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Conserved domains on  [gi|2182310562|gb|KAH9283986|]
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SID1 transmembrane family member 1 [Echinococcus granulosus]

Protein Classification

SID1 transmembrane family member( domain architecture ID 10623302)

SID1 transmembrane family member similar to Caenorhabditis elegans systemic RNA interference defective protein 1 (SID1) that plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 171-1081 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


:

Pssm-ID: 464057  Cd Length: 599  Bit Score: 609.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  171 SEPQYFLFSLSKDIDSVIVHIHSTDKLCMTVSVQAAKCPVADILDTVKYSGVYQTVTTLGAITVSKVEQNITEFLVVLVL 250
Cdd:pfam13965    1 SEPQYFFYDFPQNVDSVIVKVTSDDDICAVVSIQDANCPVYDLDNNVAFNGRYQTFTKKAGITVQKKDIPSFKFFVVFVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  251 KPEDADCGGAaTVIKPGHNsipRVKNVTITVTPTLAGYHYHLPIYGAIGIYVIFYAATAIIILVypsydkqvqyyfnsfa 330
Cdd:pfam13965   81 KPDDSACSGS-LSRKPLPN---RTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVTFF---------------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  331 gsgihFNRRNLANASPPPQANYDSqimsvtyahspvegattraRHVVGPSTSLASMSQVSISTltptastshqrpppppl 410
Cdd:pfam13965  141 -----NYKRRRSENEDEGSGTLAS-------------------SHPIPPTCNSNSDSSVEEDS----------------- 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  411 lpppshslfssssssdlndvdagsthlqsavrrkckklrrppyialsplqrtkqhhrrsmsygstrdmalrevpgrverc 490
Cdd:pfam13965      --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  491 stcsrlslgleggagstfdggsvrasdsrgalngsrglptvrqvgegllalphlqiNIDPLADAQKDRKIYLHSRTLFVS 570
Cdd:pfam13965  180 --------------------------------------------------------DYDTLADIESDKNVVRTKAFLYVS 203

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  571 DLARKRYSTLDRKYLLYFWYLIIISIFYGLPVAQLVMTYQRALHDTGNEDICYYNFECAHPLGVFTAFNNIISNIGYVML 650
Cdd:pfam13965  204 DLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAHPLGELSAFNNIISNIGYVLL 283

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  651 GLLFLGLTARRDLMHRRTKKFrvrctrdlcaiaqfcrwlcphprrsngtsntatanciagvpderqggasspvpsvasft 730
Cdd:pfam13965  284 GLLFLLIVLRREILHRRNPIP----------------------------------------------------------- 304

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  731 apmitvtrcssrrlcsrlrltcchgstsetsdshppnedsiaalkdhqsndeddtggerEMAYGIPQHYGLFYAMGLALT 810
Cdd:pfam13965  305 -----------------------------------------------------------ATEYGIPKHFGLFYAMGLALI 325

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  811 MEGLLSACYHICPSFSNFQFDTAYMYILALILMLKIYQTRHPDINASAHSAYMVMAVVILAGVTGVLYGGET--FWVLFT 888
Cdd:pfam13965  326 MEGILSACYHVCPNYSNFQFDTSFMYVIAGLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNvrFWIAFS 405

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  889 IVFLTMSVWLTAEIYYMGQWNFDICLPRRLYNLMRSDGIH-CLTPMYMERMLLLLVANCVNIGIAAFGLFTRPRDFSSFL 967
Cdd:pfam13965  406 IIHVLASLCLSTQIYYMGRWKLDSGIFRRHLMILYTDCKKqCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYL 485

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  968 LSIFMINLLMYYFFYVIMKCRFRERFHCIPVLYILLACITWGSAIYFFIQHSTTWEVTPAQSRALNQPCIFLGFYDVHDV 1047
Cdd:pfam13965  486 LGIFIGNLILYLAFYIIMKLRSRERILPLALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDL 565

                          890       900       910
                   ....*....|....*....|....*....|....
gi 2182310562 1048 WHFLSSTSMFFSFMSIMTLDDDLINTPRSEIPVF 1081
Cdd:pfam13965  566 WHFLSAIALFFSFLVLLTLDDDLDNVPRDKIPVF 599
 
Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 171-1081 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 464057  Cd Length: 599  Bit Score: 609.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  171 SEPQYFLFSLSKDIDSVIVHIHSTDKLCMTVSVQAAKCPVADILDTVKYSGVYQTVTTLGAITVSKVEQNITEFLVVLVL 250
Cdd:pfam13965    1 SEPQYFFYDFPQNVDSVIVKVTSDDDICAVVSIQDANCPVYDLDNNVAFNGRYQTFTKKAGITVQKKDIPSFKFFVVFVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  251 KPEDADCGGAaTVIKPGHNsipRVKNVTITVTPTLAGYHYHLPIYGAIGIYVIFYAATAIIILVypsydkqvqyyfnsfa 330
Cdd:pfam13965   81 KPDDSACSGS-LSRKPLPN---RTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVTFF---------------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  331 gsgihFNRRNLANASPPPQANYDSqimsvtyahspvegattraRHVVGPSTSLASMSQVSISTltptastshqrpppppl 410
Cdd:pfam13965  141 -----NYKRRRSENEDEGSGTLAS-------------------SHPIPPTCNSNSDSSVEEDS----------------- 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  411 lpppshslfssssssdlndvdagsthlqsavrrkckklrrppyialsplqrtkqhhrrsmsygstrdmalrevpgrverc 490
Cdd:pfam13965      --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  491 stcsrlslgleggagstfdggsvrasdsrgalngsrglptvrqvgegllalphlqiNIDPLADAQKDRKIYLHSRTLFVS 570
Cdd:pfam13965  180 --------------------------------------------------------DYDTLADIESDKNVVRTKAFLYVS 203

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  571 DLARKRYSTLDRKYLLYFWYLIIISIFYGLPVAQLVMTYQRALHDTGNEDICYYNFECAHPLGVFTAFNNIISNIGYVML 650
Cdd:pfam13965  204 DLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAHPLGELSAFNNIISNIGYVLL 283

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  651 GLLFLGLTARRDLMHRRTKKFrvrctrdlcaiaqfcrwlcphprrsngtsntatanciagvpderqggasspvpsvasft 730
Cdd:pfam13965  284 GLLFLLIVLRREILHRRNPIP----------------------------------------------------------- 304

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  731 apmitvtrcssrrlcsrlrltcchgstsetsdshppnedsiaalkdhqsndeddtggerEMAYGIPQHYGLFYAMGLALT 810
Cdd:pfam13965  305 -----------------------------------------------------------ATEYGIPKHFGLFYAMGLALI 325

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  811 MEGLLSACYHICPSFSNFQFDTAYMYILALILMLKIYQTRHPDINASAHSAYMVMAVVILAGVTGVLYGGET--FWVLFT 888
Cdd:pfam13965  326 MEGILSACYHVCPNYSNFQFDTSFMYVIAGLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNvrFWIAFS 405

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  889 IVFLTMSVWLTAEIYYMGQWNFDICLPRRLYNLMRSDGIH-CLTPMYMERMLLLLVANCVNIGIAAFGLFTRPRDFSSFL 967
Cdd:pfam13965  406 IIHVLASLCLSTQIYYMGRWKLDSGIFRRHLMILYTDCKKqCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYL 485

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  968 LSIFMINLLMYYFFYVIMKCRFRERFHCIPVLYILLACITWGSAIYFFIQHSTTWEVTPAQSRALNQPCIFLGFYDVHDV 1047
Cdd:pfam13965  486 LGIFIGNLILYLAFYIIMKLRSRERILPLALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDL 565

                          890       900       910
                   ....*....|....*....|....*....|....
gi 2182310562 1048 WHFLSSTSMFFSFMSIMTLDDDLINTPRSEIPVF 1081
Cdd:pfam13965  566 WHFLSAIALFFSFLVLLTLDDDLDNVPRDKIPVF 599
 
Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 171-1081 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 464057  Cd Length: 599  Bit Score: 609.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  171 SEPQYFLFSLSKDIDSVIVHIHSTDKLCMTVSVQAAKCPVADILDTVKYSGVYQTVTTLGAITVSKVEQNITEFLVVLVL 250
Cdd:pfam13965    1 SEPQYFFYDFPQNVDSVIVKVTSDDDICAVVSIQDANCPVYDLDNNVAFNGRYQTFTKKAGITVQKKDIPSFKFFVVFVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  251 KPEDADCGGAaTVIKPGHNsipRVKNVTITVTPTLAGYHYHLPIYGAIGIYVIFYAATAIIILVypsydkqvqyyfnsfa 330
Cdd:pfam13965   81 KPDDSACSGS-LSRKPLPN---RTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVTFF---------------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  331 gsgihFNRRNLANASPPPQANYDSqimsvtyahspvegattraRHVVGPSTSLASMSQVSISTltptastshqrpppppl 410
Cdd:pfam13965  141 -----NYKRRRSENEDEGSGTLAS-------------------SHPIPPTCNSNSDSSVEEDS----------------- 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  411 lpppshslfssssssdlndvdagsthlqsavrrkckklrrppyialsplqrtkqhhrrsmsygstrdmalrevpgrverc 490
Cdd:pfam13965      --------------------------------------------------------------------------------

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  491 stcsrlslgleggagstfdggsvrasdsrgalngsrglptvrqvgegllalphlqiNIDPLADAQKDRKIYLHSRTLFVS 570
Cdd:pfam13965  180 --------------------------------------------------------DYDTLADIESDKNVVRTKAFLYVS 203

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  571 DLARKRYSTLDRKYLLYFWYLIIISIFYGLPVAQLVMTYQRALHDTGNEDICYYNFECAHPLGVFTAFNNIISNIGYVML 650
Cdd:pfam13965  204 DLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAHPLGELSAFNNIISNIGYVLL 283

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  651 GLLFLGLTARRDLMHRRTKKFrvrctrdlcaiaqfcrwlcphprrsngtsntatanciagvpderqggasspvpsvasft 730
Cdd:pfam13965  284 GLLFLLIVLRREILHRRNPIP----------------------------------------------------------- 304

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  731 apmitvtrcssrrlcsrlrltcchgstsetsdshppnedsiaalkdhqsndeddtggerEMAYGIPQHYGLFYAMGLALT 810
Cdd:pfam13965  305 -----------------------------------------------------------ATEYGIPKHFGLFYAMGLALI 325

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  811 MEGLLSACYHICPSFSNFQFDTAYMYILALILMLKIYQTRHPDINASAHSAYMVMAVVILAGVTGVLYGGET--FWVLFT 888
Cdd:pfam13965  326 MEGILSACYHVCPNYSNFQFDTSFMYVIAGLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNvrFWIAFS 405

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  889 IVFLTMSVWLTAEIYYMGQWNFDICLPRRLYNLMRSDGIH-CLTPMYMERMLLLLVANCVNIGIAAFGLFTRPRDFSSFL 967
Cdd:pfam13965  406 IIHVLASLCLSTQIYYMGRWKLDSGIFRRHLMILYTDCKKqCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYL 485

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2182310562  968 LSIFMINLLMYYFFYVIMKCRFRERFHCIPVLYILLACITWGSAIYFFIQHSTTWEVTPAQSRALNQPCIFLGFYDVHDV 1047
Cdd:pfam13965  486 LGIFIGNLILYLAFYIIMKLRSRERILPLALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDL 565

                          890       900       910
                   ....*....|....*....|....*....|....
gi 2182310562 1048 WHFLSSTSMFFSFMSIMTLDDDLINTPRSEIPVF 1081
Cdd:pfam13965  566 WHFLSAIALFFSFLVLLTLDDDLDNVPRDKIPVF 599
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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