYIDKEQLPEELGGTLD 158
SEC14 cd00170
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae ...
204-344 1.78e-32

Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 238099 [Multi-domain]  Cd Length: 157  Bit Score: 121.34  E-value: 1.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336 204 FVHGIDKEGRPISIVRVKTHKI-GAHSNEAVEKFTVHQIETARLALQGNVETVVLIFDMTGFTLANM--DYQPVKFIIKC 280
Cdd:cd00170   12 YLGGRDKEGRPVLIIRAGNKDLsKSLDSEELLRYLVYTLEKLLQEDDEQVEGFVVIIDLKGLSLSHLlpDPSLLKKILKI 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557725336 281 FEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYG-VKDLEKFIDRGNIIKELGG 344
Cdd:cd00170   92 LQDNYPERLKAVYIINPPWFFKVLWKIVKPFLSEKTRKKIVFLGSdKEELLKYIDKEQLPEEYGG 156
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
102-153 8.59e-15

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 427494  Cd Length: 53  Bit Score: 68.45  E-value: 8.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557725336  102 KDFQQTIADKTPEQLRQTLWaMVKKDHPDVLLLRFLRARKWDVNKAVIMLIS 153
Cdd:pfam03765   3 DELLELLKDEDEETDREKFW-LTREDHDDACLLRFLRARKWDVEKAIKMLED 53
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
114-154 1.85e-10

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 56.02  E-value: 1.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 557725336   114 EQLRQTL---WAMVKKDHPDVLLLRFLRARKWDVNKAVIMLIST 154
Cdd:smart01100   5 EELRELLekhPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
CRAL_TRIO pfam00650
CRAL/TRIO domain;
200-344 1.49e-49

CRAL/TRIO domain;


Pssm-ID: 425800 [Multi-domain]  Cd Length: 150  Bit Score: 166.65  E-value: 1.49e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  200 MGKSFVHGIDKEGRPISIVRVKTHKIGAHSNEAVEKFTVHQIETARLAL-QGNVETVVLIFDMTGFTLANMD---YQPVK 275
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVYVLERAILLMeEGQVEGLTVIIDMKGLSLSNMDwwpISLLK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  276 FIIKCFEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYGVKD-LEKFIDRGNIIKELGG 344
Cdd:pfam00650  81 KIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEeLEKYIPPEQLPKEYGG 150
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
195-347 7.10e-33

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 122.41  E-value: 7.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336   195 IAQYKMGKSFVHGIDKEGRPISIVRVKTHKIGAHSNEAVEKFTVHQIETA--RLALQGNVETVVLIFDMTGFTLANMDYQ 272
Cdd:smart00516   2 LELLKAYIPGGRGYDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLEKIlqEEKKTGGIEGFTVIFDLKGLSMSNPDLS 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557725336   273 PVKFIIKCFEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYG--VKDLEKFIDRGNIIKELGGDDP 347
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNdsKEELLEYIDKEQLPEELGGTLD 158
SEC14 cd00170
Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae ...
204-344 1.78e-32

Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 238099 [Multi-domain]  Cd Length: 157  Bit Score: 121.34  E-value: 1.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336 204 FVHGIDKEGRPISIVRVKTHKI-GAHSNEAVEKFTVHQIETARLALQGNVETVVLIFDMTGFTLANM--DYQPVKFIIKC 280
Cdd:cd00170   12 YLGGRDKEGRPVLIIRAGNKDLsKSLDSEELLRYLVYTLEKLLQEDDEQVEGFVVIIDLKGLSLSHLlpDPSLLKKILKI 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557725336 281 FEANYPESLGFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYG-VKDLEKFIDRGNIIKELGG 344
Cdd:cd00170   92 LQDNYPERLKAVYIINPPWFFKVLWKIVKPFLSEKTRKKIVFLGSdKEELLKYIDKEQLPEEYGG 156
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
102-153 8.59e-15

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 427494  Cd Length: 53  Bit Score: 68.45  E-value: 8.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557725336  102 KDFQQTIADKTPEQLRQTLWaMVKKDHPDVLLLRFLRARKWDVNKAVIMLIS 153
Cdd:pfam03765   3 DELLELLKDEDEETDREKFW-LTREDHDDACLLRFLRARKWDVEKAIKMLED 53
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
114-154 1.85e-10

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 56.02  E-value: 1.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 557725336   114 EQLRQTL---WAMVKKDHPDVLLLRFLRARKWDVNKAVIMLIST 154
Cdd:smart01100   5 EELRELLekhPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
256-344 2.83e-04

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 404584  Cd Length: 140  Bit Score: 41.16  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557725336  256 VLIFDMTGFTLANmdYQPVKFIIKCFEA---NYPESL-GFILIHEAPWIFNSIWKIIRGWLDPVVAAKVNFTYGVKDLEK 331
Cdd:pfam13716  43 VVVVDHTGVTREN--FPSLSFLKKAYDLlprAFKKNLkAVYVVHPSTFLRTFLKTLGSLLGSKKLRKKVHYVSSLSELWE 120
                          90
                  ....*....|...
gi 557725336  332 FIDRGNIIKELGG 344
Cdd:pfam13716 121 GIDREQLPTELPG 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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